MMP15

Functionⁱ

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.1 Publication

Cofactorⁱ

Protein has several cofactor binding sites:

Zn²⁺By similarityNote: Binds 1 zinc ion per subunit.By similarity
Ca²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	111	Zinc; in inhibited formBy similarity	1
Metal bindingⁱ	259	Zinc; catalyticPROSITE-ProRule annotation	1
Active siteⁱ	260	PROSITE-ProRule annotation	1
Metal bindingⁱ	263	Zinc; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	269	Zinc; catalyticPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

enzyme activator activity
Source: ProtInc
Traceable author statementⁱ
- 7559440
metalloaminopeptidase activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 14645246
metalloendopeptidase activity Source: Reactome
zinc ion binding
Source: ProtInc
Traceable author statementⁱ
- 7649159

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 7559440
collagen catabolic process Source: Reactome
endodermal cell differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 23154389
extracellular matrix disassembly Source: Reactome
proteolysis
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 14645246
response to estradiol Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Metalloprotease, Protease
Ligand	Calcium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	3.4.24.B5 2681
Reactomeⁱ	R-HSA-1442490 Collagen degradation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1592389 Activation of Matrix Metalloproteinases

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M10.015

MEROPSⁱ

M10.015

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Matrix metalloproteinase-15 (EC:3.4.24.-) Short name: MMP-15 Alternative name(s): Membrane-type matrix metalloproteinase 2 Short name: MT-MMP 2 Short name: MTMMP2 Membrane-type-2 matrix metalloproteinase Short name: MT2-MMP Short name: MT2MMP SMCP-2
Gene namesⁱ	Name:MMP15
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102996.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7161 MMP15
MIMⁱ	602261 gene
neXtProtⁱ	NX_P51511

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	132 – 625	ExtracellularSequence analysisAdd BLAST	494
Transmembraneⁱ	626 – 646	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	647 – 669	CytoplasmicSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4324
Open Targets More...OpenTargetsⁱ	ENSG00000102996
PharmGKBⁱ	PA30873

Chemistry databases

ChEMBLⁱ	CHEMBL2963
Drug and drug target database More...DrugBankⁱ	DB00786 Marimastat
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1639

Polymorphism and mutation databases

BioMutaⁱ	MMP15
DMDMⁱ	1705988

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 41	Or 45Sequence analysisAdd BLAST	41
PropeptideⁱPRO_0000028808	42 – 131	By similarityAdd BLAST	90
ChainⁱPRO_0000028809	132 – 669	Matrix metalloproteinase-15Add BLAST	538

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	150	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	370 ↔ 559	By similarity
Modified residueⁱ	589	PhosphoserineCombined sources	1

Post-translational modificationⁱ

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

EPDⁱ	P51511
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51511
PaxDbⁱ	P51511
PeptideAtlas More...PeptideAtlasⁱ	P51511
PRIDEⁱ	P51511
ProteomicsDBⁱ	56312

PTM databases

iPTMnetⁱ	P51511
PhosphoSitePlusⁱ	P51511

Expressionⁱ

Tissue specificityⁱ

Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.

Gene expression databases

Bgeeⁱ	ENSG00000102996 Expressed in 149 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_MMP15
ExpressionAtlasⁱ	P51511 baseline and differential
Genevisibleⁱ	P51511 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002611 HPA040390

HPAⁱ

CAB002611
HPA040390

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PROC	P04070	2	EBI-1383043,EBI-1383018

With

Entry

#Exp.

IntAct

Notes

PROC

P04070

2

EBI-1383043,EBI-1383018

Protein-protein interaction databases

BioGridⁱ	110467, 2 interactors
IntActⁱ	P51511, 3 interactors
Molecular INTeraction database More...MINTⁱ	P51511
STRINGⁱ	9606.ENSP00000219271

Chemistry databases

BindingDBⁱ

P51511

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51511
SMRⁱ	P51511
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	367 – 415	Hemopexin 1Add BLAST	49
Repeatⁱ	416 – 461	Hemopexin 2Add BLAST	46
Repeatⁱ	463 – 511	Hemopexin 3Add BLAST	49
Repeatⁱ	512 – 559	Hemopexin 4Add BLAST	48

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	109 – 116	Cysteine switchBy similarity		8

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	331 – 340	Poly-Pro		10

Domainⁱ

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesⁱ

Belongs to the peptidase M10A family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1565 Eukaryota ENOG410XQ5D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118870
HOGENOMⁱ	HOG000217928
HOVERGENⁱ	HBG052484
InParanoidⁱ	P51511
KEGG Orthology (KO) More...KOⁱ	K07995
OMAⁱ	QHGDPGY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03DP
PhylomeDBⁱ	P51511
TreeFamⁱ	TF352396

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00094 HX, 1 hit cd04278 ZnMc_MMP, 1 hit
Gene3Dⁱ	2.110.10.10, 1 hit 3.40.390.10, 1 hit
InterProⁱ	View protein in InterPro IPR000585 Hemopexin-like_dom IPR036375 Hemopexin-like_dom_sf IPR018487 Hemopexin-like_repeat IPR018486 Hemopexin_CS IPR033739 M10A_MMP IPR024079 MetalloPept_cat_dom_sf IPR028729 MMP15 IPR001818 Pept_M10_metallopeptidase IPR021190 Pept_M10A IPR021805 Pept_M10A_metallopeptidase_C IPR021158 Pept_M10A_Zn_BS IPR006026 Peptidase_Metallo IPR002477 Peptidoglycan-bd-like IPR036365 PGBD-like_sf
PANTHERⁱ	PTHR10201:SF25 PTHR10201:SF25, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11857 DUF3377, 1 hit PF00045 Hemopexin, 4 hits PF00413 Peptidase_M10, 1 hit PF01471 PG_binding_1, 1 hit
PIRSFⁱ	PIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSⁱ	PR00138 MATRIXIN
SMARTⁱ	View protein in SMART SM00120 HX, 4 hits SM00235 ZnMc, 1 hit
SUPFAMⁱ	SSF47090 SSF47090, 1 hit SSF50923 SSF50923, 1 hit
PROSITEⁱ	View protein in PROSITE PS00546 CYSTEINE_SWITCH, 1 hit PS00024 HEMOPEXIN, 1 hit PS51642 HEMOPEXIN_2, 4 hits PS00142 ZINC_PROTEASE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P51511-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSDPSAPGR PGWTGSLLGD REEAARPRLL PLLLVLLGCL GLGVAAEDAE 
        60         70         80         90        100
VHAENWLRLY GYLPQPSRHM STMRSAQILA SALAEMQRFY GIPVTGVLDE 
       110        120        130        140        150
ETKEWMKRPR CGVPDQFGVR VKANLRRRRK RYALTGRKWN NHHLTFSIQN 
       160        170        180        190        200
YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ EVPYEDIRLR RQKEADIMVL 
       210        220        230        240        250
FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP WTFSSTDLHG 
       260        270        280        290        300
NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ 
       310        320        330        340        350
QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP 
       360        370        380        390        400
GPPVQPRATE RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV 
       410        420        430        440        450
LDNYPMPIGH FWRGLPGDIS AAYERQDGRF VFFKGDRYWL FREANLEPGY 
       460        470        480        490        500
PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF FQEDRYWRFN EETQRGDPGY 
       510        520        530        540        550
PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE RLRMEPGYPK 
       560        570        580        590        600
SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD 
       610        620        630        640        650
FGAGVNKDGG SRVVVQMEEV ARTVNVVMVL VPLLLLLCVL GLTYALVQMQ 
       660 
RKGAPRVLLY CKRSLQEWV

