UniProtKB - P51494 (IL6_MACMU)
Interleukin-6
IL6
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-6 receptor binding Source: InterPro
GO - Biological processi
- acute-phase response Source: UniProtKB-KW
- glucose homeostasis Source: UniProtKB
- hepatocyte proliferation Source: UniProtKB
- interleukin-6-mediated signaling pathway Source: UniProtKB
- liver regeneration Source: UniProtKB
- positive regulation of receptor signaling pathway via STAT Source: UniProtKB
- regulation of glucagon secretion Source: UniProtKB
- regulation of insulin secretion Source: UniProtKB
- response to activity Source: UniProtKB
- T-helper 17 cell lineage commitment Source: UniProtKB
- vascular endothelial growth factor production Source: UniProtKB
Keywordsi
Molecular function | Cytokine, Growth factor |
Biological process | Acute phase |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-6Short name: IL-6 |
Gene namesi | Name:IL6 |
Organismi | Macaca mulatta (Rhesus macaque) |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000015585 | 28 – 212 | Interleukin-6Add BLAST | 185 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 72 ↔ 78 | By similarity | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 81 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 101 ↔ 111 | By similarity | ||
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinInteractioni
Subunit structurei
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST.
Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling.
Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
By similarityGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-6 receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000026278 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7Q4, Eukaryota |
InParanoidi | P51494 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR003574, IL-6 IPR030474, IL-6/GCSF/MGF IPR030473, IL6/GCSF/MGF_CS |
PANTHERi | PTHR10511, PTHR10511, 1 hit PTHR10511:SF3, PTHR10511:SF3, 1 hit |
Pfami | View protein in Pfam PF00489, IL6, 1 hit |
PIRSFi | PIRSF001935, IL6_MGF_GCSF, 1 hit |
PRINTSi | PR00433, IL6GCSFMGF |
SMARTi | View protein in SMART SM00126, IL6, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00254, INTERLEUKIN_6, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV LPGEDSKNVA APHSQPLTSS
60 70 80 90 100
ERIDKHIRYI LDGISALRKE TCNRSNMCES SKEALAENNL NLPKMAEKDG
110 120 130 140 150
CFQSGFNEDT CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL
160 170 180 190 200
IQFLQKKAKN LDAITTPEPT TNASLLTKLQ AQNQWLQDMT THLILRSFKE
210
FLQSNLRALR QM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L26028 mRNA Translation: AAA99978.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L26028 mRNA Translation: AAA99978.1 |
3D structure databases
SMRi | P51494 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000026278 |
Phylogenomic databases
eggNOGi | ENOG502S7Q4, Eukaryota |
InParanoidi | P51494 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR003574, IL-6 IPR030474, IL-6/GCSF/MGF IPR030473, IL6/GCSF/MGF_CS |
PANTHERi | PTHR10511, PTHR10511, 1 hit PTHR10511:SF3, PTHR10511:SF3, 1 hit |
Pfami | View protein in Pfam PF00489, IL6, 1 hit |
PIRSFi | PIRSF001935, IL6_MGF_GCSF, 1 hit |
PRINTSi | PR00433, IL6GCSFMGF |
SMARTi | View protein in SMART SM00126, IL6, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00254, INTERLEUKIN_6, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL6_MACMU | |
Accessioni | P51494Primary (citable) accession number: P51494 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | October 7, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families