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Entry version 176 (08 May 2019)
Sequence version 1 (01 Oct 1996)
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Protein

28S ribosomal protein S29, mitochondrial

Gene

DAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mediating interferon-gamma-induced cell death.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei100GTP; via carbonyl oxygen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi128 – 135GTP1 Publication8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processApoptosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

SIGNOR Signaling Network Open Resource

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SIGNORi
P51398

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
28S ribosomal protein S29, mitochondrial
Short name:
MRP-S29
Short name:
S29mt
Alternative name(s):
Death-associated protein 3
Short name:
DAP-3
Ionizing radiation resistance conferring protein
Mitochondrial small ribosomal subunit protein mS291 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAP3
Synonyms:MRPS29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2673 DAP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602074 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51398

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7818

Open Targets

More...
OpenTargetsi
ENSG00000132676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27141

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DAP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1706299

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000008771722 – 39828S ribosomal protein S29, mitochondrialAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei175N6-acetyllysineCombined sources1
Modified residuei207N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P51398

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P51398

MaxQB - The MaxQuant DataBase

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MaxQBi
P51398

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P51398

PeptideAtlas

More...
PeptideAtlasi
P51398

PRoteomics IDEntifications database

More...
PRIDEi
P51398

ProteomicsDB human proteome resource

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ProteomicsDBi
56303
56304 [P51398-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51398

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51398

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P51398

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132676 Expressed in 235 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P51398 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P51398 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023687

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379). Interacts with DELE1 (PubMed:20563667). Interacts with NOA1 (PubMed:19103604).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NOA1Q8NC605EBI-355912,EBI-717871

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113587, 124 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P51398

Protein interaction database and analysis system

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IntActi
P51398, 48 interactors

Molecular INTeraction database

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MINTi
P51398

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357320

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AX1-398[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P51398

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3928 Eukaryota
ENOG410XSDC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000015248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046851

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P51398

KEGG Orthology (KO)

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KOi
K17408

Identification of Orthologs from Complete Genome Data

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OMAi
KIAMTEG

Database of Orthologous Groups

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OrthoDBi
1593937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51398

TreeFam database of animal gene trees

More...
TreeFami
TF313726

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR019368 Ribosomal_S23/S29_mit
IPR008092 Ribosomal_S29_mit

The PANTHER Classification System

More...
PANTHERi
PTHR12810 PTHR12810, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF10236 DAP3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01716 DEATHASSOCP3

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51398-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLKGITRLI SRIHKLDPGR FLHMGTQARQ SIAAHLDNQV PVESPRAISR
60 70 80 90 100
TNENDPAKHG DQHEGQHYNI SPQDLETVFP HGLPPRFVMQ VKTFSEACLM
110 120 130 140 150
VRKPALELLH YLKNTSFAYP AIRYLLYGEK GTGKTLSLCH VIHFCAKQDW
160 170 180 190 200
LILHIPDAHL WVKNCRDLLQ SSYNKQRFDQ PLEASTWLKN FKTTNERFLN
210 220 230 240 250
QIKVQEKYVW NKRESTEKGS PLGEVVEQGI TRVRNATDAV GIVLKELKRQ
260 270 280 290 300
SSLGMFHLLV AVDGINALWG RTTLKREDKS PIAPEELALV HNLRKMMKND
310 320 330 340 350
WHGGAIVSAL SQTGSLFKPR KAYLPQELLG KEGFDALDPF IPILVSNYNP
360 370 380 390
KEFESCIQYY LENNWLQHEK APTEEGKKEL LFLSNANPSL LERHCAYL
Length:398
Mass (Da):45,566
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i778AF183FA04DEC8
GO
Isoform 2 (identifier: P51398-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-56: Missing.

Show »
Length:357
Mass (Da):41,044
Checksum:i20E08FFBBF9C2E57
GO
Isoform 3 (identifier: P51398-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-90: Missing.

Note: No experimental confirmation available.
Show »
Length:364
Mass (Da):41,673
Checksum:iA51F7F4E1B0B12B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYA7V9GYA7_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
210Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYL9V9GYL9_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY11V9GY11_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ03V9GZ03_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYJ9V9GYJ9_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYJ3V9GYJ3_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYC9V9GYC9_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYF7V9GYF7_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ61V9GZ61_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYW1V9GYW1_HUMAN
28S ribosomal protein S29, mitochon...
DAP3
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA57443 differs from that shown. Reason: Frameshift at position 349.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157D → Y in BAG63624 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061811240V → F. Corresponds to variant dbSNP:rs57692591Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04279016 – 56Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_04463957 – 90Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18321 mRNA Translation: AAA57443.1 Frameshift.
X83544 mRNA Translation: CAA58535.1
AK293117 mRNA Translation: BAF85806.1
AK298201 mRNA Translation: BAG60471.1
AK302281 mRNA Translation: BAG63624.1
BT019494 mRNA Translation: AAV38301.1
CR749790 mRNA Translation: CAH18651.1
AL162734 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53044.1
CH471121 Genomic DNA Translation: EAW53045.1
CH471121 Genomic DNA Translation: EAW53047.1
CH471121 Genomic DNA Translation: EAW53048.1
CH471121 Genomic DNA Translation: EAW53049.1
CH471121 Genomic DNA Translation: EAW53051.1
BC107487 mRNA Translation: AAI07488.1
BC107488 mRNA Translation: AAI07489.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1120.1 [P51398-1]
CCDS55646.1 [P51398-3]
CCDS55647.1 [P51398-2]

