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Protein

RNA-binding protein Nova-1

Gene

NOVA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate RNA splicing or metabolism in a specific subset of developing neurons.

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • locomotory behavior Source: ProtInc
  • mRNA splicing, via spliceosome Source: Ensembl
  • negative regulation of cold-induced thermogenesis Source: YuBioLab
  • regulation of RNA metabolic process Source: Ensembl
  • RNA processing Source: ProtInc
  • RNA splicing Source: ProtInc

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Nova-1
Alternative name(s):
Neuro-oncological ventral antigen 1
Onconeural ventral antigen 1
Paraneoplastic Ri antigen
Ventral neuron-specific protein 1
Gene namesi
Name:NOVA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139910.19
HGNCiHGNC:7886 NOVA1
MIMi602157 gene
neXtProtiNX_P51513

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4857
OpenTargetsiENSG00000139910
PharmGKBiPA31688

Polymorphism and mutation databases

BioMutaiNOVA1
DMDMi1709303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501161 – 510RNA-binding protein Nova-1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP51513
MaxQBiP51513
PaxDbiP51513
PeptideAtlasiP51513
PRIDEiP51513
ProteomicsDBi56315
56316 [P51513-2]
56317 [P51513-3]
56318 [P51513-4]
TopDownProteomicsiP51513-2 [P51513-2]

PTM databases

iPTMnetiP51513
PhosphoSitePlusiP51513

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000139910 Expressed in 194 organ(s), highest expression level in cerebellum
CleanExiHS_NOVA1
ExpressionAtlasiP51513 baseline and differential
GenevisibleiP51513 HS

Organism-specific databases

HPAiHPA004155

Interactioni

Subunit structurei

Interacts with PTBP2; the interaction is direct.By similarity

Protein-protein interaction databases

BioGridi110919, 10 interactors
IntActiP51513, 9 interactors
MINTiP51513
STRINGi9606.ENSP00000438875

Structurei

Secondary structure

1510
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP51513
SMRiP51513
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51513

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 119KH 1PROSITE-ProRule annotationAdd BLAST71
Domaini174 – 240KH 2PROSITE-ProRule annotationAdd BLAST67
Domaini424 – 491KH 3PROSITE-ProRule annotationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 43Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 412Ala-richAdd BLAST137

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2191 Eukaryota
ENOG410XRZD LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000007833
HOVERGENiHBG082048
InParanoidiP51513
KOiK14944
OMAiVVDFIMD
OrthoDBiEOG091G185U
PhylomeDBiP51513
TreeFamiTF316981

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR033086 NOVA1
PANTHERiPTHR10288:SF223 PTHR10288:SF223, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51513-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY
60 70 80 90 100
FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKLSK SKDFYPGTTE
110 120 130 140 150
RVCLIQGTVE ALNAVHGFIA EKIREMPQNV AKTEPVSILQ PQTTVNPDRI
160 170 180 190 200
KQTLPSSPTT TKSSPSDPMT TSRANQVKII VPNSTAGLII GKGGATVKAV
210 220 230 240 250
MEQSGAWVQL SQKPDGINLQ ERVVTVSGEP EQNRKAVELI IQKIQEDPQS
260 270 280 290 300
GSCLNISYAN VTGPVANSNP TGSPYANTAE VLPTAAAAAG LLGHANLAGV
310 320 330 340 350
AAFPAVLSGF TGNDLVAITS ALNTLASYGY NLNTLGLGLS QAAATGALAA
360 370 380 390 400
AAASANPAAA AANLLATYAS EASASGSTAG GTAGTFALGS LAAATAATNG
410 420 430 440 450
YFGAASPLAA SAILGTEKST DGSKDVVEIA VPENLVGAIL GKGGKTLVEY
460 470 480 490 500
QELTGARIQI SKKGEFVPGT RNRKVTITGT PAATQAAQYL ITQRITYEQG
510
VRAANPQKVG
Length:510
Mass (Da):52,056
Last modified:October 1, 1996 - v1
Checksum:i7B9BA8B67CAB6984
GO
Isoform 2 (identifier: P51513-2) [UniParc]FASTAAdd to basket
Also known as: Tumor

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.
     177-184: VKIIVPNS → KHNISWIS
     185-510: Missing.

Show »
Length:181
Mass (Da):19,491
Checksum:i23EF1C6F5541D52D
GO
Isoform 3 (identifier: P51513-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-176: Missing.

Show »
Length:486
Mass (Da):49,581
Checksum:i7F9A8331C469877E
GO
Isoform 4 (identifier: P51513-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.

Show »
Length:507
Mass (Da):51,727
Checksum:iDBF455477988CDCA
GO
Isoform 5 (identifier: P51513-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-90: Missing.
     153-176: Missing.

Note: Gene prediction based on EST data.
Show »
Length:483
Mass (Da):49,253
Checksum:iBE44FBED4E9664E2
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWX1F8VWX1_HUMAN
RNA-binding protein Nova-1
NOVA1
173Annotation score:
F8W659F8W659_HUMAN
RNA-binding protein Nova-1
NOVA1
211Annotation score:
G8JLA5G8JLA5_HUMAN
RNA-binding protein Nova-1
NOVA1
109Annotation score:
I3L2B5I3L2B5_HUMAN
RNA-binding protein Nova-1
NOVA1
152Annotation score:
J3KQU3J3KQU3_HUMAN
RNA-binding protein Nova-1
NOVA1
277Annotation score:
F8VW64F8VW64_HUMAN
RNA-binding protein Nova-1
NOVA1
96Annotation score:
F8VYI3F8VYI3_HUMAN
RNA-binding protein Nova-1
NOVA1
121Annotation score:
H0YHZ1H0YHZ1_HUMAN
RNA-binding protein Nova-1
NOVA1
49Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00284188 – 90Missing in isoform 2, isoform 4 and isoform 5. 3 Publications3
Alternative sequenceiVSP_002842153 – 176Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_002843177 – 184VKIIVPNS → KHNISWIS in isoform 2. 2 Publications8
Alternative sequenceiVSP_002844185 – 510Missing in isoform 2. 2 PublicationsAdd BLAST326

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04840 mRNA Translation: AAA16022.1
AK289639 mRNA Translation: BAF82328.1
AK291022 mRNA Translation: BAF83711.1
AL079343 Genomic DNA No translation available.
AL132716 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65990.1
CH471078 Genomic DNA Translation: EAW65991.1
CH471078 Genomic DNA Translation: EAW65992.1
CH471078 Genomic DNA Translation: EAW65993.1
CH471078 Genomic DNA Translation: EAW65995.1
BC075038 mRNA Translation: AAH75038.1
BC075039 mRNA Translation: AAH75039.1
Z70771 mRNA Translation: CAA94810.1
CCDSiCCDS32060.1 [P51513-5]
CCDS32061.1 [P51513-4]
CCDS9635.1 [P51513-2]
PIRiI38489
RefSeqiNP_002506.2, NM_002515.2 [P51513-4]
NP_006480.2, NM_006489.2 [P51513-5]
NP_006482.1, NM_006491.2 [P51513-2]
UniGeneiHs.31588

Genome annotation databases

EnsembliENST00000344429; ENSP00000342387; ENSG00000139910 [P51513-2]
ENST00000465357; ENSP00000447391; ENSG00000139910 [P51513-5]
ENST00000539517; ENSP00000438875; ENSG00000139910 [P51513-4]
GeneIDi4857
KEGGihsa:4857
UCSCiuc001wpy.4 human [P51513-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04840 mRNA Translation: AAA16022.1
AK289639 mRNA Translation: BAF82328.1
AK291022 mRNA Translation: BAF83711.1
AL079343 Genomic DNA No translation available.
AL132716 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65990.1
CH471078 Genomic DNA Translation: EAW65991.1
CH471078 Genomic DNA Translation: EAW65992.1
CH471078 Genomic DNA Translation: EAW65993.1
CH471078 Genomic DNA Translation: EAW65995.1
BC075038 mRNA Translation: AAH75038.1
BC075039 mRNA Translation: AAH75039.1
Z70771 mRNA Translation: CAA94810.1
CCDSiCCDS32060.1 [P51513-5]
CCDS32061.1 [P51513-4]
CCDS9635.1 [P51513-2]
PIRiI38489
RefSeqiNP_002506.2, NM_002515.2 [P51513-4]
NP_006480.2, NM_006489.2 [P51513-5]
NP_006482.1, NM_006491.2 [P51513-2]
UniGeneiHs.31588

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DT4X-ray2.60A424-495[»]
2ANNX-ray2.30A49-249[»]
2ANRX-ray1.94A49-249[»]
ProteinModelPortaliP51513
SMRiP51513
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110919, 10 interactors
IntActiP51513, 9 interactors
MINTiP51513
STRINGi9606.ENSP00000438875

PTM databases

iPTMnetiP51513
PhosphoSitePlusiP51513

Polymorphism and mutation databases

BioMutaiNOVA1
DMDMi1709303

Proteomic databases

EPDiP51513
MaxQBiP51513
PaxDbiP51513
PeptideAtlasiP51513
PRIDEiP51513
ProteomicsDBi56315
56316 [P51513-2]
56317 [P51513-3]
56318 [P51513-4]
TopDownProteomicsiP51513-2 [P51513-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344429; ENSP00000342387; ENSG00000139910 [P51513-2]
ENST00000465357; ENSP00000447391; ENSG00000139910 [P51513-5]
ENST00000539517; ENSP00000438875; ENSG00000139910 [P51513-4]
GeneIDi4857
KEGGihsa:4857
UCSCiuc001wpy.4 human [P51513-1]

Organism-specific databases

CTDi4857
DisGeNETi4857
EuPathDBiHostDB:ENSG00000139910.19
GeneCardsiNOVA1
H-InvDBiHIX0037755
HGNCiHGNC:7886 NOVA1
HPAiHPA004155
MIMi602157 gene
neXtProtiNX_P51513
OpenTargetsiENSG00000139910
PharmGKBiPA31688
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2191 Eukaryota
ENOG410XRZD LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000007833
HOVERGENiHBG082048
InParanoidiP51513
KOiK14944
OMAiVVDFIMD
OrthoDBiEOG091G185U
PhylomeDBiP51513
TreeFamiTF316981

Miscellaneous databases

ChiTaRSiNOVA1 human
EvolutionaryTraceiP51513
GeneWikiiNOVA1
GenomeRNAii4857
PROiPR:P51513
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139910 Expressed in 194 organ(s), highest expression level in cerebellum
CleanExiHS_NOVA1
ExpressionAtlasiP51513 baseline and differential
GenevisibleiP51513 HS

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR033086 NOVA1
PANTHERiPTHR10288:SF223 PTHR10288:SF223, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNOVA1_HUMAN
AccessioniPrimary (citable) accession number: P51513
Secondary accession number(s): A8K0S4
, A8K4Q7, D3DS81, D3DS82, Q6B004
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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