Nuclear receptor subfamily 4 group A member 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cAMP response element binding Source: UniProtKB
• DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.2

    "NOR-2 (neuron-derived orphan receptor), a brain zinc finger protein, is highly induced during liver regeneration."
    Petropoulos I., Part D., Ochoa A., Zakin M.M., Lamas E.
    FEBS Lett. 372:273-278(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKBInferred from direct assayⁱ
  • Ref.5

    "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HOMODIMERIZATION.
• glucocorticoid receptor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.6

    "Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor."
    Martens C., Bilodeau S., Maira M., Gauthier Y., Drouin J.
    Mol. Endocrinol. 19:885-897(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH NR3C1.
• histone acetyltransferase binding Source: RGDInferred from sequence orthologyⁱ
  • "The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine."
    Wansa K.D., Harris J.M., Yan G., Ordentlich P., Muscat G.E.
    J. Biol. Chem. 278:24776-24790(2003) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor activity Source: InterPro
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.5

    "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HOMODIMERIZATION.
• protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • "DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1."
    Medunjanin S., Daniel J.M., Weinert S., Dutzmann J., Burgbacher F., Brecht S., Bruemmer D., Kaehne T., Naumann M., Sedding D.G., Zuschratter W., Braun-Dullaeus R.C.
    Cardiovasc. Res. 106:488-497(2015) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulation of S phase kinase-associated protein 2 by NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells."
    Gizard F., Zhao Y., Findeisen H.M., Qing H., Cohn D., Heywood E.B., Jones K.L., Nomiyama T., Bruemmer D.
    J. Biol. Chem. 286:35485-35493(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1."
    Zetterstrom R.H., Solomin L., Mitsiadis T., Olson L., Perlmann T.
    Mol. Endocrinol. 10:1656-1666(1996) [PubMed] [Europe PMC] [Abstract]
• steroid hormone receptor activity Source: InterPro
• transcription coactivator binding Source: RGDInferred from sequence orthologyⁱ
  • "The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine."
    Wansa K.D., Harris J.M., Yan G., Ordentlich P., Muscat G.E.
    J. Biol. Chem. 278:24776-24790(2003) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• adult behavior Source: RGDInferred from sequence orthologyⁱ
  • "The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear."
    Ponnio T., Burton Q., Pereira F.A., Wu D.K., Conneely O.M.
    Mol. Cell. Biol. 22:935-945(2002) [PubMed] [Europe PMC] [Abstract]
• animal organ regeneration Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.2

    "NOR-2 (neuron-derived orphan receptor), a brain zinc finger protein, is highly induced during liver regeneration."
    Petropoulos I., Part D., Ochoa A., Zakin M.M., Lamas E.
    FEBS Lett. 372:273-278(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
• axon guidance Source: RGDInferred from sequence orthologyⁱ
  • "nor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibility."
    Ponnio T., Conneely O.M.
    Mol. Cell. Biol. 24:9070-9078(2004) [PubMed] [Europe PMC] [Abstract]
• cellular respiration Source: UniProtKB
• cellular response to catecholamine stimulus Source: UniProtKB
• cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
• cellular response to leptin stimulus Source: UniProtKB
• common myeloid progenitor cell proliferation Source: UniProtKB
• energy homeostasis Source: UniProtKB
• fat cell differentiation Source: UniProtKB
• gastrulation Source: UniProtKB
• hippocampus development Source: RGDInferred from sequence orthologyⁱ
  • "nor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibility."
    Ponnio T., Conneely O.M.
    Mol. Cell. Biol. 24:9070-9078(2004) [PubMed] [Europe PMC] [Abstract]
• inner ear morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear."
    Ponnio T., Burton Q., Pereira F.A., Wu D.K., Conneely O.M.
    Mol. Cell. Biol. 22:935-945(2002) [PubMed] [Europe PMC] [Abstract]
• mast cell degranulation Source: UniProtKB
• mesoderm formation Source: RGDInferred from sequence orthologyⁱ
  • "The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis."
    DeYoung R.A., Baker J.C., Cado D., Winoto A.
    J. Biol. Chem. 278:47104-47109(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury."
    Nomiyama T., Zhao Y., Gizard F., Findeisen H.M., Heywood E.B., Jones K.L., Conneely O.M., Bruemmer D.
    Circulation 119:577-586(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of hydrogen peroxide-induced neuron death Source: UniProtKB
• negative regulation of neuron apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "nor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibility."
    Ponnio T., Conneely O.M.
    Mol. Cell. Biol. 24:9070-9078(2004) [PubMed] [Europe PMC] [Abstract]
  • "NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection."
    Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T.
    Proc. Natl. Acad. Sci. U.S.A. 107:12317-12322(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of oxidative stress-induced neuron death Source: RGDInferred from sequence orthologyⁱ
  • "NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection."
    Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T.
    Proc. Natl. Acad. Sci. U.S.A. 107:12317-12322(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: UniProtKB
• neuromuscular process controlling balance Source: RGDInferred from sequence orthologyⁱ
  • "The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear."
    Ponnio T., Burton Q., Pereira F.A., Wu D.K., Conneely O.M.
    Mol. Cell. Biol. 22:935-945(2002) [PubMed] [Europe PMC] [Abstract]
• platelet-derived growth factor receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1."
    Li P., Liu Y., Yi B., Wang G., You X., Zhao X., Summer R., Qin Y., Sun J.
    Cardiovasc. Res. 99:185-193(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle hypertrophy Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.10

    "The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1."
    Feng X.J., Gao H., Gao S., Li Z., Li H., Lu J., Wang J.J., Huang X.Y., Liu M., Zou J., Ye J.T., Liu P.Q.
    Br. J. Pharmacol. 172:2852-2863(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH PARP1.
• positive regulation of cell cycle Source: RGDInferred from sequence orthologyⁱ
  • "Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury."
    Nomiyama T., Zhao Y., Gizard F., Findeisen H.M., Heywood E.B., Jones K.L., Conneely O.M., Bruemmer D.
    Circulation 119:577-586(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial cell proliferation Source: UniProtKB
• positive regulation of fatty acid oxidation Source: UniProtKB
• positive regulation of feeding behavior Source: UniProtKB
• positive regulation of glucose transmembrane transport Source: UniProtKB
• positive regulation of leukocyte apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR."
    Wang T., Jiang Q., Chan C., Gorski K.S., McCadden E., Kardian D., Pardoll D., Whartenby K.A.
    Blood 113:2906-2913(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway Source: UniProtKB
• positive regulation of mast cell cytokine production Source: UniProtKB
• positive regulation of monocyte aggregation Source: UniProtKB
• positive regulation of smooth muscle cell proliferation Source: UniProtKB
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine."
    Wansa K.D., Harris J.M., Yan G., Ordentlich P., Muscat G.E.
    J. Biol. Chem. 278:24776-24790(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77."
    Rambaud J., Desroches J., Balsalobre A., Drouin J.
    J. Biol. Chem. 284:14147-14156(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH TRIM28.
• positive regulation of vascular associated smooth muscle cell migration Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1."
    Li P., Liu Y., Yi B., Wang G., You X., Zhao X., Summer R., Qin Y., Sun J.
    Cardiovasc. Res. 99:185-193(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular smooth muscle cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1."
    Li P., Liu Y., Yi B., Wang G., You X., Zhao X., Summer R., Qin Y., Sun J.
    Cardiovasc. Res. 99:185-193(2013) [PubMed] [Europe PMC] [Abstract]
• pyruvate oxidation Source: UniProtKB
• regulation of smooth muscle cell proliferation Source: UniProtKB
• regulation of type B pancreatic cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "Nkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors."
    Tessem J.S., Moss L.G., Chao L.C., Arlotto M., Lu D., Jensen M.V., Stephens S.B., Tontonoz P., Hohmeier H.E., Newgard C.B.
    Proc. Natl. Acad. Sci. U.S.A. 111:5242-5247(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• response to hydrogen peroxide Source: RGDInferred from sequence orthologyⁱ
  • "NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection."
    Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T.
    Proc. Natl. Acad. Sci. U.S.A. 107:12317-12322(2010) [PubMed] [Europe PMC] [Abstract]
• response to peptide hormone Source: RGDInferred from expression patternⁱ
  • Ref.2

    "NOR-2 (neuron-derived orphan receptor), a brain zinc finger protein, is highly induced during liver regeneration."
    Petropoulos I., Part D., Ochoa A., Zakin M.M., Lamas E.
    FEBS Lett. 372:273-278(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
• semicircular canal morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear."
    Ponnio T., Burton Q., Pereira F.A., Wu D.K., Conneely O.M.
    Mol. Cell. Biol. 22:935-945(2002) [PubMed] [Europe PMC] [Abstract]
• vestibular reflex Source: RGDInferred from sequence orthologyⁱ
  • "The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear."
    Ponnio T., Burton Q., Pereira F.A., Wu D.K., Conneely O.M.
    Mol. Cell. Biol. 22:935-945(2002) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• glucocorticoid receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.6

    "Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor."
    Martens C., Bilodeau S., Maira M., Gauthier Y., Drouin J.
    Mol. Endocrinol. 19:885-897(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH NR3C1.
• histone acetyltransferase binding Source: RGDInferred from sequence orthologyⁱ
  • "The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine."
    Wansa K.D., Harris J.M., Yan G., Ordentlich P., Muscat G.E.
    J. Biol. Chem. 278:24776-24790(2003) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.5

    "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, HOMODIMERIZATION.
• protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • "DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1."
    Medunjanin S., Daniel J.M., Weinert S., Dutzmann J., Burgbacher F., Brecht S., Bruemmer D., Kaehne T., Naumann M., Sedding D.G., Zuschratter W., Braun-Dullaeus R.C.
    Cardiovasc. Res. 106:488-497(2015) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator binding Source: RGDInferred from sequence orthologyⁱ
  • "The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine."
    Wansa K.D., Harris J.M., Yan G., Ordentlich P., Muscat G.E.
    J. Biol. Chem. 278:24776-24790(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYAKLTM DLGSTGIMAT 
        60         70         80         90        100
ATTSLPSFST FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH 
       110        120        130        140        150
HHHHHHHHHH HHQQQQPSIP PPSGPEDEVL PSTSMYFKQS PPSTPTTPGF 
       160        170        180        190        200
PPQAGALWDD ELPSAPGCIA PGPLLDPQMK AVPPMAAAAR FPIFFKPSPP 
       210        220        230        240        250
HPPAPSPAGG HHLGYDPTAA AALSLPLGAA AAAGSQAAAL EGHPYGLPLA 
       260        270        280        290        300
KRTATLTFPP LGLTASPTAS SLLGESPSLP SPPNRSSSSG EGTCAVCGDN 
       310        320        330        340        350
AACQHYGVRT CEGCKGFFKR TVQKNAKYVC LANKNCPVDK RRRNRCQYCR 
       360        370        380        390        400
FQKCLSVGMV KEVVRTDSLK GRRGRLPSKP KSPLQQEPSQ PSPPSPPICM 
       410        420        430        440        450
MNALVRALTD ATPRDLDYSR YCPTDQATAG TDAEHVQQFY NLLTASIDVS 
       460        470        480        490        500
RSWAEKIPGF TDLPKEDQTL LIESAFLELF VLRLSIRSNT AEDKFVFCNG 
       510        520        530        540        550
LVLHRLQCLR GFGEWLDSIK DFSLNLQSLN LDIQALACLS ALSMITERHG 
       560        570        580        590        600
LKEPKRVEEL CNKITSSLKD HQRKGQALEP SEPKVLRALV ELRKICTQGL 
       610        620 
QRIFYLKLED LVSPPSVIDK LFLDTLPF                         

        10         20         30         40         50
MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYAKLTM DLGSTGIMAT 
        60         70         80         90        100
ATTSLPSFST FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH 
       110        120        130        140        150
HHHHHHHHHH HHQQQQPSIP PPSGPEDEVL PSTSMYFKQS PPSTPTTPGF 
       160        170        180        190        200
PPQAGALWDD ELPSAPGCIA PGPLLDPQMK AVPPMAAAAR FPIFFKPSPP 
       210        220        230        240        250
HPPAPSPAGG HHLGYDPTAA AALSLPLGAA AAAGSQAAAL EGHPYGLPLA 
       260        270        280        290        300
KRTATLTFPP LGLTASPTAS SLLGESPSLP SPPNRSSSSG EGTCAVCGDN 
       310        320        330        340        350
AACQHYGVRT CEGCKGFFKR TVQKNAKYVC LANKNCPVDK RRRNRCQYCR 
       360        370        380        390        400
FQKCLSVGMV KEVVRTDSLK GRRGRLPSKP KSPLQQEPSQ PSPPSPPICM 
       410        420        430
MNALVRALTD ATPRDLDYSR VSSVNRFEWF                       

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families