RAB9A

Functionⁱ

Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	155	GTP; via amide nitrogenCombined sources1 Publication		1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	14 – 22	GTPCombined sources1 Publication	9
Nucleotide bindingⁱ	62 – 66	GTPBy similarity	5
Nucleotide bindingⁱ	124 – 127	GTPCombined sources1 Publication	4

GO - Molecular functionⁱ

GDP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15263003
- 20937701
GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15263003
GTP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15263003
- 21808068
identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation by host of symbiont molecular function
Source: AgBase
Inferred from mutant phenotypeⁱ
- 18787122
positive regulation of exocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19966785
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of protein localization
Source: AgBase
Inferred from mutant phenotypeⁱ
- 18787122
retrograde transport, endosome to Golgi
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SIGNORⁱ	P51151

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-9A
Gene namesⁱ	Name:RAB9A Synonyms:RAB9
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123595.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9792 RAB9A
MIMⁱ	300284 gene
neXtProtⁱ	NX_P51151

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	40	I → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication	1
Mutagenesisⁱ	44	F → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication	1
Mutagenesisⁱ	61	W → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication	1
Mutagenesisⁱ	66	Q → L: Loss of interaction with HPS4; when associated with L-40 or L-44 or L-61. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9367
Open Targets More...OpenTargetsⁱ	ENSG00000123595
PharmGKBⁱ	PA34152

Chemistry databases

ChEMBLⁱ	CHEMBL1293294
Drug and drug target database More...DrugBankⁱ	DB03793 Benzoic Acid DB04315 Guanosine-5'-Diphosphate

Polymorphism and mutation databases

BioMutaⁱ	RAB9A
DMDMⁱ	1710003

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000121139	2 – 201	Ras-related protein Rab-9AAdd BLAST		200

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	179	PhosphoserineCombined sources	1
Modified residueⁱ	187	PhosphothreonineCombined sources	1
Lipidationⁱ	200	S-geranylgeranyl cysteineBy similarity	1
Lipidationⁱ	201	S-geranylgeranyl cysteineBy similarity	1

Keywords - PTMⁱ

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	P51151
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51151
PaxDbⁱ	P51151
PeptideAtlas More...PeptideAtlasⁱ	P51151
PRIDEⁱ	P51151
ProteomicsDBⁱ	56285

PTM databases

iPTMnetⁱ	P51151
PhosphoSitePlusⁱ	P51151

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000123595 Expressed in 231 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_RAB9A
ExpressionAtlasⁱ	P51151 baseline and differential
Genevisibleⁱ	P51151 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016411 HPA003094

HPAⁱ

CAB016411
HPA003094

Interactionⁱ

Subunit structureⁱ

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (PubMed:18243103, PubMed:16885419). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). Interacts with SGSM2 (PubMed:21808068). The GTP-bound form but not the GDP-bound form interacts with HPS4 and BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NISCH	Q9Y2I1	8	EBI-4401353,EBI-2688731
PLEKHM2	Q8IWE5	4	EBI-4401353,EBI-726484

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114768, 34 interactors
CORUMⁱ	P51151
Database of interacting proteins More...DIPⁱ	DIP-46409N
IntActⁱ	P51151, 149 interactors
Molecular INTeraction database More...MINTⁱ	P51151
STRINGⁱ	9606.ENSP00000420127

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 13	Combined sources	9
Helixⁱ	20 – 29	Combined sources	10
Beta strandⁱ	41 – 51	Combined sources	11
Beta strandⁱ	54 – 62	Combined sources	9
Helixⁱ	67 – 69	Combined sources	3
Helixⁱ	70 – 73	Combined sources	4
Helixⁱ	74 – 77	Combined sources	4
Beta strandⁱ	81 – 88	Combined sources	8
Helixⁱ	92 – 96	Combined sources	5
Helixⁱ	98 – 109	Combined sources	12
Turnⁱ	114 – 116	Combined sources	3
Beta strandⁱ	119 – 124	Combined sources	6
Helixⁱ	135 – 144	Combined sources	10
Beta strandⁱ	150 – 152	Combined sources	3
Turnⁱ	155 – 157	Combined sources	3
Helixⁱ	161 – 173	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	P51151
SMRⁱ	P51151
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P51151

EvolutionaryTraceⁱ

P51151

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	36 – 44	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0394 Eukaryota ENOG410XNZV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119125
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P51151
KEGG Orthology (KO) More...KOⁱ	K07899
OMAⁱ	RSSCCMP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JIV
PhylomeDBⁱ	P51151
TreeFamⁱ	TF326442

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P51151-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE 
        60         70         80         90        100
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN 
       110        120        130        140        150
WKKEFIYYAD VKEPESFPFV ILGNKIDISE RQVSTEEAQA WCRDNGDYPY 
       160        170        180        190        200
FETSAKDATN VAAAFEEAVR RVLATEDRSD HLIQTDTVNL HRKPKPSSSC 

