UniProtKB - P51178 (PLCD1_HUMAN)
Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Gene
PLCD1
Organism
Homo sapiens (Human)
Status
Functioni
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:9188725). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PubMed:7890667, PubMed:9188725).By similarity2 Publications
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+2 PublicationsEC:3.1.4.112 PublicationsThis reaction proceeds in the forward1 Publication direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
Ca2+1 PublicationNote: Binds 3 Ca2+ ions per subunit. Two of the Ca2+ ions are bound to the C2 domain.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 311 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 312 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 341 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 343 | Calcium 1; catalyticBy similarity | 1 | |
Active sitei | 356 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 390 | Calcium 1; catalyticBy similarity | 1 | |
Binding sitei | 438 | SubstrateBy similarity | 1 | |
Binding sitei | 440 | SubstrateBy similarity | 1 | |
Binding sitei | 522 | SubstrateBy similarity | 1 | |
Binding sitei | 549 | SubstrateBy similarity | 1 | |
Metal bindingi | 651 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 653 | Calcium 2By similarity | 1 | |
Metal bindingi | 677 | Calcium 2By similarity | 1 | |
Metal bindingi | 706 | Calcium 3By similarity | 1 | |
Metal bindingi | 707 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 708 | Calcium 3By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 153 – 164 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 189 – 200 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- GTPase activating protein binding Source: BHF-UCL
- phosphatidic acid binding Source: Ensembl
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- phosphatidylinositol phospholipase C activity Source: UniProtKB
- phosphatidylserine binding Source: Ensembl
GO - Biological processi
- inositol phosphate metabolic process Source: Reactome
- lipid catabolic process Source: UniProtKB-KW
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol metabolic process Source: UniProtKB
- phospholipid metabolic process Source: ProtInc
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS07195-MONOMER |
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | P51178 |
Reactomei | R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol |
Chemistry databases
SwissLipidsi | SLP:000001065 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1Curated (EC:3.1.4.112 Publications)Alternative name(s): Phosphoinositide phospholipase C-delta-1 Phospholipase C-III Short name: PLC-III Phospholipase C-delta-1 Short name: PLC-delta-1 |
Gene namesi | Name:PLCD1Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9060, PLCD1 |
MIMi | 602142, gene |
neXtProti | NX_P51178 |
VEuPathDBi | HostDB:ENSG00000187091.13 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: MGI
Pathology & Biotechi
Involvement in diseasei
Nail disorder, non-syndromic congenital, 3 (NDNC3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata).
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066399 | 209 | T → R in NDNC3. 1 Publication | 1 | |
Natural variantiVAR_066400 | 574 | I → T in NDNC3. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 327 | E → G: No effect on hydrolysis inositol phospholipids. 1 Publication | 1 | |
Mutagenesisi | 338 | R → L: Abolishes hydrolysis inositol phospholipids. No effect on binding to phosphatidylinositol 4,5-bisphosphate. 1 Publication | 1 | |
Mutagenesisi | 341 | E → G: Abolishes hydrolysis inositol phospholipids. No effect on binding to phosphatidylinositol 4,5-bisphosphate. 1 Publication | 1 | |
Mutagenesisi | 356 | H → L: Abolishes hydrolysis inositol phospholipids. No effect on binding to phosphatidylinositol 4,5-bisphosphate. 1 Publication | 1 | |
Mutagenesisi | 381 | S → A: Decreases hydrolysis inositol phospholipids. 1 Publication | 1 | |
Mutagenesisi | 388 | S → A: No effect on hydrolysis inositol phospholipids. 1 Publication | 1 | |
Mutagenesisi | 434 | K → Q: Decreases on hydrolysis inositol phospholipids. 1 Publication | 1 | |
Mutagenesisi | 440 | K → Q: No effect on hydrolysis inositol phospholipids. 1 Publication | 1 | |
Mutagenesisi | 441 | K → Q: Decreases on hydrolysis inositol phospholipids. 1 Publication | 1 | |
Mutagenesisi | 549 | R → G: Decreases on hydrolysis inositol phospholipids. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 5333 |
MalaCardsi | PLCD1 |
MIMi | 151600, phenotype |
OpenTargetsi | ENSG00000187091 |
Orphaneti | 2387, Leukonychia totalis |
PharmGKBi | PA33388 |
Miscellaneous databases
Pharosi | P51178, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3727 |
DrugBanki | DB03401, 1D-myo-inositol 1,4,5-trisphosphate DB03956, Inositol 2,4,5-trisphosphate |
Genetic variation databases
BioMutai | PLCD1 |
DMDMi | 206729887 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088504 | 1 – 756 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1Add BLAST | 756 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 191 | O-linked (GlcNAc) serineBy similarity | 1 | |
Glycosylationi | 193 | O-linked (GlcNAc) threonineBy similarity | 1 | |
Modified residuei | 457 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 460 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P51178 |
jPOSTi | P51178 |
MassIVEi | P51178 |
MaxQBi | P51178 |
PaxDbi | P51178 |
PeptideAtlasi | P51178 |
PRIDEi | P51178 |
ProteomicsDBi | 56300 [P51178-1] 56301 [P51178-2] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00746030 |
PTM databases
GlyGeni | P51178, 2 sites |
iPTMneti | P51178 |
PhosphoSitePlusi | P51178 |
SwissPalmi | P51178 |
Expressioni
Tissue specificityi
Strongly expressed in lung, liver and heart. Also expressed at least in pancreas, kidney, skeletal muscle, placenta and brain.1 Publication
Gene expression databases
Bgeei | ENSG00000187091, Expressed in male germ cell and 237 other tissues |
ExpressionAtlasi | P51178, baseline and differential |
Genevisiblei | P51178, HS |
Organism-specific databases
HPAi | ENSG00000187091, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TGM2.
By similarityBinary interactionsi
Hide detailsGO - Molecular functioni
- GTPase activating protein binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111349, 26 interactors |
IntActi | P51178, 14 interactors |
MINTi | P51178 |
STRINGi | 9606.ENSP00000430344 |
Chemistry databases
BindingDBi | P51178 |
Miscellaneous databases
RNActi | P51178, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 130 | PHPROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 140 – 175 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 176 – 211 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 296 – 440 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 145 | |
Domaini | 492 – 609 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 611 – 737 | C2PROSITE-ProRule annotationAdd BLAST | 127 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 57 | Substrate bindingBy similarityAdd BLAST | 28 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000158392 |
HOGENOMi | CLU_002738_0_2_1 |
InParanoidi | P51178 |
OMAi | VCQNLHI |
OrthoDBi | 368239at2759 |
PhylomeDBi | P51178 |
TreeFami | TF313216 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR028391, PLC-delta1 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF80, PTHR10336:SF80, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P51178-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSGRDFLTL HGLQDDEDLQ ALLKGSQLLK VKSSSWRRER FYKLQEDCKT
60 70 80 90 100
IWQESRKVMR TPESQLFSIE DIQEVRMGHR TEGLEKFARD VPEDRCFSIV
110 120 130 140 150
FKDQRNTLDL IAPSPADAQH WVLGLHKIIH HSGSMDQRQK LQHWIHSCLR
160 170 180 190 200
KADKNKDNKM SFKELQNFLK ELNIQVDDSY ARKIFRECDH SQTDSLEDEE
210 220 230 240 250
IEAFYKMLTQ RVEIDRTFAE AAGSGETLSV DQLVTFLQHQ QREEAAGPAL
260 270 280 290 300
ALSLIERYEP SETAKAQRQM TKDGFLMYLL SADGSAFSLA HRRVYQDMGQ
310 320 330 340 350
PLSHYLVSSS HNTYLLEDQL AGPSSTEAYI RALCKGCRCL ELDCWDGPNQ
360 370 380 390 400
EPIIYHGYTF TSKILFCDVL RAIRDYAFKA SPYPVILSLE NHCTLEQQRV
410 420 430 440 450
MARHLHAILG PMLLNRPLDG VTNSLPSPEQ LKGKILLKGK KLGGLLPPGG
460 470 480 490 500
EGGPEATVVS DEDEAAEMED EAVRSRVQHK PKEDKLRLAQ ELSDMVIYCK
510 520 530 540 550
SVHFGGFSSP GTPGQAFYEM ASFSENRALR LLQESGNGFV RHNVGHLSRI
560 570 580 590 600
YPAGWRTDSS NYSPVEMWNG GCQIVALNFQ TPGPEMDVYQ GRFQDNGACG
610 620 630 640 650
YVLKPAFLRD PNGTFNPRAL AQGPWWARKR LNIRVISGQQ LPKVNKNKNS
660 670 680 690 700
IVDPKVTVEI HGVSRDVASR QTAVITNNGF NPWWDTEFAF EVVVPDLALI
710 720 730 740 750
RFLVEDYDAS SKNDFIGQST IPLNSLKQGY RHVHLMSKNG DQHPSATLFV
KISLQD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 224 | S → P in AAA73567 (PubMed:7890667).Curated | 1 | |
Sequence conflicti | 264 | A → T in AAA73567 (PubMed:7890667).Curated | 1 | |
Sequence conflicti | 591 | G → D in AAA73567 (PubMed:7890667).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066399 | 209 | T → R in NDNC3. 1 Publication | 1 | |
Natural variantiVAR_046560 | 257 | R → H. Corresponds to variant dbSNP:rs933135Ensembl. | 1 | |
Natural variantiVAR_066400 | 574 | I → T in NDNC3. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042919 | 1 – 11 | MDSGRDFLTLH → MQCLGIRSRSRSRELYLQER SLKVAALNGRRL in isoform 2. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09117 mRNA Translation: AAA73567.1 AK090774 mRNA Translation: BAG52226.1 AC144536 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64507.1 BC050382 mRNA Translation: AAH50382.2 |
CCDSi | CCDS2671.1 [P51178-1] CCDS46793.1 [P51178-2] |
PIRi | A55943 |
