UniProtKB - P51511 (MMP15_HUMAN)
Protein
Matrix metalloproteinase-15
Gene
MMP15
Organism
Homo sapiens (Human)
Status
Functioni
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.1 Publication
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 111 | Zinc; in inhibited formBy similarity | 1 | |
Metal bindingi | 259 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Active sitei | 260 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 263 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 269 | Zinc; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- enzyme activator activity Source: ProtInc
- metalloaminopeptidase activity Source: ParkinsonsUK-UCL
- metalloendopeptidase activity Source: GO_Central
- zinc ion binding Source: ProtInc
GO - Biological processi
- cellular protein modification process Source: ProtInc
- collagen catabolic process Source: GO_Central
- endodermal cell differentiation Source: UniProtKB
- extracellular matrix disassembly Source: Reactome
- extracellular matrix organization Source: GO_Central
- proteolysis Source: ParkinsonsUK-UCL
- response to estradiol Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 3.4.24.B5, 2681 |
PathwayCommonsi | P51511 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases |
Protein family/group databases
MEROPSi | M10.015 |
Names & Taxonomyi
Protein namesi | Recommended name: Matrix metalloproteinase-15 (EC:3.4.24.-)Short name: MMP-15 Alternative name(s): Membrane-type matrix metalloproteinase 2 Short name: MT-MMP 2 Short name: MTMMP2 Membrane-type-2 matrix metalloproteinase Short name: MT2-MMP Short name: MT2MMP SMCP-2 |
Gene namesi | Name:MMP15 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102996.4 |
HGNCi | HGNC:7161, MMP15 |
MIMi | 602261, gene |
neXtProti | NX_P51511 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated; Extracellular side Curated
Extracellular region or secreted
- extracellular matrix Source: InterPro
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 132 – 625 | ExtracellularSequence analysisAdd BLAST | 494 | |
Transmembranei | 626 – 646 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 647 – 669 | CytoplasmicSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4324 |
OpenTargetsi | ENSG00000102996 |
PharmGKBi | PA30873 |
Miscellaneous databases
Pharosi | P51511, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2963 |
DrugBanki | DB00786, Marimastat |
GuidetoPHARMACOLOGYi | 1639 |
Polymorphism and mutation databases
BioMutai | MMP15 |
DMDMi | 1705988 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 41 | Or 45Sequence analysisAdd BLAST | 41 | |
PropeptideiPRO_0000028808 | 42 – 131 | By similarityAdd BLAST | 90 | |
ChainiPRO_0000028809 | 132 – 669 | Matrix metalloproteinase-15Add BLAST | 538 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 150 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 370 ↔ 559 | By similarity | ||
Modified residuei | 589 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
The precursor is cleaved by a furin endopeptidase.By similarity
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, ZymogenProteomic databases
EPDi | P51511 |
jPOSTi | P51511 |
MassIVEi | P51511 |
MaxQBi | P51511 |
PaxDbi | P51511 |
PeptideAtlasi | P51511 |
PRIDEi | P51511 |
ProteomicsDBi | 56312 |
PTM databases
GlyGeni | P51511, 1 site |
iPTMneti | P51511 |
PhosphoSitePlusi | P51511 |
Expressioni
Tissue specificityi
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
Gene expression databases
Bgeei | ENSG00000102996, Expressed in heart left ventricle and 168 other tissues |
ExpressionAtlasi | P51511, baseline and differential |
Genevisiblei | P51511, HS |
Organism-specific databases
HPAi | ENSG00000102996, Tissue enhanced (intestine) |
Interactioni
Binary interactionsi
P51511
With | #Exp. | IntAct |
---|---|---|
PROC [P04070] | 2 | EBI-1383043,EBI-1383018 |
Protein-protein interaction databases
BioGRIDi | 110467, 5 interactors |
IntActi | P51511, 5 interactors |
MINTi | P51511 |
STRINGi | 9606.ENSP00000219271 |
Chemistry databases
BindingDBi | P51511 |
Miscellaneous databases
RNActi | P51511, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 367 – 415 | Hemopexin 1Add BLAST | 49 | |
Repeati | 416 – 461 | Hemopexin 2Add BLAST | 46 | |
Repeati | 463 – 511 | Hemopexin 3Add BLAST | 49 | |
Repeati | 512 – 559 | Hemopexin 4Add BLAST | 48 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 109 – 116 | Cysteine switchBy similarity | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 331 – 340 | Poly-Pro | 10 |
Domaini
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence similaritiesi
Belongs to the peptidase M10A family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000156939 |
HOGENOMi | CLU_015489_8_1_1 |
InParanoidi | P51511 |
OMAi | TGRRWSQ |
OrthoDBi | 1075463at2759 |
PhylomeDBi | P51511 |
TreeFami | TF352396 |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR028729, MMP15 IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021805, Pept_M10A_metallopeptidase_C IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
PANTHERi | PTHR10201:SF25, PTHR10201:SF25, 1 hit |
Pfami | View protein in Pfam PF11857, DUF3377, 1 hit PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits PS00142, ZINC_PROTEASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P51511-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSDPSAPGR PGWTGSLLGD REEAARPRLL PLLLVLLGCL GLGVAAEDAE
