UniProtKB - P51513 (NOVA1_HUMAN)
Protein
RNA-binding protein Nova-1
Gene
NOVA1
Organism
Homo sapiens (Human)
Status
Functioni
May regulate RNA splicing or metabolism in a specific subset of developing neurons.
GO - Molecular functioni
- mRNA 3'-UTR binding Source: Ensembl
- mRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
GO - Biological processi
- chemical synaptic transmission Source: ProtInc
- locomotory behavior Source: ProtInc
- mRNA splicing, via spliceosome Source: GO_Central
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- regulation of alternative mRNA splicing, via spliceosome Source: GO_Central
- regulation of gene expression Source: GO_Central
- regulation of RNA metabolic process Source: GO_Central
- RNA processing Source: ProtInc
- RNA splicing Source: ProtInc
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | P51513 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein Nova-1Alternative name(s): Neuro-oncological ventral antigen 1 Onconeural ventral antigen 1 Paraneoplastic Ri antigen Ventral neuron-specific protein 1 |
Gene namesi | Name:NOVA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000139910.19 |
HGNCi | HGNC:7886, NOVA1 |
MIMi | 602157, gene |
neXtProti | NX_P51513 |
Subcellular locationi
Nucleus
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: HPA
- synapse Source: GOC
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 4857 |
OpenTargetsi | ENSG00000139910 |
PharmGKBi | PA31688 |
Miscellaneous databases
Pharosi | P51513, Tbio |
Polymorphism and mutation databases
BioMutai | NOVA1 |
DMDMi | 1709303 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050116 | 1 – 507 | RNA-binding protein Nova-1Add BLAST | 507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 154 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P51513 |
jPOSTi | P51513 |
MassIVEi | P51513 |
MaxQBi | P51513 |
PaxDbi | P51513 |
PeptideAtlasi | P51513 |
PRIDEi | P51513 |
ProteomicsDBi | 12757 56316 [P51513-2] 56318 [P51513-4] |
TopDownProteomicsi | P51513-2 [P51513-2] |
PTM databases
iPTMneti | P51513 |
PhosphoSitePlusi | P51513 |
Expressioni
Tissue specificityi
Brain.
Gene expression databases
Bgeei | ENSG00000139910, Expressed in cerebellum and 207 other tissues |
ExpressionAtlasi | P51513, baseline and differential |
Genevisiblei | P51513, HS |
Organism-specific databases
HPAi | ENSG00000139910, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with PTBP2; the interaction is direct.
By similarityBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 110919, 12 interactors |
IntActi | P51513, 14 interactors |
MINTi | P51513 |
STRINGi | 9606.ENSP00000438875 |
Miscellaneous databases
RNActi | P51513, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P51513 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P51513 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 116 | KH 1PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 171 – 237 | KH 2PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 421 – 488 | KH 3PROSITE-ProRule annotationAdd BLAST | 68 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 27 – 43 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 17 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 273 – 409 | Ala-richAdd BLAST | 137 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2191, Eukaryota |
GeneTreei | ENSGT00940000155573 |
HOGENOMi | CLU_022670_1_1_1 |
InParanoidi | P51513 |
OMAi | VVDFIMD |
OrthoDBi | 1167935at2759 |
PhylomeDBi | P51513 |
TreeFami | TF316981 |
Family and domain databases
Gene3Di | 3.30.1370.10, 3 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR033086, NOVA1 |
PANTHERi | PTHR10288:SF229, PTHR10288:SF229, 1 hit |
Pfami | View protein in Pfam PF00013, KH_1, 3 hits |
SMARTi | View protein in SMART SM00322, KH, 3 hits |
SUPFAMi | SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P51513-4) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY
60 70 80 90 100
FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKSKD FYPGTTERVC
110 120 130 140 150
LIQGTVEALN AVHGFIAEKI REMPQNVAKT EPVSILQPQT TVNPDRIKQT
160 170 180 190 200
LPSSPTTTKS SPSDPMTTSR ANQVKIIVPN STAGLIIGKG GATVKAVMEQ
210 220 230 240 250
SGAWVQLSQK PDGINLQERV VTVSGEPEQN RKAVELIIQK IQEDPQSGSC
260 270 280 290 300
LNISYANVTG PVANSNPTGS PYANTAEVLP TAAAAAGLLG HANLAGVAAF
310 320 330 340 350
PAVLSGFTGN DLVAITSALN TLASYGYNLN TLGLGLSQAA ATGALAAAAA
360 370 380 390 400
SANPAAAAAN LLATYASEAS ASGSTAGGTA GTFALGSLAA ATAATNGYFG
410 420 430 440 450
AASPLAASAI LGTEKSTDGS KDVVEIAVPE NLVGAILGKG GKTLVEYQEL
460 470 480 490 500
TGARIQISKK GEFVPGTRNR KVTITGTPAA TQAAQYLITQ RITYEQGVRA
ANPQKVG
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W659 | F8W659_HUMAN | RNA-binding protein Nova-1 | NOVA1 | 211 | Annotation score: | ||
I3L2B5 | I3L2B5_HUMAN | RNA-binding protein Nova-1 | NOVA1 | 152 | Annotation score: | ||
F8VYI3 | F8VYI3_HUMAN | RNA-binding protein Nova-1 | NOVA1 | 121 | Annotation score: | ||
F8VWX1 | F8VWX1_HUMAN | RNA-binding protein Nova-1 | NOVA1 | 173 | Annotation score: | ||
F8VW64 | F8VW64_HUMAN | RNA-binding protein Nova-1 | NOVA1 | 96 | Annotation score: | ||
J3KQU3 | J3KQU3_HUMAN | RNA-binding protein Nova-1 | NOVA1 | 277 | Annotation score: | ||
G8JLA5 | G8JLA5_HUMAN | RNA-binding protein Nova-1 | NOVA1 | 109 | Annotation score: | ||
H0YHZ1 | H0YHZ1_HUMAN | RNA-binding protein Nova-1 | NOVA1 | 49 | Annotation score: |
Sequence cautioni
The sequence AAA16022 differs from that shown. Probable cloning artifact leading to an insertion into the sequence.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060046 | 150 – 173 | Missing in isoform 3. Add BLAST | 24 | |
Alternative sequenceiVSP_060047 | 174 – 181 | VKIIVPNS → KHNISWIS in isoform 2. | 8 | |
Alternative sequenceiVSP_060048 | 182 – 507 | Missing in isoform 2. Add BLAST | 326 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04840 mRNA Translation: AAA16022.1 Sequence problems. AK289639 mRNA Translation: BAF82328.1 AK291022 mRNA Translation: BAF83711.1 AL079343 Genomic DNA No translation available. AL132716 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65990.1 CH471078 Genomic DNA Translation: EAW65991.1 CH471078 Genomic DNA Translation: EAW65992.1 CH471078 Genomic DNA Translation: EAW65993.1 CH471078 Genomic DNA Translation: EAW65995.1 BC075038 mRNA Translation: AAH75038.1 BC075039 mRNA Translation: AAH75039.1 Z70771 mRNA Translation: CAA94810.1 |
CCDSi | CCDS32060.1 [P51513-5] CCDS32061.1 [P51513-4] CCDS9635.1 [P51513-2] |
PIRi | I38489 |
RefSeqi | NP_002506.2, NM_002515.2 [P51513-4] NP_006480.2, NM_006489.2 [P51513-5] NP_006482.1, NM_006491.2 [P51513-2] |
Genome annotation databases
Ensembli | ENST00000344429; ENSP00000342387; ENSG00000139910 [P51513-2] ENST00000465357; ENSP00000447391; ENSG00000139910 [P51513-5] ENST00000539517; ENSP00000438875; ENSG00000139910 [P51513-4] |
GeneIDi | 4857 |
KEGGi | hsa:4857 |
UCSCi | uc001wpy.4, human [P51513-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04840 mRNA Translation: AAA16022.1 Sequence problems. AK289639 mRNA Translation: BAF82328.1 AK291022 mRNA Translation: BAF83711.1 AL079343 Genomic DNA No translation available. AL132716 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65990.1 CH471078 Genomic DNA Translation: EAW65991.1 CH471078 Genomic DNA Translation: EAW65992.1 CH471078 Genomic DNA Translation: EAW65993.1 CH471078 Genomic DNA Translation: EAW65995.1 BC075038 mRNA Translation: AAH75038.1 BC075039 mRNA Translation: AAH75039.1 Z70771 mRNA Translation: CAA94810.1 |
CCDSi | CCDS32060.1 [P51513-5] CCDS32061.1 [P51513-4] CCDS9635.1 [P51513-2] |
PIRi | I38489 |
RefSeqi | NP_002506.2, NM_002515.2 [P51513-4] NP_006480.2, NM_006489.2 [P51513-5] NP_006482.1, NM_006491.2 [P51513-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DT4 | X-ray | 2.60 | A | 421-492 | [»] | |
2ANN | X-ray | 2.30 | A | 49-246 | [»] | |
2ANR | X-ray | 1.94 | A | 49-246 | [»] | |
SMRi | P51513 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110919, 12 interactors |
IntActi | P51513, 14 interactors |
MINTi | P51513 |
STRINGi | 9606.ENSP00000438875 |
PTM databases
iPTMneti | P51513 |
PhosphoSitePlusi | P51513 |
Polymorphism and mutation databases
BioMutai | NOVA1 |
DMDMi | 1709303 |
Proteomic databases
EPDi | P51513 |
jPOSTi | P51513 |
MassIVEi | P51513 |
MaxQBi | P51513 |
PaxDbi | P51513 |
PeptideAtlasi | P51513 |
PRIDEi | P51513 |
ProteomicsDBi | 12757 56316 [P51513-2] 56318 [P51513-4] |
TopDownProteomicsi | P51513-2 [P51513-2] |
Protocols and materials databases
Antibodypediai | 133, 249 antibodies |
Genome annotation databases
Ensembli | ENST00000344429; ENSP00000342387; ENSG00000139910 [P51513-2] ENST00000465357; ENSP00000447391; ENSG00000139910 [P51513-5] ENST00000539517; ENSP00000438875; ENSG00000139910 [P51513-4] |
GeneIDi | 4857 |
KEGGi | hsa:4857 |
UCSCi | uc001wpy.4, human [P51513-4] |
Organism-specific databases
CTDi | 4857 |
DisGeNETi | 4857 |
EuPathDBi | HostDB:ENSG00000139910.19 |
GeneCardsi | NOVA1 |
HGNCi | HGNC:7886, NOVA1 |
HPAi | ENSG00000139910, Tissue enhanced (brain) |
MIMi | 602157, gene |
neXtProti | NX_P51513 |
OpenTargetsi | ENSG00000139910 |
PharmGKBi | PA31688 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2191, Eukaryota |
GeneTreei | ENSGT00940000155573 |
HOGENOMi | CLU_022670_1_1_1 |
InParanoidi | P51513 |
OMAi | VVDFIMD |
OrthoDBi | 1167935at2759 |
PhylomeDBi | P51513 |
TreeFami | TF316981 |
Enzyme and pathway databases
PathwayCommonsi | P51513 |
Miscellaneous databases
BioGRID-ORCSi | 4857, 6 hits in 846 CRISPR screens |
ChiTaRSi | NOVA1, human |
EvolutionaryTracei | P51513 |
GeneWikii | NOVA1 |
GenomeRNAii | 4857 |
Pharosi | P51513, Tbio |
PROi | PR:P51513 |
RNActi | P51513, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139910, Expressed in cerebellum and 207 other tissues |
ExpressionAtlasi | P51513, baseline and differential |
Genevisiblei | P51513, HS |
Family and domain databases
Gene3Di | 3.30.1370.10, 3 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR033086, NOVA1 |
PANTHERi | PTHR10288:SF229, PTHR10288:SF229, 1 hit |
Pfami | View protein in Pfam PF00013, KH_1, 3 hits |
SMARTi | View protein in SMART SM00322, KH, 3 hits |
SUPFAMi | SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOVA1_HUMAN | |
Accessioni | P51513Primary (citable) accession number: P51513 Secondary accession number(s): A8K0S4 Q6B004 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | February 13, 2019 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM