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Protein

Death-associated protein 1

Gene

DAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.1 Publication

GO - Molecular functioni

  • death domain binding Source: UniProtKB

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • apoptotic process Source: MGI
  • apoptotic signaling pathway Source: UniProtKB
  • autophagy Source: UniProtKB-KW
  • cellular response to amino acid starvation Source: UniProtKB
  • negative regulation of autophagy Source: UniProtKB
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Biological processApoptosis, Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein 1
Short name:
DAP-1
Gene namesi
Name:DAP
Synonyms:DAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000112977.15
HGNCiHGNC:2672 DAP
MIMi600954 gene
neXtProtiNX_P51397

Pathology & Biotechi

Organism-specific databases

DisGeNETi1611
OpenTargetsiENSG00000112977
PharmGKBiPA27140

Polymorphism and mutation databases

BioMutaiDAP
DMDMi1706298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000797822 – 102Death-associated protein 1Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei3Phosphoserine; by MTOR2 Publications1
Modified residuei29N6-acetyllysineBy similarity1
Modified residuei49PhosphoserineCombined sources1 Publication1
Modified residuei51Phosphoserine; by MTORCombined sources2 Publications1
Modified residuei91PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP51397
MaxQBiP51397
PaxDbiP51397
PeptideAtlasiP51397
PRIDEiP51397
ProteomicsDBi56302
TopDownProteomicsiP51397

PTM databases

iPTMnetiP51397
PhosphoSitePlusiP51397

Expressioni

Gene expression databases

BgeeiENSG00000112977
CleanExiHS_DAP
ExpressionAtlasiP51397 baseline and differential
GenevisibleiP51397 HS

Interactioni

GO - Molecular functioni

  • death domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107981, 2 interactors
IntActiP51397, 1 interactor
STRINGi9606.ENSP00000230895

Structurei

3D structure databases

ProteinModelPortaliP51397
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5N Eukaryota
ENOG41122SE LUCA
GeneTreeiENSGT00510000049345
HOGENOMiHOG000039719
HOVERGENiHBG005451
InParanoidiP51397
OMAiVQKHPHS
PhylomeDBiP51397
TreeFamiTF329716

Family and domain databases

InterProiView protein in InterPro
IPR024130 DAP1/DAPL1
PANTHERiPTHR13177 PTHR13177, 1 hit
PfamiView protein in Pfam
PF15228 DAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP
60 70 80 90 100
SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP

RK
Length:102
Mass (Da):11,165
Last modified:January 23, 2007 - v3
Checksum:i52FBEFD23ABD182F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76105 mRNA Translation: CAA53713.1
CR542184 mRNA Translation: CAG46981.1
AY266680 Genomic DNA Translation: AAO89078.1
BC002726 mRNA Translation: AAH02726.2
CCDSiCCDS3880.1
PIRiI37274
RefSeqiNP_001278892.1, NM_001291963.1
NP_004385.1, NM_004394.2
UniGeneiHs.75189

Genome annotation databases

EnsembliENST00000230895; ENSP00000230895; ENSG00000112977
GeneIDi1611
KEGGihsa:1611
UCSCiuc003jez.5 human

Similar proteinsi

Entry informationi

Entry nameiDAP1_HUMAN
AccessioniPrimary (citable) accession number: P51397
Secondary accession number(s): Q6FGC3, Q9BUC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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