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Protein

Short-wave-sensitive opsin 1

Gene

Opn1sw

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Enzyme and pathway databases

ReactomeiR-MMU-2187335 The retinoid cycle in cones (daylight vision)
R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Short-wave-sensitive opsin 1
Short name:
S opsin
Alternative name(s):
Blue cone photoreceptor pigment
Blue-sensitive opsin
Short name:
BOP
Short wavelength-sensitive cone opsin
Gene namesi
Name:Opn1sw
Synonyms:Bcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99438 Opn1sw

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularAdd BLAST31
Transmembranei32 – 56Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini57 – 68CytoplasmicAdd BLAST12
Transmembranei69 – 94Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini95 – 108ExtracellularAdd BLAST14
Transmembranei109 – 128Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini129 – 147CytoplasmicAdd BLAST19
Transmembranei148 – 171Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini172 – 197ExtracellularAdd BLAST26
Transmembranei198 – 225Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini226 – 247CytoplasmicAdd BLAST22
Transmembranei248 – 271Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini272 – 279Extracellular8
Transmembranei280 – 304Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini305 – 346CytoplasmicAdd BLAST42

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001977661 – 346Short-wave-sensitive opsin 1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation
Modified residuei291N6-(retinylidene)lysine1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51491
PRIDEiP51491

PTM databases

PhosphoSitePlusiP51491

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000058831
ExpressionAtlasiP51491 baseline and differential
GenevisibleiP51491 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079289

Structurei

3D structure databases

ProteinModelPortaliP51491
SMRiP51491
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000253932
HOVERGENiHBG107442
InParanoidiP51491
KOiK04252
OMAiSEYYTWF
OrthoDBiEOG091G0BDA
PhylomeDBiP51491
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR001521 Opsin_blue
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00574 OPSINBLUE
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

P51491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEDDFYLF QNISSVGPWD GPQYHLAPVW AFRLQAAFMG FVFFVGTPLN
60 70 80 90 100
AIVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF
110 120 130 140 150
GRHVCALEAF LGSVAGLVTG WSLAFLAFER YVVICKPFGS IRFNSKHALM
160 170 180 190 200
VVLATWIIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEYYTW
210 220 230 240 250
FLFIFCFIIP LSLICFSYSQ LLRTLRAVAA QQQESATTQK AEREVSHMVV
260 270 280 290 300
VMVGSFCLCY VPYAALAMYM VNNRNHGLDL RLVTIPAFFS KSSCVYNPII
310 320 330 340
YCFMNKQFRA CILEMVCRKP MADESDVSGS QKTEVSTVSS SKVGPH
Length:346
Mass (Da):38,922
Last modified:October 1, 1996 - v1
Checksum:i8BEEAB0198EE6863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49720 mRNA Translation: AAA92458.1
U92562
, U92558, U92559, U92560, U92561 Genomic DNA Translation: AAB53320.1
AF190670 mRNA Translation: AAG17989.1
AF190671 Genomic DNA Translation: AAG17990.1
BC026021 mRNA Translation: AAH26021.1
BC058267 mRNA Translation: AAH58267.1
CCDSiCCDS19959.1
PIRiB54679
RefSeqiNP_031564.1, NM_007538.3
UniGeneiMm.56987

Genome annotation databases

EnsembliENSMUST00000080428; ENSMUSP00000079289; ENSMUSG00000058831
GeneIDi12057
KEGGimmu:12057
UCSCiuc009bdi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiOPSB_MOUSE
AccessioniPrimary (citable) accession number: P51491
Secondary accession number(s): Q548Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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