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Entry version 173 (11 Dec 2019)
Sequence version 3 (23 Nov 2004)
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Protein

Zinc finger protein 81

Gene

ZNF81

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri330 – 352C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 81
Alternative name(s):
HFZ20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF81
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197779.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13156 ZNF81

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
314998 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51508

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ZNF81 is found in a severe mental retardation patient. Translocation t(X;9)(p11.23;q34.3).1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
347344

MalaCards human disease database

More...
MalaCardsi
ZNF81

Open Targets

More...
OpenTargetsi
ENSG00000197779

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
777 X-linked non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37730

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P51508 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF81

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55977803

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473951 – 661Zinc finger protein 81Add BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P51508

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P51508

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P51508

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51508

PeptideAtlas

More...
PeptideAtlasi
P51508

PRoteomics IDEntifications database

More...
PRIDEi
P51508

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56311

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197779 Expressed in 179 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P51508 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51508 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001689

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131424, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P51508, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366153

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P51508 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51508

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 92KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri330 – 352C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri582 – 604C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri610 – 632C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri638 – 660C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162553

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51508

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSHLFAP

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51508

TreeFam database of animal gene trees

More...
TreeFami
TF350810

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P51508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPANEDAPQP GEHGSACEVS VSFEDVTVDF SREEWQQLDS TQRRLYQDVM
60 70 80 90 100
LENYSHLLSV GFEVPKPEVI FKLEQGEGPW TLEGEAPHQS CSDGKFGIKP
110 120 130 140 150
SQRRISGKST FHSEMEGEDT RDDSLYSILE ELWQDAEQIK RCQEKHNKLL
160 170 180 190 200
SRTTFLNKKI LNTEWDYEYK DFGKFVHPSP NLILSQKRPH KRDSFGKSFK
210 220 230 240 250
HNLDLHIHNK SNAAKNLDKT IGHGQVFTQN SSYSHHENTH TGVKFCERNQ
260 270 280 290 300
CGKVLSLKHS LSQNVKFPIG EKANTCTEFG KIFTQRSHFF APQKIHTVEK
310 320 330 340 350
PHELSKCVNV FTQKPLLSIY LRVHRDEKLY ICTKCGKAFI QNSELIMHEK
360 370 380 390 400
THTREKPYKC NECGKSFFQV SSLLRHQTTH TGEKLFECSE CGKGFSLNSA
410 420 430 440 450
LNIHQKIHTG ERHHKCSECG KAFTQKSTLR MHQRIHTGER SYICTQCGQA
460 470 480 490 500
FIQKAHLIAH QRIHTGEKPY ECSDCGKSFP SKSQLQMHKR IHTGEKPYIC
510 520 530 540 550
TECGKAFTNR SNLNTHQKSH TGEKSYICAE CGKAFTDRSN FNKHQTIHTG
560 570 580 590 600
EKPYVCADCG RAFIQKSELI THQRIHTTEK PYKCPDCEKS FSKKPHLKVH
610 620 630 640 650
QRIHTGEKPY ICAECGKAFT DRSNFNKHQT IHTGDKPYKC SDCGKGFTQK
660
SVLSMHRNIH T
Length:661
Mass (Da):75,960
Last modified:November 23, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6583905D2DB96975
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AJV1B1AJV1_HUMAN
Zinc finger protein 81
ZNF81
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AJV2B1AJV2_HUMAN
Zinc finger protein 81
ZNF81
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0199393A → V1 PublicationCorresponds to variant dbSNP:rs183846665EnsemblClinVar.1
Natural variantiVAR_038806117G → V. Corresponds to variant dbSNP:rs17147793EnsemblClinVar.1
Natural variantiVAR_019940157N → S1 PublicationCorresponds to variant dbSNP:rs41312157EnsemblClinVar.1
Natural variantiVAR_019941179S → N Found in a family with mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs28933691EnsemblClinVar.1
Natural variantiVAR_019942185S → L1 PublicationCorresponds to variant dbSNP:rs186251256EnsemblClinVar.1
Natural variantiVAR_052765213A → E. Corresponds to variant dbSNP:rs537825EnsemblClinVar.1
Natural variantiVAR_019943499I → V1 PublicationCorresponds to variant dbSNP:rs182239885EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY487248 mRNA Translation: AAS17752.1
AL591394 Genomic DNA No translation available.
AL022578 Genomic DNA No translation available.
Z98304 Genomic DNA No translation available.
X68011 Genomic DNA Translation: CAA48148.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43933.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S60520

NCBI Reference Sequences

More...
RefSeqi
NP_009068.2, NM_007137.3
XP_005272657.1, XM_005272600.3
XP_011542201.1, XM_011543899.2
XP_011542202.1, XM_011543900.2
XP_016884975.1, XM_017029486.1
XP_016884976.1, XM_017029487.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338637; ENSP00000341151; ENSG00000197779
ENST00000376954; ENSP00000366153; ENSG00000197779

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
347344

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:347344

UCSC genome browser

More...
UCSCi
uc010nhy.3 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY487248 mRNA Translation: AAS17752.1
AL591394 Genomic DNA No translation available.
AL022578 Genomic DNA No translation available.
Z98304 Genomic DNA No translation available.
X68011 Genomic DNA Translation: CAA48148.1
CCDSiCCDS43933.1
PIRiS60520
RefSeqiNP_009068.2, NM_007137.3
XP_005272657.1, XM_005272600.3
XP_011542201.1, XM_011543899.2
XP_011542202.1, XM_011543900.2
XP_016884975.1, XM_017029486.1
XP_016884976.1, XM_017029487.1

3D structure databases

SMRiP51508
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131424, 2 interactors
IntActiP51508, 1 interactor
STRINGi9606.ENSP00000366153

PTM databases

iPTMnetiP51508
PhosphoSitePlusiP51508

Polymorphism and mutation databases

BioMutaiZNF81
DMDMi55977803

Proteomic databases

jPOSTiP51508
MassIVEiP51508
MaxQBiP51508
PaxDbiP51508
PeptideAtlasiP51508
PRIDEiP51508
ProteomicsDBi56311

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
347344

Genome annotation databases

EnsembliENST00000338637; ENSP00000341151; ENSG00000197779
ENST00000376954; ENSP00000366153; ENSG00000197779
GeneIDi347344
KEGGihsa:347344
UCSCiuc010nhy.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
347344
DisGeNETi347344
EuPathDBiHostDB:ENSG00000197779.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF81
HGNCiHGNC:13156 ZNF81
HPAiHPA001689
MalaCardsiZNF81
MIMi314998 gene
neXtProtiNX_P51508
OpenTargetsiENSG00000197779
Orphaneti777 X-linked non-syndromic intellectual disability
PharmGKBiPA37730

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162553
HOGENOMiHOG000234617
InParanoidiP51508
KOiK09228
OMAiKSHLFAP
OrthoDBi1318335at2759
PhylomeDBiP51508
TreeFamiTF350810

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF81 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
347344
PharosiP51508 Tbio

Protein Ontology

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PROi
PR:P51508
RNActiP51508 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197779 Expressed in 179 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP51508 baseline and differential
GenevisibleiP51508 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF81_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51508
Secondary accession number(s): Q6RX22, Q96QH6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 23, 2004
Last modified: December 11, 2019
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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