UniProtKB - P51449 (RORG_HUMAN)
Protein
Nuclear receptor ROR-gamma
Gene
RORC
Organism
Homo sapiens (Human)
Status
Functioni
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376).By similarity5 Publications
Isoform 2: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4+ T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 31 – 96 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 31 – 51 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 67 – 91 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- ligand-activated transcription factor activity Source: UniProtKB
- nuclear receptor activity Source: ProtInc
- oxysterol binding Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: UniProtKB
- steroid hormone receptor activity Source: InterPro
- transcription coactivator binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- adipose tissue development Source: UniProtKB
- cellular response to sterol Source: UniProtKB
- circadian regulation of gene expression Source: UniProtKB
- cytokine-mediated signaling pathway Source: Reactome
- lymph node development Source: UniProtKB
- negative regulation of thymocyte apoptotic process Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- Peyer's patch development Source: UniProtKB
- positive regulation of circadian rhythm Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of fat cell differentiation Source: UniProtKB
- regulation of glucose metabolic process Source: UniProtKB
- regulation of steroid metabolic process Source: UniProtKB
- regulation of transcription involved in cell fate commitment Source: UniProtKB
- T-helper 17 cell differentiation Source: UniProtKB
- T-helper cell differentiation Source: UniProtKB
- transcription initiation from RNA polymerase II promoter Source: Reactome
- xenobiotic metabolic process Source: UniProtKB
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding, Receptor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration |
SIGNORi | P51449 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor ROR-gammaAlternative name(s): Nuclear receptor RZR-gamma Nuclear receptor subfamily 1 group F member 3 RAR-related orphan receptor C Retinoid-related orphan receptor-gamma |
Gene namesi | Name:RORC Synonyms:NR1F3, RORG, RZRG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000143365.16 |
HGNCi | HGNC:10260 RORC |
MIMi | 602943 gene |
neXtProti | NX_P51449 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Immunodeficiency 42 (IMD42)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency characterized by increased susceptibility to concomitant candidiasis and mycobacteriosis. Candidiasis is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida. Mycobacteriosis is characterized by infections caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. IMD42 patients vaccinated with BCG are particularly at risk for developing disseminated mycobacterial infections.
See also OMIM:616622Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073725 | 38 | S → L in IMD42; does not affect nuclear localization; loss of transcription regulatory region sequence-specific DNA binding; loss of transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs774357869EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 327 | A → F: Completely abolishes transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 378 | F → Q: Completely abolishes transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 397 | I → N: Nearly abolishes transcriptional activity. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 6097 |
MalaCardsi | RORC |
MIMi | 616622 phenotype |
OpenTargetsi | ENSG00000143365 |
Orphaneti | 477857 Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency |
PharmGKBi | PA34632 |
Chemistry databases
ChEMBLi | CHEMBL1741186 |
GuidetoPHARMACOLOGYi | 600 |
Polymorphism and mutation databases
BioMutai | RORC |
DMDMi | 49066040 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053517 | 1 – 518 | Nuclear receptor ROR-gammaAdd BLAST | 518 |
Proteomic databases
PaxDbi | P51449 |
PeptideAtlasi | P51449 |
PRIDEi | P51449 |
ProteomicsDBi | 56305 56306 [P51449-2] |
PTM databases
iPTMneti | P51449 |
PhosphoSitePlusi | P51449 |
Expressioni
Tissue specificityi
Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Inductioni
Up-regulated in the state of obesity.1 Publication
Gene expression databases
Bgeei | ENSG00000143365 Expressed in 101 organ(s), highest expression level in gastrocnemius |
ExpressionAtlasi | P51449 baseline and differential |
Genevisiblei | P51449 HS |
Organism-specific databases
HPAi | HPA065620 |
Interactioni
Subunit structurei
Interacts (via AF-2 motif) with the coactivator NCOA2 (via LXXLL motif). Interacts with the corepressor NCOR1. Interacts with CRY1. Interacts (via AF-2 motif) with the coactivators NCOA1 and PPARGC1A (via LXXLL motif) (By similarity). Interacts (via AF-2 motif) with PROX1 (By similarity). Interacts with FOXP3.By similarity4 Publications
Binary interactionsi
GO - Molecular functioni
- transcription coactivator binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 112024, 34 interactors |
DIPi | DIP-60622N |
IntActi | P51449, 28 interactors |
MINTi | P51449 |
STRINGi | 9606.ENSP00000327025 |
Chemistry databases
BindingDBi | P51449 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3B0W | X-ray | 2.20 | A/B | 265-507 | [»] | |
3KYT | X-ray | 2.35 | A | 265-507 | [»] | |
3L0J | X-ray | 2.40 | A | 265-507 | [»] | |
3L0L | X-ray | 1.74 | A/B | 260-507 | [»] | |
4NB6 | X-ray | 2.85 | A/B | 262-507 | [»] | |
4NIE | X-ray | 2.01 | A/B | 263-509 | [»] | |
4QM0 | X-ray | 2.20 | A/C | 262-507 | [»] | |
4S14 | X-ray | 3.54 | A | 262-518 | [»] | |
4WLB | X-ray | 1.70 | A/B | 262-507 | [»] | |
4WPF | X-ray | 2.20 | A/D | 262-509 | [»] | |
4WQP | X-ray | 1.99 | A/B | 262-507 | [»] | |
P | 480-492 | [»] | ||||
4XT9 | X-ray | 2.25 | A | 265-507 | [»] | |
4YMQ | X-ray | 2.00 | A | 260-507 | [»] | |
4YPQ | X-ray | 2.32 | A | 265-507 | [»] | |
4ZJR | X-ray | 2.70 | A/B/C/D | 265-487 | [»] | |
4ZJW | X-ray | 2.50 | A/B | 265-487 | [»] | |
4ZOM | X-ray | 2.27 | A/B/C/D | 265-487 | [»] | |
5APH | X-ray | 1.54 | A | 265-507 | [»] | |
5APJ | X-ray | 2.08 | A | 265-507 | [»] | |
5APK | X-ray | 2.10 | A/B | 265-507 | [»] | |
D | 480-492 | [»] | ||||
5AYG | X-ray | 2.60 | A/B | 261-518 | [»] | |
5C4O | X-ray | 2.24 | A | 267-507 | [»] | |
5C4S | X-ray | 2.23 | A | 267-507 | [»] | |
5C4T | X-ray | 1.77 | A | 267-507 | [»] | |
5C4U | X-ray | 2.08 | A | 267-507 | [»] | |
5EJV | X-ray | 2.58 | A/B | 259-518 | [»] | |
5ETH | X-ray | 2.80 | A/B | 267-487 | [»] | |
5G42 | X-ray | 1.72 | A | 265-507 | [»] | |
5G43 | X-ray | 2.58 | A | 265-507 | [»] | |
5G44 | X-ray | 1.84 | A | 265-507 | [»] | |
5G45 | X-ray | 2.07 | A | 265-507 | [»] | |
5G46 | X-ray | 1.76 | A | 265-507 | [»] | |
5IXK | X-ray | 2.35 | A/B | 268-487 | [»] | |
5IZ0 | X-ray | 2.63 | A/B/D/G | 259-518 | [»] | |
5K38 | X-ray | 2.05 | A/B | 265-507 | [»] | |
5K3L | X-ray | 2.75 | A/B/C/D | 265-507 | [»] | |
5K3M | X-ray | 2.89 | A/B | 265-507 | [»] | |
5K3N | X-ray | 2.67 | A/B/C/D | 265-507 | [»] | |
5K6E | X-ray | 2.80 | A/B | 265-507 | [»] | |
5K74 | X-ray | 2.75 | A/B | 265-507 | [»] | |
5LWP | X-ray | 2.40 | A | 265-506 | [»] | |
5M96 | X-ray | 1.77 | A/B | 263-491 | [»] | |
5NI5 | X-ray | 2.30 | A | 265-507 | [»] | |
5NI7 | X-ray | 2.45 | A | 265-507 | [»] | |
5NI8 | X-ray | 1.94 | A | 265-507 | [»] | |
5NIB | X-ray | 1.82 | A | 265-507 | [»] | |
5NTI | X-ray | 2.40 | A/B/C/D | 263-518 | [»] | |
5NTK | X-ray | 1.90 | A/B | 263-491 | [»] | |
5NTN | X-ray | 1.90 | A/B/C/D | 263-518 | [»] | |
5NTP | X-ray | 1.70 | A | 263-499 | [»] | |
5NTQ | X-ray | 2.26 | A/B | 263-499 | [»] | |
5NTW | X-ray | 1.64 | A/B/C/D | 263-518 | [»] | |
5NU1 | X-ray | 1.85 | A/B | 263-518 | [»] | |
5UFO | X-ray | 2.80 | A | 265-507 | [»] | |
5UFR | X-ray | 2.07 | A/B | 265-507 | [»] | |
5UHI | X-ray | 3.20 | A/B | 265-507 | [»] | |
5VB3 | X-ray | 1.95 | A | 260-507 | [»] | |
5VB5 | X-ray | 2.23 | A | 260-507 | [»] | |
5VB6 | X-ray | 2.04 | A | 260-507 | [»] | |
5VB7 | X-ray | 2.33 | A | 260-507 | [»] | |
5VQK | X-ray | 3.10 | A | 260-507 | [»] | |
5VQL | X-ray | 2.70 | A | 260-507 | [»] | |
5W4R | X-ray | 3.00 | A/B | 265-481 | [»] | |
5W4V | X-ray | 2.65 | A/B/C/D/E/F | 266-475 | [»] | |
5X8Q | X-ray | 2.20 | A/C/E/G | 261-518 | [»] | |
5YP5 | X-ray | 2.65 | A | 265-507 | [»] | |
5YP6 | X-ray | 2.20 | A | 265-507 | [»] | |
5ZA1 | X-ray | 2.52 | A/B | 265-494 | [»] | |
6A22 | X-ray | 2.55 | A/C/E/G | 261-518 | [»] | |
6B30 | X-ray | 2.69 | A/B | 265-479 | [»] | |
6B31 | X-ray | 3.18 | A/B | 265-492 | [»] | |
6B33 | X-ray | 2.48 | A/B | 265-482 | [»] | |
6BN6 | X-ray | 2.40 | A/B | 265-508 | [»] | |
6BR2 | X-ray | 3.18 | A/B | 265-479 | [»] | |
6BR3 | X-ray | 3.00 | A/B | 265-480 | [»] | |
6CN5 | X-ray | 2.30 | A/B | 259-518 | [»] | |
6CN6 | X-ray | 2.45 | A | 259-517 | [»] | |
6CVH | X-ray | 3.50 | A | 265-489 | [»] | |
6ESN | X-ray | 1.84 | A | 265-507 | [»] | |
6FGQ | X-ray | 2.37 | A/B | 265-507 | [»] | |
6FZU | X-ray | 1.80 | A/B | 263-518 | [»] | |
6G05 | X-ray | 1.90 | A/B | 263-518 | [»] | |
6G07 | X-ray | 1.66 | A/B/C/D | 263-518 | [»] | |
ProteinModelPortali | P51449 | |||||
SMRi | P51449 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P51449 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 269 – 508 | NR LBDPROSITE-ProRule annotationAdd BLAST | 240 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | ModulatingSequence analysisAdd BLAST | 30 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 501 – 506 | AF-2 | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 121 – 130 | Poly-Gln | 10 |
Domaini
The AF-2 (activation function-2) motif is required for recruiting coregulators containing LXXLL motifs such as NCOA1 and NCOA2.By similarity
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 31 – 51 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 67 – 91 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4216 Eukaryota ENOG410XUGR LUCA |
GeneTreei | ENSGT00940000161521 |
HOVERGENi | HBG106848 |
InParanoidi | P51449 |
KOi | K08534 |
OMAi | MDRAPQR |
OrthoDBi | 583704at2759 |
PhylomeDBi | P51449 |
TreeFami | TF319910 |
Family and domain databases
Gene3Di | 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit |
PRINTSi | PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER |
SMARTi | View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit |
SUPFAMi | SSF48508 SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative promoter usage. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P51449-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG
60 70 80 90 100
CKGFFRRSQR CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA
110 120 130 140 150
VKFGRMSKKQ RDSLHAEVQK QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT
160 170 180 190 200
LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS GSGPSYSNNL AKAGLNGASC
210 220 230 240 250
HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG LGELGQGPDS
260 270 280 290 300
YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF
310 320 330 340 350
SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI
360 370 380 390 400
VLLKAGAMEV VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI
410 420 430 440 450
FDFSHSLSAL HFSEDEIALY TALVLINAHR PGLQEKRKVE QLQYNLELAF
460 470 480 490 500
HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV ERLQIFQHLH PIVVQAAFPP
510
LYKELFSTET ESPVGLSK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2PRM4 | A0A1W2PRM4_HUMAN | Nuclear receptor ROR-gamma | RORC | 51 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073725 | 38 | S → L in IMD42; does not affect nuclear localization; loss of transcription regulatory region sequence-specific DNA binding; loss of transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs774357869EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010632 | 1 – 21 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_010633 | 22 – 24 | HTS → MRT in isoform 2. 1 Publication | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U16997 mRNA Translation: AAA64751.1 Frameshift. AL834219 mRNA Translation: CAD38900.1 AL589765 Genomic DNA No translation available. BC031554 mRNA Translation: AAH31554.1 |
CCDSi | CCDS1004.1 [P51449-1] CCDS30856.1 [P51449-2] |
PIRi | JC2494 |
RefSeqi | NP_001001523.1, NM_001001523.1 [P51449-2] NP_005051.2, NM_005060.3 [P51449-1] |
UniGenei | Hs.256022 Hs.607993 |
Genome annotation databases
Ensembli | ENST00000318247; ENSP00000327025; ENSG00000143365 [P51449-1] ENST00000356728; ENSP00000349164; ENSG00000143365 [P51449-2] |
GeneIDi | 6097 |
KEGGi | hsa:6097 |
UCSCi | uc001ezg.4 human [P51449-1] |
Keywords - Coding sequence diversityi
Alternative promoter usageSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U16997 mRNA Translation: AAA64751.1 Frameshift. AL834219 mRNA Translation: CAD38900.1 AL589765 Genomic DNA No translation available. BC031554 mRNA Translation: AAH31554.1 |
CCDSi | CCDS1004.1 [P51449-1] CCDS30856.1 [P51449-2] |
PIRi | JC2494 |
RefSeqi | NP_001001523.1, NM_001001523.1 [P51449-2] NP_005051.2, NM_005060.3 [P51449-1] |
UniGenei | Hs.256022 Hs.607993 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3B0W | X-ray | 2.20 | A/B | 265-507 | [»] | |
3KYT | X-ray | 2.35 | A | 265-507 | [»] | |
3L0J | X-ray | 2.40 | A | 265-507 | [»] | |
3L0L | X-ray | 1.74 | A/B | 260-507 | [»] | |
4NB6 | X-ray | 2.85 | A/B | 262-507 | [»] | |
4NIE | X-ray | 2.01 | A/B | 263-509 | [»] | |
4QM0 | X-ray | 2.20 | A/C | 262-507 | [»] | |
4S14 | X-ray | 3.54 | A | 262-518 | [»] | |
4WLB | X-ray | 1.70 | A/B | 262-507 | [»] | |
4WPF | X-ray | 2.20 | A/D | 262-509 | [»] | |
4WQP | X-ray | 1.99 | A/B | 262-507 | [»] | |
P | 480-492 | [»] | ||||
4XT9 | X-ray | 2.25 | A | 265-507 | [»] | |
4YMQ | X-ray | 2.00 | A | 260-507 | [»] | |
4YPQ | X-ray | 2.32 | A | 265-507 | [»] | |
4ZJR | X-ray | 2.70 | A/B/C/D | 265-487 | [»] | |
4ZJW | X-ray | 2.50 | A/B | 265-487 | [»] | |
4ZOM | X-ray | 2.27 | A/B/C/D | 265-487 | [»] | |
5APH | X-ray | 1.54 | A | 265-507 | [»] | |
5APJ | X-ray | 2.08 | A | 265-507 | [»] | |
5APK | X-ray | 2.10 | A/B | 265-507 | [»] | |
D | 480-492 | [»] | ||||
5AYG | X-ray | 2.60 | A/B | 261-518 | [»] | |
5C4O | X-ray | 2.24 | A | 267-507 | [»] | |
5C4S | X-ray | 2.23 | A | 267-507 | [»] | |
5C4T | X-ray | 1.77 | A | 267-507 | [»] | |
5C4U | X-ray | 2.08 | A | 267-507 | [»] | |
5EJV | X-ray | 2.58 | A/B | 259-518 | [»] | |
5ETH | X-ray | 2.80 | A/B | 267-487 | [»] | |
5G42 | X-ray | 1.72 | A | 265-507 | [»] | |
5G43 | X-ray | 2.58 | A | 265-507 | [»] | |
5G44 | X-ray | 1.84 | A | 265-507 | [»] | |
5G45 | X-ray | 2.07 | A | 265-507 | [»] | |
5G46 | X-ray | 1.76 | A | 265-507 | [»] | |
5IXK | X-ray | 2.35 | A/B | 268-487 | [»] | |
5IZ0 | X-ray | 2.63 | A/B/D/G | 259-518 | [»] | |
5K38 | X-ray | 2.05 | A/B | 265-507 | [»] | |
5K3L | X-ray | 2.75 | A/B/C/D | 265-507 | [»] | |
5K3M | X-ray | 2.89 | A/B | 265-507 | [»] | |
5K3N | X-ray | 2.67 | A/B/C/D | 265-507 | [»] | |
5K6E | X-ray | 2.80 | A/B | 265-507 | [»] | |
5K74 | X-ray | 2.75 | A/B | 265-507 | [»] | |
5LWP | X-ray | 2.40 | A | 265-506 | [»] | |
5M96 | X-ray | 1.77 | A/B | 263-491 | [»] | |
5NI5 | X-ray | 2.30 | A | 265-507 | [»] | |
5NI7 | X-ray | 2.45 | A | 265-507 | [»] | |
5NI8 | X-ray | 1.94 | A | 265-507 | [»] | |
5NIB | X-ray | 1.82 | A | 265-507 | [»] | |
5NTI | X-ray | 2.40 | A/B/C/D | 263-518 | [»] | |
5NTK | X-ray | 1.90 | A/B | 263-491 | [»] | |
5NTN | X-ray | 1.90 | A/B/C/D | 263-518 | [»] | |
5NTP | X-ray | 1.70 | A | 263-499 | [»] | |
5NTQ | X-ray | 2.26 | A/B | 263-499 | [»] | |
5NTW | X-ray | 1.64 | A/B/C/D | 263-518 | [»] | |
5NU1 | X-ray | 1.85 | A/B | 263-518 | [»] | |
5UFO | X-ray | 2.80 | A | 265-507 | [»] | |
5UFR | X-ray | 2.07 | A/B | 265-507 | [»] | |
5UHI | X-ray | 3.20 | A/B | 265-507 | [»] | |
5VB3 | X-ray | 1.95 | A | 260-507 | [»] | |
5VB5 | X-ray | 2.23 | A | 260-507 | [»] | |
5VB6 | X-ray | 2.04 | A | 260-507 | [»] | |
5VB7 | X-ray | 2.33 | A | 260-507 | [»] | |
5VQK | X-ray | 3.10 | A | 260-507 | [»] | |
5VQL | X-ray | 2.70 | A | 260-507 | [»] | |
5W4R | X-ray | 3.00 | A/B | 265-481 | [»] | |
5W4V | X-ray | 2.65 | A/B/C/D/E/F | 266-475 | [»] | |
5X8Q | X-ray | 2.20 | A/C/E/G | 261-518 | [»] | |
5YP5 | X-ray | 2.65 | A | 265-507 | [»] | |
5YP6 | X-ray | 2.20 | A | 265-507 | [»] | |
5ZA1 | X-ray | 2.52 | A/B | 265-494 | [»] | |
6A22 | X-ray | 2.55 | A/C/E/G | 261-518 | [»] | |
6B30 | X-ray | 2.69 | A/B | 265-479 | [»] | |
6B31 | X-ray | 3.18 | A/B | 265-492 | [»] | |
6B33 | X-ray | 2.48 | A/B | 265-482 | [»] | |
6BN6 | X-ray | 2.40 | A/B | 265-508 | [»] | |
6BR2 | X-ray | 3.18 | A/B | 265-479 | [»] | |
6BR3 | X-ray | 3.00 | A/B | 265-480 | [»] | |
6CN5 | X-ray | 2.30 | A/B | 259-518 | [»] | |
6CN6 | X-ray | 2.45 | A | 259-517 | [»] | |
6CVH | X-ray | 3.50 | A | 265-489 | [»] | |
6ESN | X-ray | 1.84 | A | 265-507 | [»] | |
6FGQ | X-ray | 2.37 | A/B | 265-507 | [»] | |
6FZU | X-ray | 1.80 | A/B | 263-518 | [»] | |
6G05 | X-ray | 1.90 | A/B | 263-518 | [»] | |
6G07 | X-ray | 1.66 | A/B/C/D | 263-518 | [»] | |
ProteinModelPortali | P51449 | |||||
SMRi | P51449 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 112024, 34 interactors |
DIPi | DIP-60622N |
IntActi | P51449, 28 interactors |
MINTi | P51449 |
STRINGi | 9606.ENSP00000327025 |
Chemistry databases
BindingDBi | P51449 |
ChEMBLi | CHEMBL1741186 |
GuidetoPHARMACOLOGYi | 600 |
PTM databases
iPTMneti | P51449 |
PhosphoSitePlusi | P51449 |
Polymorphism and mutation databases
BioMutai | RORC |
DMDMi | 49066040 |
Proteomic databases
PaxDbi | P51449 |
PeptideAtlasi | P51449 |
PRIDEi | P51449 |
ProteomicsDBi | 56305 56306 [P51449-2] |
Protocols and materials databases
DNASUi | 6097 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000318247; ENSP00000327025; ENSG00000143365 [P51449-1] ENST00000356728; ENSP00000349164; ENSG00000143365 [P51449-2] |
GeneIDi | 6097 |
KEGGi | hsa:6097 |
UCSCi | uc001ezg.4 human [P51449-1] |
Organism-specific databases
CTDi | 6097 |
DisGeNETi | 6097 |
EuPathDBi | HostDB:ENSG00000143365.16 |
GeneCardsi | RORC |
HGNCi | HGNC:10260 RORC |
HPAi | HPA065620 |
MalaCardsi | RORC |
MIMi | 602943 gene 616622 phenotype |
neXtProti | NX_P51449 |
OpenTargetsi | ENSG00000143365 |
Orphaneti | 477857 Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency |
PharmGKBi | PA34632 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4216 Eukaryota ENOG410XUGR LUCA |
GeneTreei | ENSGT00940000161521 |
HOVERGENi | HBG106848 |
InParanoidi | P51449 |
KOi | K08534 |
OMAi | MDRAPQR |
OrthoDBi | 583704at2759 |
PhylomeDBi | P51449 |
TreeFami | TF319910 |
Enzyme and pathway databases
Reactomei | R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration |
SIGNORi | P51449 |
Miscellaneous databases
EvolutionaryTracei | P51449 |
GeneWikii | RAR-related_orphan_receptor_gamma |
GenomeRNAii | 6097 |
PROi | PR:P51449 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143365 Expressed in 101 organ(s), highest expression level in gastrocnemius |
ExpressionAtlasi | P51449 baseline and differential |
Genevisiblei | P51449 HS |
Family and domain databases
Gene3Di | 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit |
PRINTSi | PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER |
SMARTi | View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit |
SUPFAMi | SSF48508 SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | RORG_HUMAN | |
Accessioni | P51449Primary (citable) accession number: P51449 Secondary accession number(s): Q5SZR9, Q8N5V7, Q8NCY8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | June 21, 2004 | |
Last modified: | February 13, 2019 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations