UniProtKB - P51523 (ZNF84_HUMAN)
Protein
Zinc finger protein 84
Gene
ZNF84
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 207 – 229 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 235 – 257 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 263 – 285 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 291 – 313 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 319 – 341 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 347 – 369 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 375 – 397 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 403 – 425 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 431 – 453 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 459 – 481 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 487 – 509 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 515 – 537 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 543 – 565 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 571 – 593 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 599 – 621 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 627 – 649 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 655 – 677 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 683 – 705 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 711 – 733 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P51523 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 84Alternative name(s): Zinc finger protein HPF2 |
Gene namesi | Name:ZNF84 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198040.10 |
HGNCi | HGNC:13159, ZNF84 |
MIMi | 618554, gene |
neXtProti | NX_P51523 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7637 |
OpenTargetsi | ENSG00000198040 |
PharmGKBi | PA37732 |
Miscellaneous databases
Pharosi | P51523, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF84 |
DMDMi | 94730445 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047397 | 1 – 738 | Zinc finger protein 84Add BLAST | 738 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 112 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 125 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 128 | PhosphoserineCombined sources | 1 | |
Cross-linki | 191 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 457 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P51523 |
jPOSTi | P51523 |
MassIVEi | P51523 |
MaxQBi | P51523 |
PaxDbi | P51523 |
PeptideAtlasi | P51523 |
PRIDEi | P51523 |
ProteomicsDBi | 56321 |
PTM databases
iPTMneti | P51523 |
PhosphoSitePlusi | P51523 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198040, Expressed in kidney and 230 other tissues |
ExpressionAtlasi | P51523, baseline and differential |
Genevisiblei | P51523, HS |
Organism-specific databases
HPAi | ENSG00000198040, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP51523
With | #Exp. | IntAct |
---|---|---|
HSF2BP [O75031] | 3 | EBI-2849074,EBI-7116203 |
LMO1 [P25800] | 3 | EBI-2849074,EBI-8639312 |
LMO3 - isoform 4 [Q8TAP4-4] | 3 | EBI-2849074,EBI-11742507 |
SPANXN2 [Q5MJ10] | 3 | EBI-2849074,EBI-12023934 |
Protein-protein interaction databases
BioGRIDi | 113453, 7 interactors |
IntActi | P51523, 11 interactors |
MINTi | P51523 |
STRINGi | 9606.ENSP00000331465 |
Miscellaneous databases
RNActi | P51523, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 79 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 207 – 229 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 235 – 257 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 263 – 285 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 291 – 313 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 319 – 341 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 347 – 369 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 375 – 397 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 403 – 425 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 431 – 453 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 459 – 481 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 487 – 509 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 515 – 537 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 543 – 565 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 571 – 593 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 599 – 621 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 627 – 649 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 655 – 677 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 683 – 705 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 711 – 733 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162931 |
InParanoidi | P51523 |
OMAi | LKYYECD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P51523 |
TreeFami | TF337898 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 18 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 19 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 19 hits PS50157, ZINC_FINGER_C2H2_2, 19 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
P51523-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE
60 70 80 90 100
VMKPDVIFKL EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI
110 120 130 140 150
IKRGHECDAF GKNFNLNMNF VPLRKSNSEG DLDGLILKHH LDLLIPKGDY
160 170 180 190 200
GKAESDDFNV FDNFFLHSKP EDTDTWLKYY DCDKYKESYK KSQIIIYHRN
210 220 230 240 250
RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC GKTFPQKSQF
260 270 280 290 300
ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF
310 320 330 340 350
SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR
360 370 380 390 400
ECGKAFSRKS QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE
410 420 430 440 450
KPYECSECRK AFRERSSLIN HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ
460 470 480 490 500
MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT HTGEKPYECS ECGKAFSEKL
510 520 530 540 550
SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE KPYECSECGK
560 570 580 590 600
AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE
610 620 630 640 650
CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT
660 670 680 690 700
GEKPFECSEC GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN
710 720 730
HQRIHTGEKP YRCIECGKAF SQKSQLINHQ RTHTVKKS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H1B1 | F5H1B1_HUMAN | Zinc finger protein 84 | ZNF84 | 236 | Annotation score: | ||
F5H630 | F5H630_HUMAN | Zinc finger protein 84 | ZNF84 | 737 | Annotation score: | ||
F5H3F5 | F5H3F5_HUMAN | Zinc finger protein 84 | ZNF84 | 145 | Annotation score: | ||
F5H6X5 | F5H6X5_HUMAN | Zinc finger protein 84 | ZNF84 | 84 | Annotation score: | ||
F5H0T0 | F5H0T0_HUMAN | Zinc finger protein 84 | ZNF84 | 55 | Annotation score: | ||
F5H1R3 | F5H1R3_HUMAN | Zinc finger protein 84 | ZNF84 | 78 | Annotation score: | ||
J3KQ53 | J3KQ53_HUMAN | Zinc finger protein 84 | ZNF84 | 69 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | Q → E in AAA79359 (PubMed:2505992).Curated | 1 | |
Sequence conflicti | 594 | T → A in AAH36656 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27878 mRNA Translation: AAA79359.1 X60156 mRNA Translation: CAB94232.2 AK314232 mRNA Translation: BAG36902.1 CH471218 Genomic DNA Translation: EAW54799.1 CH471218 Genomic DNA Translation: EAW54801.1 CH471218 Genomic DNA Translation: EAW54802.1 BC036656 mRNA Translation: AAH36656.1 BC048350 mRNA Translation: AAH48350.2 BC062552 mRNA Translation: AAH62552.1 |
CCDSi | CCDS31940.1 |
PIRi | B32891 |
RefSeqi | NP_001120844.1, NM_001127372.2 NP_001276900.1, NM_001289971.1 NP_001276901.1, NM_001289972.1 NP_003419.3, NM_003428.5 XP_005266242.1, XM_005266185.1 XP_005266243.1, XM_005266186.1 XP_011533134.1, XM_011534832.1 |
Genome annotation databases
Ensembli | ENST00000327668; ENSP00000331465; ENSG00000198040 ENST00000392319; ENSP00000376133; ENSG00000198040 ENST00000539354; ENSP00000445549; ENSG00000198040 |
GeneIDi | 7637 |
KEGGi | hsa:7637 |
UCSCi | uc001ulm.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27878 mRNA Translation: AAA79359.1 X60156 mRNA Translation: CAB94232.2 AK314232 mRNA Translation: BAG36902.1 CH471218 Genomic DNA Translation: EAW54799.1 CH471218 Genomic DNA Translation: EAW54801.1 CH471218 Genomic DNA Translation: EAW54802.1 BC036656 mRNA Translation: AAH36656.1 BC048350 mRNA Translation: AAH48350.2 BC062552 mRNA Translation: AAH62552.1 |
CCDSi | CCDS31940.1 |
PIRi | B32891 |
RefSeqi | NP_001120844.1, NM_001127372.2 NP_001276900.1, NM_001289971.1 NP_001276901.1, NM_001289972.1 NP_003419.3, NM_003428.5 XP_005266242.1, XM_005266185.1 XP_005266243.1, XM_005266186.1 XP_011533134.1, XM_011534832.1 |
3D structure databases
SMRi | P51523 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113453, 7 interactors |
IntActi | P51523, 11 interactors |
MINTi | P51523 |
STRINGi | 9606.ENSP00000331465 |
PTM databases
iPTMneti | P51523 |
PhosphoSitePlusi | P51523 |
Polymorphism and mutation databases
BioMutai | ZNF84 |
DMDMi | 94730445 |
Proteomic databases
EPDi | P51523 |
jPOSTi | P51523 |
MassIVEi | P51523 |
MaxQBi | P51523 |
PaxDbi | P51523 |
PeptideAtlasi | P51523 |
PRIDEi | P51523 |
ProteomicsDBi | 56321 |
Protocols and materials databases
Antibodypediai | 19535, 34 antibodies |
Genome annotation databases
Ensembli | ENST00000327668; ENSP00000331465; ENSG00000198040 ENST00000392319; ENSP00000376133; ENSG00000198040 ENST00000539354; ENSP00000445549; ENSG00000198040 |
GeneIDi | 7637 |
KEGGi | hsa:7637 |
UCSCi | uc001ulm.5, human |
Organism-specific databases
CTDi | 7637 |
DisGeNETi | 7637 |
EuPathDBi | HostDB:ENSG00000198040.10 |
GeneCardsi | ZNF84 |
HGNCi | HGNC:13159, ZNF84 |
HPAi | ENSG00000198040, Low tissue specificity |
MIMi | 618554, gene |
neXtProti | NX_P51523 |
OpenTargetsi | ENSG00000198040 |
PharmGKBi | PA37732 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162931 |
InParanoidi | P51523 |
OMAi | LKYYECD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P51523 |
TreeFami | TF337898 |
Enzyme and pathway databases
PathwayCommonsi | P51523 |
Miscellaneous databases
BioGRID-ORCSi | 7637, 35 hits in 861 CRISPR screens |
ChiTaRSi | ZNF84, human |
GenomeRNAii | 7637 |
Pharosi | P51523, Tdark |
PROi | PR:P51523 |
RNActi | P51523, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198040, Expressed in kidney and 230 other tissues |
ExpressionAtlasi | P51523, baseline and differential |
Genevisiblei | P51523, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 18 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 19 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 19 hits PS50157, ZINC_FINGER_C2H2_2, 19 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF84_HUMAN | |
Accessioni | P51523Primary (citable) accession number: P51523 Secondary accession number(s): B2RAK5 Q9UC18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | May 2, 2006 | |
Last modified: | December 2, 2020 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM