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Protein

Zinc finger protein 83

Gene

ZNF83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 115C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri149 – 171C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 83
Alternative name(s):
Zinc finger protein 816B
Zinc finger protein HPF1
Gene namesi
Name:ZNF83
Synonyms:ZNF816B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167766.18
HGNCiHGNC:13158 ZNF83
MIMi194558 gene
neXtProtiNX_P51522

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167766
PharmGKBiPA37731

Polymorphism and mutation databases

BioMutaiZNF83
DMDMi300669707

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473961 – 516Zinc finger protein 83Add BLAST516

Proteomic databases

PaxDbiP51522
PeptideAtlasiP51522
PRIDEiP51522
ProteomicsDBi56319
56320 [P51522-2]

PTM databases

iPTMnetiP51522
PhosphoSitePlusiP51522

Expressioni

Gene expression databases

BgeeiENSG00000167766 Expressed in 221 organ(s), highest expression level in right uterine tube
CleanExiHS_ZNF83
ExpressionAtlasiP51522 baseline and differential
GenevisibleiP51522 HS

Organism-specific databases

HPAiHPA025970

Interactioni

Protein-protein interaction databases

BioGridi120886, 3 interactors
IntActiP51522, 4 interactors
MINTiP51522
STRINGi9606.ENSP00000301096

Structurei

3D structure databases

ProteinModelPortaliP51522
SMRiP51522
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 115C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri149 – 171C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000151015
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP51522
KOiK09228
OMAiNSYLAYH
OrthoDBiEOG091G02KC
PhylomeDBiP51522
TreeFamiTF341892

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS
60 70 80 90 100
SLVSPPQRIS STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCSERGK
110 120 130 140 150
AFHQGLHFTI HQIIHTKETQ FKCDICGKIF NKKSNLASHQ RIHTGEKPYK
160 170 180 190 200
CNECGKVFHN MSHLAQHRRI HTGEKPYKCN ECGKVFNQIS HLAQHQRIHT
210 220 230 240 250
GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK VFSRNSYLVQ
260 270 280 290 300
HLIIHTGEKP YRCNVCGKVF HHISHLAQHQ RIHTGEKPYK CNECGKVFSH
310 320 330 340 350
KSSLVNHWRI HTGEKPYKCN ECGKVFSHKS SLVNHWRIHT GEKPYKCNEC
360 370 380 390 400
GKVFSRNSYL AQHLIIHAGE KPYKCDECDK AFSQNSHLVQ HHRIHTGEKP
410 420 430 440 450
YKCDECGKVF SQNSYLAYHW RIHTGEKAYK CNECGKVFGL NSSLAHHRKI
460 470 480 490 500
HTGEKPFKCN ECGKAFSMRS SLTNHHAIHT GEKHFKCNEC GKLFRDNSYL
510
VRHQRFHAGK KSNTCN
Length:516
Mass (Da):59,710
Last modified:July 13, 2010 - v3
Checksum:iA6CA428CFAEA5D69
GO
Isoform 2 (identifier: P51522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-298: Missing.

Show »
Length:488
Mass (Da):56,429
Checksum:i02D19C75A1677C48
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R183M0R183_HUMAN
Zinc finger protein 83
ZNF83
71Annotation score:
M0R0P3M0R0P3_HUMAN
Zinc finger protein 83
ZNF83
125Annotation score:
M0R099M0R099_HUMAN
Zinc finger protein 83
ZNF83
53Annotation score:
M0R1T0M0R1T0_HUMAN
Zinc finger protein 83
ZNF83
55Annotation score:
M0R3A5M0R3A5_HUMAN
Zinc finger protein 83
ZNF83
92Annotation score:
L0R8M2L0R8M2_HUMAN
Alternative protein ZNF83
ZNF83
105Annotation score:
M0R287M0R287_HUMAN
Zinc finger protein 83
ZNF83
125Annotation score:
M0QXM0M0QXM0_HUMAN
Zinc finger protein 83
ZNF83
30Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89 – 91GTE → MDR in AAG41760 (PubMed:2505992).Curated3
Sequence conflicti108 – 109FT → LP in AAG41760 (PubMed:2505992).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05820670T → I. Corresponds to variant dbSNP:rs3786490Ensembl.1
Natural variantiVAR_05820796S → N3 PublicationsCorresponds to variant dbSNP:rs1056185Ensembl.1
Natural variantiVAR_058208119T → M. Corresponds to variant dbSNP:rs329940Ensembl.1
Natural variantiVAR_058209392H → R1 PublicationCorresponds to variant dbSNP:rs11545619Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037663271 – 298Missing in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289399 mRNA Translation: BAF82088.1
AC022150 Genomic DNA No translation available.
BC050407 mRNA Translation: AAH50407.1
BC032867 mRNA Translation: AAH32867.1
M27877 mRNA Translation: AAG41760.1
CCDSiCCDS12854.1 [P51522-1]
PIRiA32891
RefSeqiNP_001099019.1, NM_001105549.1 [P51522-1]
NP_001099020.1, NM_001105550.1 [P51522-1]
NP_001099021.1, NM_001105551.1 [P51522-1]
NP_001099022.1, NM_001105552.1 [P51522-1]
NP_001264874.1, NM_001277945.1 [P51522-1]
NP_001264875.1, NM_001277946.1 [P51522-1]
NP_001264876.1, NM_001277947.1 [P51522-1]
NP_001264877.1, NM_001277948.1 [P51522-1]
NP_001264878.1, NM_001277949.1 [P51522-1]
NP_001264880.1, NM_001277951.1 [P51522-1]
NP_001264881.1, NM_001277952.1 [P51522-1]
NP_001334944.1, NM_001348015.1 [P51522-1]
NP_001334945.1, NM_001348016.1 [P51522-1]
NP_001334946.1, NM_001348017.1 [P51522-1]
NP_001334947.1, NM_001348018.1 [P51522-1]
NP_001334948.1, NM_001348019.1 [P51522-1]
NP_060770.3, NM_018300.3 [P51522-1]
UniGeneiHs.467210
Hs.659798
Hs.665751
Hs.710125
Hs.744177

Genome annotation databases

EnsembliENST00000301096; ENSP00000301096; ENSG00000167766 [P51522-1]
ENST00000536937; ENSP00000445993; ENSG00000167766 [P51522-1]
ENST00000541777; ENSP00000439681; ENSG00000167766 [P51522-1]
ENST00000545872; ENSP00000440713; ENSG00000167766 [P51522-1]
ENST00000597597; ENSP00000472619; ENSG00000167766 [P51522-1]
GeneIDi55769
KEGGihsa:55769
UCSCiuc002pzu.5 human [P51522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289399 mRNA Translation: BAF82088.1
AC022150 Genomic DNA No translation available.
BC050407 mRNA Translation: AAH50407.1
BC032867 mRNA Translation: AAH32867.1
M27877 mRNA Translation: AAG41760.1
CCDSiCCDS12854.1 [P51522-1]
PIRiA32891
RefSeqiNP_001099019.1, NM_001105549.1 [P51522-1]
NP_001099020.1, NM_001105550.1 [P51522-1]
NP_001099021.1, NM_001105551.1 [P51522-1]
NP_001099022.1, NM_001105552.1 [P51522-1]
NP_001264874.1, NM_001277945.1 [P51522-1]
NP_001264875.1, NM_001277946.1 [P51522-1]
NP_001264876.1, NM_001277947.1 [P51522-1]
NP_001264877.1, NM_001277948.1 [P51522-1]
NP_001264878.1, NM_001277949.1 [P51522-1]
NP_001264880.1, NM_001277951.1 [P51522-1]
NP_001264881.1, NM_001277952.1 [P51522-1]
NP_001334944.1, NM_001348015.1 [P51522-1]
NP_001334945.1, NM_001348016.1 [P51522-1]
NP_001334946.1, NM_001348017.1 [P51522-1]
NP_001334947.1, NM_001348018.1 [P51522-1]
NP_001334948.1, NM_001348019.1 [P51522-1]
NP_060770.3, NM_018300.3 [P51522-1]
UniGeneiHs.467210
Hs.659798
Hs.665751
Hs.710125
Hs.744177

3D structure databases

ProteinModelPortaliP51522
SMRiP51522
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120886, 3 interactors
IntActiP51522, 4 interactors
MINTiP51522
STRINGi9606.ENSP00000301096

PTM databases

iPTMnetiP51522
PhosphoSitePlusiP51522

Polymorphism and mutation databases

BioMutaiZNF83
DMDMi300669707

Proteomic databases

PaxDbiP51522
PeptideAtlasiP51522
PRIDEiP51522
ProteomicsDBi56319
56320 [P51522-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301096; ENSP00000301096; ENSG00000167766 [P51522-1]
ENST00000536937; ENSP00000445993; ENSG00000167766 [P51522-1]
ENST00000541777; ENSP00000439681; ENSG00000167766 [P51522-1]
ENST00000545872; ENSP00000440713; ENSG00000167766 [P51522-1]
ENST00000597597; ENSP00000472619; ENSG00000167766 [P51522-1]
GeneIDi55769
KEGGihsa:55769
UCSCiuc002pzu.5 human [P51522-1]

Organism-specific databases

CTDi55769
EuPathDBiHostDB:ENSG00000167766.18
GeneCardsiZNF83
HGNCiHGNC:13158 ZNF83
HPAiHPA025970
MIMi194558 gene
neXtProtiNX_P51522
OpenTargetsiENSG00000167766
PharmGKBiPA37731
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000151015
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP51522
KOiK09228
OMAiNSYLAYH
OrthoDBiEOG091G02KC
PhylomeDBiP51522
TreeFamiTF341892

Miscellaneous databases

ChiTaRSiZNF83 human
GeneWikiiZNF83
GenomeRNAii55769
PROiPR:P51522
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167766 Expressed in 221 organ(s), highest expression level in right uterine tube
CleanExiHS_ZNF83
ExpressionAtlasiP51522 baseline and differential
GenevisibleiP51522 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF83_HUMAN
AccessioniPrimary (citable) accession number: P51522
Secondary accession number(s): A8MT75, Q3ZCX0, Q6PI08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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