60 70 80 90 100
VHAENWLRLY GYLPQPSRHM STMRSAQILA SALAEMQRFY GIPVTGVLDE
110 120 130 140 150
ETKEWMKRPR CGVPDQFGVR VKANLRRRRK RYALTGRKWN NHHLTFSIQN
160 170 180 190 200
YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ EVPYEDIRLR RQKEADIMVL
210 220 230 240 250
FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP WTFSSTDLHG
260 270 280 290 300
NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ
310 320 330 340 350
QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP
360 370 380 390 400
GPPVQPRATE RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV
410 420 430 440 450
LDNYPMPIGH FWRGLPGDIS AAYERQDGRF VFFKGDRYWL FREANLEPGY
460 470 480 490 500
PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF FQEDRYWRFN EETQRGDPGY
510 520 530 540 550
PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE RLRMEPGYPK
560 570 580 590 600
SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD
610 620 630 640 650
FGAGVNKDGG SRVVVQMEEV ARTVNVVMVL VPLLLLLCVL GLTYALVQMQ
660
RKGAPRVLLY CKRSLQEWV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BT97 | H3BT97_HUMAN | Matrix metalloproteinase-15 | MMP15 | 97 | Annotation score: |
Sequence cautioni
The sequence BAA13071 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030523 | 200 | L → P1 PublicationCorresponds to variant dbSNP:rs41340745Ensembl. | 1 | |
Natural variantiVAR_030524 | 350 | P → L1 PublicationCorresponds to variant dbSNP:rs41335851Ensembl. | 1 | |
Natural variantiVAR_030525 | 596 | D → G2 PublicationsCorresponds to variant dbSNP:rs41504346Ensembl. | 1 | |
Natural variantiVAR_020055 | 609 | G → R2 PublicationsCorresponds to variant dbSNP:rs3743563Ensembl. | 1 | |
Natural variantiVAR_030526 | 622 | R → W1 PublicationCorresponds to variant dbSNP:rs41434246Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48482 mRNA Translation: CAA88373.1 EF032329 Genomic DNA Translation: ABJ53423.1 BC036495 mRNA Translation: AAH36495.1 BC055428 mRNA Translation: AAH55428.1 D86331 mRNA Translation: BAA13071.1 Different initiation. D85510 mRNA Translation: BAA22225.1 |
CCDSi | CCDS10792.1 |
PIRi | I38029 |
RefSeqi | NP_002419.1, NM_002428.3 |
Genome annotation databases
Ensembli | ENST00000219271; ENSP00000219271; ENSG00000102996 |
GeneIDi | 4324 |
KEGGi | hsa:4324 |
UCSCi | uc002ena.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48482 mRNA Translation: CAA88373.1 EF032329 Genomic DNA Translation: ABJ53423.1 BC036495 mRNA Translation: AAH36495.1 BC055428 mRNA Translation: AAH55428.1 D86331 mRNA Translation: BAA13071.1 Different initiation. D85510 mRNA Translation: BAA22225.1 |
CCDSi | CCDS10792.1 |
PIRi | I38029 |
RefSeqi | NP_002419.1, NM_002428.3 |
3D structure databases
SMRi | P51511 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110467, 5 interactors |
IntActi | P51511, 5 interactors |
MINTi | P51511 |
STRINGi | 9606.ENSP00000219271 |
Chemistry databases
BindingDBi | P51511 |
ChEMBLi | CHEMBL2963 |
DrugBanki | DB00786, Marimastat |
GuidetoPHARMACOLOGYi | 1639 |
Protein family/group databases
MEROPSi | M10.015 |
PTM databases
GlyGeni | P51511, 1 site |
iPTMneti | P51511 |
PhosphoSitePlusi | P51511 |
Polymorphism and mutation databases
BioMutai | MMP15 |
DMDMi | 1705988 |
Proteomic databases
EPDi | P51511 |
jPOSTi | P51511 |
MassIVEi | P51511 |
MaxQBi | P51511 |
PaxDbi | P51511 |
PeptideAtlasi | P51511 |
PRIDEi | P51511 |
ProteomicsDBi | 56312 |
Protocols and materials databases
Antibodypediai | 3619, 476 antibodies |
DNASUi | 4324 |
Genome annotation databases
Ensembli | ENST00000219271; ENSP00000219271; ENSG00000102996 |
GeneIDi | 4324 |
KEGGi | hsa:4324 |
UCSCi | uc002ena.4, human |
Organism-specific databases
CTDi | 4324 |
DisGeNETi | 4324 |
EuPathDBi | HostDB:ENSG00000102996.4 |
GeneCardsi | MMP15 |
HGNCi | HGNC:7161, MMP15 |
HPAi | ENSG00000102996, Tissue enhanced (intestine) |
MIMi | 602261, gene |
neXtProti | NX_P51511 |
OpenTargetsi | ENSG00000102996 |
PharmGKBi | PA30873 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000156939 |
HOGENOMi | CLU_015489_8_1_1 |
InParanoidi | P51511 |
OMAi | TGRRWSQ |
OrthoDBi | 1075463at2759 |
PhylomeDBi | P51511 |
TreeFami | TF352396 |
Enzyme and pathway databases
BRENDAi | 3.4.24.B5, 2681 |
PathwayCommonsi | P51511 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases |
Miscellaneous databases
BioGRID-ORCSi | 4324, 8 hits in 842 CRISPR screens |
GeneWikii | MMP15 |
GenomeRNAii | 4324 |
Pharosi | P51511, Tchem |
PROi | PR:P51511 |
RNActi | P51511, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102996, Expressed in heart left ventricle and 168 other tissues |
ExpressionAtlasi | P51511, baseline and differential |
Genevisiblei | P51511, HS |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR028729, MMP15 IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021805, Pept_M10A_metallopeptidase_C IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
PANTHERi | PTHR10201:SF25, PTHR10201:SF25, 1 hit |
Pfami | View protein in Pfam PF11857, DUF3377, 1 hit PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MMP15_HUMAN | |
Accessioni | P51511Primary (citable) accession number: P51511 Secondary accession number(s): A0A2U6, Q14111 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries