Rab7a

Functionⁱ

Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (PubMed:23708524). Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	15 – 22	GTPBy similarity	8
Nucleotide bindingⁱ	34 – 40	GTPBy similarity	7
Nucleotide bindingⁱ	63 – 67	GTPBy similarity	5
Nucleotide bindingⁱ	125 – 128	GTPBy similarity	4
Nucleotide bindingⁱ	156 – 157	GTPBy similarity	2

GO - Molecular functionⁱ

GDP binding Source: MGI
GTPase activity Source: MGI
GTP binding Source: MGI
Rac GTPase binding Source: MGI
retromer complex binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagosome assembly Source: MGI
bone resorption Source: MGI
early endosome to late endosome transport Source: UniProtKB
endosome to lysosome transport Source: MGI
epidermal growth factor catabolic process Source: MGI
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lipid catabolic process Source: UniProtKB-KW
lipophagy
Source: GO_Central
Inferred from mutant phenotypeⁱ
- 23708524
negative regulation of exosomal secretion Source: MGI
phagosome acidification Source: UniProtKB
phagosome-lysosome fusion Source: UniProtKB
positive regulation of exosomal secretion Source: MGI
positive regulation of protein catabolic process Source: MGI
positive regulation of viral process Source: MGI
protein targeting to lysosome Source: MGI
protein to membrane docking Source: MGI
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retrograde transport, endosome to Golgi Source: MGI
viral release from host cell Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy, Lipid degradation, Lipid metabolism, Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2132295 MHC class II antigen presentation R-MMU-6798695 Neutrophil degranulation R-MMU-8854214 TBC/RABGAPs R-MMU-8873719 RAB geranylgeranylation R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-MMU-2132295 MHC class II antigen presentation
R-MMU-6798695 Neutrophil degranulation
R-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-7a
Gene namesⁱ	Name:Rab7a Synonyms:Rab7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:105068 Rab7

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Endosome, Lipid droplet, Lysosome, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Reduces both the basal and, to a greater degree, agonist-stimulated glycerol releases. the ADRB2-stimulated liposlysis.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000121122	2 – 207	Ras-related protein Rab-7aAdd BLAST		206

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonineBy similarity	1
Modified residueⁱ	72	PhosphoserineCombined sources	1
Lipidationⁱ	205	S-geranylgeranyl cysteineBy similarity	1
Modified residueⁱ	207	Cysteine methyl esterBy similarity	1
Lipidationⁱ	207	S-geranylgeranyl cysteineBy similarity	1

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	P51150
PaxDbⁱ	P51150
PeptideAtlas More...PeptideAtlasⁱ	P51150
PRIDEⁱ	P51150

PTM databases

iPTMnetⁱ	P51150
PhosphoSitePlusⁱ	P51150
SwissPalmⁱ	P51150

Expressionⁱ

Tissue specificityⁱ

Widely expressed. High expression in liver, heart and kidney. Found in sensory and motor neurons.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000079477 Expressed in 300 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_RAB7
ExpressionAtlasⁱ	P51150 baseline and differential
Genevisibleⁱ	P51150 MM

Interactionⁱ

Subunit structureⁱ

Interacts with NTRK1/TRKA (By similarity), RILP (By similarity), PSMA7 (By similarity), RNF115 (PubMed:12972561) and FYCO1 (By similarity). Interacts with the PIK3C3/VPS34-PIK3R4 complex (By similarity). The GTP-bound form interacts with OSBPL1A and RAC1 (By similarity). Interacts with CLN3 (By similarity). Interacts with CHM, the substrate-binding subunit of the Rab geranylgeranyltransferase complex (By similarity). Interacts with C9orf72 (PubMed:24549040). Does not interact with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) (PubMed:20048159). Interacts with CLN5 (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (PubMed:27777970). Interacts with RUFY4 (By similarity).By similarity4 Publications

GO - Molecular functionⁱ

Rac GTPase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202553, 13 interactors
Database of interacting proteins More...DIPⁱ	DIP-60513N
IntActⁱ	P51150, 15 interactors
Molecular INTeraction database More...MINTⁱ	P51150
STRINGⁱ	10090.ENSMUSP00000092658

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	7 – 15	Combined sources	9
Helixⁱ	21 – 30	Combined sources	10
Beta strandⁱ	44 – 52	Combined sources	9
Beta strandⁱ	55 – 63	Combined sources	9
Turnⁱ	68 – 70	Combined sources	3
Helixⁱ	71 – 74	Combined sources	4
Helixⁱ	75 – 77	Combined sources	3
Beta strandⁱ	82 – 89	Combined sources	8
Helixⁱ	93 – 97	Combined sources	5
Helixⁱ	99 – 110	Combined sources	12
Helixⁱ	115 – 117	Combined sources	3
Beta strandⁱ	120 – 125	Combined sources	6
Beta strandⁱ	129 – 131	Combined sources	3
Helixⁱ	136 – 145	Combined sources	10
Beta strandⁱ	151 – 153	Combined sources	3
Turnⁱ	156 – 159	Combined sources	4
Helixⁱ	162 – 174	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	P51150
SMRⁱ	P51150
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	37 – 45	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0394 Eukaryota ENOG410XNZV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119125
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P51150
KEGG Orthology (KO) More...KOⁱ	K07897
OMAⁱ	DVTMPNT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JIV
PhylomeDBⁱ	P51150
TreeFamⁱ	TF105605

