PLCD1

Functionⁱ

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.

Catalytic activityⁱ

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactorⁱ

Ca²⁺By similarityNote: Binds 3 Ca²⁺ ions per subunit. Two of the Ca²⁺ ions are bound to the C2 domain.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	311	PROSITE-ProRule annotation	1
Metal bindingⁱ	312	Calcium 1; catalyticBy similarity	1
Metal bindingⁱ	341	Calcium 1; catalyticBy similarity	1
Metal bindingⁱ	343	Calcium 1; catalyticBy similarity	1
Active siteⁱ	356	PROSITE-ProRule annotation	1
Metal bindingⁱ	390	Calcium 1; catalyticBy similarity	1
Binding siteⁱ	438	SubstrateBy similarity	1
Binding siteⁱ	440	SubstrateBy similarity	1
Binding siteⁱ	522	SubstrateBy similarity	1
Binding siteⁱ	549	SubstrateBy similarity	1
Metal bindingⁱ	651	Calcium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	653	Calcium 2By similarity	1
Metal bindingⁱ	677	Calcium 2By similarity	1
Metal bindingⁱ	706	Calcium 3By similarity	1
Metal bindingⁱ	707	Calcium 3; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	708	Calcium 3By similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	153 – 164	1PROSITE-ProRule annotationAdd BLAST		12
Calcium bindingⁱ	189 – 200	2PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
GTPase activating protein binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18434237
phosphatidic acid binding Source: Ensembl
phosphatidylinositol-4,5-bisphosphate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11001876
phosphatidylinositol phospholipase C activity Source: Reactome
phosphatidylserine binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
inositol phosphate metabolic process Source: Reactome
intracellular signal transduction Source: InterPro
labyrinthine layer blood vessel development Source: Ensembl
lipid catabolic process Source: UniProtKB-KW
phospholipid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 9588182
regulation of cell proliferation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Transducer
Biological process	Lipid degradation, Lipid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS07195-MONOMER
BRENDAⁱ	3.1.4.11 2681
Reactomeⁱ	R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol

Chemistry databases

SwissLipidsⁱ	SLP:000001065

SwissLipidsⁱ

SLP:000001065

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC:3.1.4.11) Alternative name(s): Phosphoinositide phospholipase C-delta-1 Phospholipase C-III Short name: PLC-III Phospholipase C-delta-1 Short name: PLC-delta-1
Gene namesⁱ	Name:PLCD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000187091.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9060 PLCD1
MIMⁱ	602142 gene
neXtProtⁱ	NX_P51178

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Nail disorder, non-syndromic congenital, 3 (NDNC3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata).

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5333
MalaCards human disease database More...MalaCardsⁱ	PLCD1
MIMⁱ	151600 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000187091
Orphanetⁱ	2387 Leukonychia totalis
PharmGKBⁱ	PA33388

Chemistry databases

ChEMBLⁱ	CHEMBL3727

ChEMBLⁱ

CHEMBL3727

Polymorphism and mutation databases

BioMutaⁱ	PLCD1
DMDMⁱ	206729887

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000088504	1 – 756	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1Add BLAST		756

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	191	O-linked (GlcNAc) serineBy similarity	1
Glycosylationⁱ	193	O-linked (GlcNAc) threonineBy similarity	1
Modified residueⁱ	457	PhosphothreonineBy similarity	1
Modified residueⁱ	460	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P51178
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51178
PaxDbⁱ	P51178
PeptideAtlas More...PeptideAtlasⁱ	P51178
PRIDEⁱ	P51178
ProteomicsDBⁱ	56300 56301 [P51178-2]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00746030

REPRODUCTION-2DPAGEⁱ

IPI00746030

PTM databases

iPTMnetⁱ	P51178
PhosphoSitePlusⁱ	P51178
SwissPalmⁱ	P51178

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000187091 Expressed in 225 organ(s), highest expression level in male germ cell
CleanExⁱ	HS_PLCD1
Genevisibleⁱ	P51178 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009913 HPA020107 HPA021677

HPAⁱ

CAB009913
HPA020107
HPA021677

Interactionⁱ

GO - Molecular functionⁱ

GTPase activating protein binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18434237

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111349, 17 interactors
IntActⁱ	P51178, 3 interactors
Molecular INTeraction database More...MINTⁱ	P51178
STRINGⁱ	9606.ENSP00000430344

Chemistry databases

BindingDBⁱ

P51178

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51178
SMRⁱ	P51178
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	21 – 130	PHPROSITE-ProRule annotationAdd BLAST	110
Domainⁱ	140 – 175	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	176 – 211	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	296 – 440	PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST	145
Domainⁱ	492 – 609	PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST	118
Domainⁱ	616 – 720	C2PROSITE-ProRule annotationAdd BLAST	105

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	30 – 57	Substrate bindingBy similarityAdd BLAST		28

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0169 Eukaryota ENOG410XPSW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118936
HOGENOMⁱ	HOG000006871
HOVERGENⁱ	HBG053610
InParanoidⁱ	P51178
KEGG Orthology (KO) More...KOⁱ	K05857
OMAⁱ	CKTIWQE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KH
PhylomeDBⁱ	P51178
TreeFamⁱ	TF313216

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR001192 PI-PLC_fam IPR028391 PLC-delta1 IPR017946 PLC-like_Pdiesterase_TIM-brl IPR015359 PLC_EF-hand-like IPR000909 PLipase_C_PInositol-sp_X_dom IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERⁱ	PTHR10336 PTHR10336, 1 hit PTHR10336:SF80 PTHR10336:SF80, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF09279 EF-hand_like, 1 hit PF00388 PI-PLC-X, 1 hit PF00387 PI-PLC-Y, 1 hit
PRINTSⁱ	PR00390 PHPHLIPASEC
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00054 EFh, 2 hits SM00233 PH, 1 hit SM00148 PLCXc, 1 hit SM00149 PLCYc, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF51695 SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 2 hits PS50003 PH_DOMAIN, 1 hit PS50007 PIPLC_X_DOMAIN, 1 hit PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P51178-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSGRDFLTL HGLQDDEDLQ ALLKGSQLLK VKSSSWRRER FYKLQEDCKT 
        60         70         80         90        100
IWQESRKVMR TPESQLFSIE DIQEVRMGHR TEGLEKFARD VPEDRCFSIV 
       110        120        130        140        150
FKDQRNTLDL IAPSPADAQH WVLGLHKIIH HSGSMDQRQK LQHWIHSCLR 
       160        170        180        190        200
KADKNKDNKM SFKELQNFLK ELNIQVDDSY ARKIFRECDH SQTDSLEDEE 
       210        220        230        240        250
IEAFYKMLTQ RVEIDRTFAE AAGSGETLSV DQLVTFLQHQ QREEAAGPAL 
       260        270        280        290        300
ALSLIERYEP SETAKAQRQM TKDGFLMYLL SADGSAFSLA HRRVYQDMGQ 
       310        320        330        340        350
PLSHYLVSSS HNTYLLEDQL AGPSSTEAYI RALCKGCRCL ELDCWDGPNQ 
       360        370        380        390        400
EPIIYHGYTF TSKILFCDVL RAIRDYAFKA SPYPVILSLE NHCTLEQQRV 
       410        420        430        440        450
MARHLHAILG PMLLNRPLDG VTNSLPSPEQ LKGKILLKGK KLGGLLPPGG 
       460        470        480        490        500
EGGPEATVVS DEDEAAEMED EAVRSRVQHK PKEDKLRLAQ ELSDMVIYCK 
       510        520        530        540        550
SVHFGGFSSP GTPGQAFYEM ASFSENRALR LLQESGNGFV RHNVGHLSRI 
       560        570        580        590        600
YPAGWRTDSS NYSPVEMWNG GCQIVALNFQ TPGPEMDVYQ GRFQDNGACG 
       610        620        630        640        650
YVLKPAFLRD PNGTFNPRAL AQGPWWARKR LNIRVISGQQ LPKVNKNKNS 
       660        670        680        690        700
IVDPKVTVEI HGVSRDVASR QTAVITNNGF NPWWDTEFAF EVVVPDLALI 
       710        720        730        740        750
RFLVEDYDAS SKNDFIGQST IPLNSLKQGY RHVHLMSKNG DQHPSATLFV 

KISLQD

Length:756

Mass (Da):85,665

Last modified:September 23, 2008 - v2

Checksum:ⁱ6C6FD7F89BA08C83

GO

Isoform 2 (identifier: P51178-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-11: MDSGRDFLTLH → MQCLGIRSRSRSRELYLQERSLKVAALNGRRL

« Hide

        10         20         30         40         50
MQCLGIRSRS RSRELYLQER SLKVAALNGR RLGLQDDEDL QALLKGSQLL 
        60         70         80         90        100
KVKSSSWRRE RFYKLQEDCK TIWQESRKVM RTPESQLFSI EDIQEVRMGH 
       110        120        130        140        150
RTEGLEKFAR DVPEDRCFSI VFKDQRNTLD LIAPSPADAQ HWVLGLHKII 
       160        170        180        190        200
HHSGSMDQRQ KLQHWIHSCL RKADKNKDNK MSFKELQNFL KELNIQVDDS 
       210        220        230        240        250
YARKIFRECD HSQTDSLEDE EIEAFYKMLT QRVEIDRTFA EAAGSGETLS 
       260        270        280        290        300
VDQLVTFLQH QQREEAAGPA LALSLIERYE PSETAKAQRQ MTKDGFLMYL 
       310        320        330        340        350
LSADGSAFSL AHRRVYQDMG QPLSHYLVSS SHNTYLLEDQ LAGPSSTEAY 
       360        370        380        390        400
IRALCKGCRC LELDCWDGPN QEPIIYHGYT FTSKILFCDV LRAIRDYAFK 
       410        420        430        440        450
ASPYPVILSL ENHCTLEQQR VMARHLHAIL GPMLLNRPLD GVTNSLPSPE 
       460        470        480        490        500
QLKGKILLKG KKLGGLLPPG GEGGPEATVV SDEDEAAEME DEAVRSRVQH 
       510        520        530        540        550
KPKEDKLRLA QELSDMVIYC KSVHFGGFSS PGTPGQAFYE MASFSENRAL 
       560        570        580        590        600
RLLQESGNGF VRHNVGHLSR IYPAGWRTDS SNYSPVEMWN GGCQIVALNF 
       610        620        630        640        650
QTPGPEMDVY QGRFQDNGAC GYVLKPAFLR DPNGTFNPRA LAQGPWWARK 
       660        670        680        690        700
RLNIRVISGQ QLPKVNKNKN SIVDPKVTVE IHGVSRDVAS RQTAVITNNG 
       710        720        730        740        750
FNPWWDTEFA FEVVVPDLAL IRFLVEDYDA SSKNDFIGQS TIPLNSLKQG 
       760        770 
YRHVHLMSKN GDQHPSATLF VKISLQD

Note: No experimental confirmation available.

Show »

Length:777

Mass (Da):88,135

Checksum:ⁱ6260C76BE397266B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	224	S → P in AAA73567 (PubMed:7890667).Curated	1
Sequence conflictⁱ	264	A → T in AAA73567 (PubMed:7890667).Curated	1
Sequence conflictⁱ	591	G → D in AAA73567 (PubMed:7890667).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_066399	209	T → R in NDNC3. 1 Publication	1
Natural variantⁱVAR_046560	257	R → H. Corresponds to variant dbSNP:rs933135Ensembl.	1
Natural variantⁱVAR_066400	574	I → T in NDNC3. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042919	1 – 11	MDSGRDFLTLH → MQCLGIRSRSRSRELYLQER SLKVAALNGRRL in isoform 2. 1 PublicationAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09117 mRNA Translation: AAA73567.1 AK090774 mRNA Translation: BAG52226.1 AC144536 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64507.1 BC050382 mRNA Translation: AAH50382.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2671.1 [P51178-1] CCDS46793.1 [P51178-2]
PIRⁱ	A55943
NCBI Reference Sequences More...RefSeqⁱ	NP_001124436.1, NM_001130964.1 [P51178-2] NP_006216.2, NM_006225.3 [P51178-1]
UniGeneⁱ	Hs.80776

Genome annotation databases

Ensemblⁱ	ENST00000334661; ENSP00000335600; ENSG00000187091 [P51178-1] ENST00000463876; ENSP00000430344; ENSG00000187091 [P51178-2]
GeneIDⁱ	5333
KEGGⁱ	hsa:5333
UCSC genome browser More...UCSCⁱ	uc003chm.4 human [P51178-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	)	RAT		756	UniRef90_P10688
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1		BOVIN		756
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1		MOUSE		756
Phosphoinositide phospholipase C		CERAT		784
Phosphoinositide phospholipase C (Fragment)		AILME		783
+169

Protein	Similar proteins		Species	Score	Length	Source
P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	)	RAT		756	UniRef50_P10688
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1		MOUSE		756
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1		BOVIN		756
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4		XENLA		758
Phosphoinositide phospholipase C		CERAT		784
+821

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09117 mRNA Translation: AAA73567.1 AK090774 mRNA Translation: BAG52226.1 AC144536 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64507.1 BC050382 mRNA Translation: AAH50382.2
CCDSⁱ	CCDS2671.1 [P51178-1] CCDS46793.1 [P51178-2]
PIRⁱ	A55943
RefSeqⁱ	NP_001124436.1, NM_001130964.1 [P51178-2] NP_006216.2, NM_006225.3 [P51178-1]
UniGeneⁱ	Hs.80776

3D structure databases

ProteinModelPortalⁱ	P51178
SMRⁱ	P51178
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111349, 17 interactors
IntActⁱ	P51178, 3 interactors
MINTⁱ	P51178
STRINGⁱ	9606.ENSP00000430344

Chemistry databases

BindingDBⁱ	P51178
ChEMBLⁱ	CHEMBL3727
SwissLipidsⁱ	SLP:000001065

PTM databases

iPTMnetⁱ	P51178
PhosphoSitePlusⁱ	P51178
SwissPalmⁱ	P51178

Polymorphism and mutation databases

BioMutaⁱ	PLCD1
DMDMⁱ	206729887

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00746030

REPRODUCTION-2DPAGEⁱ

IPI00746030

Proteomic databases

EPDⁱ	P51178
MaxQBⁱ	P51178
PaxDbⁱ	P51178
PeptideAtlasⁱ	P51178
PRIDEⁱ	P51178
ProteomicsDBⁱ	56300 56301 [P51178-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000334661; ENSP00000335600; ENSG00000187091 [P51178-1] ENST00000463876; ENSP00000430344; ENSG00000187091 [P51178-2]
GeneIDⁱ	5333
KEGGⁱ	hsa:5333
UCSCⁱ	uc003chm.4 human [P51178-1]

Organism-specific databases

CTDⁱ	5333
DisGeNETⁱ	5333
EuPathDBⁱ	HostDB:ENSG00000187091.13
GeneCardsⁱ	PLCD1
H-InvDBⁱ	HIX0003175
HGNCⁱ	HGNC:9060 PLCD1
HPAⁱ	CAB009913 HPA020107 HPA021677
MalaCardsⁱ	PLCD1
MIMⁱ	151600 phenotype 602142 gene
neXtProtⁱ	NX_P51178
OpenTargetsⁱ	ENSG00000187091
Orphanetⁱ	2387 Leukonychia totalis
PharmGKBⁱ	PA33388
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0169 Eukaryota ENOG410XPSW LUCA
GeneTreeⁱ	ENSGT00760000118936
HOGENOMⁱ	HOG000006871
HOVERGENⁱ	HBG053610
InParanoidⁱ	P51178
KOⁱ	K05857
OMAⁱ	CKTIWQE
OrthoDBⁱ	EOG091G02KH
PhylomeDBⁱ	P51178
TreeFamⁱ	TF313216

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS07195-MONOMER
BRENDAⁱ	3.1.4.11 2681
Reactomeⁱ	R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol

Miscellaneous databases

ChiTaRSⁱ	PLCD1 human
GeneWikiⁱ	PLCD1
GenomeRNAiⁱ	5333
Protein Ontology More...PROⁱ	PR:P51178
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000187091 Expressed in 225 organ(s), highest expression level in male germ cell
CleanExⁱ	HS_PLCD1
Genevisibleⁱ	P51178 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR001192 PI-PLC_fam IPR028391 PLC-delta1 IPR017946 PLC-like_Pdiesterase_TIM-brl IPR015359 PLC_EF-hand-like IPR000909 PLipase_C_PInositol-sp_X_dom IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERⁱ	PTHR10336 PTHR10336, 1 hit PTHR10336:SF80 PTHR10336:SF80, 1 hit
Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF09279 EF-hand_like, 1 hit PF00388 PI-PLC-X, 1 hit PF00387 PI-PLC-Y, 1 hit
PRINTSⁱ	PR00390 PHPHLIPASEC
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00054 EFh, 2 hits SM00233 PH, 1 hit SM00148 PLCXc, 1 hit SM00149 PLCYc, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF51695 SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 2 hits PS50003 PH_DOMAIN, 1 hit PS50007 PIPLC_X_DOMAIN, 1 hit PS50008 PIPLC_Y_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLCD1_HUMAN
Accessionⁱ	P51178Primary (citable) accession number: P51178 Secondary accession number(s): B3KR14, Q86VN8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	September 23, 2008
	Last modified:	September 12, 2018
	This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P51178 (PLCD1_HUMAN)

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