UniProtKB - P51491 (OPSB_MOUSE)
Short-wave-sensitive opsin 1
Opn1sw
Functioni
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity).
Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (PubMed:21219924, PubMed:25416279).
Involved in ensuring correct abundance and localization of retinal membrane proteins (PubMed:25416279).
May increase spectral sensitivity in dim light (PubMed:11055434).
By similarity3 PublicationsGO - Molecular functioni
- G protein-coupled photoreceptor activity Source: GO_Central
GO - Biological processi
- cellular response to light stimulus Source: GO_Central
- cellular response to UV-A Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: GO_Central
- phototransduction Source: GO_Central
- protein-chromophore linkage Source: UniProtKB-KW
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer |
Biological process | Sensory transduction, Vision |
Ligand | Chromophore |
Enzyme and pathway databases
Reactomei | R-MMU-2187335, The retinoid cycle in cones (daylight vision) R-MMU-418594, G alpha (i) signalling events R-MMU-419771, Opsins |
Names & Taxonomyi
Protein namesi | Recommended name: Short-wave-sensitive opsin 1Short name: S opsin Alternative name(s): Blue cone photoreceptor pigment Blue-sensitive opsin Short name: BOP Short wavelength-sensitive cone opsin |
Gene namesi | Name:Opn1sw Synonyms:Bcp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99438, Opn1sw |
VEuPathDBi | HostDB:ENSMUSG00000058831 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- Photoreceptor inner segment 1 Publication
- photoreceptor outer segment 1 Publication
- perinuclear region By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell body Source: MGI
- perinuclear region of cytoplasm Source: UniProtKB
- photoreceptor inner segment Source: UniProtKB-SubCell
- photoreceptor outer segment Source: MGI
- terminal bouton Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | ExtracellularAdd BLAST | 31 | |
Transmembranei | 32 – 56 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 57 – 68 | CytoplasmicAdd BLAST | 12 | |
Transmembranei | 69 – 94 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 95 – 108 | ExtracellularAdd BLAST | 14 | |
Transmembranei | 109 – 128 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 129 – 147 | CytoplasmicAdd BLAST | 19 | |
Transmembranei | 148 – 171 | Helical; Name=4Sequence analysisAdd BLAST | 24 | |
Topological domaini | 172 – 197 | ExtracellularAdd BLAST | 26 | |
Transmembranei | 198 – 225 | Helical; Name=5Sequence analysisAdd BLAST | 28 | |
Topological domaini | 226 – 247 | CytoplasmicAdd BLAST | 22 | |
Transmembranei | 248 – 271 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 272 – 279 | Extracellular | 8 | |
Transmembranei | 280 – 304 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 305 – 346 | CytoplasmicAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197766 | 1 – 346 | Short-wave-sensitive opsin 1Add BLAST | 346 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 12 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Disulfide bondi | 105 ↔ 182 | PROSITE-ProRule annotation | ||
Modified residuei | 291 | N6-(retinylidene)lysine | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P51491 |
PRIDEi | P51491 |
ProteomicsDBi | 294393 |
PTM databases
GlyGeni | P51491, 1 site |
PhosphoSitePlusi | P51491 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000058831, Expressed in retina and 81 other tissues |
ExpressionAtlasi | P51491, baseline and differential |
Genevisiblei | P51491, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000079289 |
Miscellaneous databases
RNActi | P51491, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 324 – 346 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 326 – 346 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234549 |
HOGENOMi | CLU_009579_3_0_1 |
InParanoidi | P51491 |
OMAi | QFRACIM |
OrthoDBi | 940057at2759 |
PhylomeDBi | P51491 |
TreeFami | TF324998 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001760, Opsin IPR001521, Opsin_blue IPR027430, Retinal_BS |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00238, OPSIN PR00574, OPSINBLUE |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit PS00238, OPSIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN
60 70 80 90 100
AIVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF
110 120 130 140 150
GRHVCALEAF LGSVAGLVTG WSLAFLAFER YVVICKPFGS IRFNSKHALM
160 170 180 190 200
VVLATWIIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEYYTW
210 220 230 240 250
FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK AEREVSHMVV
260 270 280 290 300
VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII
310 320 330 340
YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UXM0 | G3UXM0_MOUSE | Blue cone photoreceptor pigment | Opn1sw | 283 | Annotation score: | ||
G3UX34 | G3UX34_MOUSE | Short-wave-sensitive opsin 1 | Opn1sw | 61 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U49720 mRNA Translation: AAA92458.1 U92562 , U92558, U92559, U92560, U92561 Genomic DNA Translation: AAB53320.1 AF190670 mRNA Translation: AAG17989.1 AF190671 Genomic DNA Translation: AAG17990.1 BC026021 mRNA Translation: AAH26021.1 BC058267 mRNA Translation: AAH58267.1 |
CCDSi | CCDS19959.1 |
PIRi | B54679 |
RefSeqi | NP_031564.1, NM_007538.3 |
Genome annotation databases
Ensembli | ENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831 |
GeneIDi | 12057 |
KEGGi | mmu:12057 |
UCSCi | uc009bdi.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U49720 mRNA Translation: AAA92458.1 U92562 , U92558, U92559, U92560, U92561 Genomic DNA Translation: AAB53320.1 AF190670 mRNA Translation: AAG17989.1 AF190671 Genomic DNA Translation: AAG17990.1 BC026021 mRNA Translation: AAH26021.1 BC058267 mRNA Translation: AAH58267.1 |
CCDSi | CCDS19959.1 |
PIRi | B54679 |
RefSeqi | NP_031564.1, NM_007538.3 |
3D structure databases
SMRi | P51491 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000079289 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P51491, 1 site |
PhosphoSitePlusi | P51491 |
Proteomic databases
PaxDbi | P51491 |
PRIDEi | P51491 |
ProteomicsDBi | 294393 |
Protocols and materials databases
Antibodypediai | 31899, 81 antibodies from 19 providers |
DNASUi | 12057 |
Genome annotation databases
Ensembli | ENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831 |
GeneIDi | 12057 |
KEGGi | mmu:12057 |
UCSCi | uc009bdi.2, mouse |
Organism-specific databases
CTDi | 611 |
MGIi | MGI:99438, Opn1sw |
VEuPathDBi | HostDB:ENSMUSG00000058831 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234549 |
HOGENOMi | CLU_009579_3_0_1 |
InParanoidi | P51491 |
OMAi | QFRACIM |
OrthoDBi | 940057at2759 |
PhylomeDBi | P51491 |
TreeFami | TF324998 |
Enzyme and pathway databases
Reactomei | R-MMU-2187335, The retinoid cycle in cones (daylight vision) R-MMU-418594, G alpha (i) signalling events R-MMU-419771, Opsins |
Miscellaneous databases
BioGRID-ORCSi | 12057, 1 hit in 65 CRISPR screens |
ChiTaRSi | Opn1sw, mouse |
PROi | PR:P51491 |
RNActi | P51491, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000058831, Expressed in retina and 81 other tissues |
ExpressionAtlasi | P51491, baseline and differential |
Genevisiblei | P51491, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001760, Opsin IPR001521, Opsin_blue IPR027430, Retinal_BS |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00238, OPSIN PR00574, OPSINBLUE |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit PS00238, OPSIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OPSB_MOUSE | |
Accessioni | P51491Primary (citable) accession number: P51491 Secondary accession number(s): Q548Z8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families