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Protein

Ras-related protein Rab-9A

Gene

RAB9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei155GTP; via amide nitrogenCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPCombined sources1 Publication9
Nucleotide bindingi62 – 66GTPBy similarity5
Nucleotide bindingi124 – 127GTPCombined sources1 Publication4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • identical protein binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SIGNORiP51151

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-9A
Gene namesi
Name:RAB9A
Synonyms:RAB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000123595.6
HGNCiHGNC:9792 RAB9A
MIMi300284 gene
neXtProtiNX_P51151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40I → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication1
Mutagenesisi44F → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication1
Mutagenesisi61W → L: Loss of interaction with HPS4; when associated with L-66. 1 Publication1
Mutagenesisi66Q → L: Loss of interaction with HPS4; when associated with L-40 or L-44 or L-61. 1 Publication1

Organism-specific databases

DisGeNETi9367
OpenTargetsiENSG00000123595
PharmGKBiPA34152

Chemistry databases

ChEMBLiCHEMBL1293294
DrugBankiDB03793 Benzoic Acid
DB04315 Guanosine-5'-Diphosphate

Polymorphism and mutation databases

BioMutaiRAB9A
DMDMi1710003

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001211392 – 201Ras-related protein Rab-9AAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei187PhosphothreonineCombined sources1
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiP51151
MaxQBiP51151
PaxDbiP51151
PeptideAtlasiP51151
PRIDEiP51151
ProteomicsDBi56285

PTM databases

iPTMnetiP51151
PhosphoSitePlusiP51151

Expressioni

Gene expression databases

BgeeiENSG00000123595 Expressed in 231 organ(s), highest expression level in amniotic fluid
CleanExiHS_RAB9A
ExpressionAtlasiP51151 baseline and differential
GenevisibleiP51151 HS

Organism-specific databases

HPAiCAB016411
HPA003094

Interactioni

Subunit structurei

Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (PubMed:18243103, PubMed:16885419). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). Interacts with SGSM2 (PubMed:21808068). The GTP-bound form but not the GDP-bound form interacts with HPS4 and BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159).5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114768, 34 interactors
CORUMiP51151
DIPiDIP-46409N
IntActiP51151, 149 interactors
MINTiP51151
STRINGi9606.ENSP00000420127

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP51151
SMRiP51151
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51151

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP51151
KOiK07899
OMAiRSSCCMP
OrthoDBiEOG091G0JIV
PhylomeDBiP51151
TreeFamiTF326442

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P51151-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE
60 70 80 90 100
VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN
110 120 130 140 150
WKKEFIYYAD VKEPESFPFV ILGNKIDISE RQVSTEEAQA WCRDNGDYPY
160 170 180 190 200
FETSAKDATN VAAAFEEAVR RVLATEDRSD HLIQTDTVNL HRKPKPSSSC

C
Length:201
Mass (Da):22,838
Last modified:October 1, 1996 - v1
Checksum:i65B502C21E97DB72
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUI0A0A1B0GUI0_HUMAN
Ras-related protein Rab-9A
RAB9A
23Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44103 mRNA Translation: AAC51200.1
AF498944 mRNA Translation: AAM21092.1
CR450362 mRNA Translation: CAG29358.1
AK290505 mRNA Translation: BAF83194.1
CH471074 Genomic DNA Translation: EAW98826.1
BC017265 mRNA Translation: AAH17265.1
CCDSiCCDS14156.1
PIRiG02361
RefSeqiNP_001182257.1, NM_001195328.1
NP_004242.1, NM_004251.4
XP_016885453.1, XM_017029964.1
UniGeneiHs.495704

Genome annotation databases

EnsembliENST00000464506; ENSP00000420127; ENSG00000123595
ENST00000618931; ENSP00000480777; ENSG00000123595
GeneIDi9367
KEGGihsa:9367
UCSCiuc004cvm.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44103 mRNA Translation: AAC51200.1
AF498944 mRNA Translation: AAM21092.1
CR450362 mRNA Translation: CAG29358.1
AK290505 mRNA Translation: BAF83194.1
CH471074 Genomic DNA Translation: EAW98826.1
BC017265 mRNA Translation: AAH17265.1
CCDSiCCDS14156.1
PIRiG02361
RefSeqiNP_001182257.1, NM_001195328.1
NP_004242.1, NM_004251.4
XP_016885453.1, XM_017029964.1
UniGeneiHs.495704

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMSX-ray1.25A/B1-177[»]
ProteinModelPortaliP51151
SMRiP51151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114768, 34 interactors
CORUMiP51151
DIPiDIP-46409N
IntActiP51151, 149 interactors
MINTiP51151
STRINGi9606.ENSP00000420127

Chemistry databases

ChEMBLiCHEMBL1293294
DrugBankiDB03793 Benzoic Acid
DB04315 Guanosine-5'-Diphosphate

PTM databases

iPTMnetiP51151
PhosphoSitePlusiP51151

Polymorphism and mutation databases

BioMutaiRAB9A
DMDMi1710003

Proteomic databases

EPDiP51151
MaxQBiP51151
PaxDbiP51151
PeptideAtlasiP51151
PRIDEiP51151
ProteomicsDBi56285

Protocols and materials databases

DNASUi9367
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000464506; ENSP00000420127; ENSG00000123595
ENST00000618931; ENSP00000480777; ENSG00000123595
GeneIDi9367
KEGGihsa:9367
UCSCiuc004cvm.5 human

Organism-specific databases

CTDi9367
DisGeNETi9367
EuPathDBiHostDB:ENSG00000123595.6
GeneCardsiRAB9A
HGNCiHGNC:9792 RAB9A
HPAiCAB016411
HPA003094
MIMi300284 gene
neXtProtiNX_P51151
OpenTargetsiENSG00000123595
PharmGKBiPA34152
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0394 Eukaryota
ENOG410XNZV LUCA
GeneTreeiENSGT00760000119125
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP51151
KOiK07899
OMAiRSSCCMP
OrthoDBiEOG091G0JIV
PhylomeDBiP51151
TreeFamiTF326442

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SIGNORiP51151

Miscellaneous databases

ChiTaRSiRAB9A human
EvolutionaryTraceiP51151
GeneWikiiRAB9A
GenomeRNAii9367
PROiPR:P51151
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123595 Expressed in 231 organ(s), highest expression level in amniotic fluid
CleanExiHS_RAB9A
ExpressionAtlasiP51151 baseline and differential
GenevisibleiP51151 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB9A_HUMAN
AccessioniPrimary (citable) accession number: P51151
Secondary accession number(s): A8K390, Q6ICN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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