UniProtKB - P51530 (DNA2_HUMAN)
Protein
DNA replication ATP-dependent helicase/nuclease DNA2
Gene
DNA2
Organism
Homo sapiens (Human)
Status
Functioni
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.8 Publications
Catalytic activityi
- EC:3.6.4.121 Publication
Cofactori
[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 136 | Iron-sulfur (4Fe-4S)By similarity | 1 | |
Metal bindingi | 393 | Iron-sulfur (4Fe-4S)By similarity | 1 | |
Metal bindingi | 396 | Iron-sulfur (4Fe-4S)By similarity | 1 | |
Metal bindingi | 402 | Iron-sulfur (4Fe-4S)By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 648 – 655 | ATPSequence analysis | 8 |
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- 5'-3' DNA helicase activity Source: UniProtKB
- 5'-flap endonuclease activity Source: UniProtKB
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB
- DNA helicase activity Source: UniProtKB
- helicase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- nuclease activity Source: UniProtKB
- RNA binding Source: GO_Central
- single-stranded DNA helicase activity Source: UniProtKB
- site-specific endodeoxyribonuclease activity, specific for altered base Source: UniProtKB
GO - Biological processi
- base-excision repair Source: UniProtKB
- DNA double-strand break processing Source: UniProtKB
- DNA replication Source: UniProtKB
- DNA replication, Okazaki fragment processing Source: UniProtKB
- DNA replication, removal of RNA primer Source: UniProtKB
- DNA replication checkpoint Source: UniProtKB
- G-quadruplex DNA unwinding Source: BHF-UCL
- mitochondrial DNA repair Source: UniProtKB
- mitochondrial DNA replication Source: UniProtKB
- mitotic telomere maintenance via semi-conservative replication Source: BHF-UCL
- nucleic acid phosphodiester bond hydrolysis Source: BHF-UCL
- positive regulation of DNA replication Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: Reactome
- replication fork reversal Source: GO_Central
- t-circle formation Source: BHF-UCL
- telomere maintenance Source: BHF-UCL
- telomere maintenance via semi-conservative replication Source: Reactome
Keywordsi
Molecular function | DNA-binding, Endonuclease, Helicase, Hydrolase, Multifunctional enzyme, Nuclease |
Biological process | DNA damage, DNA repair, DNA replication |
Ligand | 4Fe-4S, ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P51530 |
Reactomei | R-HSA-174437, Removal of the Flap Intermediate from the C-strand R-HSA-5685938, HDR through Single Strand Annealing (SSA) R-HSA-5685942, HDR through Homologous Recombination (HRR) R-HSA-5693554, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693579, Homologous DNA Pairing and Strand Exchange R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-69166, Removal of the Flap Intermediate R-HSA-69473, G2/M DNA damage checkpoint |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DNA2 Synonyms:DNA2L, KIAA0083 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2939, DNA2 |
MIMi | 601810, gene |
neXtProti | NX_P51530 |
VEuPathDBi | HostDB:ENSG00000138346.14 |
Subcellular locationi
Mitochondrion
- mitochondrial nucleoid Source: UniProtKB
- mitochondrion Source: HPA
Nucleus
- nuclear chromosome, telomeric region Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 6 (PEOA6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by muscle weakness, mainly affecting the lower limbs, external ophthalmoplegia, exercise intolerance, and mitochondrial DNA deletions on muscle biopsy. Symptoms may appear in childhood or adulthood and show slow progression.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069905 | 198 | R → H in PEOA6; the mutant protein has a complete loss of nuclease activity and severely impaired helicase activity; consistent with a loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs1272393477Ensembl. | 1 | |
Natural variantiVAR_069906 | 227 | K → E in PEOA6; the mutant protein has significantly reduced nuclease and helicase activity; consistent with a loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs760412883Ensembl. | 1 | |
Natural variantiVAR_069907 | 637 | V → I in PEOA6; the mutant protein has decreased nuclease activity (30% of wild-type) and enhanced helicase activity; consistent with a loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs746522359EnsemblClinVar. | 1 |
Seckel syndrome 8 (SCKL8)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 277 | D → A: Abolishes ability to resect DNA in present of BLM. 3 Publications | 1 | |
Mutagenesisi | 654 | K → E: Abolishes ability to unwind DNA, while it does not affect ability to resect DNA. 4 Publications | 1 |
Keywords - Diseasei
Disease variant, Dwarfism, Mental retardation, Primary mitochondrial disease, Progressive external ophthalmoplegiaOrganism-specific databases
DisGeNETi | 1763 |
MalaCardsi | DNA2 |
MIMi | 615156, phenotype 615807, phenotype |
OpenTargetsi | ENSG00000138346 |
Orphaneti | 352470, DNA2-related mitochondrial DNA deletion syndrome |
Miscellaneous databases
Pharosi | P51530, Tbio |
Genetic variation databases
BioMutai | DNA2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080712 | 1 – 1060 | DNA replication ATP-dependent helicase/nuclease DNA2Add BLAST | 1060 |
Post-translational modificationi
Acetylated by EP300, leading to stimulate the 5'-3' endonuclease, the 5'-3' helicase and DNA-dependent ATPase activities, possibly by increasing DNA substrate affinity.1 Publication
Keywords - PTMi
AcetylationProteomic databases
EPDi | P51530 |
jPOSTi | P51530 |
MassIVEi | P51530 |
MaxQBi | P51530 |
PaxDbi | P51530 |
PeptideAtlasi | P51530 |
PRIDEi | P51530 |
ProteomicsDBi | 56322 [P51530-1] 56323 [P51530-2] 56324 [P51530-3] |
PTM databases
iPTMneti | P51530 |
PhosphoSitePlusi | P51530 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138346, Expressed in kidney and 161 other tissues |
ExpressionAtlasi | P51530, baseline and differential |
Genevisiblei | P51530, HS |
Organism-specific databases
HPAi | ENSG00000138346, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Interacts with BLM and WDHD1.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 108103, 55 interactors |
IntActi | P51530, 22 interactors |
STRINGi | 9606.ENSP00000351185 |
Miscellaneous databases
RNActi | P51530, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P51530 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 81 – 519 | Nuclease activityBy similarityAdd BLAST | 439 | |
Regioni | 520 – 1060 | Helicase activityBy similarityAdd BLAST | 541 |
Sequence similaritiesi
Belongs to the DNA2/NAM7 helicase family.Curated
Phylogenomic databases
eggNOGi | KOG1805, Eukaryota |
GeneTreei | ENSGT00780000122010 |
HOGENOMi | CLU_001666_2_0_1 |
InParanoidi | P51530 |
OMAi | IEEDIWS |
OrthoDBi | 633768at2759 |
PhylomeDBi | P51530 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
InterProi | View protein in InterPro IPR026851, Dna2 IPR041679, DNA2/NAM7-like_C IPR041677, DNA2/NAM7_AAA_11 IPR014808, DNA_replication_fac_Dna2_N IPR027417, P-loop_NTPase |
PANTHERi | PTHR10887:SF433, PTHR10887:SF433, 1 hit |
Pfami | View protein in Pfam PF13086, AAA_11, 2 hits PF13087, AAA_12, 1 hit PF08696, Dna2, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P51530-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQLNELELL MEKSFWEEAE LPAELFQKKV VASFPRTVLS TGMDNRYLVL
60 70 80 90 100
AVNTVQNKEG NCEKRLVITA SQSLENKELC ILRNDWCSVP VEPGDIIHLE
110 120 130 140 150
GDCTSDTWII DKDFGYLILY PDMLISGTSI ASSIRCMRRA VLSETFRSSD
160 170 180 190 200
PATRQMLIGT VLHEVFQKAI NNSFAPEKLQ ELAFQTIQEI RHLKEMYRLN
210 220 230 240 250
LSQDEIKQEV EDYLPSFCKW AGDFMHKNTS TDFPQMQLSL PSDNSKDNST
260 270 280 290 300
CNIEVVKPMD IEESIWSPRF GLKGKIDVTV GVKIHRGYKT KYKIMPLELK
310 320 330 340 350
TGKESNSIEH RSQVVLYTLL SQERRADPEA GLLLYLKTGQ MYPVPANHLD
360 370 380 390 400
KRELLKLRNQ MAFSLFHRIS KSATRQKTQL ASLPQIIEEE KTCKYCSQIG
410 420 430 440 450
NCALYSRAVE QQMDCSSVPI VMLPKIEEET QHLKQTHLEY FSLWCLMLTL
460 470 480 490 500
ESQSKDNKKN HQNIWLMPAS EMEKSGSCIG NLIRMEHVKI VCDGQYLHNF
510 520 530 540 550
QCKHGAIPVT NLMAGDRVIV SGEERSLFAL SRGYVKEINM TTVTCLLDRN
560 570 580 590 600
LSVLPESTLF RLDQEEKNCD IDTPLGNLSK LMENTFVSKK LRDLIIDFRE
610 620 630 640 650
PQFISYLSSV LPHDAKDTVA CILKGLNKPQ RQAMKKVLLS KDYTLIVGMP
660 670 680 690 700
GTGKTTTICT LVRILYACGF SVLLTSYTHS AVDNILLKLA KFKIGFLRLG
710 720 730 740 750
QIQKVHPAIQ QFTEQEICRS KSIKSLALLE ELYNSQLIVA TTCMGINHPI
760 770 780 790 800
FSRKIFDFCI VDEASQISQP ICLGPLFFSR RFVLVGDHQQ LPPLVLNREA
810 820 830 840 850
RALGMSESLF KRLEQNKSAV VQLTVQYRMN SKIMSLSNKL TYEGKLECGS
860 870 880 890 900
DKVANAVINL RHFKDVKLEL EFYADYSDNP WLMGVFEPNN PVCFLNTDKV
910 920 930 940 950
PAPEQVEKGG VSNVTEAKLI VFLTSIFVKA GCSPSDIGII APYRQQLKII
960 970 980 990 1000
NDLLARSIGM VEVNTVDKYQ GRDKSIVLVS FVRSNKDGTV GELLKDWRRL
1010 1020 1030 1040 1050
NVAITRAKHK LILLGCVPSL NCYPPLEKLL NHLNSEKLII DLPSREHESL
1060
CHILGDFQRE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VR31 | F8VR31_HUMAN | DNA replication ATP-dependent helic... | DNA2 | 867 | Annotation score: | ||
H0Y455 | H0Y455_HUMAN | DNA replication ATP-dependent helic... | DNA2 | 375 | Annotation score: | ||
F8VPM6 | F8VPM6_HUMAN | DNA replication ATP-dependent helic... | DNA2 | 39 | Annotation score: |
Sequence cautioni
The sequence AAH28188 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH63664 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA07647 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 986 | K → N in AAH28188 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069905 | 198 | R → H in PEOA6; the mutant protein has a complete loss of nuclease activity and severely impaired helicase activity; consistent with a loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs1272393477Ensembl. | 1 | |
Natural variantiVAR_069906 | 227 | K → E in PEOA6; the mutant protein has significantly reduced nuclease and helicase activity; consistent with a loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs760412883Ensembl. | 1 | |
Natural variantiVAR_069907 | 637 | V → I in PEOA6; the mutant protein has decreased nuclease activity (30% of wild-type) and enhanced helicase activity; consistent with a loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs746522359EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021869 | 663 – 900 | Missing in isoform 3. 1 PublicationAdd BLAST | 238 | |
Alternative sequenceiVSP_021870 | 664 – 687 | ILYAC…DNILL → FRRFIQLSSNLQSKKFADQS PLNP in isoform 2. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_021871 | 688 – 1060 | Missing in isoform 2. 1 PublicationAdd BLAST | 373 | |
Alternative sequenceiVSP_044185 | 1040 – 1060 | IDLPS…DFQRE → SFFFCIWSHLIAL in isoform 4. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D42046 mRNA Translation: BAA07647.1 Different initiation. AL136233 Genomic DNA No translation available. BC041115 mRNA Translation: AAH41115.1 BC053574 mRNA Translation: AAH53574.1 BC063664 mRNA Translation: AAH63664.1 Different initiation. BC111740 mRNA Translation: AAI11741.1 BC028188 mRNA Translation: AAH28188.1 Different initiation. |
CCDSi | CCDS44415.2 [P51530-1] |
PIRi | T50697 |
RefSeqi | NP_001073918.2, NM_001080449.2 [P51530-1] |
Genome annotation databases
Ensembli | ENST00000358410; ENSP00000351185; ENSG00000138346 [P51530-1] ENST00000399179; ENSP00000382132; ENSG00000138346 [P51530-2] ENST00000399180; ENSP00000382133; ENSG00000138346 [P51530-2] |
