UniProtKB - P51151 (RAB9A_HUMAN)
Ras-related protein Rab-9A
RAB9A
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 155 | GTP; via amide nitrogenCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 14 – 22 | GTPCombined sources1 Publication | 9 | |
Nucleotide bindingi | 62 – 66 | GTPBy similarity | 5 | |
Nucleotide bindingi | 124 – 127 | GTPCombined sources1 Publication | 4 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
- identical protein binding Source: Ensembl
GO - Biological processi
- negative regulation by host of symbiont molecular function Source: AgBase
- positive regulation of exocytosis Source: UniProtKB
- protein transport Source: UniProtKB-KW
- Rab protein signal transduction Source: InterPro
- regulation of protein localization Source: AgBase
- retrograde transport, endosome to Golgi Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P51151 |
Reactomei | R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network R-HSA-8873719, RAB geranylgeranylation R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SIGNORi | P51151 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-9A |
Gene namesi | Name:RAB9A Synonyms:RAB9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9792, RAB9A |
MIMi | 300284, gene |
neXtProti | NX_P51151 |
VEuPathDBi | HostDB:ENSG00000123595.6 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Endosome
- Late endosome 1 Publication
Golgi apparatus
- Golgi apparatus membrane Curated
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated
Other locations
- phagosome membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
- phagosome 1 Publication
- Cytoplasmic vesicle membrane By similarity
- Melanosome By similarity
Note: Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).2 Publications
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Endosome
- late endosome Source: MGI
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- trans-Golgi network membrane Source: Reactome
Lysosome
- lysosome Source: MGI
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- melanosome Source: UniProtKB
- phagocytic vesicle Source: UniProtKB
- phagocytic vesicle membrane Source: UniProtKB-SubCell
- transport vesicle Source: Reactome
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 40 | I → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication | 1 | |
Mutagenesisi | 44 | F → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication | 1 | |
Mutagenesisi | 61 | W → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication | 1 | |
Mutagenesisi | 66 | Q → L: Loss of interaction with HPS4; when associated with L-40 or L-44 or L-61. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9367 |
OpenTargetsi | ENSG00000123595 |
PharmGKBi | PA34152 |
Miscellaneous databases
Pharosi | P51151, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1293294 |
DrugBanki | DB04315, Guanosine-5'-Diphosphate |
Genetic variation databases
BioMutai | RAB9A |
DMDMi | 1710003 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000121139 | 2 – 201 | Ras-related protein Rab-9AAdd BLAST | 200 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 179 | PhosphoserineCombined sources | 1 | |
Modified residuei | 187 | PhosphothreonineCombined sources | 1 | |
Lipidationi | 200 | S-geranylgeranyl cysteineBy similarity | 1 | |
Lipidationi | 201 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, Phosphoprotein, PrenylationProteomic databases
EPDi | P51151 |
jPOSTi | P51151 |
MassIVEi | P51151 |
MaxQBi | P51151 |
PaxDbi | P51151 |
PeptideAtlasi | P51151 |
PRIDEi | P51151 |
ProteomicsDBi | 56285 |
PTM databases
iPTMneti | P51151 |
PhosphoSitePlusi | P51151 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123595, Expressed in amniotic fluid and 242 other tissues |
ExpressionAtlasi | P51151, baseline and differential |
Genevisiblei | P51151, HS |
Organism-specific databases
HPAi | ENSG00000123595, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (PubMed:18243103, PubMed:16885419).
Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480).
Interacts with SGSM2 (PubMed:21808068). The GTP-bound form but not the GDP-bound form interacts with HPS4 and BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159).
5 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114768, 187 interactors |
CORUMi | P51151 |
DIPi | DIP-46409N |
IntActi | P51151, 167 interactors |
MINTi | P51151 |
STRINGi | 9606.ENSP00000420127 |
Miscellaneous databases
RNActi | P51151, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P51151 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P51151 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 36 – 44 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0394, Eukaryota |
GeneTreei | ENSGT00940000158619 |
HOGENOMi | CLU_041217_10_6_1 |
InParanoidi | P51151 |
OMAi | DYPYYET |
OrthoDBi | 1172019at2759 |
PhylomeDBi | P51151 |
TreeFami | TF326442 |
Family and domain databases
CDDi | cd04116, Rab9, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041824, Rab9 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE
60 70 80 90 100
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN
110 120 130 140 150
WKKEFIYYAD VKEPESFPFV ILGNKIDISE RQVSTEEAQA WCRDNGDYPY
160 170 180 190 200
FETSAKDATN VAAAFEEAVR RVLATEDRSD HLIQTDTVNL HRKPKPSSSC
C
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GUI0 | A0A1B0GUI0_HUMAN | Ras-related protein Rab-9A | RAB9A | 23 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U44103 mRNA Translation: AAC51200.1 AF498944 mRNA Translation: AAM21092.1 CR450362 mRNA Translation: CAG29358.1 AK290505 mRNA Translation: BAF83194.1 CH471074 Genomic DNA Translation: EAW98826.1 BC017265 mRNA Translation: AAH17265.1 |
CCDSi | CCDS14156.1 |
PIRi | G02361 |
RefSeqi | NP_001182257.1, NM_001195328.1 NP_004242.1, NM_004251.4 XP_016885453.1, XM_017029964.1 |
Genome annotation databases
Ensembli | ENST00000464506; ENSP00000420127; ENSG00000123595 ENST00000618931; ENSP00000480777; ENSG00000123595 |
GeneIDi | 9367 |
KEGGi | hsa:9367 |
UCSCi | uc004cvm.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U44103 mRNA Translation: AAC51200.1 AF498944 mRNA Translation: AAM21092.1 CR450362 mRNA Translation: CAG29358.1 AK290505 mRNA Translation: BAF83194.1 CH471074 Genomic DNA Translation: EAW98826.1 BC017265 mRNA Translation: AAH17265.1 |
CCDSi | CCDS14156.1 |
PIRi | G02361 |
RefSeqi | NP_001182257.1, NM_001195328.1 NP_004242.1, NM_004251.4 XP_016885453.1, XM_017029964.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WMS | X-ray | 1.25 | A/B | 1-177 | [»] | |
SMRi | P51151 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114768, 187 interactors |
CORUMi | P51151 |
DIPi | DIP-46409N |
IntActi | P51151, 167 interactors |
MINTi | P51151 |
STRINGi | 9606.ENSP00000420127 |
Chemistry databases
ChEMBLi | CHEMBL1293294 |
DrugBanki | DB04315, Guanosine-5'-Diphosphate |
PTM databases
iPTMneti | P51151 |
PhosphoSitePlusi | P51151 |
Genetic variation databases
BioMutai | RAB9A |
DMDMi | 1710003 |
Proteomic databases
EPDi | P51151 |
jPOSTi | P51151 |
MassIVEi | P51151 |
MaxQBi | P51151 |
PaxDbi | P51151 |
PeptideAtlasi | P51151 |
PRIDEi | P51151 |
ProteomicsDBi | 56285 |
Protocols and materials databases
Antibodypediai | 513, 268 antibodies |
DNASUi | 9367 |
Genome annotation databases
Ensembli | ENST00000464506; ENSP00000420127; ENSG00000123595 ENST00000618931; ENSP00000480777; ENSG00000123595 |
GeneIDi | 9367 |
KEGGi | hsa:9367 |
UCSCi | uc004cvm.5, human |
Organism-specific databases
CTDi | 9367 |
DisGeNETi | 9367 |
GeneCardsi | RAB9A |
HGNCi | HGNC:9792, RAB9A |
HPAi | ENSG00000123595, Low tissue specificity |
MIMi | 300284, gene |
neXtProti | NX_P51151 |
OpenTargetsi | ENSG00000123595 |
PharmGKBi | PA34152 |
VEuPathDBi | HostDB:ENSG00000123595.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0394, Eukaryota |
GeneTreei | ENSGT00940000158619 |
HOGENOMi | CLU_041217_10_6_1 |
InParanoidi | P51151 |
OMAi | DYPYYET |
OrthoDBi | 1172019at2759 |
PhylomeDBi | P51151 |
TreeFami | TF326442 |
Enzyme and pathway databases
PathwayCommonsi | P51151 |
Reactomei | R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network R-HSA-8873719, RAB geranylgeranylation R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SIGNORi | P51151 |
Miscellaneous databases
BioGRID-ORCSi | 9367, 9 hits in 502 CRISPR screens |
ChiTaRSi | RAB9A, human |
EvolutionaryTracei | P51151 |
GeneWikii | RAB9A |
GenomeRNAii | 9367 |
Pharosi | P51151, Tbio |
PROi | PR:P51151 |
RNActi | P51151, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123595, Expressed in amniotic fluid and 242 other tissues |
ExpressionAtlasi | P51151, baseline and differential |
Genevisiblei | P51151, HS |
Family and domain databases
CDDi | cd04116, Rab9, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041824, Rab9 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB9A_HUMAN | |
Accessioni | P51151Primary (citable) accession number: P51151 Secondary accession number(s): A8K390, Q6ICN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 203 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families