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UniProtKB - P51523 (ZNF84_HUMAN)

Entry version 180 (02 Dec 2020)
Sequence version 2 (02 May 2006)
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Protein

Zinc finger protein 84

Gene

ZNF84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri207 – 229C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri711 – 733C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P51523

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 84
Alternative name(s):
Zinc finger protein HPF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF84
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000198040.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:13159, ZNF84

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618554, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P51523

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7637

Open Targets

More...OpenTargetsi		ENSG00000198040

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37732

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P51523, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF84

Domain mapping of disease mutations (DMDM)

More...DMDMi		94730445

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473971 – 738Zinc finger protein 84Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei128PhosphoserineCombined sources1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P51523

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P51523

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P51523

MaxQB - The MaxQuant DataBase

More...MaxQBi		P51523

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P51523

PeptideAtlas

More...PeptideAtlasi		P51523

PRoteomics IDEntifications database

More...PRIDEi		P51523

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56321

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P51523

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P51523

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198040, Expressed in kidney and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P51523, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P51523, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198040, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113453, 7 interactors

Protein interaction database and analysis system

More...IntActi		P51523, 11 interactors

Molecular INTeraction database

More...MINTi		P51523

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000331465

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P51523, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P51523

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 229C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri711 – 733C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162931

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P51523

Identification of Orthologs from Complete Genome Data

More...OMAi		LKYYECD

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P51523

TreeFam database of animal gene trees

More...TreeFami		TF337898

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 19 hits
PS50157, ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P51523-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE 
        60         70         80         90        100
VMKPDVIFKL EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI 
       110        120        130        140        150
IKRGHECDAF GKNFNLNMNF VPLRKSNSEG DLDGLILKHH LDLLIPKGDY 
       160        170        180        190        200
GKAESDDFNV FDNFFLHSKP EDTDTWLKYY DCDKYKESYK KSQIIIYHRN 
       210        220        230        240        250
RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC GKTFPQKSQF 
       260        270        280        290        300
ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF 
       310        320        330        340        350
SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR 
       360        370        380        390        400
ECGKAFSRKS QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE 
       410        420        430        440        450
KPYECSECRK AFRERSSLIN HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ 
       460        470        480        490        500
MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT HTGEKPYECS ECGKAFSEKL 
       510        520        530        540        550
SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE KPYECSECGK 
       560        570        580        590        600
AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE 
       610        620        630        640        650
CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT 
       660        670        680        690        700
GEKPFECSEC GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN 
       710        720        730 
HQRIHTGEKP YRCIECGKAF SQKSQLINHQ RTHTVKKS
Length:738
Mass (Da):85,457
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE682053680438D5F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H1B1F5H1B1_HUMAN
Zinc finger protein 84
ZNF84
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H630F5H630_HUMAN
Zinc finger protein 84
ZNF84
737Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3F5F5H3F5_HUMAN
Zinc finger protein 84
ZNF84
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6X5F5H6X5_HUMAN
Zinc finger protein 84
ZNF84
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0T0F5H0T0_HUMAN
Zinc finger protein 84
ZNF84
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1R3F5H1R3_HUMAN
Zinc finger protein 84
ZNF84
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQ53J3KQ53_HUMAN
Zinc finger protein 84
ZNF84
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62Q → E in AAA79359 (PubMed:2505992).Curated1
Sequence conflicti594T → A in AAH36656 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M27878 mRNA Translation: AAA79359.1
X60156 mRNA Translation: CAB94232.2
AK314232 mRNA Translation: BAG36902.1
CH471218 Genomic DNA Translation: EAW54799.1
CH471218 Genomic DNA Translation: EAW54801.1
CH471218 Genomic DNA Translation: EAW54802.1
BC036656 mRNA Translation: AAH36656.1
BC048350 mRNA Translation: AAH48350.2
BC062552 mRNA Translation: AAH62552.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31940.1

Protein sequence database of the Protein Information Resource

More...PIRi		B32891

NCBI Reference Sequences

More...RefSeqi		NP_001120844.1, NM_001127372.2
NP_001276900.1, NM_001289971.1
NP_001276901.1, NM_001289972.1
NP_003419.3, NM_003428.5
XP_005266242.1, XM_005266185.1
XP_005266243.1, XM_005266186.1
XP_011533134.1, XM_011534832.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327668; ENSP00000331465; ENSG00000198040
ENST00000392319; ENSP00000376133; ENSG00000198040
ENST00000539354; ENSP00000445549; ENSG00000198040

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7637

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7637

UCSC genome browser

More...UCSCi		uc001ulm.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27878 mRNA Translation: AAA79359.1
X60156 mRNA Translation: CAB94232.2
AK314232 mRNA Translation: BAG36902.1
CH471218 Genomic DNA Translation: EAW54799.1
CH471218 Genomic DNA Translation: EAW54801.1
CH471218 Genomic DNA Translation: EAW54802.1
BC036656 mRNA Translation: AAH36656.1
BC048350 mRNA Translation: AAH48350.2
BC062552 mRNA Translation: AAH62552.1
CCDSiCCDS31940.1
PIRiB32891
RefSeqiNP_001120844.1, NM_001127372.2
NP_001276900.1, NM_001289971.1
NP_001276901.1, NM_001289972.1
NP_003419.3, NM_003428.5
XP_005266242.1, XM_005266185.1
XP_005266243.1, XM_005266186.1
XP_011533134.1, XM_011534832.1

3D structure databases

SMRiP51523
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113453, 7 interactors
IntActiP51523, 11 interactors
MINTiP51523
STRINGi9606.ENSP00000331465

PTM databases

iPTMnetiP51523
PhosphoSitePlusiP51523

Polymorphism and mutation databases

BioMutaiZNF84
DMDMi94730445

Proteomic databases

EPDiP51523
jPOSTiP51523
MassIVEiP51523
MaxQBiP51523
PaxDbiP51523
PeptideAtlasiP51523
PRIDEiP51523
ProteomicsDBi56321

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19535, 34 antibodies

Genome annotation databases

EnsembliENST00000327668; ENSP00000331465; ENSG00000198040
ENST00000392319; ENSP00000376133; ENSG00000198040
ENST00000539354; ENSP00000445549; ENSG00000198040
GeneIDi7637
KEGGihsa:7637
UCSCiuc001ulm.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7637
DisGeNETi7637
EuPathDBiHostDB:ENSG00000198040.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF84
HGNCiHGNC:13159, ZNF84
HPAiENSG00000198040, Low tissue specificity
MIMi618554, gene
neXtProtiNX_P51523
OpenTargetsiENSG00000198040
PharmGKBiPA37732

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162931
InParanoidiP51523
OMAiLKYYECD
OrthoDBi1318335at2759
PhylomeDBiP51523
TreeFamiTF337898

Enzyme and pathway databases

PathwayCommonsiP51523

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7637, 35 hits in 861 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF84, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7637
PharosiP51523, Tdark

Protein Ontology

More...PROi		PR:P51523
RNActiP51523, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198040, Expressed in kidney and 230 other tissues
ExpressionAtlasiP51523, baseline and differential
GenevisibleiP51523, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 19 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 19 hits
PS50157, ZINC_FINGER_C2H2_2, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF84_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51523
Secondary accession number(s): B2RAK5
, D3DXJ1, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 2, 2006
Last modified: December 2, 2020
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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