GeneIDi | 1763 |
KEGGi | hsa:1763 |
UCSCi | uc057tqx.1, human [P51530-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D42046 mRNA Translation: BAA07647.1 Different initiation. AL136233 Genomic DNA No translation available. BC041115 mRNA Translation: AAH41115.1 BC053574 mRNA Translation: AAH53574.1 BC063664 mRNA Translation: AAH63664.1 Different initiation. BC111740 mRNA Translation: AAI11741.1 BC028188 mRNA Translation: AAH28188.1 Different initiation. |
CCDSi | CCDS44415.2 [P51530-1] |
PIRi | T50697 |
RefSeqi | NP_001073918.2, NM_001080449.2 [P51530-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5EAY | X-ray | 1.55 | E/F/G/H | 5-17 | [»] | |
SMRi | P51530 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108103, 55 interactors |
IntActi | P51530, 22 interactors |
STRINGi | 9606.ENSP00000351185 |
PTM databases
iPTMneti | P51530 |
PhosphoSitePlusi | P51530 |
Genetic variation databases
BioMutai | DNA2 |
Proteomic databases
EPDi | P51530 |
jPOSTi | P51530 |
MassIVEi | P51530 |
MaxQBi | P51530 |
PaxDbi | P51530 |
PeptideAtlasi | P51530 |
PRIDEi | P51530 |
ProteomicsDBi | 56322 [P51530-1] 56323 [P51530-2] 56324 [P51530-3] |
Protocols and materials databases
Antibodypediai | 28503, 138 antibodies |
Genome annotation databases
Ensembli | ENST00000358410; ENSP00000351185; ENSG00000138346 [P51530-1] ENST00000399179; ENSP00000382132; ENSG00000138346 [P51530-2] ENST00000399180; ENSP00000382133; ENSG00000138346 [P51530-2] |
GeneIDi | 1763 |
KEGGi | hsa:1763 |
UCSCi | uc057tqx.1, human [P51530-1] |
Organism-specific databases
CTDi | 1763 |
DisGeNETi | 1763 |
GeneCardsi | DNA2 |
HGNCi | HGNC:2939, DNA2 |
HPAi | ENSG00000138346, Tissue enriched (lymphoid) |
MalaCardsi | DNA2 |
MIMi | 601810, gene 615156, phenotype 615807, phenotype |
neXtProti | NX_P51530 |
OpenTargetsi | ENSG00000138346 |
Orphaneti | 352470, DNA2-related mitochondrial DNA deletion syndrome |
VEuPathDBi | HostDB:ENSG00000138346.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1805, Eukaryota |
GeneTreei | ENSGT00780000122010 |
HOGENOMi | CLU_001666_2_0_1 |
InParanoidi | P51530 |
OMAi | IEEDIWS |
OrthoDBi | 633768at2759 |
PhylomeDBi | P51530 |
Enzyme and pathway databases
PathwayCommonsi | P51530 |
Reactomei | R-HSA-174437, Removal of the Flap Intermediate from the C-strand R-HSA-5685938, HDR through Single Strand Annealing (SSA) R-HSA-5685942, HDR through Homologous Recombination (HRR) R-HSA-5693554, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693579, Homologous DNA Pairing and Strand Exchange R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-5693616, Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-69166, Removal of the Flap Intermediate R-HSA-69473, G2/M DNA damage checkpoint |
Miscellaneous databases
BioGRID-ORCSi | 1763, 30 hits in 111 CRISPR screens |
ChiTaRSi | DNA2, human |
GeneWikii | DNA2L |
GenomeRNAii | 1763 |
Pharosi | P51530, Tbio |
PROi | PR:P51530 |
RNActi | P51530, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138346, Expressed in kidney and 161 other tissues |
ExpressionAtlasi | P51530, baseline and differential |
Genevisiblei | P51530, HS |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
InterProi | View protein in InterPro IPR026851, Dna2 IPR041679, DNA2/NAM7-like_C IPR041677, DNA2/NAM7_AAA_11 IPR014808, DNA_replication_fac_Dna2_N IPR027417, P-loop_NTPase |
PANTHERi | PTHR10887:SF433, PTHR10887:SF433, 1 hit |
Pfami | View protein in Pfam PF13086, AAA_11, 2 hits PF13087, AAA_12, 1 hit PF08696, Dna2, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNA2_HUMAN | |
Accessioni | P51530Primary (citable) accession number: P51530 Secondary accession number(s): Q2NKM1 Q8N346 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families