Protein sequence database of the Protein Information Resource

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PIRi
G01589

NCBI Reference Sequences

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RefSeqi
NP_001186778.1, NM_001199849.1 [P51398-1]
NP_001186779.1, NM_001199850.1 [P51398-3]
NP_001186780.1, NM_001199851.1 [P51398-2]
NP_004623.1, NM_004632.3 [P51398-1]
NP_387506.1, NM_033657.2 [P51398-1]
XP_005245537.1, XM_005245480.2 [P51398-3]
XP_005245538.1, XM_005245481.2 [P51398-2]
XP_016857780.1, XM_017002291.1 [P51398-3]
XP_016857781.1, XM_017002292.1 [P51398-2]
XP_016857782.1, XM_017002293.1 [P51398-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343043; ENSP00000341692; ENSG00000132676 [P51398-1]
ENST00000368336; ENSP00000357320; ENSG00000132676 [P51398-1]
ENST00000421487; ENSP00000412605; ENSG00000132676 [P51398-3]
ENST00000471642; ENSP00000476592; ENSG00000132676 [P51398-2]
ENST00000535183; ENSP00000445003; ENSG00000132676 [P51398-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7818

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7818

UCSC genome browser

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UCSCi
uc001flq.4 human [P51398-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18321 mRNA Translation: AAA57443.1 Frameshift.
X83544 mRNA Translation: CAA58535.1
AK293117 mRNA Translation: BAF85806.1
AK298201 mRNA Translation: BAG60471.1
AK302281 mRNA Translation: BAG63624.1
BT019494 mRNA Translation: AAV38301.1
CR749790 mRNA Translation: CAH18651.1
AL162734 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53044.1
CH471121 Genomic DNA Translation: EAW53045.1
CH471121 Genomic DNA Translation: EAW53047.1
CH471121 Genomic DNA Translation: EAW53048.1
CH471121 Genomic DNA Translation: EAW53049.1
CH471121 Genomic DNA Translation: EAW53051.1
BC107487 mRNA Translation: AAI07488.1
BC107488 mRNA Translation: AAI07489.1
CCDSiCCDS1120.1 [P51398-1]
CCDS55646.1 [P51398-3]
CCDS55647.1 [P51398-2]
PIRiG01589
RefSeqiNP_001186778.1, NM_001199849.1 [P51398-1]
NP_001186779.1, NM_001199850.1 [P51398-3]
NP_001186780.1, NM_001199851.1 [P51398-2]
NP_004623.1, NM_004632.3 [P51398-1]
NP_387506.1, NM_033657.2 [P51398-1]
XP_005245537.1, XM_005245480.2 [P51398-3]
XP_005245538.1, XM_005245481.2 [P51398-2]
XP_016857780.1, XM_017002291.1 [P51398-3]
XP_016857781.1, XM_017002292.1 [P51398-2]
XP_016857782.1, XM_017002293.1 [P51398-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AX1-398[»]
SMRiP51398
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113587, 124 interactors
CORUMiP51398
IntActiP51398, 48 interactors
MINTiP51398
STRINGi9606.ENSP00000357320

PTM databases

iPTMnetiP51398
PhosphoSitePlusiP51398
SwissPalmiP51398

Polymorphism and mutation databases

BioMutaiDAP3
DMDMi1706299

Proteomic databases

EPDiP51398
jPOSTiP51398
MaxQBiP51398
PaxDbiP51398
PeptideAtlasiP51398
PRIDEiP51398
ProteomicsDBi56303
56304 [P51398-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7818
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343043; ENSP00000341692; ENSG00000132676 [P51398-1]
ENST00000368336; ENSP00000357320; ENSG00000132676 [P51398-1]
ENST00000421487; ENSP00000412605; ENSG00000132676 [P51398-3]
ENST00000471642; ENSP00000476592; ENSG00000132676 [P51398-2]
ENST00000535183; ENSP00000445003; ENSG00000132676 [P51398-2]
GeneIDi7818
KEGGihsa:7818
UCSCiuc001flq.4 human [P51398-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7818
DisGeNETi7818

GeneCards: human genes, protein and diseases

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GeneCardsi
DAP3
HGNCiHGNC:2673 DAP3
HPAiHPA023687
MIMi602074 gene
neXtProtiNX_P51398
OpenTargetsiENSG00000132676
PharmGKBiPA27141

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3928 Eukaryota
ENOG410XSDC LUCA
GeneTreeiENSGT00390000015248
HOGENOMiHOG000046851
InParanoidiP51398
KOiK17408
OMAiKIAMTEG
OrthoDBi1593937at2759
PhylomeDBiP51398
TreeFamiTF313726

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination
SIGNORiP51398

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DAP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7818

Protein Ontology

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PROi
PR:P51398

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132676 Expressed in 235 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiP51398 baseline and differential
GenevisibleiP51398 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR019368 Ribosomal_S23/S29_mit
IPR008092 Ribosomal_S29_mit
PANTHERiPTHR12810 PTHR12810, 1 hit
PfamiView protein in Pfam
PF10236 DAP3, 1 hit
PRINTSiPR01716 DEATHASSOCP3
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRT29_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51398
Secondary accession number(s): B4DP59
, B4DY62, E7EM60, Q13044, Q68CT7, Q96Q20
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 8, 2019
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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