UniProtKB - P51398 (RT29_HUMAN)
28S ribosomal protein S29, mitochondrial
DAP3
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 100 | GTP; via carbonyl oxygen1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 128 – 135 | GTP1 Publication | 8 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- apoptotic signaling pathway Source: ProtInc
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Biological process | Apoptosis |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P51398 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | P51398 |
Names & Taxonomyi
Protein namesi | Recommended name: 28S ribosomal protein S29, mitochondrialShort name: MRP-S29 Short name: S29mt Alternative name(s): Death-associated protein 3 Short name: DAP-3 Ionizing radiation resistance conferring protein Mitochondrial small ribosomal subunit protein mS291 Publication |
Gene namesi | Name:DAP3 Synonyms:MRPS29 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2673, DAP3 |
MIMi | 602074, gene |
neXtProti | NX_P51398 |
VEuPathDBi | HostDB:ENSG00000132676.15 |
Subcellular locationi
Mitochondrion
- Mitochondrion 2 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial small ribosomal subunit Source: UniProtKB
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 7818 |
OpenTargetsi | ENSG00000132676 |
PharmGKBi | PA27141 |
Miscellaneous databases
Pharosi | P51398, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295776 |
Genetic variation databases
BioMutai | DAP3 |
DMDMi | 1706299 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 21 | MitochondrionSequence analysisAdd BLAST | 21 | |
ChainiPRO_0000087717 | 22 – 398 | 28S ribosomal protein S29, mitochondrialAdd BLAST | 377 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 175 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 207 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P51398 |
jPOSTi | P51398 |
MassIVEi | P51398 |
MaxQBi | P51398 |
PaxDbi | P51398 |
PeptideAtlasi | P51398 |
PRIDEi | P51398 |
ProteomicsDBi | 16866 56303 [P51398-1] 56304 [P51398-2] |
PTM databases
iPTMneti | P51398 |
PhosphoSitePlusi | P51398 |
SwissPalmi | P51398 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000132676, Expressed in left adrenal gland and 245 other tissues |
ExpressionAtlasi | P51398, baseline and differential |
Genevisiblei | P51398, HS |
Organism-specific databases
HPAi | ENSG00000132676, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379).
Interacts with DELE1 (PubMed:20563667).
Interacts with NOA1 (PubMed:19103604).
3 PublicationsBinary interactionsi
P51398
With | #Exp. | IntAct |
---|---|---|
NOA1 [Q8NC60] | 5 | EBI-355912,EBI-717871 |
Protein-protein interaction databases
BioGRIDi | 113587, 235 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | P51398 |
IntActi | P51398, 90 interactors |
MINTi | P51398 |
STRINGi | 9606.ENSP00000357320 |
Miscellaneous databases
RNActi | P51398, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3928, Eukaryota |
GeneTreei | ENSGT00390000015248 |
HOGENOMi | CLU_048181_0_0_1 |
InParanoidi | P51398 |
OMAi | KIAMTEG |
OrthoDBi | 1593937at2759 |
PhylomeDBi | P51398 |
TreeFami | TF313726 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR019368, Ribosomal_S23/S29_mit IPR008092, Ribosomal_S29_mit |
PANTHERi | PTHR12810, PTHR12810, 1 hit |
Pfami | View protein in Pfam PF10236, DAP3, 1 hit |
PRINTSi | PR01716, DEATHASSOCP3 |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMLKGITRLI SRIHKLDPGR FLHMGTQARQ SIAAHLDNQV PVESPRAISR
60 70 80 90 100
TNENDPAKHG DQHEGQHYNI SPQDLETVFP HGLPPRFVMQ VKTFSEACLM
110 120 130 140 150
VRKPALELLH YLKNTSFAYP AIRYLLYGEK GTGKTLSLCH VIHFCAKQDW
160 170 180 190 200
LILHIPDAHL WVKNCRDLLQ SSYNKQRFDQ PLEASTWLKN FKTTNERFLN
210 220 230 240 250
QIKVQEKYVW NKRESTEKGS PLGEVVEQGI TRVRNATDAV GIVLKELKRQ
260 270 280 290 300
SSLGMFHLLV AVDGINALWG RTTLKREDKS PIAPEELALV HNLRKMMKND
310 320 330 340 350
WHGGAIVSAL SQTGSLFKPR KAYLPQELLG KEGFDALDPF IPILVSNYNP
360 370 380 390
KEFESCIQYY LENNWLQHEK APTEEGKKEL LFLSNANPSL LERHCAYL
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketV9GYA7 | V9GYA7_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 210 | Annotation score: | ||
V9GY11 | V9GY11_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 181 | Annotation score: | ||
V9GYJ9 | V9GYJ9_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 266 | Annotation score: | ||
V9GYL9 | V9GYL9_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 299 | Annotation score: | ||
V9GZ03 | V9GZ03_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 242 | Annotation score: | ||
V9GYJ3 | V9GYJ3_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 119 | Annotation score: | ||
V9GYL4 | V9GYL4_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 113 | Annotation score: | ||
V9GYC9 | V9GYC9_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 115 | Annotation score: | ||
V9GYW1 | V9GYW1_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 140 | Annotation score: | ||
V9GZ61 | V9GZ61_HUMAN | 28S ribosomal protein S29, mitochon... | DAP3 | 106 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 157 | D → Y in BAG63624 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061811 | 240 | V → F. Corresponds to variant dbSNP:rs57692591EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042790 | 16 – 56 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_044639 | 57 – 90 | Missing in isoform 3. 1 PublicationAdd BLAST | 34 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000343043; ENSP00000341692; ENSG00000132676 [P51398-1] ENST00000368336; ENSP00000357320; ENSG00000132676 [P51398-1] ENST00000421487; ENSP00000412605; ENSG00000132676 [P51398-3] ENST00000471642; ENSP00000476592; ENSG00000132676 [P51398-2] ENST00000535183; ENSP00000445003; ENSG00000132676 [P51398-2] |
GeneIDi | 7818 |
KEGGi | hsa:7818 |
UCSCi | uc001flq.4, human [P51398-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J9M | electron microscopy | 3.50 | AX | 1-398 | [»] | |
6NU2 | electron microscopy | 3.90 | AX | 51-398 | [»] | |
6NU3 | electron microscopy | 4.40 | AX | 1-398 | [»] | |
6RW4 | electron microscopy | 2.97 | X | 1-398 | [»] | |
6RW5 | electron microscopy | 3.14 | X | 1-398 | [»] | |
6VLZ | electron microscopy | 2.97 | AX | 1-398 | [»] | |
6VMI | electron microscopy | 2.96 | AX | 1-398 | [»] | |
6ZM5 | electron microscopy | 2.89 | AX | 1-398 | [»] | |
6ZM6 | electron microscopy | 2.59 | AX | 1-398 | [»] | |
6ZS9 | electron microscopy | 4.00 | AX | 51-398 | [»] | |
6ZSA | electron microscopy | 4.00 | AX | 51-398 | [»] | |
6ZSB | electron microscopy | 4.50 | AX | 51-398 | [»] | |
6ZSC | electron microscopy | 3.50 | AX | 51-398 | [»] | |
6ZSD | electron microscopy | 3.70 | AX | 51-398 | [»] | |
6ZSE | electron microscopy | 5.00 | AX | 51-398 | [»] | |
6ZSG | electron microscopy | 4.00 | AX | 51-398 | [»] | |
7A5F | electron microscopy | 4.40 | X6 | 1-398 | [»] | |
7A5G | electron microscopy | 4.33 | X6 | 1-398 | [»] | |
7A5I | electron microscopy | 3.70 | X6 | 1-398 | [»] | |
7A5K | electron microscopy | 3.70 | X6 | 1-398 | [»] | |
SMRi | P51398 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113587, 235 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | P51398 |
IntActi | P51398, 90 interactors |
MINTi | P51398 |
STRINGi | 9606.ENSP00000357320 |
Chemistry databases
ChEMBLi | CHEMBL4295776 |
PTM databases
iPTMneti | P51398 |
PhosphoSitePlusi | P51398 |
SwissPalmi | P51398 |
Genetic variation databases
BioMutai | DAP3 |
DMDMi | 1706299 |
Proteomic databases
EPDi | P51398 |
jPOSTi | P51398 |
MassIVEi | P51398 |
MaxQBi | P51398 |
PaxDbi | P51398 |
PeptideAtlasi | P51398 |
PRIDEi | P51398 |
ProteomicsDBi | 16866 56303 [P51398-1] 56304 [P51398-2] |
Protocols and materials databases
Antibodypediai | 1656, 468 antibodies |
DNASUi | 7818 |
Genome annotation databases
Ensembli | ENST00000343043; ENSP00000341692; ENSG00000132676 [P51398-1] ENST00000368336; ENSP00000357320; ENSG00000132676 [P51398-1] ENST00000421487; ENSP00000412605; ENSG00000132676 [P51398-3] ENST00000471642; ENSP00000476592; ENSG00000132676 [P51398-2] ENST00000535183; ENSP00000445003; ENSG00000132676 [P51398-2] |
GeneIDi | 7818 |
KEGGi | hsa:7818 |
UCSCi | uc001flq.4, human [P51398-1] |
Organism-specific databases
CTDi | 7818 |
DisGeNETi | 7818 |
GeneCardsi | DAP3 |
HGNCi | HGNC:2673, DAP3 |
HPAi | ENSG00000132676, Low tissue specificity |
MIMi | 602074, gene |
neXtProti | NX_P51398 |
OpenTargetsi | ENSG00000132676 |
PharmGKBi | PA27141 |
VEuPathDBi | HostDB:ENSG00000132676.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3928, Eukaryota |
GeneTreei | ENSGT00390000015248 |
HOGENOMi | CLU_048181_0_0_1 |
InParanoidi | P51398 |
OMAi | KIAMTEG |
OrthoDBi | 1593937at2759 |
PhylomeDBi | P51398 |
TreeFami | TF313726 |
Enzyme and pathway databases
PathwayCommonsi | P51398 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | P51398 |
Miscellaneous databases
BioGRID-ORCSi | 7818, 488 hits in 1020 CRISPR screens |
ChiTaRSi | DAP3, human |
GeneWikii | DAP3 |
GenomeRNAii | 7818 |
Pharosi | P51398, Tbio |
PROi | PR:P51398 |
RNActi | P51398, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132676, Expressed in left adrenal gland and 245 other tissues |
ExpressionAtlasi | P51398, baseline and differential |
Genevisiblei | P51398, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR019368, Ribosomal_S23/S29_mit IPR008092, Ribosomal_S29_mit |
PANTHERi | PTHR12810, PTHR12810, 1 hit |
Pfami | View protein in Pfam PF10236, DAP3, 1 hit |
PRINTSi | PR01716, DEATHASSOCP3 |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RT29_HUMAN | |
Accessioni | P51398Primary (citable) accession number: P51398 Secondary accession number(s): B4DP59 Q96Q20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families