C

Length:201

Mass (Da):22,838

Last modified:October 1, 1996 - v1

Checksum:ⁱ65B502C21E97DB72

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1B0GUI0	A0A1B0GUI0_HUMAN		Ras-related protein Rab-9A Ras-related protein Rab-9A	RAB9A	23	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44103 mRNA Translation: AAC51200.1 AF498944 mRNA Translation: AAM21092.1 CR450362 mRNA Translation: CAG29358.1 AK290505 mRNA Translation: BAF83194.1 CH471074 Genomic DNA Translation: EAW98826.1 BC017265 mRNA Translation: AAH17265.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14156.1
PIRⁱ	G02361
NCBI Reference Sequences More...RefSeqⁱ	NP_001182257.1, NM_001195328.1 NP_004242.1, NM_004251.4 XP_016885453.1, XM_017029964.1
UniGeneⁱ	Hs.495704

Genome annotation databases

Ensemblⁱ	ENST00000464506; ENSP00000420127; ENSG00000123595 ENST00000618931; ENSP00000480777; ENSG00000123595
GeneIDⁱ	9367
KEGGⁱ	hsa:9367
UCSC genome browser More...UCSCⁱ	uc004cvm.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51151	RAB9A, member RAS oncogene family, isoform CRA_a		HUMAN		201	UniRef100_P51151
RAB9A, member RAS oncogene family		PANTR		201
RAB9A, member RAS oncogene family		CALJA		201
ras-related protein Rab-9A		TARSY		201
RAB9A isoform 1		PONAB		201
+8

Protein	Similar proteins		Species	Score	Length	Source
P51151	RAB9A, member RAS oncogene family, isoform CRA_a		HUMAN		201	UniRef90_P51151
RAB9A, member RAS oncogene family		PANTR		201
RAB9A, member RAS oncogene family		CALJA		201
ras-related protein Rab-9A		TARSY		201
RAB9A isoform 1		PONAB		201
+10

Protein	Similar proteins		Species	Score	Length	Source
P51151	Ras-related protein Rab-9A	)	CANLF		201	UniRef50_P51151
RAB9A, member RAS oncogene family, isoform CRA_a		HUMAN		201
RAB9A, member RAS oncogene family		PANTR		201
RAB9A, member RAS oncogene family		CALJA		201
ras-related protein Rab-9A		TARSY		201
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44103 mRNA Translation: AAC51200.1 AF498944 mRNA Translation: AAM21092.1 CR450362 mRNA Translation: CAG29358.1 AK290505 mRNA Translation: BAF83194.1 CH471074 Genomic DNA Translation: EAW98826.1 BC017265 mRNA Translation: AAH17265.1
CCDSⁱ	CCDS14156.1
PIRⁱ	G02361
RefSeqⁱ	NP_001182257.1, NM_001195328.1 NP_004242.1, NM_004251.4 XP_016885453.1, XM_017029964.1
UniGeneⁱ	Hs.495704

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WMS	X-ray	1.25	A/B	1-177	[»]
ProteinModelPortalⁱ	P51151
SMRⁱ	P51151
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114768, 34 interactors
CORUMⁱ	P51151
DIPⁱ	DIP-46409N
IntActⁱ	P51151, 149 interactors
MINTⁱ	P51151
STRINGⁱ	9606.ENSP00000420127

Chemistry databases

ChEMBLⁱ	CHEMBL1293294
DrugBankⁱ	DB03793 Benzoic Acid DB04315 Guanosine-5'-Diphosphate

PTM databases

iPTMnetⁱ	P51151
PhosphoSitePlusⁱ	P51151

Polymorphism and mutation databases

BioMutaⁱ	RAB9A
DMDMⁱ	1710003

Proteomic databases

EPDⁱ	P51151
MaxQBⁱ	P51151
PaxDbⁱ	P51151
PeptideAtlasⁱ	P51151
PRIDEⁱ	P51151
ProteomicsDBⁱ	56285

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9367
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000464506; ENSP00000420127; ENSG00000123595 ENST00000618931; ENSP00000480777; ENSG00000123595
GeneIDⁱ	9367
KEGGⁱ	hsa:9367
UCSCⁱ	uc004cvm.5 human

Organism-specific databases

CTDⁱ	9367
DisGeNETⁱ	9367
EuPathDBⁱ	HostDB:ENSG00000123595.6
GeneCardsⁱ	RAB9A
HGNCⁱ	HGNC:9792 RAB9A
HPAⁱ	CAB016411 HPA003094
MIMⁱ	300284 gene
neXtProtⁱ	NX_P51151
OpenTargetsⁱ	ENSG00000123595
PharmGKBⁱ	PA34152
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0394 Eukaryota ENOG410XNZV LUCA
GeneTreeⁱ	ENSGT00760000119125
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P51151
KOⁱ	K07899
OMAⁱ	RSSCCMP
OrthoDBⁱ	EOG091G0JIV
PhylomeDBⁱ	P51151
TreeFamⁱ	TF326442

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SIGNORⁱ	P51151

Miscellaneous databases

ChiTaRSⁱ	RAB9A human
EvolutionaryTraceⁱ	P51151
GeneWikiⁱ	RAB9A
GenomeRNAiⁱ	9367
Protein Ontology More...PROⁱ	PR:P51151
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123595 Expressed in 231 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_RAB9A
ExpressionAtlasⁱ	P51151 baseline and differential
Genevisibleⁱ	P51151 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB9A_HUMAN
Accessionⁱ	P51151Primary (citable) accession number: P51151 Secondary accession number(s): A8K390, Q6ICN1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51151 (RAB9A_HUMAN)

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Ras-related protein Rab-9A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Endoplasmic reticulum

Endosome

Other locations

Cytosol

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