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Protein

Ras-related protein Rab-5C

Gene

RAB5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36GTPBy similarity9
Nucleotide bindingi47 – 53GTPBy similarity7
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4
Nucleotide bindingi164 – 166GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • neutrophil degranulation Source: Reactome
  • plasma membrane to endosome transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-8854214 TBC/RABGAPs
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkiP51148

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5C
Alternative name(s):
L1880
RAB5L
Gene namesi
Name:RAB5C
Synonyms:RABL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108774.14
HGNCiHGNC:9785 RAB5C
MIMi604037 gene
neXtProtiNX_P51148

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5878
OpenTargetsiENSG00000108774
PharmGKBiPA34145

Polymorphism and mutation databases

BioMutaiRAB5C
DMDMi38258923

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211101 – 216Ras-related protein Rab-5CAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Lipidationi214S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP51148
MaxQBiP51148
PaxDbiP51148
PeptideAtlasiP51148
PRIDEiP51148
ProteomicsDBi56283
TopDownProteomicsiP51148-1 [P51148-1]

PTM databases

iPTMnetiP51148
PhosphoSitePlusiP51148
SwissPalmiP51148

Expressioni

Gene expression databases

BgeeiENSG00000108774
CleanExiHS_RAB5C
ExpressionAtlasiP51148 baseline and differential
GenevisibleiP51148 HS

Organism-specific databases

HPAiHPA003426
HPA004167

Interactioni

Subunit structurei

Binds EEA1.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111816, 155 interactors
IntActiP51148, 131 interactors
MINTiP51148
STRINGi9606.ENSP00000345689

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 27Combined sources8
Helixi34 – 41Combined sources8
Beta strandi55 – 65Combined sources11
Beta strandi68 – 77Combined sources10
Helixi81 – 86Combined sources6
Helixi87 – 91Combined sources5
Beta strandi95 – 102Combined sources8
Helixi106 – 122Combined sources17
Beta strandi128 – 134Combined sources7
Helixi139 – 141Combined sources3
Helixi146 – 155Combined sources10
Beta strandi159 – 162Combined sources4
Turni165 – 168Combined sources4
Helixi171 – 181Combined sources11

3D structure databases

ProteinModelPortaliP51148
SMRiP51148
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 58Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP51148
KOiK07889
OMAiLIKAKHW
OrthoDBiEOG091G0HKN
PhylomeDBiP51148
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51148-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ
60 70 80 90 100
ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV
110 120 130 140 150
YDITNTDTFA RAKNWVKELQ RQASPNIVIA LAGNKADLAS KRAVEFQEAQ
160 170 180 190 200
AYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA TGAPGRNRGV
210
DLQENNPASR SQCCSN
Length:216
Mass (Da):23,483
Last modified:October 31, 2003 - v2
Checksum:iAA42096C6EED77ED
GO
Isoform 2 (identifier: P51148-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MELSWRSPSPLSASLHSTSPHPHALWTTTAGRAM

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):27,036
Checksum:iCAF9CB42B04DBDEF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8A → R (PubMed:8646882).Curated1
Sequence conflicti8A → R (PubMed:7951316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03641440R → H in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0460351M → MELSWRSPSPLSASLHSTSP HPHALWTTTAGRAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18420 mRNA Translation: AAB08927.1
U11293 mRNA Translation: AAA74081.1
AF141304 mRNA Translation: AAF66594.1
AF498938 mRNA Translation: AAM21086.1
AK310234 mRNA No translation available.
CR541901 mRNA Translation: CAG46699.1
BT019484 mRNA Translation: AAV38291.1
AC003104 Genomic DNA No translation available.
AC099811 Genomic DNA No translation available.
AC105024 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60805.1
BC106039 mRNA Translation: AAI06040.1
BC114439 mRNA Translation: AAI14440.1
CCDSiCCDS11419.1 [P51148-1]
CCDS58551.1 [P51148-2]
PIRiI38703
RefSeqiNP_001238968.1, NM_001252039.1 [P51148-2]
NP_004574.2, NM_004583.3 [P51148-1]
NP_958842.1, NM_201434.2 [P51148-1]
XP_011523392.1, XM_011525090.1 [P51148-1]
XP_011523393.1, XM_011525091.1 [P51148-1]
UniGeneiHs.650382

Genome annotation databases

EnsembliENST00000346213; ENSP00000345689; ENSG00000108774 [P51148-1]
ENST00000393860; ENSP00000377440; ENSG00000108774 [P51148-1]
ENST00000547517; ENSP00000447053; ENSG00000108774 [P51148-2]
GeneIDi5878
KEGGihsa:5878
UCSCiuc002hza.4 human [P51148-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRAB5C_HUMAN
AccessioniPrimary (citable) accession number: P51148
Secondary accession number(s): F8W1H5, Q6FH55, Q9P0Y5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 31, 2003
Last modified: July 18, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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