SCNN1G

Functionⁱ

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.1 Publication1 Publication

Activity regulationⁱ

Activated by WNK1, WNK2, WNK3 and WNK4.By similarity

GO - Molecular functionⁱ

ion channel activity
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22864553
ligand-gated sodium channel activity
Source: ProtInc
Traceable author statementⁱ
- 8640238
sodium channel activity
Source: ProtInc
Traceable author statementⁱ
- 8521520
WW domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10642508

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

excretion
Source: ProtInc
Traceable author statementⁱ
- 8640238
multicellular organismal water homeostasis
Source: UniProtKB
Inferred from direct assayⁱ
- 24124190
response to stimulus Source: UniProtKB-KW
sensory perception of taste Source: UniProtKB-KW
sodium ion homeostasis
Source: UniProtKB
Inferred from direct assayⁱ
- 24124190
sodium ion transmembrane transport
Source: UniProtKB
Inferred from direct assayⁱ
- 24124190
sodium ion transport
Source: ProtInc
Traceable author statementⁱ
- 8521520

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Sodium channel
Biological process	Ion transport, Sensory transduction, Sodium transport, Taste, Transport
Ligand	Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2672351 Stimuli-sensing channels
SIGNORⁱ	P51170

Protein family/group databases

TCDBⁱ	1.A.6.1.1 the epithelial na(+) channel (enac) family

TCDBⁱ

1.A.6.1.1 the epithelial na(+) channel (enac) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amiloride-sensitive sodium channel subunit gamma Alternative name(s): Epithelial Na(+) channel subunit gamma Short name: ENaCG Short name: Gamma-ENaC Gamma-NaCH Nonvoltage-gated sodium channel 1 subunit gamma SCNEG
Gene namesⁱ	Name:SCNN1G
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166828.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10602 SCNN1G
MIMⁱ	600761 gene
neXtProtⁱ	NX_P51170

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 55	CytoplasmicBy similarityAdd BLAST	55
Transmembraneⁱ	56 – 76	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	77 – 541	ExtracellularBy similarityAdd BLAST	465
Transmembraneⁱ	542 – 562	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	563 – 649	CytoplasmicBy similarityAdd BLAST	87

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Liddle syndrome (LIDLS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant disorder characterized by hypertension, hypokalemic alkalosis, and suppression of plasma renin activity and aldosterone secretion.

Bronchiectasis with or without elevated sweat chloride 3 (BESC3)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6340
MalaCards human disease database More...MalaCardsⁱ	SCNN1G
MIMⁱ	177200 phenotype 613071 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000166828
Orphanetⁱ	171876 Generalized pseudohypoaldosteronism type 1 60033 Idiopathic bronchiectasis 526 Liddle syndrome
PharmGKBⁱ	PA307

Chemistry databases

ChEMBLⁱ	CHEMBL2107836
Drug and drug target database More...DrugBankⁱ	DB00594 Amiloride DB00384 Triamterene
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	741

Polymorphism and mutation databases

BioMutaⁱ	SCNN1G
DMDMⁱ	108885072

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181276	1 – 649	Amiloride-sensitive sodium channel subunit gammaAdd BLAST		649

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	209	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	497	N-linked (GlcNAc...) asparagineSequence analysis		1

Post-translational modificationⁱ

Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.By similarity

Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.By similarity

ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.2 Publications

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P51170
PaxDbⁱ	P51170
PeptideAtlas More...PeptideAtlasⁱ	P51170
PRIDEⁱ	P51170
ProteomicsDBⁱ	56297

PTM databases

iPTMnetⁱ	P51170
PhosphoSitePlusⁱ	P51170

Expressionⁱ

Tissue specificityⁱ

Expressed in kidney (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000166828 Expressed in 94 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	P51170 baseline and differential
Genevisibleⁱ	P51170 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071194

HPAⁱ

HPA071194

Interactionⁱ

Subunit structureⁱ

Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (PubMed:7762608). Interacts with NEDD4; via the WW domains (PubMed:11244092, PubMed:12167593). Interacts with NEDD4L; via the WW domains (PubMed:11244092). Interacts with WWP1; via the WW domains (PubMed:9169421). Interacts with WWP2; via the WW domains (PubMed:9169421, PubMed:12167593). Interacts with the full-length immature form of PCSK9 (pro-PCSK9) (PubMed:22493497).7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SCNN1A	P37088	3	EBI-2547354,EBI-7845444

With

Entry

#Exp.

IntAct

Notes

SCNN1A

P37088

3

EBI-2547354,EBI-7845444

GO - Molecular functionⁱ

WW domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10642508

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112244, 14 interactors
ComplexPortalⁱ	CPX-2188 Amiloride-sensitive sodium channel complex, alpha-beta-gamma CPX-312 Amiloride-sensitive sodium channel complex, delta-alpha-beta-gamma CPX-313 Amiloride-sensitive sodium channel complex, delta-beta-gamma
CORUMⁱ	P51170
ELMⁱ	P51170
IntActⁱ	P51170, 3 interactors
Molecular INTeraction database More...MINTⁱ	P51170
STRINGⁱ	9606.ENSP00000300061

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51170
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4294 Eukaryota ENOG410ZNFK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119120
HOVERGENⁱ	HBG058435
InParanoidⁱ	P51170
KEGG Orthology (KO) More...KOⁱ	K04827
OMAⁱ	NWMYCYY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KW6
PhylomeDBⁱ	P51170
TreeFamⁱ	TF330663

Family and domain databases

InterProⁱ	View protein in InterPro IPR001873 ENaC IPR004724 ENaC_chordates IPR020903 ENaC_CS
PANTHERⁱ	PTHR11690 PTHR11690, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00858 ASC, 1 hit
PRINTSⁱ	PR01078 AMINACHANNEL
TIGRFAMsⁱ	TIGR00859 ENaC, 1 hit
PROSITEⁱ	View protein in PROSITE PS01206 ASC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P51170-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR 
        60         70         80         90        100
LRRLLWIGFT LTAVALILWQ CALLVFSFYT VSVSIKVHFR KLDFPAVTIC 
       110        120        130        140        150
NINPYKYSTV RHLLADLEQE TREALKSLYG FPESRKRREA ESWNSVSEGK 
       160        170        180        190        200
QPRFSHRIPL LIFDQDEKGK ARDFFTGRKR KVGGSIIHKA SNVMHIESKQ 
       210        220        230        240        250
VVGFQLCSND TSDCATYTFS SGINAIQEWY KLHYMNIMAQ VPLEKKINMS 
       260        270        280        290        300
YSAEELLVTC FFDGVSCDAR NFTLFHHPMH GNCYTFNNRE NETILSTSMG 
       310        320        330        340        350
GSEYGLQVIL YINEEEYNPF LVSSTGAKVI IHRQDEYPFV EDVGTEIETA 
       360        370        380        390        400
MVTSIGMHLT ESFKLSEPYS QCTEDGSDVP IRNIYNAAYS LQICLHSCFQ 
       410        420        430        440        450
TKMVEKCGCA QYSQPLPPAA NYCNYQQHPN WMYCYYQLHR AFVQEELGCQ 
       460        470        480        490        500
SVCKEACSFK EWTLTTSLAQ WPSVVSEKWL LPVLTWDQGR QVNKKLNKTD 
       510        520        530        540        550
LAKLLIFYKD LNQRSIMESP ANSIEMLLSN FGGQLGLWMS CSVVCVIEII 
       560        570        580        590        600
EVFFIDFFSI IARRQWQKAK EWWAWKQAPP CPEAPRSPQG QDNPALDIDD 
       610        620        630        640 
DLPTFNSALH LPPALGTQVP GTPPPKYNTL RLERAFSNQL TDTQMLDEL

Length:649

Mass (Da):74,270

Last modified:May 30, 2006 - v4

Checksum:ⁱF67ED45F03A9BF3F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	339	F → S in CAA60633 (PubMed:7490094).Curated	1
Sequence conflictⁱ	350	A → T in CAA60633 (PubMed:7490094).Curated	1
Sequence conflictⁱ	369	Y → S in CAA60633 (PubMed:7490094).Curated	1
Sequence conflictⁱ	375	D → G in CAA60633 (PubMed:7490094).Curated	1
Sequence conflictⁱ	458	S → R in CAA60633 (PubMed:7490094).Curated	1
Sequence conflictⁱ	461 – 463	EWT → DGH in AAC50758 (PubMed:8824247).Curated	3

