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UniProtKB - P51511 (MMP15_HUMAN)

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Protein

Matrix metalloproteinase-15

Gene

MMP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.1 Publication

Cofactori

Protein has several cofactor binding sites:
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
  • Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi111Zinc; in inhibited formBy similarity1
Metal bindingi259Zinc; catalyticPROSITE-ProRule annotation1
Active sitei260PROSITE-ProRule annotation1
Metal bindingi263Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi269Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

  • enzyme activator activity Source: ProtInc
  • metalloaminopeptidase activity Source: ParkinsonsUK-UCL
  • metalloendopeptidase activity Source: Reactome
  • zinc ion binding Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cellular protein modification process Source: ProtInc
  • collagen catabolic process Source: Reactome
  • endodermal cell differentiation Source: UniProtKB
  • extracellular matrix disassembly Source: Reactome
  • proteolysis Source: ParkinsonsUK-UCL
  • response to estradiol Source: Ensembl
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B5 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases

Protein family/group databases

MEROPSiM10.015

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinase-15 (EC:3.4.24.-)
Short name:
MMP-15
Alternative name(s):
Membrane-type matrix metalloproteinase 2
Short name:
MT-MMP 2
Short name:
MTMMP2
Membrane-type-2 matrix metalloproteinase
Short name:
MT2-MMP
Short name:
MT2MMP
SMCP-2
Gene namesi
Name:MMP15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102996.4
HGNCiHGNC:7161 MMP15
MIMi602261 gene
neXtProtiNX_P51511

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini132 – 625ExtracellularSequence analysisAdd BLAST494
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21
Topological domaini647 – 669CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4324
OpenTargetsiENSG00000102996
PharmGKBiPA30873

Chemistry databases

ChEMBLiCHEMBL2963
DrugBankiDB00786 Marimastat
GuidetoPHARMACOLOGYi1639

Polymorphism and mutation databases

BioMutaiMMP15
DMDMi1705988

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Or 45Sequence analysisAdd BLAST41
PropeptideiPRO_000002880842 – 131By similarityAdd BLAST90
ChainiPRO_0000028809132 – 669Matrix metalloproteinase-15Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi370 ↔ 559By similarity
Modified residuei589PhosphoserineCombined sources1

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

EPDiP51511
MaxQBiP51511
PaxDbiP51511
PeptideAtlasiP51511
PRIDEiP51511
ProteomicsDBi56312

PTM databases

iPTMnetiP51511
PhosphoSitePlusiP51511

Expressioni

Tissue specificityi

Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000102996
CleanExiHS_MMP15
ExpressionAtlasiP51511 baseline and differential
GenevisibleiP51511 HS

Organism-specific databases

HPAiCAB002611
HPA040390

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PROCP040702EBI-1383043,EBI-1383018

Protein-protein interaction databases

BioGridi110467, 2 interactors
IntActiP51511, 3 interactors
MINTiP51511
STRINGi9606.ENSP00000219271

Chemistry databases

BindingDBiP51511

Structurei

3D structure databases

ProteinModelPortaliP51511
SMRiP51511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati367 – 415Hemopexin 1Add BLAST49
Repeati416 – 461Hemopexin 2Add BLAST46
Repeati463 – 511Hemopexin 3Add BLAST49
Repeati512 – 559Hemopexin 4Add BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi109 – 116Cysteine switchBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi331 – 340Poly-Pro10

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000217928
HOVERGENiHBG052484
InParanoidiP51511
KOiK07995
OMAiMQRKGAP
OrthoDBiEOG091G03DP
PhylomeDBiP51511
TreeFamiTF352396

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028729 MMP15
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021805 Pept_M10A_metallopeptidase_C
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PANTHERiPTHR10201:SF25 PTHR10201:SF25, 1 hit
PfamiView protein in Pfam
PF11857 DUF3377, 1 hit
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSDPSAPGR PGWTGSLLGD REEAARPRLL PLLLVLLGCL GLGVAAEDAE 
        60         70         80         90        100
VHAENWLRLY GYLPQPSRHM STMRSAQILA SALAEMQRFY GIPVTGVLDE 
       110        120        130        140        150
ETKEWMKRPR CGVPDQFGVR VKANLRRRRK RYALTGRKWN NHHLTFSIQN 
       160        170        180        190        200
YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ EVPYEDIRLR RQKEADIMVL 
       210        220        230        240        250
FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP WTFSSTDLHG 
       260        270        280        290        300
NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ 
       310        320        330        340        350
QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP 
       360        370        380        390        400
GPPVQPRATE RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV 
       410        420        430        440        450
LDNYPMPIGH FWRGLPGDIS AAYERQDGRF VFFKGDRYWL FREANLEPGY 
       460        470        480        490        500
PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF FQEDRYWRFN EETQRGDPGY 
       510        520        530        540        550
PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE RLRMEPGYPK 
       560        570        580        590        600
SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD 
       610        620        630        640        650
FGAGVNKDGG SRVVVQMEEV ARTVNVVMVL VPLLLLLCVL GLTYALVQMQ 
       660 
RKGAPRVLLY CKRSLQEWV
Length:669
Mass (Da):75,807
Last modified:October 1, 1996 - v1
Checksum:iFE875EC0674B297F
GO

Sequence cautioni

The sequence BAA13071 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030523200L → P1 PublicationCorresponds to variant dbSNP:rs41340745Ensembl.1
Natural variantiVAR_030524350P → L1 PublicationCorresponds to variant dbSNP:rs41335851Ensembl.1
Natural variantiVAR_030525596D → G2 PublicationsCorresponds to variant dbSNP:rs41504346Ensembl.1
Natural variantiVAR_020055609G → R2 PublicationsCorresponds to variant dbSNP:rs3743563Ensembl.1
Natural variantiVAR_030526622R → W1 PublicationCorresponds to variant dbSNP:rs41434246Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48482 mRNA Translation: CAA88373.1
EF032329 Genomic DNA Translation: ABJ53423.1
BC036495 mRNA Translation: AAH36495.1
BC055428 mRNA Translation: AAH55428.1
D86331 mRNA Translation: BAA13071.1 Different initiation.
D85510 mRNA Translation: BAA22225.1
CCDSiCCDS10792.1
PIRiI38029
RefSeqiNP_002419.1, NM_002428.3
UniGeneiHs.80343

Genome annotation databases

EnsembliENST00000219271; ENSP00000219271; ENSG00000102996
GeneIDi4324
KEGGihsa:4324
UCSCiuc002ena.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMMP15_HUMAN
AccessioniPrimary (citable) accession number: P51511
Secondary accession number(s): A0A2U6, Q14111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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