Opn1sw

Functionⁱ

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

GO - Molecular functionⁱ

G-protein coupled photoreceptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phototransduction Source: UniProtKB-KW
protein-chromophore linkage Source: UniProtKB-KW
visual perception Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process	Sensory transduction, Vision
Ligand	Chromophore

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2187335 The retinoid cycle in cones (daylight vision) R-MMU-418594 G alpha (i) signalling events R-MMU-419771 Opsins

Reactomeⁱ

R-MMU-2187335 The retinoid cycle in cones (daylight vision)
R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Short-wave-sensitive opsin 1 Short name: S opsin Alternative name(s): Blue cone photoreceptor pigment Blue-sensitive opsin Short name: BOP Short wavelength-sensitive cone opsin
Gene namesⁱ	Name:Opn1sw Synonyms:Bcp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:99438 Opn1sw

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 31	ExtracellularAdd BLAST	31
Transmembraneⁱ	32 – 56	Helical; Name=1Sequence analysisAdd BLAST	25
Topological domainⁱ	57 – 68	CytoplasmicAdd BLAST	12
Transmembraneⁱ	69 – 94	Helical; Name=2Sequence analysisAdd BLAST	26
Topological domainⁱ	95 – 108	ExtracellularAdd BLAST	14
Transmembraneⁱ	109 – 128	Helical; Name=3Sequence analysisAdd BLAST	20
Topological domainⁱ	129 – 147	CytoplasmicAdd BLAST	19
Transmembraneⁱ	148 – 171	Helical; Name=4Sequence analysisAdd BLAST	24
Topological domainⁱ	172 – 197	ExtracellularAdd BLAST	26
Transmembraneⁱ	198 – 225	Helical; Name=5Sequence analysisAdd BLAST	28
Topological domainⁱ	226 – 247	CytoplasmicAdd BLAST	22
Transmembraneⁱ	248 – 271	Helical; Name=6Sequence analysisAdd BLAST	24
Topological domainⁱ	272 – 279	Extracellular	8
Transmembraneⁱ	280 – 304	Helical; Name=7Sequence analysisAdd BLAST	25
Topological domainⁱ	305 – 346	CytoplasmicAdd BLAST	42

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197766	1 – 346	Short-wave-sensitive opsin 1Add BLAST		346

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	12	N-linked (GlcNAc...) asparagineCurated	1
Disulfide bondⁱ	105 ↔ 182	PROSITE-ProRule annotation
Modified residueⁱ	291	N6-(retinylidene)lysine	1

Post-translational modificationⁱ

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P51491
PRIDEⁱ	P51491

PTM databases

PhosphoSitePlusⁱ	P51491

PhosphoSitePlusⁱ

P51491

Expressionⁱ

Tissue specificityⁱ

Expressed in cone photoreceptor cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000058831
ExpressionAtlasⁱ	P51491 baseline and differential
Genevisibleⁱ	P51491 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000079289

STRINGⁱ

10090.ENSMUSP00000079289

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51491
SMRⁱ	P51491
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000253932
HOVERGENⁱ	HBG107442
InParanoidⁱ	P51491
KEGG Orthology (KO) More...KOⁱ	K04252
OMAⁱ	SEYYTWF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDA
PhylomeDBⁱ	P51491
TreeFamⁱ	TF324998

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001760 Opsin IPR001521 Opsin_blue IPR027430 Retinal_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00238 OPSIN PR00574 OPSINBLUE
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P51491-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN 
        60         70         80         90        100
AIVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF 
       110        120        130        140        150
GRHVCALEAF LGSVAGLVTG WSLAFLAFER YVVICKPFGS IRFNSKHALM 
       160        170        180        190        200
VVLATWIIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEYYTW 
       210        220        230        240        250
FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK AEREVSHMVV 
       260        270        280        290        300
VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII 
       310        320        330        340 
YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH

Length:346

Mass (Da):38,922

Last modified:October 1, 1996 - v1

Checksum:ⁱ8BEEAB0198EE6863

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U49720 mRNA Translation: AAA92458.1 U92562 , U92558, U92559, U92560, U92561 Genomic DNA Translation: AAB53320.1 AF190670 mRNA Translation: AAG17989.1 AF190671 Genomic DNA Translation: AAG17990.1 BC026021 mRNA Translation: AAH26021.1 BC058267 mRNA Translation: AAH58267.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19959.1
PIRⁱ	B54679
NCBI Reference Sequences More...RefSeqⁱ	NP_031564.1, NM_007538.3
UniGeneⁱ	Mm.56987

Genome annotation databases

Ensemblⁱ	ENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831
GeneIDⁱ	12057
KEGGⁱ	mmu:12057
UCSC genome browser More...UCSCⁱ	uc009bdi.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P51491	Short-wave-sensitive opsin 1		RAT		346
Blue-sensitive opsin		PTEAL		360
Short-wave sensitive type 1 opsin (Fragment)		LEPRU		56
SWS1 cone opsin (Fragment)		Eurasian sparrowhawk		38
Opsin 1, short wave sensitive		FELCA		355
+82

Protein	Similar proteins		Species	Score	Length
P51491	Short-wave-sensitive opsin 1	)	HUMAN		348
Short-wave-sensitive opsin 1		PANPA		348
Short-wave-sensitive opsin 1		PANTR		348
Opsin 1, short wave sensitive		CALJA		350
Blue opsin (Fragment)		ALOPA		349
+643

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U49720 mRNA Translation: AAA92458.1 U92562 , U92558, U92559, U92560, U92561 Genomic DNA Translation: AAB53320.1 AF190670 mRNA Translation: AAG17989.1 AF190671 Genomic DNA Translation: AAG17990.1 BC026021 mRNA Translation: AAH26021.1 BC058267 mRNA Translation: AAH58267.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19959.1
PIRⁱ	B54679
NCBI Reference Sequences More...RefSeqⁱ	NP_031564.1, NM_007538.3
UniGeneⁱ	Mm.56987

3D structure databases

ProteinModelPortalⁱ	P51491
SMRⁱ	P51491
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000079289

STRINGⁱ

10090.ENSMUSP00000079289

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	P51491

PhosphoSitePlusⁱ

P51491

Proteomic databases

PaxDbⁱ	P51491
PRIDEⁱ	P51491

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831
GeneIDⁱ	12057
KEGGⁱ	mmu:12057
UCSC genome browser More...UCSCⁱ	uc009bdi.2 mouse

Organism-specific databases

CTDⁱ	611
MGIⁱ	MGI:99438 Opn1sw

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000253932
HOVERGENⁱ	HBG107442
InParanoidⁱ	P51491
KEGG Orthology (KO) More...KOⁱ	K04252
OMAⁱ	SEYYTWF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDA
PhylomeDBⁱ	P51491
TreeFamⁱ	TF324998

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2187335 The retinoid cycle in cones (daylight vision) R-MMU-418594 G alpha (i) signalling events R-MMU-419771 Opsins

Reactomeⁱ

R-MMU-2187335 The retinoid cycle in cones (daylight vision)
R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Miscellaneous databases

ChiTaRSⁱ	Opn1sw mouse
Protein Ontology More...PROⁱ	PR:P51491
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000058831
ExpressionAtlasⁱ	P51491 baseline and differential
Genevisibleⁱ	P51491 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001760 Opsin IPR001521 Opsin_blue IPR027430 Retinal_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00238 OPSIN PR00574 OPSINBLUE
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OPSB_MOUSE
Accessionⁱ	P51491Primary (citable) accession number: P51491 Secondary accession number(s): Q548Z8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	July 18, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - P51491 (OPSB_MOUSE)

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Short-wave-sensitive opsin 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