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Protein

Gastrotropin

Gene

Fabp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (PubMed:23251388). Stimulates gastric acid and pepsinogen secretion (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • bile acid metabolic process Source: MGI
  • lipid transport Source: UniProtKB-KW

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts
R-MMU-163560 Triglyceride catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrotropin
Short name:
GT
Alternative name(s):
Fatty acid-binding protein 6
Ileal lipid-binding protein
Short name:
ILBP
Gene namesi
Name:Fabp6
Synonyms:Illbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96565 Fabp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673812 – 128GastrotropinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP51162
PaxDbiP51162
PeptideAtlasiP51162
PRIDEiP51162

PTM databases

PhosphoSitePlusiP51162

Expressioni

Tissue specificityi

Expressed in ovary granulosa and luteal cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000020405 Expressed in 86 organ(s), highest expression level in ileum
GenevisibleiP51162 MM

Interactioni

Protein-protein interaction databases

IntActiP51162, 1 interactor
STRINGi10090.ENSMUSP00000020672

Structurei

3D structure databases

ProteinModelPortaliP51162
SMRiP51162
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00390000012034
HOGENOMiHOG000004830
HOVERGENiHBG005633
InParanoidiP51162
KOiK08755
OMAiDGQNFTW
OrthoDBiEOG091G16BV
PhylomeDBiP51162
TreeFamiTF330348

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031257 Gastrotropin
IPR031259 ILBP
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF69 PTHR11955:SF69, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51162-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFSGKYEFE SEKNYDEFMK RLGLPGDVIE RGRNFKIITE VQQDGQDFTW
60 70 80 90 100
SQSYSGGNIM SNKFTIGKEC EMQTMGGKKF KATVKMEGGK VVAEFPNYHQ
110 120
TSEVVGDKLV EISTIGDVTY ERVSKRLA
Length:128
Mass (Da):14,486
Last modified:January 23, 2007 - v2
Checksum:i9FF64BDD0AFA2909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00938 Genomic DNA Translation: AAC27352.1
AL670472 Genomic DNA Translation: CAI24826.1
CH466575 Genomic DNA Translation: EDL33855.1
BC119289 mRNA Translation: AAI19290.1
BC120767 mRNA Translation: AAI20768.1
CCDSiCCDS24560.1
PIRiA54797
RefSeqiNP_032401.1, NM_008375.2
UniGeneiMm.142716

Genome annotation databases

EnsembliENSMUST00000020672; ENSMUSP00000020672; ENSMUSG00000020405
GeneIDi16204
KEGGimmu:16204
UCSCiuc007imt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00938 Genomic DNA Translation: AAC27352.1
AL670472 Genomic DNA Translation: CAI24826.1
CH466575 Genomic DNA Translation: EDL33855.1
BC119289 mRNA Translation: AAI19290.1
BC120767 mRNA Translation: AAI20768.1
CCDSiCCDS24560.1
PIRiA54797
RefSeqiNP_032401.1, NM_008375.2
UniGeneiMm.142716

3D structure databases

ProteinModelPortaliP51162
SMRiP51162
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51162, 1 interactor
STRINGi10090.ENSMUSP00000020672

PTM databases

PhosphoSitePlusiP51162

Proteomic databases

MaxQBiP51162
PaxDbiP51162
PeptideAtlasiP51162
PRIDEiP51162

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020672; ENSMUSP00000020672; ENSMUSG00000020405
GeneIDi16204
KEGGimmu:16204
UCSCiuc007imt.2 mouse

Organism-specific databases

CTDi2172
MGIiMGI:96565 Fabp6

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00390000012034
HOGENOMiHOG000004830
HOVERGENiHBG005633
InParanoidiP51162
KOiK08755
OMAiDGQNFTW
OrthoDBiEOG091G16BV
PhylomeDBiP51162
TreeFamiTF330348

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts
R-MMU-163560 Triglyceride catabolism

Miscellaneous databases

PROiPR:P51162
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020405 Expressed in 86 organ(s), highest expression level in ileum
GenevisibleiP51162 MM

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031257 Gastrotropin
IPR031259 ILBP
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF69 PTHR11955:SF69, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFABP6_MOUSE
AccessioniPrimary (citable) accession number: P51162
Secondary accession number(s): Q5SRT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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