Segment polarity protein dishevelled

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• frizzled binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• phosphatidic acid binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization."
    Simons M., Gault W.J., Gotthardt D., Rohatgi R., Klein T.J., Shao Y., Lee H.J., Wu A.L., Fang Y., Satlin L.M., Dow J.T., Chen J., Zheng J., Boutros M., Mlodzik M.
    Nat. Cell Biol. 11:286-294(2009) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling."
    Wharton K.A. Jr., Zimmermann G., Rousset R., Scott M.P.
    Dev. Biol. 234:93-106(2001) [PubMed] [Europe PMC] [Abstract]
• receptor signaling complex adaptor activity Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled."
    Mendoza-Topaz C., Mieszczanek J., Bienz M.
    Open Biol 1:110013-110013(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• axon extension Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A signaling network for patterning of neuronal connectivity in the Drosophila brain."
    Srahna M., Leyssen M., Choi C.M., Fradkin L.G., Noordermeer J.N., Hassan B.A.
    PLoS Biol. 4:e348-e348(2006) [PubMed] [Europe PMC] [Abstract]
• axon guidance Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/beta-catenin pathway in a Drosophila model for intellectual disability."
    Vandewalle J., Langen M., Zschatzsch M., Zschaetzsch M., Nijhof B., Kramer J.M., Brems H., Bauters M., Lauwers E., Srahna M., Marynen P., Verstreken P., Schenck A., Hassan B.A., Froyen G.
    PLoS ONE 8:e81791-e81791(2013) [PubMed] [Europe PMC] [Abstract]
• border follicle cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis."
    Bastock R., Strutt D.
    Development 134:3055-3064(2007) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway Source: FlyBaseInferred from direct assayⁱ
  • "Biochemical characterization of the Drosophila axin protein."
    Yanagawa S., Lee J.S., Matsuda Y., Ishimoto A.
    FEBS Lett. 474:189-194(2000) [PubMed] [Europe PMC] [Abstract]
• cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis."
    Cohen E.D., Mariol M.-C., Wallace R.M.H., Weyers J., Kamberov Y.G., Pradel J., Wilder E.L.
    Dev. Cell 2:437-448(2002) [PubMed] [Europe PMC] [Abstract]
• compound eye morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Patterning the peripheral retina of the fly: decoding a gradient."
    Tomlinson A.
    Dev. Cell 5:799-809(2003) [PubMed] [Europe PMC] [Abstract]
• compound eye photoreceptor cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The APC/C Coordinates Retinal Differentiation with G1 Arrest through the Nek2-Dependent Modulation of Wingless Signaling."
    Martins T., Meghini F., Florio F., Kimata Y.
    Dev. Cell 40:67-80(2017) [PubMed] [Europe PMC] [Abstract]
• dorsal closure Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Planar polarity and actin dynamics in the epidermis of Drosophila."
    Kaltschmidt J.A., Lawrence N., Morel V., Balayo T., Fernandez B.G., Pelissier A., Jacinto A., Martinez Arias A.
    Nat. Cell Biol. 4:937-944(2002) [PubMed] [Europe PMC] [Abstract]
• epidermis morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis."
    Kaplan N.A., Tolwinski N.S.
    J. Cell. Sci. 123:3157-3165(2010) [PubMed] [Europe PMC] [Abstract]
• establishment of epithelial cell apical/basal polarity Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Fidelity in planar cell polarity signalling."
    Ma D., Yang C.H., McNeill H., Simon M.A., Axelrod J.D.
    Nature 421:543-547(2003) [PubMed] [Europe PMC] [Abstract]
• establishment of epithelial cell planar polarity Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis."
    Kaplan N.A., Tolwinski N.S.
    J. Cell. Sci. 123:3157-3165(2010) [PubMed] [Europe PMC] [Abstract]
• establishment of imaginal disc-derived wing hair orientation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium."
    Lee A., Treisman J.E.
    Mol. Biol. Cell 15:3285-3295(2004) [PubMed] [Europe PMC] [Abstract]
  • "Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila."
    Strutt H., Price M.A., Strutt D.
    Curr. Biol. 16:1329-1336(2006) [PubMed] [Europe PMC] [Abstract]
• establishment of mitotic spindle orientation Source: FlyBaseInferred from direct assayⁱ
  • "The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish."
    Segalen M., Johnston C.A., Martin C.A., Dumortier J.G., Prehoda K.E., David N.B., Doe C.Q., Bellaiche Y.
    Dev. Cell 19:740-752(2010) [PubMed] [Europe PMC] [Abstract]
• establishment of ommatidial planar polarity Source: FlyBaseInferred from mutant phenotypeⁱ
  • "frizzled regulates mirror-symmetric pattern formation in the Drosophila eye."
    Zheng L., Zhang J., Carthew R.W.
    Development 121:3045-3055(1995) [PubMed] [Europe PMC] [Abstract]
• establishment of planar polarity Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Functional dissection of phosphorylation of Disheveled in Drosophila."
    Yanfeng W.A., Berhane H., Mola M., Singh J., Jenny A., Mlodzik M.
    Dev. Biol. 360:132-142(2011) [PubMed] [Europe PMC] [Abstract]
• establishment of tissue polarity Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Roles of the JNK signaling pathway in Drosophila morphogenesis."
    Noselli S., Agnes F.
    Curr. Opin. Genet. Dev. 9:466-472(1999) [PubMed] [Europe PMC] [Abstract]
• female gonad development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis."
    Cohen E.D., Mariol M.-C., Wallace R.M.H., Weyers J., Kamberov Y.G., Pradel J., Wilder E.L.
    Dev. Cell 2:437-448(2002) [PubMed] [Europe PMC] [Abstract]
• germ-line stem-cell niche homeostasis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche."
    Wang S., Gao Y., Song X., Ma X., Zhu X., Mao Y., Yang Z., Ni J., Li H., Malanowski K.E., Anoja P., Park J., Haug J., Xie T.
    Elife 4:e08174-e08174(2015) [PubMed] [Europe PMC] [Abstract]
• heart formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The wingless signaling pathway is directly involved in Drosophila heart development."
    Park M., Wu X., Golden K., Axelrod J.D., Bodmer R.
    Dev. Biol. 177:104-116(1996) [PubMed] [Europe PMC] [Abstract]
• imaginal disc-derived wing hair organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium."
    Lee A., Treisman J.E.
    Mol. Biol. Cell 15:3285-3295(2004) [PubMed] [Europe PMC] [Abstract]
• imaginal disc-derived wing margin morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The wingless signalling pathway and the patterning of the wing margin in Drosophila."
    Couso J.P., Bishop S.A., Martinez Arias A.
    Development 120:621-636(1994) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: InterPro
• motor neuron axon guidance Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Wnt4 is a local repulsive cue that determines synaptic target specificity."
    Inaki M., Yoshikawa S., Thomas J.B., Aburatani H., Nose A.
    Curr. Biol. 17:1574-1579(2007) [PubMed] [Europe PMC] [Abstract]
• oogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila."
    Song X., Xie T.
    Development 130:3259-3268(2003) [PubMed] [Europe PMC] [Abstract]
• ovarian follicle cell development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary."
    Kirilly D., Spana E.P., Perrimon N., Padgett R.W., Xie T.
    Dev. Cell 9:651-662(2005) [PubMed] [Europe PMC] [Abstract]
  • "Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells."
    Jordan K.C., Schaeffer V., Fischer K.A., Gray E.E., Ruohola-Baker H.
    BMC Dev. Biol. 6:16-16(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of axon extension Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila."
    Gombos R., Migh E., Antal O., Mukherjee A., Jenny A., Mihaly J.
    J. Neurosci. 35:10154-10167(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of axon guidance Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila."
    Gombos R., Migh E., Antal O., Mukherjee A., Jenny A., Mihaly J.
    J. Neurosci. 35:10154-10167(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of actin filament bundle assembly Source: FlyBaseInferred from genetic interactionⁱ
  • "Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton."
    Winter C.G., Wang B., Ballew A., Royou A., Karess R., Axelrod J.D., Luo L.
    Cell 105:81-91(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of compound eye pigmentation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Organization of the peripheral fly eye: the roles of Snail family transcription factors in peripheral retinal apoptosis."
    Lim H.Y., Tomlinson A.
    Development 133:3529-3537(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of tube length, open tracheal system Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length."
    Chung S., Vining M.S., Bradley P.L., Chan C.C., Wharton K.A. Jr., Andrew D.J.
    PLoS Genet. 5:e1000746-e1000746(2009) [PubMed] [Europe PMC] [Abstract]
• retinal ganglion cell axon guidance Source: FlyBaseInferred from mutant phenotypeⁱ
  • "DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system."
    Sato M., Umetsu D., Murakami S., Yasugi T., Tabata T.
    Nat. Neurosci. 9:67-75(2006) [PubMed] [Europe PMC] [Abstract]
• salivary gland morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration."
    Harris K.E., Beckendorf S.K.
    Development 134:2017-2025(2007) [PubMed] [Europe PMC] [Abstract]
• segment polarity determination Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity."
    Tolwinski N.S., Wehrli M., Rives A., Erdeniz N., DiNardo S., Wieschaus E.
    Dev. Cell 4:407-418(2003) [PubMed] [Europe PMC] [Abstract]
• somatic stem cell population maintenance Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila."
    Song X., Xie T.
    Development 130:3259-3268(2003) [PubMed] [Europe PMC] [Abstract]
  • "BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary."
    Kirilly D., Spana E.P., Perrimon N., Padgett R.W., Xie T.
    Dev. Cell 9:651-662(2005) [PubMed] [Europe PMC] [Abstract]
• synaptic target inhibition Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Wnt4 is a local repulsive cue that determines synaptic target specificity."
    Inaki M., Yoshikawa S., Thomas J.B., Aburatani H., Nose A.
    Curr. Biol. 17:1574-1579(2007) [PubMed] [Europe PMC] [Abstract]
• wing and notum subfield formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila."
    Mohit P., Makhijani K., Madhavi M.B., Bharathi V., Lal A., Sirdesai G., Reddy V.R., Ramesh P., Kannan R., Dhawan J., Shashidhara L.S.
    Dev. Biol. 291:356-367(2006) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway, planar cell polarity pathway Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: FlyBaseInferred from physical interactionⁱ
  • "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling."
    Wharton K.A. Jr., Zimmermann G., Rousset R., Scott M.P.
    Dev. Biol. 234:93-106(2001) [PubMed] [Europe PMC] [Abstract]
• receptor signaling complex adaptor activity Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled."
    Mendoza-Topaz C., Mieszczanek J., Bienz M.
    Open Biol 1:110013-110013(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDADRGGGQE TKVIYHIDDE TTPYLVKIPI PSAQVTLRDF KLVLNKQNNN 
        60         70         80         90        100
YKYFFKSMDA DFGVVKEEIA DDSTILPCFN GRVVSWLVSA DGTNQSDNCS 
       110        120        130        140        150
ELPTSECELG MGLTNRKLQQ QQQQHQQQQQ QQQQQHQQQQ QQQQQQVQPV 
       160        170        180        190        200
QLAQQQQQQV LHHQKMMGNP LLQPPPLTYQ SASVLSSDLD STSLFGTESE 
       210        220        230        240        250
LTLDRDMTDY SSVQRLQVRK KPQRRKKRAP SMSRTSSYSS ITDSTMSLNI 
       260        270        280        290        300
ITVSINMEAV NFLGISIVGQ SNRGGDGGIY VGSIMKGGAV ALDGRIEPGD 
       310        320        330        340        350
MILQVNDVNF ENMTNDEAVR VLREVVQKPG PIKLVVAKCW DPNPKGYFTI 
       360        370        380        390        400
PRTEPVRPID PGAWVAHTQA LTSHDSIIAD IAEPIKERLD QNNLEEIVKA 
       410        420        430        440        450
MTKPDSGLEI RDRMWLKITI PNAFIGADAV NWVLENVEDV QDRREARRIV 
       460        470        480        490        500
SAMLRSNYIK HTVNKLTFSE QCYYVVNEER NPNLLGRGHL HPHQLPHGHG 
       510        520        530        540        550
GHALSHADTE SITSDIGPLP NPPIYMPYSA TYNPSHGYQP IQYGIAERHI 
       560        570        580        590        600
SSGSSSSDVL TSKDISASQS DITSVIHQAN QLTIAAHGSN KSSGSSNRGG 
       610        620 
GGGGGGGGNN TNDQDVSVFN YVL                              

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase