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Protein

40S ribosomal protein S6-2

Gene

RPS6B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.By similarity

GO - Molecular functioni

  • mRNA binding Source: TAIR
  • structural constituent of ribosome Source: CAFA

GO - Biological processi

  • response to cytokinin Source: TAIR
  • ribosomal small subunit biogenesis Source: GO_Central
  • rRNA processing Source: GO_Central
  • translation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-ATH-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-ATH-166208 mTORC1-mediated signalling
R-ATH-1799339 SRP-dependent cotranslational protein targeting to membrane
R-ATH-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-ATH-72689 Formation of a pool of free 40S subunits
R-ATH-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-ATH-72702 Ribosomal scanning and start codon recognition
R-ATH-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-ATH-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-ATH-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S6-2
Alternative name(s):
Protein EMBRYO DEFECTIVE 3010
Gene namesi
Name:RPS6B
Synonyms:EMB3010, RPS6
Ordered Locus Names:At5g10360
ORF Names:F12B17_290
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G10360
TAIRilocus:2142464 AT5G10360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373301 – 24940S ribosomal protein S6-2Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei237PhosphoserineBy similarity1

Post-translational modificationi

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP51430
PRIDEiP51430

PTM databases

iPTMnetiP51430

Expressioni

Gene expression databases

ExpressionAtlasiP51430 baseline and differential
GenevisibleiP51430 AT

Interactioni

Protein-protein interaction databases

BioGridi16178, 7 interactors
IntActiP51430, 3 interactors
STRINGi3702.AT5G10360.1

Structurei

3D structure databases

ProteinModelPortaliP51430
SMRiP51430
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1646 Eukaryota
COG2125 LUCA
HOGENOMiHOG000190952
InParanoidiP51430
KOiK02991
OMAiRVLTHGC
OrthoDBiEOG09360NOW
PhylomeDBiP51430

Family and domain databases

InterProiView protein in InterPro
IPR014401 Ribosomal_S6_euk
IPR001377 Ribosomal_S6e
IPR018282 Ribosomal_S6e_CS
PANTHERiPTHR11502 PTHR11502, 1 hit
PfamiView protein in Pfam
PF01092 Ribosomal_S6e, 1 hit
PIRSFiPIRSF002129 Ribosom_S6_euk, 1 hit
SMARTiView protein in SMART
SM01405 Ribosomal_S6e, 1 hit
PROSITEiView protein in PROSITE
PS00578 RIBOSOMAL_S6E, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P51430-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFNVANPTT GCQKKLEIDD DQKLRAFFDK RLSQEVSGDA LGEEFKGYVF
60 70 80 90 100
KIMGGCDKQG FPMKQGVLTP GRVRLLLHRG TPCFRGHGRR TGERRRKSVR
110 120 130 140 150
GCIVSPDLSV LNLVIVKKGV SDLPGLTDTE KPRMRGPKRA SKIRKLFNLG
160 170 180 190 200
KEDDVRKYVN TYRRTFTNKK GKKVSKAPKI QRLVTPLTLQ RKRARIADKK
210 220 230 240
KRIAKANSDA ADYQKLLASR LKEQRDRRSE SLAKKRSRLS SAPAKPVAA
Length:249
Mass (Da):28,162
Last modified:June 20, 2002 - v3
Checksum:i910A2F0EBBF32D2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209D → N in CAA74381 (PubMed:9528776).Curated1
Sequence conflicti243P → A in CAA81278 (PubMed:8580968).Curated1
Sequence conflicti246P → PS (PubMed:8580968).Curated1
Sequence conflicti248A → T (PubMed:8580968).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14052 mRNA Translation: CAA74381.1
AL353995 Genomic DNA Translation: CAB89407.1
CP002688 Genomic DNA Translation: AED91531.1
AY045594 mRNA Translation: AAK73952.1
AY057634 mRNA Translation: AAL15265.1
AY093783 mRNA Translation: AAM10399.1
Z26511 mRNA Translation: CAA81278.1
PIRiT50003
RefSeqiNP_196598.1, NM_121074.5 [P51430-1]
UniGeneiAt.217
At.22261

Genome annotation databases

EnsemblPlantsiAT5G10360.1; AT5G10360.1; AT5G10360 [P51430-1]
GeneIDi830900
GrameneiAT5G10360.1; AT5G10360.1; AT5G10360 [P51430-1]
KEGGiath:AT5G10360

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRS62_ARATH
AccessioniPrimary (citable) accession number: P51430
Secondary accession number(s): O04670, Q9LX91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 20, 2002
Last modified: April 25, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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