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Protein

Ras-related protein Rab-26

Gene

Rab26

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 79GTPBy similarity9
Nucleotide bindingi120 – 124GTPBy similarity5
Nucleotide bindingi178 – 181GTPBy similarity4
Nucleotide bindingi208 – 210GTPBy similarity3

GO - Molecular functioni

  • GMP binding Source: UniProtKB
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-26
Gene namesi
Name:Rab26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620890 Rab26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212201 – 257Ras-related protein Rab-26Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi254S-geranylgeranyl cysteineBy similarity1
Lipidationi255S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiP51156
PRIDEiP51156

PTM databases

iPTMnetiP51156
PhosphoSitePlusiP51156

Expressioni

Tissue specificityi

Expressed in pancreas, kidney, brain, submandibular gland, and lung.1 Publication

Gene expression databases

BgeeiENSRNOG00000042086 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP51156 RN

Interactioni

Subunit structurei

Interacts with ADRA2B. Interacts with RIMS1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004249

Structurei

3D structure databases

ProteinModelPortaliP51156
SMRiP51156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi94 – 102Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0083 Eukaryota
ENOG410Z9H6 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP51156
KOiK07913
OMAiVRGSGCC
OrthoDBiEOG091G0JXU
PhylomeDBiP51156

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

P51156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRKKTPKSK GGSVPAASTL PAAANGPRLA HPRTARPGPE APPNGPPQSG
60 70 80 90 100
RPSLGGTGDF YDVAFKVMLV GDSGVGKTCL LVRFKDGAFL AGTFISTVGI
110 120 130 140 150
DFRNKVLDVD GMKVKLQIWD TAGQERFRSV THAYYRDAHA LLLLYDITNK
160 170 180 190 200
DSFDNIQAWL TEIQEYAQQD VVLMLLGNKV DSTQERVVKR EDGEKLAKEY
210 220 230 240 250
GLPFMETSAK SGLNVDLAFT AIAKELKQRS TKAPSEPRFR LHDYVKREGR

GVSCCRL
Length:257
Mass (Da):28,203
Last modified:September 27, 2005 - v2
Checksum:i3C4A12A2B8333474
GO

Sequence cautioni

The sequence AAA69955 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061984 mRNA Translation: AAH61984.1
U18771 mRNA Translation: AAA69955.1 Different initiation.
PIRiJC2528
RefSeqiNP_598264.1, NM_133580.1
UniGeneiRn.10975

Genome annotation databases

EnsembliENSRNOT00000004249; ENSRNOP00000004249; ENSRNOG00000042086
GeneIDi171111
KEGGirno:171111
UCSCiRGD:620890 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061984 mRNA Translation: AAH61984.1
U18771 mRNA Translation: AAA69955.1 Different initiation.
PIRiJC2528
RefSeqiNP_598264.1, NM_133580.1
UniGeneiRn.10975

3D structure databases

ProteinModelPortaliP51156
SMRiP51156
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004249

PTM databases

iPTMnetiP51156
PhosphoSitePlusiP51156

Proteomic databases

PaxDbiP51156
PRIDEiP51156

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004249; ENSRNOP00000004249; ENSRNOG00000042086
GeneIDi171111
KEGGirno:171111
UCSCiRGD:620890 rat

Organism-specific databases

CTDi25837
RGDi620890 Rab26

Phylogenomic databases

eggNOGiKOG0083 Eukaryota
ENOG410Z9H6 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP51156
KOiK07913
OMAiVRGSGCC
OrthoDBiEOG091G0JXU
PhylomeDBiP51156

Enzyme and pathway databases

ReactomeiR-RNO-8873719 RAB geranylgeranylation

Miscellaneous databases

PROiPR:P51156

Gene expression databases

BgeeiENSRNOG00000042086 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP51156 RN

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB26_RAT
AccessioniPrimary (citable) accession number: P51156
Secondary accession number(s): Q6P6W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 27, 2005
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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