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014893	49	G → C1 PublicationCorresponds to variant dbSNP:rs5733Ensembl.	1
Natural variantⁱVAR_036483	58	G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1183385193Ensembl.	1
Natural variantⁱVAR_015842	178	R → W2 Publications	1
Natural variantⁱVAR_014894	183	G → S in a patient with bronchiectasis. 2 PublicationsCorresponds to variant dbSNP:rs5736EnsemblClinVar.	1
Natural variantⁱVAR_034485	197	E → K in a patient with bronchiectasis. 1 PublicationCorresponds to variant dbSNP:rs5738EnsemblClinVar.	1
Natural variantⁱVAR_015843	502	A → P4 Publications	1
Natural variantⁱVAR_015844	614	A → S2 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X87160 mRNA Translation: CAA60633.1 L36592 mRNA Translation: AAA75460.1 AF356502 AF356501 Genomic DNA Translation: AAK50910.1 BC059391 mRNA Translation: AAH59391.1 BC069652 mRNA Translation: AAH69652.1 U48936 mRNA Translation: AAC50737.1 U53836 Genomic DNA Translation: AAC50744.1 U53837 Genomic DNA Translation: AAC50745.1 U53841 Genomic DNA Translation: AAC50749.1 U53844 Genomic DNA Translation: AAC50752.1 U53845 Genomic DNA Translation: AAC50753.1 U53846 Genomic DNA Translation: AAC50754.1 U53847 Genomic DNA Translation: AAC50755.1 U53850 Genomic DNA Translation: AAC50758.1 U53852 Genomic DNA Translation: AAC50760.1 U35630 Genomic DNA Translation: AAC50217.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10608.1
PIRⁱ	I38204 I64847
NCBI Reference Sequences More...RefSeqⁱ	NP_001030.2, NM_001039.3
UniGeneⁱ	Hs.371727

Genome annotation databases

Ensemblⁱ	ENST00000300061; ENSP00000300061; ENSG00000166828
GeneIDⁱ	6340
KEGGⁱ	hsa:6340
UCSC genome browser More...UCSCⁱ	uc002dlm.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51170	Amiloride-sensitive sodium channel gamma-subunit		HUMAN		649	UniRef100_P51170

Protein	Similar proteins		Species	Score	Length	Source
P51170	Amiloride-sensitive sodium channel gamma-subunit		HUMAN		649	UniRef90_P51170
Uncharacterized protein		AOTNA		698
Uncharacterized protein		RHIBE		690
Uncharacterized protein		MACFA		690
Uncharacterized protein		MACNE		690
+33

Protein	Similar proteins		Species	Score	Length	Source
P51170	Amiloride-sensitive sodium channel gamma-subunit		HUMAN		649	UniRef50_P51170
Uncharacterized protein		AOTNA		698
Uncharacterized protein		MACNE		690
Sodium channel epithelial 1 gamma subunit		MACMU		690
Uncharacterized protein		MACFA		690
+127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X87160 mRNA Translation: CAA60633.1 L36592 mRNA Translation: AAA75460.1 AF356502 AF356501 Genomic DNA Translation: AAK50910.1 BC059391 mRNA Translation: AAH59391.1 BC069652 mRNA Translation: AAH69652.1 U48936 mRNA Translation: AAC50737.1 U53836 Genomic DNA Translation: AAC50744.1 U53837 Genomic DNA Translation: AAC50745.1 U53841 Genomic DNA Translation: AAC50749.1 U53844 Genomic DNA Translation: AAC50752.1 U53845 Genomic DNA Translation: AAC50753.1 U53846 Genomic DNA Translation: AAC50754.1 U53847 Genomic DNA Translation: AAC50755.1 U53850 Genomic DNA Translation: AAC50758.1 U53852 Genomic DNA Translation: AAC50760.1 U35630 Genomic DNA Translation: AAC50217.1
CCDSⁱ	CCDS10608.1
PIRⁱ	I38204 I64847
RefSeqⁱ	NP_001030.2, NM_001039.3
UniGeneⁱ	Hs.371727

3D structure databases

ProteinModelPortalⁱ	P51170
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112244, 14 interactors
ComplexPortalⁱ	CPX-2188 Amiloride-sensitive sodium channel complex, alpha-beta-gamma CPX-312 Amiloride-sensitive sodium channel complex, delta-alpha-beta-gamma CPX-313 Amiloride-sensitive sodium channel complex, delta-beta-gamma
CORUMⁱ	P51170
ELMⁱ	P51170
IntActⁱ	P51170, 3 interactors
MINTⁱ	P51170
STRINGⁱ	9606.ENSP00000300061

Chemistry databases

ChEMBLⁱ	CHEMBL2107836
DrugBankⁱ	DB00594 Amiloride DB00384 Triamterene
GuidetoPHARMACOLOGYⁱ	741

Protein family/group databases

TCDBⁱ	1.A.6.1.1 the epithelial na(+) channel (enac) family

TCDBⁱ

1.A.6.1.1 the epithelial na(+) channel (enac) family

PTM databases

iPTMnetⁱ	P51170
PhosphoSitePlusⁱ	P51170

Polymorphism and mutation databases

BioMutaⁱ	SCNN1G
DMDMⁱ	108885072

Proteomic databases

EPDⁱ	P51170
PaxDbⁱ	P51170
PeptideAtlasⁱ	P51170
PRIDEⁱ	P51170
ProteomicsDBⁱ	56297

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000300061; ENSP00000300061; ENSG00000166828
GeneIDⁱ	6340
KEGGⁱ	hsa:6340
UCSCⁱ	uc002dlm.2 human

Organism-specific databases

CTDⁱ	6340
DisGeNETⁱ	6340
EuPathDBⁱ	HostDB:ENSG00000166828.2
GeneCardsⁱ	SCNN1G
HGNCⁱ	HGNC:10602 SCNN1G
HPAⁱ	HPA071194
MalaCardsⁱ	SCNN1G
MIMⁱ	177200 phenotype 600761 gene 613071 phenotype
neXtProtⁱ	NX_P51170
OpenTargetsⁱ	ENSG00000166828
Orphanetⁱ	171876 Generalized pseudohypoaldosteronism type 1 60033 Idiopathic bronchiectasis 526 Liddle syndrome
PharmGKBⁱ	PA307
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4294 Eukaryota ENOG410ZNFK LUCA
GeneTreeⁱ	ENSGT00760000119120
HOVERGENⁱ	HBG058435
InParanoidⁱ	P51170
KOⁱ	K04827
OMAⁱ	NWMYCYY
OrthoDBⁱ	EOG091G0KW6
PhylomeDBⁱ	P51170
TreeFamⁱ	TF330663

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2672351 Stimuli-sensing channels
SIGNORⁱ	P51170

Miscellaneous databases

GeneWikiⁱ	SCNN1G
GenomeRNAiⁱ	6340
Protein Ontology More...PROⁱ	PR:P51170
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166828 Expressed in 94 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	P51170 baseline and differential
Genevisibleⁱ	P51170 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001873 ENaC IPR004724 ENaC_chordates IPR020903 ENaC_CS
PANTHERⁱ	PTHR11690 PTHR11690, 1 hit
Pfamⁱ	View protein in Pfam PF00858 ASC, 1 hit
PRINTSⁱ	PR01078 AMINACHANNEL
TIGRFAMsⁱ	TIGR00859 ENaC, 1 hit
PROSITEⁱ	View protein in PROSITE PS01206 ASC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCNNG_HUMAN
Accessionⁱ	P51170Primary (citable) accession number: P51170 Secondary accession number(s): P78437 Q96TD2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	May 30, 2006
	Last modified:	October 10, 2018
	This is version 182 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Help

UniRef

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Supporting data

UniProtKB - P51170 (SCNNG_HUMAN)

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Amiloride-sensitive sodium channel subunit gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