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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Porphyra purpurea (Red seaweed) (Ulva purpurea)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Synonyms:odpA
Encoded oniPlastid; Chloroplast
OrganismiPorphyra purpurea (Red seaweed) (Ulva purpurea)
Taxonomic identifieri2787 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePorphyra

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622151 – 344Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST344

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Structurei

3D structure databases

ProteinModelPortaliP51267
SMRiP51267
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit

Sequencei

Sequence statusi: Complete.

P51267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPKKVELP LTNCNQINLT KHKLLVLYED MLLGRNFEDM CAQMYYKGKM
60 70 80 90 100
FGFVHLYNGQ EAVSTGVIKL LDSKDYVCST YRDHVHALSK GVPSQNVMAE
110 120 130 140 150
LFGKETGCSR GRGGSMHIFS APHNFLGGFA FIAEGIPVAT GAAFQSIYRQ
160 170 180 190 200
QVLKEPGELR VTACFFGDGT TNNGQFFECL NMAVLWKLPI IFVVENNQWA
210 220 230 240 250
IGMAHHRSSS IPEIHKKAEA FGLPGIEVDG MDVLAVRQVA EKAVERARQG
260 270 280 290 300
QGPTLIEALT YRFRGHSLAD PDELRSRQEK EAWVARDPIK KLKKHILDNQ
310 320 330 340
IASSDELNDI QSSVKIDLEQ SVEFAMSSPE PNISELKRYL FADN
Length:344
Mass (Da):38,507
Last modified:October 1, 1996 - v1
Checksum:i799BD9AFA06FF455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38804 Genomic DNA Translation: AAC08153.1
PIRiS73188
RefSeqiNP_053877.1, NC_000925.1

Genome annotation databases

GeneIDi809896

Similar proteinsi

Entry informationi

Entry nameiODPA_PORPU
AccessioniPrimary (citable) accession number: P51267
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 12, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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