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Entry version 175 (22 Apr 2020)
Sequence version 2 (30 Aug 2005)
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Protein

Transcriptional regulator ovo

Gene

ovo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator with essential functions in the germline and soma (PubMed:9012532, PubMed:12915226, PubMed:10421370). Plays an essential role in regulating the formation of apical cell extensions such as denticles and aristae, and initiating cytoskeletal remodeling during epidermal differentiation (PubMed:12915226, PubMed:10421370).3 Publications
Transcriptional repressor which functions in postembryonic development (PubMed:21527259, PubMed:26383956). The full-length unprocessed form acts as a transcriptional repressor (Transcriptional repressor svb) (PubMed:26383956).2 Publications
Transcriptional activator which initiates trichome development and also promotes tarsal joint development (PubMed:21527259, PubMed:20647469, PubMed:26383956). Has an essential somatic role regulating the tal-dependent formation of trichomes, and initiating cytoskeletal remodeling during epidermal differentiation (PubMed:20647469, PubMed:21527259, PubMed:25344753, PubMed:26383956). Function with SoxN is required for correct denticle morphogenesis on the embryonic epidermis (PubMed:28506986). SoxN and svb appear to act both independently and in conjunction with each other to activate certain genes involved in denticle morphogenesis; Svb appears to be involved in regulating denticle length whereas SoxN regulates the denticle base circumference (PubMed:28506986). Also functions in the development of other apical cell extensions such as bristles (PubMed:25344753). Also has an important role in tarsal joint development, repressing expression of the N ligand Dl and defining its signaling boundary (PubMed:21527259).5 Publications
Transcriptional repressor which is specifically involved in female germline development, where it functions antagonistically to isoform D (PubMed:10648246, PubMed:28059165). Negatively regulates expression of otu and may also have autoregulatory activity (PubMed:10648246). Negatively regulates expression of piwi in the primordial germ cells (PGCs) (PubMed:28059165).2 Publications
Transcriptional activator which is specifically involved in female germline development, where it functions antagonistically to isoform C (PubMed:10648246, PubMed:1712294, PubMed:3428601, PubMed:8652413). Necessary and sufficient for normal oogenesis (PubMed:1712294, PubMed:12051822). Required in the primordial germ cells (PGCs) for normal development of male and female germline cells (PubMed:28059165). Plays a role in germline sex determination (PubMed:2116356). Binds the promoter DNA and positively regulates the transcription of the otu gene in a stage-specific manner (PubMed:10525184, PubMed:11290304, PubMed:9634487). May have autoregulatory activity (PubMed:11290304, PubMed:9634487).10 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1197 – 1219C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1253 – 1276C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1292 – 1315C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Oogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional regulator ovo1 Publication
Alternative name(s):
Transcriptional repressor shavenbaby1 Publication
Short name:
Transcriptional repressor svb1 Publication
Cleaved into the following chain:
Transcriptional activator shavenbaby1 Publication
Short name:
Transcriptional activator svb1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ovo1 PublicationImported
Synonyms:svb1 PublicationImported
ORF Names:CG6824Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003028 ovo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Adult lethal (PubMed:12915226). In the rare adult escapers, trichomes are often absent from large areas of the thorax and wing, or they are sparse and atrophied (PubMed:12915226). In the aristae, the central core is shorter and lateral cells either fail to develop or are strongly reduced in size (PubMed:12915226). Embryos display a smooth cuticle with sparse atrophied denticles (PubMed:12915226). Isoform D: No visible phenotype (PubMed:3428601). Isoform D: Males are viable whereas females are sterile and do not lay eggs (PubMed:3428601). Isoform D: Ovaries are atrophic and slightly larger than the oviducts at the posterior end of the ovaries, and egg chambers and germline cells are not visible (PubMed:3428601). Isoform D: In female embryos undergoing gastrulation, pole cells undergo cell death and are consequently either absent or reduced in number (PubMed:3428601). Isoform D: Pole cell morphology and their position in the embryo is unaffected (PubMed:3428601). Isoform D: Embryonic germline cells are unaffected while, in female larvae, germline cells undergo cell death and by the third instar stage, the germline cells in most mutants are either absent or reduced in number whereas, in the remaining mutants, the number of germline cells are not affected (PubMed:8652413). Isoform B: RNAi-mediated knockdown results in reduced expression of miniature (m) in the developing embryo (PubMed:28506986).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi3K → G: Decreases but does not prevent tal-dependent cleavage. Abolishes tal-dependent cleavage; when associated with G-8. Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-8 and G-28. 1 Publication1
Mutagenesisi8K → G: No effect on tal-dependent cleavage. Abolishes tal-dependent cleavage; when associated with G-3. Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-3 and G-28. 1 Publication1
Mutagenesisi28K → G: Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-3 and G-8. 1 Publication1
Mutagenesisi208K → M in ovo-D1; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected. 3 Publications1
Mutagenesisi226K → M in ovo-D3; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected. 3 Publications1
Mutagenesisi305V → M in ovo-D2; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected. 3 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470101 – 1351Transcriptional regulator ovoAdd BLAST1351
ChainiPRO_0000441819446 – 1351Transcriptional activator shavenbaby1 PublicationAdd BLAST906

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-terminus is proteolytically cleaved and ubiquitinated via a tal-dependent mechanism, leading to the proteolytic degradation of the N-terminus and the production of transcriptional activator shavenbaby, a truncated form with transcriptional activator activity.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei445 – 446Cleavage1 Publication2

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51521

PRoteomics IDEntifications database

More...
PRIDEi
P51521

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically (PubMed:7935398, PubMed:9012532, PubMed:1712294, PubMed:17246162, PubMed:28059165). Isoform B: Expressed in the notum from early pupation to 36 h after puparium formation, disappearing once epidermal cells develop apical extensions (at protein level) (PubMed:25344753). Isoform B: Expressed in the trichomes of stages 11 and 12 embryos and disappears by stage 15 but the cleaved transcriptional activator form svb is still present (at protein level) (PubMed:20647469). Isoform B: Not detected until the blastoderm stage when it is expressed in the head (PubMed:7748792). Isoform B: No expression in the primordial germ cells (PGCs) (PubMed:28059165). Isoform B: In stage 12 embryos, expressed in the trunk, and in stage 14 embryos expressed in the region of denticle belt setae and dorsal hairs (PubMed:7748792). Isoform B: Not detected in the pole cells throughout embryogenesis (PubMed:7748792). Isoform B: Expressed in the pupal tarsal segments in several segmentally separated stripes (PubMed:21527259). Isoform D: Expressed in the germinal stem cells of the germarium and later in the nurse cells (at protein level) (PubMed:7748792). Isoform D: Uniformly expressed in early cleavage and blastoderm stage embryos (at protein level) (PubMed:7748792). Isoform D: At germ band extension (stage 8), expression levels decrease rapidly and becomes localized to the pole cells in the posterior midgut pocket (at protein level) (PubMed:7748792). Isoform D: In stage 14 embryos, expressed in the forming gonads and some dispersed cells presumed to be pole cells lost during cell migration (at protein level) (PubMed:7748792). Isoform D: Expressed in male and female embryos, and in the germ cell in the gonads of male and female larvae (at protein level) (PubMed:7748792). Isoform D: Detected in adults, and in males is expressed in the apical part of each testis (at protein level) (PubMed:7748792). Isoform D: Expressed during early oogenesis in all female germline cells with slightly lower expression in early egg chambers (stages 2-4) (PubMed:10648246, PubMed:15371353). Isoform D: Weakly expressed in the apex of the testis (PubMed:12051822, PubMed:15371353). Isoform D: Expression levels in PGCs remain constant from stage 4 to stage 11, but decrease from stage 12 to stage 17 (PubMed:28059165). Isoform C: Weakly expressed in female germline stem cells and dividing cystocytes, and is very weak in early to middle stages of egg chamber differentiation (PubMed:10648246, PubMed:15371353). Isoform C: Expression levels are highest from middle to late stages of egg maturity but this is still relatively weak compared to isoform D (PubMed:10648246). Isoform C: Expressed in PGCs throughout embryogenesis but at a much lower level than isoform D (PubMed:28059165). Isoform C: Weakly expressed in the apex of the testis (PubMed:12051822, PubMed:15371353).12 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003028 Expressed in cleaving embryo and 42 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P51521 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with Ubr3; the interaction is mediated by tal.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
57942, 29 interactors

Protein interaction database and analysis system

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IntActi
P51521, 20 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0291128

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P51521

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31Required for Ubr3 binding and tal-dependent proteolytic processing1 PublicationAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi196 – 239Glu-richAdd BLAST44
Compositional biasi309 – 342Pro-richAdd BLAST34
Compositional biasi448 – 618Gly-richAdd BLAST171
Compositional biasi620 – 660Asn-richAdd BLAST41
Compositional biasi645 – 653His-rich9
Compositional biasi837 – 1158Gln-richAdd BLAST322
Compositional biasi1001 – 1059Ala-richAdd BLAST59
Compositional biasi1025 – 1045Ser-richAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Only 3 of the 4 C2H2-type zinc-fingers are required for DNA-binding. Based on its marked lack of evolutionary conservation, the fourth zinc-finger is unlikely to be required.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1197 – 1219C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1253 – 1276C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1292 – 1315C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3576 Eukaryota
ENOG4111H28 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161363

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P51521

KEGG Orthology (KO)

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KOi
K09216

Identification of Orthologs from Complete Genome Data

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OMAi
QLTHNMA

Database for complete collections of gene phylogenies

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PhylomeDBi
P51521

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027756 Ovo-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

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PANTHERi
PTHR10032 PTHR10032, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform BImported (identifier: P51521-1) [UniParc]FASTAAdd to basket
Also known as: EImported, svb3 Publications

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKIFLIKNR LHQQQQRLLE SQNLLQHKNQ DDERLVPPLS PSGSGSGPSP
60 70 80 90 100
TPTSQPPPEP QGQGQQVLGQ VPDSDQQPLS LTRKRFHHRR HYFGQSRHSL
110 120 130 140 150
DHLNQNQSPN PNANANPNQI QNPAELEVEC ATGQVQNENF AAELLQRLTP
160 170 180 190 200
NTATTAQNNI VNNLVNNSRA ATSVLATKDC TIENSPISIP KNQRAEDEEE
210 220 230 240 250
QEDQEKEKPA EREREKSDER TEQVEKEERV EREEEEDDEV DVGVEAPRPR
260 270 280 290 300
FYNTGVVLTQ AQRKEYPQEP KDLSLTIAKS SPASPHIHSD SESDSDSDGG
310 320 330 340 350
CKLIVDEKPP LPVIKPLSLR LRSTPPPADQ RPSPPPPRDP APAVRCSVIQ
360 370 380 390 400
RAPQSQLPTS RAGFLLPPLD QLGPEQQEPI DYHVPKRRSP SYDSDEELNA
410 420 430 440 450
RRLERARQVR EARRRSTILA ARVLLAQSQR LNPRLVRSLP GILAAAAGHG
460 470 480 490 500
RNSSSSSGAA GQGFQSSGFG SQNSGSGSSS GNQNAGSGAG SPGSGAGGGG
510 520 530 540 550
GMGGGRDGRG NYGPNSPPTG ALPPFYESLK SGQQSTASNN TGQSPGANHS
560 570 580 590 600
HFNANPANFL QNAAAAAYIM SAGSGGGGCT GNGGGGASGP GGGPSANSGG
610 620 630 640 650
GGGGGGGNGY INCGGVGGPN NSLDGNNLLN FASVSNYNES NSKFHNHHHH
660 670 680 690 700
HQHNNNNNNN GGQTSMMGHP FYGGNPSAYG IILKDEPDIE YDEAKIDIGT
710 720 730 740 750
FAQNIIQATM GSSGQFNASA YEDAIMSDLA SSGQCPNGAV DPLQFTATLM
760 770 780 790 800
LSSQTDHLLE QLSDAVDLSS FLQRSCVDDE ESTSPRQDFE LVSTPSLTPD
810 820 830 840 850
SVTPVEQHNT NTTQLDVLHE NLLTQLTHNI VRGGSNQQQQ HHQQHGVQQQ
860 870 880 890 900
QQQQHSVQQQ QQHNVQQQHG VQQQHVQQQP PPSYQHATRG LMMQQQPQHG
910 920 930 940 950
GYQQQAAIMS QQQQQLLSQQ QQQSHHQQQQ QQQHAAAYQQ HNIYAQQQQQ
960 970 980 990 1000
QQQQHHQQQQ QQQHHHFHHQ QQQQPQPQSH HSHHHGHGHD NSNMSLPSPT
1010 1020 1030 1040 1050
AAAAAAAAAA AAAAAAAAHL QRPMSSSSSS GGTNSSNSSG GSSNSPLLDA
1060 1070 1080 1090 1100
NAAAAAAAAL LDTKPLIQSL GLPPDLQLEF VNGGHGIKNP LAVENAHGGH
1110 1120 1130 1140 1150
HRIRNIDCID DLSKHGHHSQ HQQQQGSPQQ QNMQQSVQQQ SVQQQQSLQQ
1160 1170 1180 1190 1200
QQQQQHHQHH SNSSASSNAS SHGSAEALCM GSSGGANEDS SSGNNKFVCR
1210 1220 1230 1240 1250
VCMKTFSLQR LLNRHMKCHS DIKRYLCTFC GKGFNDTFDL KRHTRTHTGV
1260 1270 1280 1290 1300
RPYKCNLCEK SFTQRCSLES HCQKVHSVQH QYAYKERRAK MYVCEECGHT
1310 1320 1330 1340 1350
TCEPEVHYLH LKNNHPFSPA LLKFYDKRHF KFTNSQFANN LLGQLPMPVH

N
Length:1,351
Mass (Da):146,788
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FB5CDF3496F08A0
GO
Isoform AImported (identifier: P51521-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-501: Missing.
     625-677: Missing.
     1069-1069: S → SVSNPIGQPL...LNESKVLQRR

Note: Produced by alternative promoter usage and alternative splicing.1 Publication
Show »
Length:975
Mass (Da):104,797
Checksum:i5E7114D4844AF014
GO
Isoform CImported (identifier: P51521-3) [UniParc]FASTAAdd to basket
Also known as: ovoA3 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     130-138: CATGQVQNE → MNVNKNDLQ

Note: Produced by alternative promoter usage.1 Publication
Show »
Length:1,222
Mass (Da):132,356
Checksum:iE5ACE1E23071515F
GO
Isoform DImported (identifier: P51521-4) [UniParc]FASTAAdd to basket
Also known as: ovoB3 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     1-501: Missing.
     1069-1069: S → SVSNPIGQPL...LNESKVLQRR

Note: Produced by alternative promoter usage.1 Publication
Show »
Length:1,028
Mass (Da):110,706
Checksum:iF304D8C465A16944
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB36921 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti957 – 959Missing in CAD23206 (PubMed:10648246).Curated3
Sequence conflicti957 – 959Missing in CAD23207 (PubMed:12915226).Curated3
Sequence conflicti1018A → AAAA in CAD23206 (PubMed:10648246).Curated1
Sequence conflicti1018A → AAAA in CAD23207 (PubMed:12915226).Curated1
Sequence conflicti1055A → R in CAD23206 (PubMed:10648246).Curated1
Sequence conflicti1055A → R in CAD23207 (PubMed:12915226).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152681 – 501Missing in isoform A and isoform D. 2 PublicationsAdd BLAST501
Alternative sequenceiVSP_0152671 – 129Missing in isoform C. 1 PublicationAdd BLAST129
Alternative sequenceiVSP_015269130 – 138CATGQVQNE → MNVNKNDLQ in isoform C. 1 Publication9
Alternative sequenceiVSP_015270625 – 677Missing in isoform A. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_0152711069S → SVSNPIGQPLNTQSQQQKQG QQITLMKTTRYTEFVEMVSM DVTVKPELFSELKPEMTEIT AEELTLEAETTAAAAAAAAA AAAATTTSATEGTQVLAAAP APLSSGRKLRGRAKAVAYGS TMITLISTLKSSPEVPATKT VHRTTLRSLATAAAATAAGL LAPSPTVSVLNESKVLQRR in isoform A and isoform D. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U11383 mRNA Translation: AAB60216.1
AJ430589 mRNA Translation: CAD23207.1
AJ430588 mRNA Translation: CAD23206.1
AE014298 Genomic DNA Translation: AAF46001.2
AE014298 Genomic DNA Translation: AAF46002.2
AE014298 Genomic DNA Translation: AAF46003.2
AE014298 Genomic DNA Translation: ABC67174.1
AE014298 Genomic DNA Translation: ACZ95210.1
AY094838 mRNA Translation: AAM11191.1
AY119649 mRNA Translation: AAM50303.1
S83520 Genomic DNA Translation: AAB50918.1
S83520 Genomic DNA Translation: AAB50919.1
X59772 Genomic DNA Translation: CAB36921.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
A56038
S16356

NCBI Reference Sequences

More...
RefSeqi
NP_001033831.1, NM_001038742.3 [P51521-4]
NP_001162673.1, NM_001169202.2 [P51521-1]
NP_525077.2, NM_080338.5 [P51521-2]
NP_726971.1, NM_167026.4 [P51521-1]
NP_726972.1, NM_167027.4 [P51521-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070738; FBpp0070706; FBgn0003028 [P51521-1]
FBtr0070739; FBpp0070707; FBgn0003028 [P51521-3]
FBtr0070740; FBpp0070708; FBgn0003028 [P51521-2]
FBtr0100408; FBpp0099822; FBgn0003028 [P51521-4]
FBtr0301914; FBpp0291128; FBgn0003028 [P51521-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6824

UCSC genome browser

More...
UCSCi
CG6824-RD d. melanogaster

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11383 mRNA Translation: AAB60216.1
AJ430589 mRNA Translation: CAD23207.1
AJ430588 mRNA Translation: CAD23206.1
AE014298 Genomic DNA Translation: AAF46001.2
AE014298 Genomic DNA Translation: AAF46002.2
AE014298 Genomic DNA Translation: AAF46003.2
AE014298 Genomic DNA Translation: ABC67174.1
AE014298 Genomic DNA Translation: ACZ95210.1
AY094838 mRNA Translation: AAM11191.1
AY119649 mRNA Translation: AAM50303.1
S83520 Genomic DNA Translation: AAB50918.1
S83520 Genomic DNA Translation: AAB50919.1
X59772 Genomic DNA Translation: CAB36921.1 Sequence problems.
PIRiA56038
S16356
RefSeqiNP_001033831.1, NM_001038742.3 [P51521-4]
NP_001162673.1, NM_001169202.2 [P51521-1]
NP_525077.2, NM_080338.5 [P51521-2]
NP_726971.1, NM_167026.4 [P51521-1]
NP_726972.1, NM_167027.4 [P51521-3]

3D structure databases

SMRiP51521
ModBaseiSearch...

Protein-protein interaction databases

BioGridi57942, 29 interactors
IntActiP51521, 20 interactors
STRINGi7227.FBpp0291128

Proteomic databases

PaxDbiP51521
PRIDEiP51521

Genome annotation databases

EnsemblMetazoaiFBtr0070738; FBpp0070706; FBgn0003028 [P51521-1]
FBtr0070739; FBpp0070707; FBgn0003028 [P51521-3]
FBtr0070740; FBpp0070708; FBgn0003028 [P51521-2]
FBtr0100408; FBpp0099822; FBgn0003028 [P51521-4]
FBtr0301914; FBpp0291128; FBgn0003028 [P51521-1]
GeneIDi31429
KEGGidme:Dmel_CG6824
UCSCiCG6824-RD d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31429
FlyBaseiFBgn0003028 ovo

Phylogenomic databases

eggNOGiKOG3576 Eukaryota
ENOG4111H28 LUCA
GeneTreeiENSGT00940000161363
InParanoidiP51521
KOiK09216
OMAiQLTHNMA
PhylomeDBiP51521

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31429

Protein Ontology

More...
PROi
PR:P51521

Gene expression databases

BgeeiFBgn0003028 Expressed in cleaving embryo and 42 other tissues
GenevisibleiP51521 DM

Family and domain databases

InterProiView protein in InterPro
IPR027756 Ovo-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR10032 PTHR10032, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOVO_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51521
Secondary accession number(s): E1JJE5
, O02468, Q2PE28, Q8MPN4, Q8SX56, Q8T8L9, Q9W4F0, Q9W4F1, Q9W4F2, Q9XZU4, Q9Y046
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 30, 2005
Last modified: April 22, 2020
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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