RefSeqi | NP_001124436.1, NM_001130964.1 [P51178-2] NP_006216.2, NM_006225.3 [P51178-1] |
Genome annotation databases
Ensembli | ENST00000334661; ENSP00000335600; ENSG00000187091 [P51178-1] ENST00000463876; ENSP00000430344; ENSG00000187091 [P51178-2] |
GeneIDi | 5333 |
KEGGi | hsa:5333 |
UCSCi | uc003chm.4, human [P51178-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09117 mRNA Translation: AAA73567.1 AK090774 mRNA Translation: BAG52226.1 AC144536 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64507.1 BC050382 mRNA Translation: AAH50382.2 |
CCDSi | CCDS2671.1 [P51178-1] CCDS46793.1 [P51178-2] |
PIRi | A55943 |
RefSeqi | NP_001124436.1, NM_001130964.1 [P51178-2] NP_006216.2, NM_006225.3 [P51178-1] |
3D structure databases
SMRi | P51178 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111349, 26 interactors |
IntActi | P51178, 14 interactors |
MINTi | P51178 |
STRINGi | 9606.ENSP00000430344 |
Chemistry databases
BindingDBi | P51178 |
ChEMBLi | CHEMBL3727 |
DrugBanki | DB03401, 1D-myo-inositol 1,4,5-trisphosphate DB03956, Inositol 2,4,5-trisphosphate |
SwissLipidsi | SLP:000001065 |
PTM databases
GlyGeni | P51178, 2 sites |
iPTMneti | P51178 |
PhosphoSitePlusi | P51178 |
SwissPalmi | P51178 |
Genetic variation databases
BioMutai | PLCD1 |
DMDMi | 206729887 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00746030 |
Proteomic databases
EPDi | P51178 |
jPOSTi | P51178 |
MassIVEi | P51178 |
MaxQBi | P51178 |
PaxDbi | P51178 |
PeptideAtlasi | P51178 |
PRIDEi | P51178 |
ProteomicsDBi | 56300 [P51178-1] 56301 [P51178-2] |
Protocols and materials databases
Antibodypediai | 4086, 171 antibodies |
Genome annotation databases
Ensembli | ENST00000334661; ENSP00000335600; ENSG00000187091 [P51178-1] ENST00000463876; ENSP00000430344; ENSG00000187091 [P51178-2] |
GeneIDi | 5333 |
KEGGi | hsa:5333 |
UCSCi | uc003chm.4, human [P51178-1] |
Organism-specific databases
CTDi | 5333 |
DisGeNETi | 5333 |
GeneCardsi | PLCD1 |
HGNCi | HGNC:9060, PLCD1 |
HPAi | ENSG00000187091, Low tissue specificity |
MalaCardsi | PLCD1 |
MIMi | 151600, phenotype 602142, gene |
neXtProti | NX_P51178 |
OpenTargetsi | ENSG00000187091 |
Orphaneti | 2387, Leukonychia totalis |
PharmGKBi | PA33388 |
VEuPathDBi | HostDB:ENSG00000187091.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000158392 |
HOGENOMi | CLU_002738_0_2_1 |
InParanoidi | P51178 |
OMAi | VCQNLHI |
OrthoDBi | 368239at2759 |
PhylomeDBi | P51178 |
TreeFami | TF313216 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS07195-MONOMER |
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | P51178 |
Reactomei | R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol |
Miscellaneous databases
BioGRID-ORCSi | 5333, 7 hits in 997 CRISPR screens |
GeneWikii | PLCD1 |
GenomeRNAii | 5333 |
Pharosi | P51178, Tchem |
PROi | PR:P51178 |
RNActi | P51178, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187091, Expressed in male germ cell and 237 other tissues |
ExpressionAtlasi | P51178, baseline and differential |
Genevisiblei | P51178, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR028391, PLC-delta1 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF80, PTHR10336:SF80, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCD1_HUMAN | |
Accessioni | P51178Primary (citable) accession number: P51178 Secondary accession number(s): B3KR14, Q86VN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot