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UniProtKB - P51164 (ATP4B_HUMAN)

Entry version 163 (02 Jun 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Potassium-transporting ATPase subunit beta

Gene

ATP4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The beta subunit of the gastric H+/K+ ATPase pump which transports H+ ions in exchange for K+ ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity).

Within a transport cycle, the transfer of a H+ ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:G66-33511-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P51164

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-936837, Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.3.1.2, the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP4BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:820, ATP4B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		137217, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P51164

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186009.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 291ExtracellularSequence analysisAdd BLAST234

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		496

Open Targets

More...OpenTargetsi		ENSG00000186009

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25114

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P51164, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2095173

Drug and drug target database

More...DrugBanki		DB05351, Dexlansoprazole
DB13620, Potassium gluconate

DrugCentral

More...DrugCentrali		P51164

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP4B

Domain mapping of disease mutations (DMDM)

More...DMDMi		1703461

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002190911 – 291Potassium-transporting ATPase subunit betaAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi103N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi130N-linked (GlcNAc...) asparagineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi131 ↔ 152By similarity
Glycosylationi146N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi161N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi201 ↔ 263By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation is necessary for assembly and functional expression of the pump at the plasma membrane.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P51164

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P51164

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P51164

PeptideAtlas

More...PeptideAtlasi		P51164

PRoteomics IDEntifications database

More...PRIDEi		P51164

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56294

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P51164, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P51164

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P51164

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186009, Expressed in body of stomach and 90 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P51164, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186009, Tissue enriched (stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The ATPase pump is composed of two subunits: alpha (catalytic) and beta (regulatory).

Interacts with alpha subunit ATP12A; this interaction is required for the formation of a functionally active pump and targeting at the plasma membrane (By similarity).

Interacts (via N-terminus) with alpha subunit ATP4A (via the P-domain) (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106986, 7 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2160, Hydrogen:potassium-exchanging ATPase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P51164

Protein interaction database and analysis system

More...IntActi		P51164, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000334216

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P51164

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P51164, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P51164

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni194 – 291immunoglobulin-likeAdd BLAST98

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the X(+)/potassium ATPases subunit beta family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3927, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234579

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_057702_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P51164

Identification of Orthologs from Complete Genome Data

More...OMAi		CKILADH

Database for complete collections of gene phylogenies

More...PhylomeDBi		P51164

TreeFam database of animal gene trees

More...TreeFami		TF314618

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1660, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000402, Na/K_ATPase_sub_beta
IPR038702, Na/K_ATPase_sub_beta_sf

The PANTHER Classification System

More...PANTHERi		PTHR11523, PTHR11523, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00287, Na_K-ATPase, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01107, Na_K_ATPase_bet, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00390, ATPASE_NA_K_BETA_1, 1 hit
PS00391, ATPASE_NA_K_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P51164-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV 
        60         70         80         90        100
MTGLFALCLY VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV 
       110        120        130        140        150
SDNRTWADLT QTLHAFLAGY SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF 
       160        170        180        190        200
SCKFTADMLQ NCSGLADPNF GFEEGKPCFI IKMNRIVKFL PSNGSAPRVD 
       210        220        230        240        250
CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH YSNPLVAAKL 
       260        270        280        290 
LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K
Length:291
Mass (Da):33,367
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i573F6D729CED1C3D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M75110 mRNA Translation: AAA35987.1
BX537316 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09221.1
BC029059 mRNA Translation: AAH29059.1
AB008783 Genomic DNA Translation: BAA23425.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9539.1

Protein sequence database of the Protein Information Resource

More...PIRi		JH0480

NCBI Reference Sequences

More...RefSeqi		NP_000696.1, NM_000705.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000335288; ENSP00000334216; ENSG00000186009
ENST00000672885; ENSP00000500492; ENSG00000288359

Database of genes from NCBI RefSeq genomes

More...GeneIDi		496

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:496

UCSC genome browser

More...UCSCi		uc001vtz.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75110 mRNA Translation: AAA35987.1
BX537316 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09221.1
BC029059 mRNA Translation: AAH29059.1
AB008783 Genomic DNA Translation: BAA23425.1
CCDSiCCDS9539.1
PIRiJH0480
RefSeqiNP_000696.1, NM_000705.3

3D structure databases

SMRiP51164
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106986, 7 interactors
ComplexPortaliCPX-2160, Hydrogen:potassium-exchanging ATPase complex
CORUMiP51164
IntActiP51164, 6 interactors
STRINGi9606.ENSP00000334216

Chemistry databases

BindingDBiP51164
ChEMBLiCHEMBL2095173
DrugBankiDB05351, Dexlansoprazole
DB13620, Potassium gluconate
DrugCentraliP51164

Protein family/group databases

TCDBi3.A.3.1.2, the p-type atpase (p-atpase) superfamily

PTM databases

GlyGeniP51164, 7 sites
iPTMnetiP51164
PhosphoSitePlusiP51164

Genetic variation databases

BioMutaiATP4B
DMDMi1703461

Proteomic databases

jPOSTiP51164
MassIVEiP51164
PaxDbiP51164
PeptideAtlasiP51164
PRIDEiP51164
ProteomicsDBi56294

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25980, 264 antibodies

The DNASU plasmid repository

More...DNASUi		496

Genome annotation databases

EnsembliENST00000335288; ENSP00000334216; ENSG00000186009
ENST00000672885; ENSP00000500492; ENSG00000288359
GeneIDi496
KEGGihsa:496
UCSCiuc001vtz.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		496
DisGeNETi496

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP4B
HGNCiHGNC:820, ATP4B
HPAiENSG00000186009, Tissue enriched (stomach)
MIMi137217, gene
neXtProtiNX_P51164
OpenTargetsiENSG00000186009
PharmGKBiPA25114
VEuPathDBiHostDB:ENSG00000186009.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3927, Eukaryota
GeneTreeiENSGT01030000234579
HOGENOMiCLU_057702_1_1_1
InParanoidiP51164
OMAiCKILADH
PhylomeDBiP51164
TreeFamiTF314618

Enzyme and pathway databases

BioCyciMetaCyc:G66-33511-MONOMER
PathwayCommonsiP51164
ReactomeiR-HSA-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		496, 3 hits in 978 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		496
PharosiP51164, Tclin

Protein Ontology

More...PROi		PR:P51164
RNActiP51164, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186009, Expressed in body of stomach and 90 other tissues
GenevisibleiP51164, HS

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402, Na/K_ATPase_sub_beta
IPR038702, Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523, PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287, Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107, Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390, ATPASE_NA_K_BETA_1, 1 hit
PS00391, ATPASE_NA_K_BETA_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATP4B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51164
Secondary accession number(s): B1B0N8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 2, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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