UniProtKB - P51514 (HTF4_RAT)

BLAST

>sp|P51514|HTF4_RAT Transcription factor 12 OS=Rattus norvegicus OX=10116 GN=Tcf12 PE=1 SV=1
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGMDERGGTTSW
GTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPFMNSNLIGKTSERGSFSLY
SRDSGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDSVALDPLQA
KKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSSDLWSS
SNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRG
STSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNP
STPVGSPSPLTAGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVC
EQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPTSHSDIHSLLGPSHNAPIGNLNSNYGGSS
LVTNSRSASMVGTHREDSVSLNGNHSVLSSTVAASNTELNHKTPESFRGGVQNQSGSVVP
TEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIERE
KERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVR
ERNLNPKAACLKRREEEKVSAASAEPPTTLPGTHPGLSETTNPMGHL

Align

Format
Add to basket Added to basket
History
Entry version 152 (07 Nov 2018)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Transcription factor 12

Gene

Tcf12

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity).By similarity

GO - Molecular functionⁱ

bHLH transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cAMP response element binding
Source: RGD
Inferred from direct assayⁱ
- 7683670
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
E-box binding Source: UniProtKB
HMG box domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16582099
protein heterodimerization activity Source: UniProtKB
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SMAD binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of neuron differentiation Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: RGD
Inferred from direct assayⁱ
- 7683670

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-375170 CDO in myogenesis R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Reactomeⁱ

R-RNO-375170 CDO in myogenesis
R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor 12 Short name: TCF-12 Alternative name(s): DNA-binding protein HTF4 E-box-binding protein Salivary-specific cAMP response element-binding protein alpha Short name: SCBP-alpha Transcription factor HTF-4
Gene namesⁱ	Name:Tcf12
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 8

Organism-specific databases

Rat genome database More...RGDⁱ	3829 Tcf12

RGDⁱ

3829 Tcf12

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127232	1 – 707	Transcription factor 12Add BLAST		707

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	47	PhosphoserineBy similarity	1
Modified residueⁱ	67	PhosphoserineCombined sources	1
Modified residueⁱ	79	PhosphoserineCombined sources	1
Modified residueⁱ	98	PhosphoserineBy similarity	1
Cross-linkⁱ	110	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	116	PhosphoserineBy similarity	1
Modified residueⁱ	124	PhosphoserineBy similarity	1
Cross-linkⁱ	181	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	313	PhosphothreonineBy similarity	1
Modified residueⁱ	333	PhosphoserineBy similarity	1
Cross-linkⁱ	544	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	565	PhosphoserineBy similarity	1
Cross-linkⁱ	575	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	582	PhosphothreonineBy similarity	1
Modified residueⁱ	583	PhosphoserineBy similarity	1
Modified residueⁱ	584	PhosphoserineBy similarity	1
Cross-linkⁱ	634	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	678	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P51514
PRIDEⁱ	P51514

PTM databases

iPTMnetⁱ	P51514
PhosphoSitePlusⁱ	P51514

Expressionⁱ

Tissue specificityⁱ

Isoform gamma is highly expressed in lung, kidney, spleen, and is expressed at reduced levels in heart, muscle, liver, pituitary, brain and the trigeminal ganglion. The expression of isoform alpha predominates over isoform gamma in the pituitary and the brain.

Gene expression databases

Bgeeⁱ	ENSRNOG00000057754 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	P51514 baseline and differential
Genevisibleⁱ	P51514 RN

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins. Interacts with PTF1. Interacts with RUNX1T1. Interacts with NEUROD2 (By similarity). Interacts with BHLHA9.By similarity

GO - Molecular functionⁱ

bHLH transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
HMG box domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16582099
protein heterodimerization activity Source: UniProtKB
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SMAD binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	P51514
STRINGⁱ	10116.ENSRNOP00000023634

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51514
SMRⁱ	P51514
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	602 – 655	bHLHPROSITE-ProRule annotationAdd BLAST		54

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	119 – 140	Leucine-zipperAdd BLAST		22
Regionⁱ	657 – 680	Class A specific domainAdd BLAST		24

Phylogenomic databases

eggNOGⁱ	KOG3910 Eukaryota ENOG410XYUA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046438
HOGENOMⁱ	HOG000234180
HOVERGENⁱ	HBG003854
InParanoidⁱ	P51514
KEGG Orthology (KO) More...KOⁱ	K15603
OMAⁱ	FADSPHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07E2
PhylomeDBⁱ	P51514

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform Alpha (identifier: P51514-1) [UniParc]FASTA Add to basket

Also known as: Beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG 
        60         70         80         90        100
MDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGTHEGLSPT 
       110        120        130        140        150
PFMNSNLIGK TSERGSFSLY SRDSGLSGCQ SSLLRQDLGL GSPAQLSSSG 
       160        170        180        190        200
KPGTPYYSFS ATSSRRRPLH DSVALDPLQA KKVRKVPPGL PSSVYAPSPN 
       210        220        230        240        250
SDDFNRESPS YPSPKPPTSM FASTFFMQDG THSSSDLWSS SNGMSQPGFG 
       260        270        280        290        300
GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 
       310        320        330        340        350
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD 
       360        370        380        390        400
HTSSSFPSNP STPVGSPSPL TAGTSQWPRA GGQAPSSPSY ENSLHSLKNR 
       410        420        430        440        450
VEQQLHEHLQ DAMSFLKDVC EQSRMEDRLD RLDDAIHVLR NHAVGPSTSL 
       460        470        480        490        500
PTSHSDIHSL LGPSHNAPIG NLNSNYGGSS LVTNSRSASM VGTHREDSVS 
       510        520        530        540        550
LNGNHSVLSS TVAASNTELN HKTPESFRGG VQNQSGSVVP TEIKTENKEK 
       560        570        580        590        600
DENLHEPPSS DDMKSDDESS QKDIKVSSRG RTSSTNEDED LNPEQKIERE 
       610        620        630        640        650
KERRMANNAR ERLRVRDINE AFKELGRMCQ LHLKSEKPQT KLLILHQAVA 
       660        670        680        690        700
VILSLEQQVR ERNLNPKAAC LKRREEEKVS AASAEPPTTL PGTHPGLSET 

TNPMGHL

Length:707

Mass (Da):75,896

Last modified:October 1, 1996 - v1

Checksum:ⁱCC4AC60294601E2B

Isoform Beta (identifier: P51514-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
422-422: Missing.

« Hide

        10         20         30         40         50
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG 
        60         70         80         90        100
MDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGTHEGLSPT 
       110        120        130        140        150
PFMNSNLIGK TSERGSFSLY SRDSGLSGCQ SSLLRQDLGL GSPAQLSSSG 
       160        170        180        190        200
KPGTPYYSFS ATSSRRRPLH DSVALDPLQA KKVRKVPPGL PSSVYAPSPN 
       210        220        230        240        250
SDDFNRESPS YPSPKPPTSM FASTFFMQDG THSSSDLWSS SNGMSQPGFG 
       260        270        280        290        300
GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 
       310        320        330        340        350
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD 
       360        370        380        390        400
HTSSSFPSNP STPVGSPSPL TAGTSQWPRA GGQAPSSPSY ENSLHSLKNR 
       410        420        430        440        450
VEQQLHEHLQ DAMSFLKDVC ESRMEDRLDR LDDAIHVLRN HAVGPSTSLP 
       460        470        480        490        500
TSHSDIHSLL GPSHNAPIGN LNSNYGGSSL VTNSRSASMV GTHREDSVSL 
       510        520        530        540        550
NGNHSVLSST VAASNTELNH KTPESFRGGV QNQSGSVVPT EIKTENKEKD 
       560        570        580        590        600
ENLHEPPSSD DMKSDDESSQ KDIKVSSRGR TSSTNEDEDL NPEQKIEREK 
       610        620        630        640        650
ERRMANNARE RLRVRDINEA FKELGRMCQL HLKSEKPQTK LLILHQAVAV 
       660        670        680        690        700
ILSLEQQVRE RNLNPKAACL KRREEEKVSA ASAEPPTTLP GTHPGLSETT 

NPMGHL

Show »

Length:706

Mass (Da):75,768

Checksum:ⁱA99DEED24928875E

Isoform Gamma (identifier: P51514-3) [UniParc]FASTA Add to basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
398-422: Missing.

« Hide

        10         20         30         40         50
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG 
        60         70         80         90        100
MDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGTHEGLSPT 
       110        120        130        140        150
PFMNSNLIGK TSERGSFSLY SRDSGLSGCQ SSLLRQDLGL GSPAQLSSSG 
       160        170        180        190        200
KPGTPYYSFS ATSSRRRPLH DSVALDPLQA KKVRKVPPGL PSSVYAPSPN 
       210        220        230        240        250
SDDFNRESPS YPSPKPPTSM FASTFFMQDG THSSSDLWSS SNGMSQPGFG 
       260        270        280        290        300
GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 
       310        320        330        340        350
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD 
       360        370        380        390        400
HTSSSFPSNP STPVGSPSPL TAGTSQWPRA GGQAPSSPSY ENSLHSLSRM 
       410        420        430        440        450
EDRLDRLDDA IHVLRNHAVG PSTSLPTSHS DIHSLLGPSH NAPIGNLNSN 
       460        470        480        490        500
YGGSSLVTNS RSASMVGTHR EDSVSLNGNH SVLSSTVAAS NTELNHKTPE 
       510        520        530        540        550
SFRGGVQNQS GSVVPTEIKT ENKEKDENLH EPPSSDDMKS DDESSQKDIK 
       560        570        580        590        600
VSSRGRTSST NEDEDLNPEQ KIEREKERRM ANNARERLRV RDINEAFKEL 
       610        620        630        640        650
GRMCQLHLKS EKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE 
       660        670        680 
EEKVSAASAE PPTTLPGTHP GLSETTNPMG HL

Show »

Length:682

Mass (Da):72,888

Checksum:ⁱ3F82ADCDD66FA050

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2K188	A0A0G2K188_RAT		Transcription factor 12 Transcription factor 12	Tcf12	537	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	80	P → A in AAB25128 (PubMed:8422988).Curated	1
Sequence conflictⁱ	80	P → A in AAB25129 (PubMed:8422988).Curated	1
Sequence conflictⁱ	124	S → C in AAB25128 (PubMed:8422988).Curated	1
Sequence conflictⁱ	124	S → C in AAB25129 (PubMed:8422988).Curated	1
Sequence conflictⁱ	159	F → S in AAB25128 (PubMed:8422988).Curated	1
Sequence conflictⁱ	159	F → S in AAB25129 (PubMed:8422988).Curated	1
Sequence conflictⁱ	541	T → N in AAB25128 (PubMed:8422988).Curated	1
Sequence conflictⁱ	541	T → N in AAB25129 (PubMed:8422988).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002106	398 – 422	Missing in isoform Gamma. CuratedAdd BLAST		25
Alternative sequenceⁱVSP_002107	422	Missing in isoform Beta. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L09656 mRNA Translation: AAA42115.1 S53913 mRNA Translation: AAB25128.2 S53920 mRNA Translation: AAB25129.2 Sequence problems. S53922 Genomic DNA No translation available. S53921 Genomic DNA No translation available.
PIRⁱ	A46691
NCBI Reference Sequences More...RefSeqⁱ	NP_037308.1, NM_013176.2 [P51514-1] XP_006243408.1, XM_006243346.2 [P51514-2] XP_006243411.1, XM_006243349.2 [P51514-3]
UniGeneⁱ	Rn.165133 Rn.9916