Length:669

Mass (Da):75,807

Last modified:October 1, 1996 - v1

Checksum:ⁱFE875EC0674B297F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BT97	H3BT97_HUMAN		Matrix metalloproteinase Matrix metalloproteinase, EC 3.4.24.-	MMP15	97	Annotation score:

Sequence cautionⁱ

The sequence BAA13071 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030523	200	L → P1 PublicationCorresponds to variant dbSNP:rs41340745Ensembl.	1
Natural variantⁱVAR_030524	350	P → L1 PublicationCorresponds to variant dbSNP:rs41335851Ensembl.	1
Natural variantⁱVAR_030525	596	D → G2 PublicationsCorresponds to variant dbSNP:rs41504346Ensembl.	1
Natural variantⁱVAR_020055	609	G → R2 PublicationsCorresponds to variant dbSNP:rs3743563Ensembl.	1
Natural variantⁱVAR_030526	622	R → W1 PublicationCorresponds to variant dbSNP:rs41434246Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z48482 mRNA Translation: CAA88373.1 EF032329 Genomic DNA Translation: ABJ53423.1 BC036495 mRNA Translation: AAH36495.1 BC055428 mRNA Translation: AAH55428.1 D86331 mRNA Translation: BAA13071.1 Different initiation. D85510 mRNA Translation: BAA22225.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10792.1
PIRⁱ	I38029
NCBI Reference Sequences More...RefSeqⁱ	NP_002419.1, NM_002428.3
UniGeneⁱ	Hs.80343

Genome annotation databases

Ensemblⁱ	ENST00000219271; ENSP00000219271; ENSG00000102996
GeneIDⁱ	4324
KEGGⁱ	hsa:4324
UCSC genome browser More...UCSCⁱ	uc002ena.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51511	Matrix metallopeptidase 15 (Membrane-inserted), isoform CRA_a		HUMAN		669	UniRef100_P51511

Protein	Similar proteins		Species	Score	Length	Source
P51511	Matrix metallopeptidase 15 (Membrane-inserted), isoform CRA_a		HUMAN		669	UniRef90_P51511
matrix metalloproteinase-15		Enhydra lutris kenyoni		676
Matrix metalloproteinase		BOVIN		675
Matrix metalloproteinase		MUSPF		674
Matrix metalloproteinase		PROCO		673
+50

Protein	Similar proteins		Species	Score	Length	Source
P51511	Matrix metalloproteinase-15		MOUSE		657	UniRef50_P51511
Matrix metallopeptidase 15 (Membrane-inserted), isoform CRA_a		HUMAN		669
matrix metalloproteinase-15		Enhydra lutris kenyoni		676
Matrix metalloproteinase		BOVIN		675
Matrix metalloproteinase		MUSPF		674
+387

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z48482 mRNA Translation: CAA88373.1 EF032329 Genomic DNA Translation: ABJ53423.1 BC036495 mRNA Translation: AAH36495.1 BC055428 mRNA Translation: AAH55428.1 D86331 mRNA Translation: BAA13071.1 Different initiation. D85510 mRNA Translation: BAA22225.1
CCDSⁱ	CCDS10792.1
PIRⁱ	I38029
RefSeqⁱ	NP_002419.1, NM_002428.3
UniGeneⁱ	Hs.80343

3D structure databases

ProteinModelPortalⁱ	P51511
SMRⁱ	P51511
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110467, 2 interactors
IntActⁱ	P51511, 3 interactors
MINTⁱ	P51511
STRINGⁱ	9606.ENSP00000219271

Chemistry databases

BindingDBⁱ	P51511
ChEMBLⁱ	CHEMBL2963
DrugBankⁱ	DB00786 Marimastat
GuidetoPHARMACOLOGYⁱ	1639

Protein family/group databases

MEROPSⁱ	M10.015

MEROPSⁱ

M10.015

PTM databases

iPTMnetⁱ	P51511
PhosphoSitePlusⁱ	P51511

Polymorphism and mutation databases

BioMutaⁱ	MMP15
DMDMⁱ	1705988

Proteomic databases

EPDⁱ	P51511
MaxQBⁱ	P51511
PaxDbⁱ	P51511
PeptideAtlasⁱ	P51511
PRIDEⁱ	P51511
ProteomicsDBⁱ	56312

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4324
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000219271; ENSP00000219271; ENSG00000102996
GeneIDⁱ	4324
KEGGⁱ	hsa:4324
UCSCⁱ	uc002ena.4 human

Organism-specific databases

CTDⁱ	4324
DisGeNETⁱ	4324
EuPathDBⁱ	HostDB:ENSG00000102996.4
GeneCardsⁱ	MMP15
HGNCⁱ	HGNC:7161 MMP15
HPAⁱ	CAB002611 HPA040390
MIMⁱ	602261 gene
neXtProtⁱ	NX_P51511
OpenTargetsⁱ	ENSG00000102996
PharmGKBⁱ	PA30873
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1565 Eukaryota ENOG410XQ5D LUCA
GeneTreeⁱ	ENSGT00760000118870
HOGENOMⁱ	HOG000217928
HOVERGENⁱ	HBG052484
InParanoidⁱ	P51511
KOⁱ	K07995
OMAⁱ	QHGDPGY
OrthoDBⁱ	EOG091G03DP
PhylomeDBⁱ	P51511
TreeFamⁱ	TF352396

Enzyme and pathway databases

BRENDAⁱ	3.4.24.B5 2681
Reactomeⁱ	R-HSA-1442490 Collagen degradation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1592389 Activation of Matrix Metalloproteinases

Miscellaneous databases

GeneWikiⁱ	MMP15
GenomeRNAiⁱ	4324
Protein Ontology More...PROⁱ	PR:P51511
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102996 Expressed in 149 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_MMP15
ExpressionAtlasⁱ	P51511 baseline and differential
Genevisibleⁱ	P51511 HS

Family and domain databases

CDDⁱ	cd00094 HX, 1 hit cd04278 ZnMc_MMP, 1 hit
Gene3Dⁱ	2.110.10.10, 1 hit 3.40.390.10, 1 hit
InterProⁱ	View protein in InterPro IPR000585 Hemopexin-like_dom IPR036375 Hemopexin-like_dom_sf IPR018487 Hemopexin-like_repeat IPR018486 Hemopexin_CS IPR033739 M10A_MMP IPR024079 MetalloPept_cat_dom_sf IPR028729 MMP15 IPR001818 Pept_M10_metallopeptidase IPR021190 Pept_M10A IPR021805 Pept_M10A_metallopeptidase_C IPR021158 Pept_M10A_Zn_BS IPR006026 Peptidase_Metallo IPR002477 Peptidoglycan-bd-like IPR036365 PGBD-like_sf
PANTHERⁱ	PTHR10201:SF25 PTHR10201:SF25, 1 hit
Pfamⁱ	View protein in Pfam PF11857 DUF3377, 1 hit PF00045 Hemopexin, 4 hits PF00413 Peptidase_M10, 1 hit PF01471 PG_binding_1, 1 hit
PIRSFⁱ	PIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSⁱ	PR00138 MATRIXIN
SMARTⁱ	View protein in SMART SM00120 HX, 4 hits SM00235 ZnMc, 1 hit
SUPFAMⁱ	SSF47090 SSF47090, 1 hit SSF50923 SSF50923, 1 hit
PROSITEⁱ	View protein in PROSITE PS00546 CYSTEINE_SWITCH, 1 hit PS00024 HEMOPEXIN, 1 hit PS51642 HEMOPEXIN_2, 4 hits PS00142 ZINC_PROTEASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MMP15_HUMAN
Accessionⁱ	P51511Primary (citable) accession number: P51511 Secondary accession number(s): A0A2U6, Q14111
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Peptidase families
Classification of peptidase families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - P51511 (MMP15_HUMAN)

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Matrix metalloproteinase-15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