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UniProtKB - P51398 (RT29_HUMAN)

Entry version 191 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

28S ribosomal protein S29, mitochondrial

Gene

DAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mediating interferon-gamma-induced cell death.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei100GTP; via carbonyl oxygen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi128 – 135GTP1 Publication8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processApoptosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P51398

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5368286, Mitochondrial translation initiation
R-HSA-5389840, Mitochondrial translation elongation
R-HSA-5419276, Mitochondrial translation termination

SIGNOR Signaling Network Open Resource

More...SIGNORi		P51398

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
28S ribosomal protein S29, mitochondrial
Short name:
MRP-S29
Short name:
S29mt
Alternative name(s):
Death-associated protein 3
Short name:
DAP-3
Ionizing radiation resistance conferring protein
Mitochondrial small ribosomal subunit protein mS291 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAP3
Synonyms:MRPS29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2673, DAP3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602074, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P51398

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132676.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7818

Open Targets

More...OpenTargetsi		ENSG00000132676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27141

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P51398, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295776

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DAP3

Domain mapping of disease mutations (DMDM)

More...DMDMi		1706299

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000008771722 – 39828S ribosomal protein S29, mitochondrialAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei175N6-acetyllysineCombined sources1
Modified residuei207N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P51398

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P51398

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P51398

MaxQB - The MaxQuant DataBase

More...MaxQBi		P51398

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P51398

PeptideAtlas

More...PeptideAtlasi		P51398

PRoteomics IDEntifications database

More...PRIDEi		P51398

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		16866
56303 [P51398-1]
56304 [P51398-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P51398

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P51398

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P51398

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132676, Expressed in left adrenal gland and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P51398, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P51398, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132676, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379).

Interacts with DELE1 (PubMed:20563667).

Interacts with NOA1 (PubMed:19103604).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113587, 235 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5225, 28S mitochondrial small ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P51398

Protein interaction database and analysis system

More...IntActi		P51398, 90 interactors

Molecular INTeraction database

More...MINTi		P51398

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357320

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P51398, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P51398

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mitochondrion-specific ribosomal protein mS29 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3928, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048181_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P51398

Identification of Orthologs from Complete Genome Data

More...OMAi		KIAMTEG

Database of Orthologous Groups

More...OrthoDBi		1593937at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P51398

TreeFam database of animal gene trees

More...TreeFami		TF313726

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR019368, Ribosomal_S23/S29_mit
IPR008092, Ribosomal_S29_mit

The PANTHER Classification System

More...PANTHERi		PTHR12810, PTHR12810, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10236, DAP3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01716, DEATHASSOCP3

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51398-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLKGITRLI SRIHKLDPGR FLHMGTQARQ SIAAHLDNQV PVESPRAISR 
        60         70         80         90        100
TNENDPAKHG DQHEGQHYNI SPQDLETVFP HGLPPRFVMQ VKTFSEACLM 
       110        120        130        140        150
VRKPALELLH YLKNTSFAYP AIRYLLYGEK GTGKTLSLCH VIHFCAKQDW 
       160        170        180        190        200
LILHIPDAHL WVKNCRDLLQ SSYNKQRFDQ PLEASTWLKN FKTTNERFLN 
       210        220        230        240        250
QIKVQEKYVW NKRESTEKGS PLGEVVEQGI TRVRNATDAV GIVLKELKRQ 
       260        270        280        290        300
SSLGMFHLLV AVDGINALWG RTTLKREDKS PIAPEELALV HNLRKMMKND 
       310        320        330        340        350
WHGGAIVSAL SQTGSLFKPR KAYLPQELLG KEGFDALDPF IPILVSNYNP 
       360        370        380        390 
KEFESCIQYY LENNWLQHEK APTEEGKKEL LFLSNANPSL LERHCAYL
Length:398
Mass (Da):45,566
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i778AF183FA04DEC8
GO
Isoform 2 (identifier: P51398-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-56: Missing.

Show »
Length:357
Mass (Da):41,044
Checksum:i20E08FFBBF9C2E57
GO
Isoform 3 (identifier: P51398-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-90: Missing.

Show »
Length:364
Mass (Da):41,673
Checksum:iA51F7F4E1B0B12B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYA7V9GYA7_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
210Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY11V9GY11_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYJ9V9GYJ9_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYL9V9GYL9_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ03V9GZ03_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYJ3V9GYJ3_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYL4V9GYL4_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYC9V9GYC9_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYW1V9GYW1_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ61V9GZ61_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA57443 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157D → Y in BAG63624 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061811240V → F. Corresponds to variant dbSNP:rs57692591EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04279016 – 56Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_04463957 – 90Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U18321 mRNA Translation: AAA57443.1 Frameshift.
X83544 mRNA Translation: CAA58535.1
AK293117 mRNA Translation: BAF85806.1
AK298201 mRNA Translation: BAG60471.1
AK302281 mRNA Translation: BAG63624.1
BT019494 mRNA Translation: AAV38301.1
CR749790 mRNA Translation: CAH18651.1
AL162734 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53044.1
CH471121 Genomic DNA Translation: EAW53045.1
CH471121 Genomic DNA Translation: EAW53047.1
CH471121 Genomic DNA Translation: EAW53048.1
CH471121 Genomic DNA Translation: EAW53049.1
CH471121 Genomic DNA Translation: EAW53051.1
BC107487 mRNA Translation: AAI07488.1
BC107488 mRNA Translation: AAI07489.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1120.1 [P51398-1]
CCDS55646.1 [P51398-3]
CCDS55647.1 [P51398-2]

Protein sequence database of the Protein Information Resource

More...PIRi		G01589

NCBI Reference Sequences

More...RefSeqi		NP_001186778.1, NM_001199849.1 [P51398-1]
NP_001186779.1, NM_001199850.1 [P51398-3]
NP_001186780.1, NM_001199851.1 [P51398-2]
NP_004623.1, NM_004632.3 [P51398-1]
NP_387506.1, NM_033657.2 [P51398-1]
XP_005245537.1, XM_005245480.2 [P51398-3]
XP_005245538.1, XM_005245481.2 [P51398-2]
XP_016857780.1, XM_017002291.1 [P51398-3]
XP_016857781.1, XM_017002292.1 [P51398-2]
XP_016857782.1, XM_017002293.1 [P51398-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343043; ENSP00000341692; ENSG00000132676 [P51398-1]
ENST00000368336; ENSP00000357320; ENSG00000132676 [P51398-1]
ENST00000421487; ENSP00000412605; ENSG00000132676 [P51398-3]
ENST00000471642; ENSP00000476592; ENSG00000132676 [P51398-2]
ENST00000535183; ENSP00000445003; ENSG00000132676 [P51398-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7818

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7818

UCSC genome browser

More...UCSCi		uc001flq.4, human [P51398-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18321 mRNA Translation: AAA57443.1 Frameshift.
X83544 mRNA Translation: CAA58535.1
AK293117 mRNA Translation: BAF85806.1
AK298201 mRNA Translation: BAG60471.1
AK302281 mRNA Translation: BAG63624.1
BT019494 mRNA Translation: AAV38301.1
CR749790 mRNA Translation: CAH18651.1
AL162734 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53044.1
CH471121 Genomic DNA Translation: EAW53045.1
CH471121 Genomic DNA Translation: EAW53047.1
CH471121 Genomic DNA Translation: EAW53048.1
CH471121 Genomic DNA Translation: EAW53049.1
CH471121 Genomic DNA Translation: EAW53051.1
BC107487 mRNA Translation: AAI07488.1
BC107488 mRNA Translation: AAI07489.1
CCDSiCCDS1120.1 [P51398-1]
CCDS55646.1 [P51398-3]
CCDS55647.1 [P51398-2]
PIRiG01589
RefSeqiNP_001186778.1, NM_001199849.1 [P51398-1]
NP_001186779.1, NM_001199850.1 [P51398-3]
NP_001186780.1, NM_001199851.1 [P51398-2]
NP_004623.1, NM_004632.3 [P51398-1]
NP_387506.1, NM_033657.2 [P51398-1]
XP_005245537.1, XM_005245480.2 [P51398-3]
XP_005245538.1, XM_005245481.2 [P51398-2]
XP_016857780.1, XM_017002291.1 [P51398-3]
XP_016857781.1, XM_017002292.1 [P51398-2]
XP_016857782.1, XM_017002293.1 [P51398-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AX1-398[»]
6NU2electron microscopy3.90AX51-398[»]
6NU3electron microscopy4.40AX1-398[»]
6RW4electron microscopy2.97X1-398[»]
6RW5electron microscopy3.14X1-398[»]
6VLZelectron microscopy2.97AX1-398[»]
6VMIelectron microscopy2.96AX1-398[»]
6ZM5electron microscopy2.89AX1-398[»]
6ZM6electron microscopy2.59AX1-398[»]
6ZS9electron microscopy4.00AX51-398[»]
6ZSAelectron microscopy4.00AX51-398[»]
6ZSBelectron microscopy4.50AX51-398[»]
6ZSCelectron microscopy3.50AX51-398[»]
6ZSDelectron microscopy3.70AX51-398[»]
6ZSEelectron microscopy5.00AX51-398[»]
6ZSGelectron microscopy4.00AX51-398[»]
7A5Felectron microscopy4.40X61-398[»]
7A5Gelectron microscopy4.33X61-398[»]
7A5Ielectron microscopy3.70X61-398[»]
7A5Kelectron microscopy3.70X61-398[»]
SMRiP51398
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113587, 235 interactors
ComplexPortaliCPX-5225, 28S mitochondrial small ribosomal subunit
CORUMiP51398
IntActiP51398, 90 interactors
MINTiP51398
STRINGi9606.ENSP00000357320

Chemistry databases

ChEMBLiCHEMBL4295776

PTM databases

iPTMnetiP51398
PhosphoSitePlusiP51398
SwissPalmiP51398

Genetic variation databases

BioMutaiDAP3
DMDMi1706299

Proteomic databases

EPDiP51398
jPOSTiP51398
MassIVEiP51398
MaxQBiP51398
PaxDbiP51398
PeptideAtlasiP51398
PRIDEiP51398
ProteomicsDBi16866
56303 [P51398-1]
56304 [P51398-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1656, 468 antibodies

The DNASU plasmid repository

More...DNASUi		7818

Genome annotation databases

EnsembliENST00000343043; ENSP00000341692; ENSG00000132676 [P51398-1]
ENST00000368336; ENSP00000357320; ENSG00000132676 [P51398-1]
ENST00000421487; ENSP00000412605; ENSG00000132676 [P51398-3]
ENST00000471642; ENSP00000476592; ENSG00000132676 [P51398-2]
ENST00000535183; ENSP00000445003; ENSG00000132676 [P51398-2]
GeneIDi7818
KEGGihsa:7818
UCSCiuc001flq.4, human [P51398-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7818
DisGeNETi7818

GeneCards: human genes, protein and diseases

More...GeneCardsi		DAP3
HGNCiHGNC:2673, DAP3
HPAiENSG00000132676, Low tissue specificity
MIMi602074, gene
neXtProtiNX_P51398
OpenTargetsiENSG00000132676
PharmGKBiPA27141
VEuPathDBiHostDB:ENSG00000132676.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3928, Eukaryota
GeneTreeiENSGT00390000015248
HOGENOMiCLU_048181_0_0_1
InParanoidiP51398
OMAiKIAMTEG
OrthoDBi1593937at2759
PhylomeDBiP51398
TreeFamiTF313726

Enzyme and pathway databases

PathwayCommonsiP51398
ReactomeiR-HSA-5368286, Mitochondrial translation initiation
R-HSA-5389840, Mitochondrial translation elongation
R-HSA-5419276, Mitochondrial translation termination
SIGNORiP51398

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7818, 488 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DAP3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DAP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7818
PharosiP51398, Tbio

Protein Ontology

More...PROi		PR:P51398
RNActiP51398, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132676, Expressed in left adrenal gland and 245 other tissues
ExpressionAtlasiP51398, baseline and differential
GenevisibleiP51398, HS

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR019368, Ribosomal_S23/S29_mit
IPR008092, Ribosomal_S29_mit
PANTHERiPTHR12810, PTHR12810, 1 hit
PfamiView protein in Pfam
PF10236, DAP3, 1 hit
PRINTSiPR01716, DEATHASSOCP3
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRT29_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51398
Secondary accession number(s): B4DP59
, B4DY62, E7EM60, Q13044, Q68CT7, Q96Q20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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