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P51150-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV 
        60         70         80         90        100
MVDDRLVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD 
       110        120        130        140        150
SWRDEFLIQA SPRDPENFPF VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP 
       160        170        180        190        200
YFETSAKEAI NVEQAFQTIA RNALKQETEV ELYNEFPEPI KLDKNDRAKA 

SAESCSC

Length:207

Mass (Da):23,490

Last modified:April 13, 2004 - v2

Checksum:ⁱA2AF33B16A672971

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0N4SVG9	A0A0N4SVG9_MOUSE	RAB7, member RAS oncogene family RAB7, member RAS oncogene family	Rab7	98	Annotation score:
A0A0N4SVR6	A0A0N4SVR6_MOUSE	RAB7, member RAS oncogene family RAB7, member RAS oncogene family	Rab7	88	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	145	S → R in CAA61797 (PubMed:8547311).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X89650 mRNA Translation: CAA61797.1 AK005004 mRNA Translation: BAB23738.1 BC004597 mRNA Translation: AAH04597.1 BC086793 mRNA Translation: AAH86793.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39552.1
PIRⁱ	S62733
NCBI Reference Sequences More...RefSeqⁱ	NP_001280581.1, NM_001293652.1 NP_001280582.1, NM_001293653.1 NP_001280583.1, NM_001293654.1 NP_001280584.1, NM_001293655.1 NP_033031.2, NM_009005.3
UniGeneⁱ	Mm.333233 Mm.471618 Mm.486309

Genome annotation databases

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51150	Ras-related protein Rab-7a	)	HUMAN		207	UniRef100_P51149
RAB7A, member RAS oncogene family		MACMU		207
Ras-related protein Rab-7a		CALJA		207
RAB7A isoform 1		PANTR		207
ras-related protein Rab-7a		TARSY		207
+41

Protein	Similar proteins		Species	Score	Length	Source
P51150	Ras-related protein Rab-7a	)	HUMAN		207	UniRef90_P51149
Ras-related protein Rab-7a	)	RAT		207
Ras-related protein Rab-7a		RABIT		207
Ras-related protein Rab-7a		BOVIN		207
Ras-related protein Rab-7a		PONAB		207
+221

Protein	Similar proteins		Species	Score	Length	Source
P51150	Ras-related protein Rab-7a	)	HUMAN		207	UniRef50_P51149
Ras-related protein Rab-7a		RABIT		207
Ras-related protein Rab-7a		PONAB		207
Ras-related protein Rab-7a		BOVIN		207
Ras-related protein Rab-7a		CANLF		207
+250

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X89650 mRNA Translation: CAA61797.1 AK005004 mRNA Translation: BAB23738.1 BC004597 mRNA Translation: AAH04597.1 BC086793 mRNA Translation: AAH86793.1
CCDSⁱ	CCDS39552.1
PIRⁱ	S62733
RefSeqⁱ	NP_001280581.1, NM_001293652.1 NP_001280582.1, NM_001293653.1 NP_001280583.1, NM_001293654.1 NP_001280584.1, NM_001293655.1 NP_033031.2, NM_009005.3
UniGeneⁱ	Mm.333233 Mm.471618 Mm.486309

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5Z2M	X-ray	2.14	A/C	1-176	[»]
ProteinModelPortalⁱ	P51150
SMRⁱ	P51150
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202553, 13 interactors
DIPⁱ	DIP-60513N
IntActⁱ	P51150, 15 interactors
MINTⁱ	P51150
STRINGⁱ	10090.ENSMUSP00000092658

PTM databases

iPTMnetⁱ	P51150
PhosphoSitePlusⁱ	P51150
SwissPalmⁱ	P51150

Proteomic databases

EPDⁱ	P51150
PaxDbⁱ	P51150
PeptideAtlasⁱ	P51150
PRIDEⁱ	P51150

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000095048; ENSMUSP00000092658; ENSMUSG00000079477 ENSMUST00000113596; ENSMUSP00000109226; ENSMUSG00000079477 ENSMUST00000113597; ENSMUSP00000109227; ENSMUSG00000079477 ENSMUST00000113598; ENSMUSP00000109228; ENSMUSG00000079477 ENSMUST00000113600; ENSMUSP00000109230; ENSMUSG00000079477
GeneIDⁱ	19349
KEGGⁱ	mmu:19349
UCSCⁱ	uc009cuv.2 mouse

Organism-specific databases

CTDⁱ	19349
MGIⁱ	MGI:105068 Rab7

Phylogenomic databases

eggNOGⁱ	KOG0394 Eukaryota ENOG410XNZV LUCA
GeneTreeⁱ	ENSGT00760000119125
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P51150
KOⁱ	K07897
OMAⁱ	DVTMPNT
OrthoDBⁱ	EOG091G0JIV
PhylomeDBⁱ	P51150
TreeFamⁱ	TF105605

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2132295 MHC class II antigen presentation R-MMU-6798695 Neutrophil degranulation R-MMU-8854214 TBC/RABGAPs R-MMU-8873719 RAB geranylgeranylation R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-MMU-2132295 MHC class II antigen presentation
R-MMU-6798695 Neutrophil degranulation
R-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	Rab7 mouse
Protein Ontology More...PROⁱ	PR:P51150
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000079477 Expressed in 300 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_RAB7
ExpressionAtlasⁱ	P51150 baseline and differential
Genevisibleⁱ	P51150 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB7A_MOUSE
Accessionⁱ	P51150Primary (citable) accession number: P51150
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	April 13, 2004
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P51150 (RAB7A_MOUSE)

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Ras-related protein Rab-7a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Lysosome

Other locations

Cytosol

Endosome

Golgi apparatus

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