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Entry version 110 (07 Oct 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Insulin-like 3

Gene

INSL3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-418555, G alpha (s) signalling events
R-SSC-444821, Relaxin receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like 3
Alternative name(s):
Leydig insulin-like peptide
Short name:
Ley-I-L
Relaxin-like factor
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INSL3
Synonyms:RLF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2
  • UP000008227 Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26By similarityAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001614927 – 56Insulin-like 3 B chainAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001615058 – 103C peptide likeSequence analysisAdd BLAST46
PeptideiPRO_0000016151106 – 131Insulin-like 3 A chainAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 116Interchain (between B and A chains)By similarity
Disulfide bondi46 ↔ 129Interchain (between B and A chains)By similarity
Disulfide bondi115 ↔ 120By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51461

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed exclusively in prenatal and postnatal Leydig cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000013887, Expressed in testis and 6 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51461, SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000014767

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51461

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TFQI, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163613

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_164865_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51461

KEGG Orthology (KO)

More...
KOi
K21999

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPAHHCC

Database of Orthologous Groups

More...
OrthoDBi
1570392at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106361

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040113, INSL3
IPR043387, INSL3/INSL4
IPR016179, Insulin-like
IPR036438, Insulin-like_sf
IPR022353, Insulin_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10423, PTHR10423, 1 hit
PTHR10423:SF4, PTHR10423:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00049, Insulin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00078, IlGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56994, SSF56994, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00262, INSULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P51461-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPHPLTWAL VLLGPALALS RAPAPAQEAP EKLCGHHFVR ALVRLCGGPR
60 70 80 90 100
WSPEDGRAVA GGDRELLQWL EGQHLFHGLM ASGDPMLVLA PQPPPQASGH
110 120 130
HHHRRAAATN PARHCCLSGC TRQDLLTLCP H
Length:131
Mass (Da):14,134
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AB718870859EF3A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68369 mRNA Translation: CAA48449.1
X73636 Genomic DNA Translation: CAA52016.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A53024

NCBI Reference Sequences

More...
RefSeqi
NP_999135.1, NM_213970.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000015173; ENSSSCP00000014767; ENSSSCG00000013887
ENSSSCT00015109318; ENSSSCP00015046461; ENSSSCG00015080416
ENSSSCT00025063112; ENSSSCP00025026866; ENSSSCG00025046452
ENSSSCT00030077875; ENSSSCP00030035579; ENSSSCG00030055891
ENSSSCT00035027250; ENSSSCP00035010421; ENSSSCG00035020931
ENSSSCT00040065681; ENSSSCP00040027817; ENSSSCG00040048743
ENSSSCT00045037752; ENSSSCP00045026242; ENSSSCG00045022115
ENSSSCT00050097668; ENSSSCP00050042083; ENSSSCG00050071610
ENSSSCT00055052190; ENSSSCP00055041698; ENSSSCG00055026398
ENSSSCT00060036887; ENSSSCP00060015703; ENSSSCG00060027239
ENSSSCT00065010555; ENSSSCP00065004386; ENSSSCG00065007868
ENSSSCT00070031208; ENSSSCP00070026013; ENSSSCG00070015894

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397024

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397024

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68369 mRNA Translation: CAA48449.1
X73636 Genomic DNA Translation: CAA52016.1
PIRiA53024
RefSeqiNP_999135.1, NM_213970.1

3D structure databases

SMRiP51461
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014767

Proteomic databases

PaxDbiP51461

Genome annotation databases

EnsembliENSSSCT00000015173; ENSSSCP00000014767; ENSSSCG00000013887
ENSSSCT00015109318; ENSSSCP00015046461; ENSSSCG00015080416
ENSSSCT00025063112; ENSSSCP00025026866; ENSSSCG00025046452
ENSSSCT00030077875; ENSSSCP00030035579; ENSSSCG00030055891
ENSSSCT00035027250; ENSSSCP00035010421; ENSSSCG00035020931
ENSSSCT00040065681; ENSSSCP00040027817; ENSSSCG00040048743
ENSSSCT00045037752; ENSSSCP00045026242; ENSSSCG00045022115
ENSSSCT00050097668; ENSSSCP00050042083; ENSSSCG00050071610
ENSSSCT00055052190; ENSSSCP00055041698; ENSSSCG00055026398
ENSSSCT00060036887; ENSSSCP00060015703; ENSSSCG00060027239
ENSSSCT00065010555; ENSSSCP00065004386; ENSSSCG00065007868
ENSSSCT00070031208; ENSSSCP00070026013; ENSSSCG00070015894
GeneIDi397024
KEGGissc:397024

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3640

Phylogenomic databases

eggNOGiENOG502TFQI, Eukaryota
GeneTreeiENSGT00940000163613
HOGENOMiCLU_164865_0_0_1
InParanoidiP51461
KOiK21999
OMAiNPAHHCC
OrthoDBi1570392at2759
TreeFamiTF106361

Enzyme and pathway databases

ReactomeiR-SSC-418555, G alpha (s) signalling events
R-SSC-444821, Relaxin receptors

Gene expression databases

BgeeiENSSSCG00000013887, Expressed in testis and 6 other tissues
GenevisibleiP51461, SS

Family and domain databases

InterProiView protein in InterPro
IPR040113, INSL3
IPR043387, INSL3/INSL4
IPR016179, Insulin-like
IPR036438, Insulin-like_sf
IPR022353, Insulin_CS
PANTHERiPTHR10423, PTHR10423, 1 hit
PTHR10423:SF4, PTHR10423:SF4, 1 hit
PfamiView protein in Pfam
PF00049, Insulin, 1 hit
SMARTiView protein in SMART
SM00078, IlGF, 1 hit
SUPFAMiSSF56994, SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262, INSULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINSL3_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51461
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 7, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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