UniProtKB - P51170 (SCNNG_HUMAN)
Amiloride-sensitive sodium channel subunit gamma
SCNN1G
Functioni
Activity regulationi
GO - Molecular functioni
- ion channel activity Source: CACAO
- ligand-gated sodium channel activity Source: ProtInc
- sodium channel activity Source: ProtInc
- WW domain binding Source: BHF-UCL
GO - Biological processi
- cellular response to aldosterone Source: Ensembl
- excretion Source: ProtInc
- ion transmembrane transport Source: Reactome
- multicellular organismal water homeostasis Source: UniProtKB
- sensory perception of taste Source: UniProtKB-KW
- sodium ion homeostasis Source: UniProtKB
- sodium ion transmembrane transport Source: UniProtKB
- sodium ion transport Source: ProtInc
Keywordsi
Molecular function | Ion channel, Sodium channel |
Biological process | Ion transport, Sensory transduction, Sodium transport, Taste, Transport |
Ligand | Sodium |
Enzyme and pathway databases
PathwayCommonsi | P51170 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
SIGNORi | P51170 |
Protein family/group databases
TCDBi | 1.A.6.1.1, the epithelial na(+) channel (enac) family |
Names & Taxonomyi
Protein namesi | Recommended name: Amiloride-sensitive sodium channel subunit gammaAlternative name(s): Epithelial Na(+) channel subunit gamma Short name: ENaCG Short name: Gamma-ENaC Gamma-NaCH Nonvoltage-gated sodium channel 1 subunit gamma SCNEG |
Gene namesi | Name:SCNN1G |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10602, SCNN1G |
MIMi | 600761, gene |
neXtProti | NX_P51170 |
VEuPathDBi | HostDB:ENSG00000166828.2 |
Subcellular locationi
Plasma membrane
- Apical cell membrane 1 Publication1 Publication; Multi-pass membrane protein By similarity
Note: Apical membrane of epithelial cells.1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: HPA
- plasma membrane protein complex Source: Ensembl
Other locations
- sodium channel complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 55 | CytoplasmicBy similarityAdd BLAST | 55 | |
Transmembranei | 56 – 76 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 541 | ExtracellularBy similarityAdd BLAST | 465 | |
Transmembranei | 542 – 562 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 563 – 649 | CytoplasmicBy similarityAdd BLAST | 87 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Liddle syndrome 2 (LIDLS2)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081180 | 573 – 649 | Missing in LIDLS2; increased sodium channel activity. 1 PublicationAdd BLAST | 77 |
Bronchiectasis with or without elevated sweat chloride 3 (BESC3)2 Publications
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6340 |
MalaCardsi | SCNN1G |
MIMi | 613071, phenotype 618114, phenotype |
OpenTargetsi | ENSG00000166828 |
Orphaneti | 171876, Generalized pseudohypoaldosteronism type 1 60033, Idiopathic bronchiectasis 526, Liddle syndrome |
PharmGKBi | PA307 |
Miscellaneous databases
Pharosi | P51170, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1628484 |
DrugBanki | DB00594, Amiloride DB14509, Lithium carbonate DB00384, Triamterene |
DrugCentrali | P51170 |
GuidetoPHARMACOLOGYi | 741 |
Genetic variation databases
BioMutai | SCNN1G |
DMDMi | 108885072 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181276 | 1 – 649 | Amiloride-sensitive sodium channel subunit gammaAdd BLAST | 649 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 209 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 497 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P51170 |
MassIVEi | P51170 |
PaxDbi | P51170 |
PeptideAtlasi | P51170 |
PRIDEi | P51170 |
ProteomicsDBi | 56297 |
PTM databases
GlyGeni | P51170, 2 sites |
iPTMneti | P51170 |
PhosphoSitePlusi | P51170 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000166828, Expressed in adult mammalian kidney and 111 other tissues |
ExpressionAtlasi | P51170, baseline and differential |
Genevisiblei | P51170, HS |
Organism-specific databases
HPAi | ENSG00000166828, Tissue enhanced (kidney, salivary gland) |
Interactioni
Subunit structurei
Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (PubMed:7762608).
Interacts with NEDD4; via the WW domains (PubMed:11244092, PubMed:12167593).
Interacts with NEDD4L; via the WW domains (PubMed:11244092).
Interacts with WWP1; via the WW domains (PubMed:9169421).
Interacts with WWP2; via the WW domains (PubMed:9169421, PubMed:12167593).
Interacts with the full-length immature form of PCSK9 (pro-PCSK9) (PubMed:22493497).
7 PublicationsBinary interactionsi
P51170
With | #Exp. | IntAct |
---|---|---|
SCNN1A [P37088] | 3 | EBI-2547354,EBI-7845444 |
GO - Molecular functioni
- WW domain binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112244, 17 interactors |
ComplexPortali | CPX-2188, Amiloride-sensitive sodium channel complex, alpha-beta-gamma CPX-312, Amiloride-sensitive sodium channel complex, delta-alpha-beta-gamma CPX-313, Amiloride-sensitive sodium channel complex, delta-beta-gamma |
CORUMi | P51170 |
ELMi | P51170 |
IntActi | P51170, 5 interactors |
MINTi | P51170 |
STRINGi | 9606.ENSP00000300061 |
Miscellaneous databases
RNActi | P51170, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4294, Eukaryota |
GeneTreei | ENSGT00940000160352 |
HOGENOMi | CLU_020415_0_0_1 |
InParanoidi | P51170 |
OMAi | YCYYKLH |
OrthoDBi | 686369at2759 |
PhylomeDBi | P51170 |
TreeFami | TF330663 |
Family and domain databases
InterProi | View protein in InterPro IPR001873, ENaC IPR004724, ENaC_chordates IPR020903, ENaC_CS |
PANTHERi | PTHR11690, PTHR11690, 1 hit |
Pfami | View protein in Pfam PF00858, ASC, 1 hit |
PRINTSi | PR01078, AMINACHANNEL |
TIGRFAMsi | TIGR00859, ENaC, 1 hit |
PROSITEi | View protein in PROSITE PS01206, ASC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR
60 70 80 90 100
LRRLLWIGFT LTAVALILWQ CALLVFSFYT VSVSIKVHFR KLDFPAVTIC
110 120 130 140 150
NINPYKYSTV RHLLADLEQE TREALKSLYG FPESRKRREA ESWNSVSEGK
160 170 180 190 200
QPRFSHRIPL LIFDQDEKGK ARDFFTGRKR KVGGSIIHKA SNVMHIESKQ
210 220 230 240 250
VVGFQLCSND TSDCATYTFS SGINAIQEWY KLHYMNIMAQ VPLEKKINMS
260 270 280 290 300
YSAEELLVTC FFDGVSCDAR NFTLFHHPMH GNCYTFNNRE NETILSTSMG
310 320 330 340 350
GSEYGLQVIL YINEEEYNPF LVSSTGAKVI IHRQDEYPFV EDVGTEIETA
360 370 380 390 400
MVTSIGMHLT ESFKLSEPYS QCTEDGSDVP IRNIYNAAYS LQICLHSCFQ
410 420 430 440 450
TKMVEKCGCA QYSQPLPPAA NYCNYQQHPN WMYCYYQLHR AFVQEELGCQ
460 470 480 490 500
SVCKEACSFK EWTLTTSLAQ WPSVVSEKWL LPVLTWDQGR QVNKKLNKTD
510 520 530 540 550
LAKLLIFYKD LNQRSIMESP ANSIEMLLSN FGGQLGLWMS CSVVCVIEII
560 570 580 590 600
EVFFIDFFSI IARRQWQKAK EWWAWKQAPP CPEAPRSPQG QDNPALDIDD
610 620 630 640
DLPTFNSALH LPPALGTQVP GTPPPKYNTL RLERAFSNQL TDTQMLDEL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 339 | F → S in CAA60633 (PubMed:7490094).Curated | 1 | |
Sequence conflicti | 350 | A → T in CAA60633 (PubMed:7490094).Curated | 1 | |
Sequence conflicti | 369 | Y → S in CAA60633 (PubMed:7490094).Curated | 1 | |
Sequence conflicti | 375 | D → G in CAA60633 (PubMed:7490094).Curated | 1 | |
Sequence conflicti | 458 | S → R in CAA60633 (PubMed:7490094).Curated | 1 | |
Sequence conflicti | 461 – 463 | EWT → DGH in AAC50758 (PubMed:8824247).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014893 | 49 | G → C1 PublicationCorresponds to variant dbSNP:rs5733Ensembl. | 1 | |
Natural variantiVAR_036483 | 58 | G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1183385193Ensembl. | 1 | |
Natural variantiVAR_015842 | 178 | R → W2 Publications | 1 | |
Natural variantiVAR_014894 | 183 | G → S in a patient with bronchiectasis. 2 PublicationsCorresponds to variant dbSNP:rs5736EnsemblClinVar. | 1 | |
Natural variantiVAR_034485 | 197 | E → K in a patient with bronchiectasis. 1 PublicationCorresponds to variant dbSNP:rs5738EnsemblClinVar. | 1 | |
Natural variantiVAR_015843 | 502 | A → P4 Publications | 1 | |
Natural variantiVAR_081180 | 573 – 649 | Missing in LIDLS2; increased sodium channel activity. 1 PublicationAdd BLAST | 77 | |
Natural variantiVAR_015844 | 614 | A → S2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87160 mRNA Translation: CAA60633.1 L36592 mRNA Translation: AAA75460.1 AF356502 , AF356493, AF356494, AF356495, AF356496, AF356497, AF356498, AF356499, AF356500, AF356501 Genomic DNA Translation: AAK50910.1 BC059391 mRNA Translation: AAH59391.1 BC069652 mRNA Translation: AAH69652.1 U48936 mRNA Translation: AAC50737.1 U53836 Genomic DNA Translation: AAC50744.1 U53837 Genomic DNA Translation: AAC50745.1 U53841 Genomic DNA Translation: AAC50749.1 U53844 Genomic DNA Translation: AAC50752.1 U53845 Genomic DNA Translation: AAC50753.1 U53846 Genomic DNA Translation: AAC50754.1 U53847 Genomic DNA Translation: AAC50755.1 U53850 Genomic DNA Translation: AAC50758.1 U53852 Genomic DNA Translation: AAC50760.1 U35630 Genomic DNA Translation: AAC50217.1 |
CCDSi | CCDS10608.1 |
PIRi | I38204 I64847 |
RefSeqi | NP_001030.2, NM_001039.3 |
Genome annotation databases
Ensembli | ENST00000300061; ENSP00000300061; ENSG00000166828 |
GeneIDi | 6340 |
KEGGi | hsa:6340 |
UCSCi | uc002dlm.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X87160 mRNA Translation: CAA60633.1 L36592 mRNA Translation: AAA75460.1 AF356502 , AF356493, AF356494, AF356495, AF356496, AF356497, AF356498, AF356499, AF356500, AF356501 Genomic DNA Translation: AAK50910.1 BC059391 mRNA Translation: AAH59391.1 BC069652 mRNA Translation: AAH69652.1 U48936 mRNA Translation: AAC50737.1 U53836 Genomic DNA Translation: AAC50744.1 U53837 Genomic DNA Translation: AAC50745.1 U53841 Genomic DNA Translation: AAC50749.1 U53844 Genomic DNA Translation: AAC50752.1 U53845 Genomic DNA Translation: AAC50753.1 U53846 Genomic DNA Translation: AAC50754.1 U53847 Genomic DNA Translation: AAC50755.1 U53850 Genomic DNA Translation: AAC50758.1 U53852 Genomic DNA Translation: AAC50760.1 U35630 Genomic DNA Translation: AAC50217.1 |
CCDSi | CCDS10608.1 |
PIRi | I38204 I64847 |
RefSeqi | NP_001030.2, NM_001039.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6BQN | electron microscopy | 3.90 | C | 78-524 | [»] | |
6WTH | electron microscopy | 3.06 | C | 1-649 | [»] | |
SMRi | P51170 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112244, 17 interactors |
ComplexPortali | CPX-2188, Amiloride-sensitive sodium channel complex, alpha-beta-gamma CPX-312, Amiloride-sensitive sodium channel complex, delta-alpha-beta-gamma CPX-313, Amiloride-sensitive sodium channel complex, delta-beta-gamma |
CORUMi | P51170 |
ELMi | P51170 |
IntActi | P51170, 5 interactors |
MINTi | P51170 |
STRINGi | 9606.ENSP00000300061 |
Chemistry databases
ChEMBLi | CHEMBL1628484 |
DrugBanki | DB00594, Amiloride DB14509, Lithium carbonate DB00384, Triamterene |
DrugCentrali | P51170 |
GuidetoPHARMACOLOGYi | 741 |
Protein family/group databases
TCDBi | 1.A.6.1.1, the epithelial na(+) channel (enac) family |
PTM databases
GlyGeni | P51170, 2 sites |
iPTMneti | P51170 |
PhosphoSitePlusi | P51170 |
Genetic variation databases
BioMutai | SCNN1G |
DMDMi | 108885072 |
Proteomic databases
EPDi | P51170 |
MassIVEi | P51170 |
PaxDbi | P51170 |
PeptideAtlasi | P51170 |
PRIDEi | P51170 |
ProteomicsDBi | 56297 |
Protocols and materials databases
Antibodypediai | 25924, 378 antibodies |
Genome annotation databases
Ensembli | ENST00000300061; ENSP00000300061; ENSG00000166828 |
GeneIDi | 6340 |
KEGGi | hsa:6340 |
UCSCi | uc002dlm.2, human |
Organism-specific databases
CTDi | 6340 |
DisGeNETi | 6340 |
GeneCardsi | SCNN1G |
HGNCi | HGNC:10602, SCNN1G |
HPAi | ENSG00000166828, Tissue enhanced (kidney, salivary gland) |
MalaCardsi | SCNN1G |
MIMi | 600761, gene 613071, phenotype 618114, phenotype |
neXtProti | NX_P51170 |
OpenTargetsi | ENSG00000166828 |
Orphaneti | 171876, Generalized pseudohypoaldosteronism type 1 60033, Idiopathic bronchiectasis 526, Liddle syndrome |
PharmGKBi | PA307 |
VEuPathDBi | HostDB:ENSG00000166828.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4294, Eukaryota |
GeneTreei | ENSGT00940000160352 |
HOGENOMi | CLU_020415_0_0_1 |
InParanoidi | P51170 |
OMAi | YCYYKLH |
OrthoDBi | 686369at2759 |
PhylomeDBi | P51170 |
TreeFami | TF330663 |
Enzyme and pathway databases
PathwayCommonsi | P51170 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
SIGNORi | P51170 |
Miscellaneous databases
BioGRID-ORCSi | 6340, 3 hits in 874 CRISPR screens |
ChiTaRSi | SCNN1G, human |
GeneWikii | SCNN1G |
GenomeRNAii | 6340 |
Pharosi | P51170, Tclin |
PROi | PR:P51170 |
RNActi | P51170, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166828, Expressed in adult mammalian kidney and 111 other tissues |
ExpressionAtlasi | P51170, baseline and differential |
Genevisiblei | P51170, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001873, ENaC IPR004724, ENaC_chordates IPR020903, ENaC_CS |
PANTHERi | PTHR11690, PTHR11690, 1 hit |
Pfami | View protein in Pfam PF00858, ASC, 1 hit |
PRINTSi | PR01078, AMINACHANNEL |
TIGRFAMsi | TIGR00859, ENaC, 1 hit |
PROSITEi | View protein in PROSITE PS01206, ASC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCNNG_HUMAN | |
Accessioni | P51170Primary (citable) accession number: P51170 Secondary accession number(s): P78437 Q96TD2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | May 30, 2006 | |
Last modified: | February 10, 2021 | |
This is version 199 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants