We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P51538 (CP3A9_RAT)
Protein
Cytochrome P450 3A9
Gene
Cyp3a9
Organism
Rattus norvegicus (Rat)
Status
Functioni
This isozyme seems to be implicated in olfaction. Active in the demethylation of erythromycin as well as benzphetamine.
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 442 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- estrogen 16-alpha-hydroxylase activity Source: RGD
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB
- oxidoreductase activity Source: RGD
- retinoic acid 4-hydroxylase activity Source: RGD
- steroid hydroxylase activity Source: GO_Central
- testosterone 6-beta-hydroxylase activity Source: GO_Central
GO - Biological processi
- alkaloid catabolic process Source: RGD
- estrogen metabolic process Source: RGD
- female pregnancy Source: RGD
- lipid hydroxylation Source: RGD
- oxidative demethylation Source: RGD
- positive regulation of gene expression Source: RGD
- response to dexamethasone Source: RGD
- response to estradiol Source: RGD
- response to estrogen Source: RGD
- response to ethanol Source: RGD
- response to zinc ion Source: RGD
- retinoic acid metabolic process Source: RGD
- sensory perception of smell Source: UniProtKB-KW
- steroid metabolic process Source: RGD
- xenobiotic catabolic process Source: RGD
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Olfaction, Sensory transduction |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-RNO-211958, Miscellaneous substrates R-RNO-211981, Xenobiotics |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 3A9 (EC:1.14.14.1)Alternative name(s): 3AH15 CYPIIIA9 Cytochrome P450 olfactive 3 Cytochrome P450-OLF3 |
Gene namesi | Name:Cyp3a9 Synonyms:Cyp3a13 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708392, Cyp3a9 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051792 | 1 – 503 | Cytochrome P450 3A9Add BLAST | 503 |
Expressioni
Tissue specificityi
Mainly expressed in olfactory epithelium.
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
InParanoidi | P51538 |
PhylomeDBi | P51538 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P51538-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLIPNFSME TWLLLVISLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI
60 70 80 90 100
LAYRKGFWEF DKYCHKKYGK LWGLYDGRQP VLAITDPDII KTVLVKECYS
110 120 130 140 150
TFTNRRNFGP VGILKKAISI SEDEEWKRIR ALLSPTFTSG KLKEMFPIIN
160 170 180 190 200
QYTDMLVRNM RQGSEEGKPT SMKDIFGAYS MDVITATSFG VNVDSLNNPQ
210 220 230 240 250
DPFVEKVKKL LKFDIFDPLF LSVTLFPFLT PLFEALNVSM FPRDVIDFFK
260 270 280 290 300
TSVERMKENR MKEKEKQRMD FLQLMINSQN SKVKDSHKAL SDVEIVAQSV
310 320 330 340 350
IFIFAGYETT SSALSFVLYL LAIHPDIQKK LQDEIDAALP NKAHATYDTL
360 370 380 390 400
LQMEYLDMVV NETLRLYPIA GRLERVCKTD VEINGVFIPK GTVVMIPTFA
410 420 430 440 450
LHKDPHYWPE PEEFRPERFS KKNQDNINPY MYLPFGNGPR NCIGMRFALM
460 470 480 490 500
NMKVALFRVL QNFSFQPCKE TQIPLKLSKQ GLLQPEKPLL LKVVSRDETV
NGA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0RDI0 | M0RDI0_RAT | Cytochrome P450 3A | Cyp3a9 | 503 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 457 | F → V in AAC52582 (PubMed:8660328).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U60085 mRNA Translation: AAB03662.1 U46118 mRNA Translation: AAC52582.1 |
PIRi | JC4702 |
Genome annotation databases
UCSCi | RGD:708392, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U60085 mRNA Translation: AAB03662.1 U46118 mRNA Translation: AAC52582.1 |
PIRi | JC4702 |
3D structure databases
SMRi | P51538 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067681 |
Chemistry databases
ChEMBLi | CHEMBL3430866 |
Genome annotation databases
UCSCi | RGD:708392, rat |
Organism-specific databases
RGDi | 708392, Cyp3a9 |
Phylogenomic databases
InParanoidi | P51538 |
PhylomeDBi | P51538 |
Enzyme and pathway databases
Reactomei | R-RNO-211958, Miscellaneous substrates R-RNO-211981, Xenobiotics |
Miscellaneous databases
PROi | PR:P51538 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP3A9_RAT | |
Accessioni | P51538Primary (citable) accession number: P51538 Secondary accession number(s): Q64557, Q64631 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families