Genome annotation databases

Ensemblⁱ	ENSRNOT00000081185; ENSRNOP00000074384; ENSRNOG00000057754 [P51514-1]
GeneIDⁱ	25720
KEGGⁱ	rno:25720
UCSC genome browser More...UCSCⁱ	RGD:3829 rat [P51514-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51514	Transcription factor 12		MOUSE		706	UniRef90_Q61286
Transcription factor 12 (Fragment)		PAPHA		160
Uncharacterized protein		AOTNA		764
Transcription factor 12 (Fragment)		HUMAN		69
transcription factor 12 isoform X1		DELLE		721
+239
P51514-3	Isoform ALF1A of Transcription factor 12		MOUSE		682	UniRef90_Q61286-2
Uncharacterized protein		CHLSB		682
TCF12 isoform 27 (Fragment)		PONAB		47
TCF12 isoform 1 (Fragment)		PANTR		47
Transcription factor 12 (Fragment)		HUMAN		48
+28

Protein	Similar proteins		Species	Score	Length	Source
P51514	Transcription factor 12		MOUSE		706	UniRef50_Q61286
Transcription factor 12 (Fragment)		PAPHA		160
Transcription factor 12 (Fragment)		CHICK		657
Uncharacterized protein		AOTNA		764
Transcription factor 12 (Fragment)		HUMAN		69
+752
P51514-3	Transcription factor 4	)	HUMAN		667	UniRef50_P15884
Transcription factor 4		MOUSE		670
Transcription factor 4		CANLF		642
Transcription factor 4		RAT		589
Transcription factor 4 (Fragment)		CHICK		85
+1660

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L09656 mRNA Translation: AAA42115.1 S53913 mRNA Translation: AAB25128.2 S53920 mRNA Translation: AAB25129.2 Sequence problems. S53922 Genomic DNA No translation available. S53921 Genomic DNA No translation available.
PIRⁱ	A46691
RefSeqⁱ	NP_037308.1, NM_013176.2 [P51514-1] XP_006243408.1, XM_006243346.2 [P51514-2] XP_006243411.1, XM_006243349.2 [P51514-3]
UniGeneⁱ	Rn.165133 Rn.9916

3D structure databases

ProteinModelPortalⁱ	P51514
SMRⁱ	P51514
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	P51514
STRINGⁱ	10116.ENSRNOP00000023634

PTM databases

iPTMnetⁱ	P51514
PhosphoSitePlusⁱ	P51514

Proteomic databases

PaxDbⁱ	P51514
PRIDEⁱ	P51514

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000081185; ENSRNOP00000074384; ENSRNOG00000057754 [P51514-1]
GeneIDⁱ	25720
KEGGⁱ	rno:25720
UCSCⁱ	RGD:3829 rat [P51514-1]

Organism-specific databases

CTDⁱ	6938
RGDⁱ	3829 Tcf12

Phylogenomic databases

eggNOGⁱ	KOG3910 Eukaryota ENOG410XYUA LUCA
GeneTreeⁱ	ENSGT00510000046438
HOGENOMⁱ	HOG000234180
HOVERGENⁱ	HBG003854
InParanoidⁱ	P51514
KOⁱ	K15603
OMAⁱ	FADSPHY
OrthoDBⁱ	EOG091G07E2
PhylomeDBⁱ	P51514

Enzyme and pathway databases

Reactomeⁱ	R-RNO-375170 CDO in myogenesis R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Reactomeⁱ

R-RNO-375170 CDO in myogenesis
R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P51514

PROⁱ

PR:P51514

Gene expression databases

Bgeeⁱ	ENSRNOG00000057754 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	P51514 baseline and differential
Genevisibleⁱ	P51514 RN

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HTF4_RAT
Accessionⁱ	P51514Primary (citable) accession number: P51514
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51514 (HTF4_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription factor 12

Tcf12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