RORC

Functionⁱ

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376).By similarity5 Publications

Isoform 2: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4⁺ T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	31 – 96	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	66
Zinc fingerⁱ	31 – 51	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	67 – 91	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding Source: UniProtKB
DNA-binding transcription factor activity Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
nuclear receptor activity
Source: ProtInc
Traceable author statementⁱ
- 7811290
oxysterol binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19965867
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 20427770
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 20427770
sequence-specific DNA binding Source: UniProtKB
steroid hormone receptor activity Source: InterPro
transcription coactivator binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor activity, direct ligand regulated sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19965867
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adipose tissue development Source: UniProtKB
cellular response to sterol
Source: UniProtKB
Inferred from direct assayⁱ
- 19965867
circadian regulation of gene expression Source: UniProtKB
cytokine-mediated signaling pathway Source: Reactome
lymph node development Source: UniProtKB
negative regulation of thymocyte apoptotic process Source: UniProtKB
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 20427770
Peyer's patch development Source: UniProtKB
positive regulation of circadian rhythm Source: UniProtKB
positive regulation of transcription, DNA-templated Source: UniProtKB
regulation of fat cell differentiation Source: UniProtKB
regulation of glucose metabolic process Source: UniProtKB
regulation of steroid metabolic process Source: UniProtKB
regulation of transcription involved in cell fate commitment Source: UniProtKB
T-helper 17 cell differentiation Source: UniProtKB
T-helper cell differentiation Source: UniProtKB
transcription initiation from RNA polymerase II promoter Source: Reactome
xenobiotic metabolic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Receptor
Biological process	Biological rhythms, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
SIGNORⁱ	P51449

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor ROR-gamma Alternative name(s): Nuclear receptor RZR-gamma Nuclear receptor subfamily 1 group F member 3 RAR-related orphan receptor C Retinoid-related orphan receptor-gamma
Gene namesⁱ	Name:RORC Synonyms:NR1F3, RORG, RZRG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143365.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10260 RORC
MIMⁱ	602943 gene
neXtProtⁱ	NX_P51449

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency 42 (IMD42)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive primary immunodeficiency characterized by increased susceptibility to concomitant candidiasis and mycobacteriosis. Candidiasis is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida. Mycobacteriosis is characterized by infections caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. IMD42 patients vaccinated with BCG are particularly at risk for developing disseminated mycobacterial infections.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	327	A → F: Completely abolishes transcriptional activity. 1 Publication	1
Mutagenesisⁱ	378	F → Q: Completely abolishes transcriptional activity. 1 Publication	1
Mutagenesisⁱ	397	I → N: Nearly abolishes transcriptional activity. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6097
MalaCards human disease database More...MalaCardsⁱ	RORC
MIMⁱ	616622 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000143365
Orphanetⁱ	477857 Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency
PharmGKBⁱ	PA34632

Chemistry databases

ChEMBLⁱ	CHEMBL1741186
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	600

Polymorphism and mutation databases

BioMutaⁱ	RORC
DMDMⁱ	49066040

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053517	1 – 518	Nuclear receptor ROR-gammaAdd BLAST		518

Proteomic databases

PaxDbⁱ	P51449
PeptideAtlas More...PeptideAtlasⁱ	P51449
PRIDEⁱ	P51449
ProteomicsDBⁱ	56305 56306 [P51449-2]

PTM databases

iPTMnetⁱ	P51449
PhosphoSitePlusⁱ	P51449

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.

Inductionⁱ

Up-regulated in the state of obesity.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000143365 Expressed in 101 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_RORC
ExpressionAtlasⁱ	P51449 baseline and differential
Genevisibleⁱ	P51449 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065620

HPAⁱ

HPA065620

Interactionⁱ

Subunit structureⁱ

Interacts (via AF-2 motif) with the coactivator NCOA2 (via LXXLL motif). Interacts with the corepressor NCOR1. Interacts with CRY1. Interacts (via AF-2 motif) with the coactivators NCOA1 and PPARGC1A (via LXXLL motif) (By similarity). Interacts (via AF-2 motif) with PROX1 (By similarity). Interacts with FOXP3.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Arntl	Q9WTL8	2	EBI-3908771,EBI-644534	From Mus musculus.
Clock	O08785	2	EBI-3908771,EBI-79859	From Mus musculus.
NCOA1	Q15788	2	EBI-3908771,EBI-455189

GO - Molecular functionⁱ

transcription coactivator binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112024, 34 interactors
Database of interacting proteins More...DIPⁱ	DIP-60622N
IntActⁱ	P51449, 28 interactors
Molecular INTeraction database More...MINTⁱ	P51449
STRINGⁱ	9606.ENSP00000327025

Chemistry databases

BindingDBⁱ

P51449

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	267 – 282	Combined sources	16
Beta strandⁱ	285 – 287	Combined sources	3
Helixⁱ	289 – 294	Combined sources	6
Helixⁱ	295 – 297	Combined sources	3
Helixⁱ	302 – 310	Combined sources	9
Helixⁱ	313 – 337	Combined sources	25
Helixⁱ	341 – 343	Combined sources	3
Helixⁱ	346 – 364	Combined sources	19
Helixⁱ	365 – 368	Combined sources	4
Turnⁱ	371 – 374	Combined sources	4
Beta strandⁱ	375 – 378	Combined sources	4
Beta strandⁱ	381 – 383	Combined sources	3
Helixⁱ	385 – 391	Combined sources	7
Helixⁱ	394 – 408	Combined sources	15
Turnⁱ	409 – 411	Combined sources	3
Helixⁱ	414 – 425	Combined sources	12
Beta strandⁱ	430 – 432	Combined sources	3
Helixⁱ	436 – 456	Combined sources	21
Helixⁱ	460 – 465	Combined sources	6
Helixⁱ	469 – 489	Combined sources	21
Helixⁱ	491 – 497	Combined sources	7
Helixⁱ	500 – 506	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P51449
SMRⁱ	P51449
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P51449

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	269 – 508	NR LBDPROSITE-ProRule annotationAdd BLAST		240

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 30	ModulatingSequence analysisAdd BLAST		30
Regionⁱ	97 – 268	HingeSequence analysisAdd BLAST		172

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	501 – 506	AF-2		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	121 – 130	Poly-Gln		10

Domainⁱ

The AF-2 (activation function-2) motif is required for recruiting coregulators containing LXXLL motifs such as NCOA1 and NCOA2.By similarity

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	31 – 51	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	67 – 91	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4216 Eukaryota ENOG410XUGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388
HOVERGENⁱ	HBG106848
InParanoidⁱ	P51449
KEGG Orthology (KO) More...KOⁱ	K08534
OMAⁱ	MDRAPQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0649
PhylomeDBⁱ	P51449
TreeFamⁱ	TF319910

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative promoter usage. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P51449-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG 
        60         70         80         90        100
CKGFFRRSQR CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA 
       110        120        130        140        150
VKFGRMSKKQ RDSLHAEVQK QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT 
       160        170        180        190        200
LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS GSGPSYSNNL AKAGLNGASC 
       210        220        230        240        250
HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG LGELGQGPDS 
       260        270        280        290        300
YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF 
       310        320        330        340        350
SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI 
       360        370        380        390        400
VLLKAGAMEV VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI 
       410        420        430        440        450
FDFSHSLSAL HFSEDEIALY TALVLINAHR PGLQEKRKVE QLQYNLELAF 
       460        470        480        490        500
HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV ERLQIFQHLH PIVVQAAFPP 
       510 
LYKELFSTET ESPVGLSK

Length:518

Mass (Da):58,195

Last modified:June 21, 2004 - v2

Checksum:ⁱ7F423140BD7922BE

GO

Isoform 2 (identifier: P51449-2) [UniParc]FASTA Add to basket

Also known as: RORgT

The sequence of this isoform differs from the canonical sequence as follows:
1-21: Missing.
22-24: HTS → MRT

« Hide

        10         20         30         40         50
MRTQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQRC NAAYSCTRQQ 
        60         70         80         90        100
NCPIDRTSRN RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLHAEVQKQ 
       110        120        130        140        150
LQQRQQQQQE PVVKTPPAGA QGADTLTYTL GLPDGQLPLG SSPDLPEASA 
       160        170        180        190        200
CPPGLLKASG SGPSYSNNLA KAGLNGASCH LEYSPERGKA EGRESFYSTG 
       210        220        230        240        250
SQLTPDRCGL RFEEHRHPGL GELGQGPDSY GSPSFRSTPE APYASLTEIE 
       260        270        280        290        300
HLVQSVCKSY RETCQLRLED LLRQRSNIFS REEVTGYQRK SMWEMWERCA 
       310        320        330        340        350
HHLTEAIQYV VEFAKRLSGF MELCQNDQIV LLKAGAMEVV LVRMCRAYNA 
       360        370        380        390        400
DNRTVFFEGK YGGMELFRAL GCSELISSIF DFSHSLSALH FSEDEIALYT 
       410        420        430        440        450
ALVLINAHRP GLQEKRKVEQ LQYNLELAFH HHLCKTHRQS ILAKLPPKGK 
       460        470        480        490 
LRSLCSQHVE RLQIFQHLHP IVVQAAFPPL YKELFSTETE SPVGLSK

Show »

Length:497

Mass (Da):55,813

Checksum:ⁱ6D0048673483EA11

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1W2PRM4	A0A1W2PRM4_HUMAN		Nuclear receptor ROR-gamma Nuclear receptor ROR-gamma	RORC	51	Annotation score:

Sequence cautionⁱ

The sequence AAA64751 differs from that shown. Reason: Frameshift at position 516.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_073725	38	S → L in IMD42; does not affect nuclear localization; loss of transcription regulatory region sequence-specific DNA binding; loss of transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs774357869EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010632	1 – 21	Missing in isoform 2. 1 PublicationAdd BLAST		21
Alternative sequenceⁱVSP_010633	22 – 24	HTS → MRT in isoform 2. 1 Publication		3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U16997 mRNA Translation: AAA64751.1 Frameshift. AL834219 mRNA Translation: CAD38900.1 AL589765 Genomic DNA No translation available. BC031554 mRNA Translation: AAH31554.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1004.1 [P51449-1] CCDS30856.1 [P51449-2]
PIRⁱ	JC2494
NCBI Reference Sequences More...RefSeqⁱ	NP_001001523.1, NM_001001523.1 [P51449-2] NP_005051.2, NM_005060.3 [P51449-1]
UniGeneⁱ	Hs.256022 Hs.607993

Genome annotation databases

Ensemblⁱ	ENST00000318247; ENSP00000327025; ENSG00000143365 [P51449-1] ENST00000356728; ENSP00000349164; ENSG00000143365 [P51449-2]
GeneIDⁱ	6097
KEGGⁱ	hsa:6097
UCSC genome browser More...UCSCⁱ	uc001ezg.4 human [P51449-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51449	RAR-related orphan receptor C, isoform CRA_a		HUMAN		574	UniRef100_P51449
RAR-related orphan receptor C		HUMAN		518
P51449-2	RAR-related orphan nuclear receptor variant 2		HUMAN		497	UniRef100_F1D8P6

Protein	Similar proteins		Species	Score	Length	Source
P51449	Nuclear receptor ROR-gamma		PONAB		518	UniRef90_P51449
RAR-related orphan receptor C, isoform CRA_a		HUMAN		574
Uncharacterized protein		CHLSB		573
Uncharacterized protein		PROCO		520
Uncharacterized protein		RHIBE		519
+53
P51449-2	RAR related orphan receptor C		BOVIN		506	UniRef90_F1N7B3
nuclear receptor ROR-gamma isoform X1		Florida manatee		518
nuclear receptor ROR-gamma isoform X1		LIPVE		518
Uncharacterized protein		OTOGA		516
Uncharacterized protein		Cebus capucinus imitator		513
+104

Protein	Similar proteins		Species	Score	Length	Source
P51449	Nuclear receptor ROR-gamma		PONAB		518	UniRef50_P51449
RAR-related orphan receptor C, isoform CRA_a		HUMAN		574
Uncharacterized protein		CHLSB		573
Uncharacterized protein		PROCO		520
Uncharacterized protein		RHIRO		519
+114
P51449-2	Nuclear receptor ROR-gamma		MOUSE		516	UniRef50_P51450
nuclear receptor ROR-gamma isoform X1		MESAU		526
Nuclear receptor ROR-gamma isoform 1		CRIGR		521
Uncharacterized protein		NEOLE		513
RAR-related orphan receptor C		RAT		487
+335

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U16997 mRNA Translation: AAA64751.1 Frameshift. AL834219 mRNA Translation: CAD38900.1 AL589765 Genomic DNA No translation available. BC031554 mRNA Translation: AAH31554.1
CCDSⁱ	CCDS1004.1 [P51449-1] CCDS30856.1 [P51449-2]
PIRⁱ	JC2494
RefSeqⁱ	NP_001001523.1, NM_001001523.1 [P51449-2] NP_005051.2, NM_005060.3 [P51449-1]
UniGeneⁱ	Hs.256022 Hs.607993

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3B0W	X-ray	2.20	A/B	265-507	[»]
	3KYT	X-ray	2.35	A	265-507	[»]
	3L0J	X-ray	2.40	A	265-507	[»]
	3L0L	X-ray	1.74	A/B	260-507	[»]
	4NB6	X-ray	2.85	A/B	262-507	[»]
	4NIE	X-ray	2.01	A/B	263-509	[»]
	4QM0	X-ray	2.20	A/C	262-507	[»]
	4S14	X-ray	3.54	A	262-518	[»]
	4WLB	X-ray	1.70	A/B	262-507	[»]
	4WPF	X-ray	2.20	A/D	262-509	[»]
	4WQP	X-ray	1.99	A/B	262-507	[»]
				P	480-492	[»]
	4XT9	X-ray	2.25	A	265-507	[»]
	4YMQ	X-ray	2.00	A	260-507	[»]
	4YPQ	X-ray	2.32	A	265-507	[»]
	4ZJR	X-ray	2.70	A/B/C/D	265-487	[»]
	4ZJW	X-ray	2.50	A/B	265-487	[»]
	4ZOM	X-ray	2.27	A/B/C/D	265-487	[»]
	5APH	X-ray	1.54	A	265-507	[»]
	5APJ	X-ray	2.08	A	265-507	[»]
	5APK	X-ray	2.10	A/B	265-507	[»]
				D	480-492	[»]
	5AYG	X-ray	2.60	A/B	261-518	[»]
	5C4O	X-ray	2.24	A	267-507	[»]
	5C4S	X-ray	2.23	A	267-507	[»]
	5C4T	X-ray	1.77	A	267-507	[»]
	5C4U	X-ray	2.08	A	267-507	[»]
	5EJV	X-ray	2.58	A/B	259-518	[»]
	5ETH	X-ray	2.80	A/B	267-487	[»]
	5G42	X-ray	1.72	A	265-507	[»]
	5G43	X-ray	2.58	A	265-507	[»]
	5G44	X-ray	1.84	A	265-507	[»]
	5G45	X-ray	2.07	A	265-507	[»]
	5G46	X-ray	1.76	A	265-507	[»]
	5IXK	X-ray	2.35	A/B	268-487	[»]
	5IZ0	X-ray	2.63	A/B/D/G	259-518	[»]
	5K38	X-ray	2.05	A/B	265-507	[»]
	5K3L	X-ray	2.75	A/B/C/D	265-507	[»]
	5K3M	X-ray	2.89	A/B	265-507	[»]
	5K3N	X-ray	2.67	A/B/C/D	265-507	[»]
	5K6E	X-ray	2.80	A/B	265-507	[»]
	5K74	X-ray	2.75	A/B	265-507	[»]
	5LWP	X-ray	2.40	A	265-506	[»]
	5M96	X-ray	1.77	A/B	263-491	[»]
	5NI5	X-ray	2.30	A	265-507	[»]
	5NI7	X-ray	2.45	A	265-507	[»]
	5NI8	X-ray	1.94	A	265-507	[»]
	5NIB	X-ray	1.82	A	265-507	[»]
	5NTI	X-ray	2.40	A/B/C/D	263-518	[»]
	5NTK	X-ray	1.90	A/B	263-491	[»]
	5NTN	X-ray	1.90	A/B/C/D	263-518	[»]
	5NTP	X-ray	1.70	A	263-499	[»]
	5NTQ	X-ray	2.26	A/B	263-499	[»]
	5NTW	X-ray	1.64	A/B/C/D	263-518	[»]
	5NU1	X-ray	1.85	A/B	263-518	[»]
	5UFO	X-ray	2.80	A	265-507	[»]
	5UFR	X-ray	2.07	A/B	265-507	[»]
	5UHI	X-ray	3.20	A/B	265-507	[»]
	5VB3	X-ray	1.95	A	260-507	[»]
	5VB5	X-ray	2.23	A	260-507	[»]
	5VB6	X-ray	2.04	A	260-507	[»]
	5VB7	X-ray	2.33	A	260-507	[»]
	5VQK	X-ray	3.10	A	260-507	[»]
5VQL	X-ray	2.70	A	260-507	[»]
5W4R	X-ray	3.00	A/B	265-481	[»]
5W4V	X-ray	2.65	A/B/C/D/E/F	266-475	[»]
5X8Q	X-ray	2.20	A/C/E/G	261-518	[»]
5YP5	X-ray	2.65	A	265-507	[»]
5YP6	X-ray	2.20	A	265-507	[»]
6B30	X-ray	2.69	A/B	265-479	[»]
6B31	X-ray	3.18	A/B	265-492	[»]
6BN6	X-ray	2.40	A/B	265-508	[»]
6BR2	X-ray	3.18	A/B	265-479	[»]
6BR3	X-ray	3.00	A/B	265-480	[»]
6CN5	X-ray	2.30	A/B	259-518	[»]
6CN6	X-ray	2.45	A	259-517	[»]
6CVH	X-ray	3.50	A	265-489	[»]
6ESN	X-ray	1.84	A	265-507	[»]
6FGQ	X-ray	2.37	A/B	265-507	[»]
6FZU	X-ray	1.80	A/B	263-518	[»]
6G05	X-ray	1.90	A/B	263-518	[»]
6G07	X-ray	1.66	A/B/C/D	263-518	[»]
ProteinModelPortalⁱ	P51449
SMRⁱ	P51449
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112024, 34 interactors
DIPⁱ	DIP-60622N
IntActⁱ	P51449, 28 interactors
MINTⁱ	P51449
STRINGⁱ	9606.ENSP00000327025

Chemistry databases

BindingDBⁱ	P51449
ChEMBLⁱ	CHEMBL1741186
GuidetoPHARMACOLOGYⁱ	600

PTM databases

iPTMnetⁱ	P51449
PhosphoSitePlusⁱ	P51449

Polymorphism and mutation databases

BioMutaⁱ	RORC
DMDMⁱ	49066040

Proteomic databases

PaxDbⁱ	P51449
PeptideAtlasⁱ	P51449
PRIDEⁱ	P51449
ProteomicsDBⁱ	56305 56306 [P51449-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6097
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000318247; ENSP00000327025; ENSG00000143365 [P51449-1] ENST00000356728; ENSP00000349164; ENSG00000143365 [P51449-2]
GeneIDⁱ	6097
KEGGⁱ	hsa:6097
UCSCⁱ	uc001ezg.4 human [P51449-1]

Organism-specific databases

CTDⁱ	6097
DisGeNETⁱ	6097
EuPathDBⁱ	HostDB:ENSG00000143365.16
GeneCardsⁱ	RORC
HGNCⁱ	HGNC:10260 RORC
HPAⁱ	HPA065620
MalaCardsⁱ	RORC
MIMⁱ	602943 gene 616622 phenotype
neXtProtⁱ	NX_P51449
OpenTargetsⁱ	ENSG00000143365
Orphanetⁱ	477857 Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency
PharmGKBⁱ	PA34632
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4216 Eukaryota ENOG410XUGR LUCA
GeneTreeⁱ	ENSGT00870000136388
HOVERGENⁱ	HBG106848
InParanoidⁱ	P51449
KOⁱ	K08534
OMAⁱ	MDRAPQR
OrthoDBⁱ	EOG091G0649
PhylomeDBⁱ	P51449
TreeFamⁱ	TF319910

Enzyme and pathway databases

Reactomeⁱ	R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
SIGNORⁱ	P51449

Miscellaneous databases

EvolutionaryTraceⁱ	P51449
GeneWikiⁱ	RAR-related_orphan_receptor_gamma
GenomeRNAiⁱ	6097
Protein Ontology More...PROⁱ	PR:P51449
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143365 Expressed in 101 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_RORC
ExpressionAtlasⁱ	P51449 baseline and differential
Genevisibleⁱ	P51449 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RORG_HUMAN
Accessionⁱ	P51449Primary (citable) accession number: P51449 Secondary accession number(s): Q5SZR9, Q8N5V7, Q8NCY8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	June 21, 2004
	Last modified:	November 7, 2018
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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UniProtKB - P51449 (RORG_HUMAN)

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Nuclear receptor ROR-gamma

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