UniProtKB - P51140 (DSH_DROME)
Protein
Segment polarity protein dishevelled
Gene
dsh
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity.3 Publications
GO - Molecular functioni
- frizzled binding Source: GO_Central
- phosphatidic acid binding Source: FlyBase
- protein domain specific binding Source: FlyBase
- signaling receptor complex adaptor activity Source: FlyBase
GO - Biological processi
- axon extension Source: FlyBase
- border follicle cell migration Source: FlyBase
- canonical Wnt signaling pathway Source: FlyBase
- cell migration Source: FlyBase
- compound eye morphogenesis Source: FlyBase
- compound eye photoreceptor cell differentiation Source: FlyBase
- dorsal closure Source: FlyBase
- epidermis morphogenesis Source: FlyBase
- establishment of epithelial cell planar polarity Source: FlyBase
- establishment of imaginal disc-derived wing hair orientation Source: FlyBase
- establishment of mitotic spindle orientation Source: FlyBase
- establishment of ommatidial planar polarity Source: FlyBase
- establishment of planar polarity Source: FlyBase
- female gonad development Source: FlyBase
- germ-line stem-cell niche homeostasis Source: FlyBase
- heart formation Source: FlyBase
- imaginal disc-derived wing hair organization Source: FlyBase
- imaginal disc-derived wing margin morphogenesis Source: FlyBase
- intracellular signal transduction Source: InterPro
- motor neuron axon guidance Source: FlyBase
- oogenesis Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- positive regulation of axon extension Source: FlyBase
- positive regulation of axon guidance Source: FlyBase
- regulation of actin filament bundle assembly Source: FlyBase
- regulation of axonogenesis Source: FlyBase
- regulation of compound eye pigmentation Source: FlyBase
- regulation of tube length, open tracheal system Source: FlyBase
- retinal ganglion cell axon guidance Source: FlyBase
- salivary gland morphogenesis Source: FlyBase
- segment polarity determination Source: FlyBase
- somatic stem cell population maintenance Source: FlyBase
- synaptic target inhibition Source: FlyBase
- wing and notum subfield formation Source: FlyBase
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Molecular function | Developmental protein, Segmentation polarity protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-DME-201688, WNT mediated activation of DVL R-DME-209440, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-350368, Activation of RHO1 by FZ:DSH complex R-DME-350369, Negative feedback loop regulates asymmetric localisation R-DME-350376, Activation of RAC1:GTP by FZ:DSH complex R-DME-350411, Formation and asymmetric localisation of transmembrane complexes R-DME-350480, Activation of non-muscle Myosin II R-DME-4086400, PCP/CE pathway R-DME-450728, Inhibition of actin polymerisation R-DME-4608870, Asymmetric localization of PCP proteins R-DME-4641258, Degradation of DVL R-DME-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-5099900, WNT5A-dependent internalization of FZD4 R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis R-DME-8856828, Clathrin-mediated endocytosis |
SignaLinki | P51140 |
Names & Taxonomyi
Protein namesi | Recommended name: Segment polarity protein dishevelled |
Gene namesi | Name:dsh ORF Names:CG18361 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000499, dsh |
Subcellular locationi
Nucleus
Other locations
Note: Associated with the membrane when hyperphosphorylated.
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: FlyBase
Other locations
- apical cortex Source: FlyBase
- cytoplasm Source: FlyBase
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000145740 | 1 – 623 | Segment polarity protein dishevelledAdd BLAST | 623 |
Post-translational modificationi
Phosphorylated. Wg signaling generates the hyperphosphorylated active forms.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P51140 |
PRIDEi | P51140 |
PTM databases
iPTMneti | P51140 |
Expressioni
Tissue specificityi
Found in egg chambers of the ovary and ubiquitously throughout embryogenesis and in disks. Expression is not seen in salivary glands, muscles or ventral ganglia but is observed in brain lobes.
Developmental stagei
Expressed at high levels at 0-1 hour and from 5-17 hours. Also expressed at high levels in early pupae.1 Publication
Gene expression databases
Bgeei | FBgn0000499, Expressed in embryo and 33 other tissues |
Genevisiblei | P51140, DM |
Interactioni
Subunit structurei
Interacts with nkd. This interaction may require zinc.
3 PublicationsBinary interactionsi
Hide detailsP51140
With | #Exp. | IntAct |
---|---|---|
cno [Q24279] | 3 | EBI-499383,EBI-868783 |
dgo [Q7JUF2] | 5 | EBI-499383,EBI-1158635 |
nkd [Q9VVV9] | 10 | EBI-499383,EBI-125843 |
Nkd1 [Q99MH6] from Mus musculus. | 2 | EBI-499383,EBI-1538321 |
GO - Molecular functioni
- frizzled binding Source: GO_Central
- protein domain specific binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 58490, 131 interactors |
IntActi | P51140, 17 interactors |
MINTi | P51140 |
STRINGi | 7227.FBpp0073310 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 91 | DIXPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 252 – 324 | PDZPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 404 – 478 | DEPPROSITE-ProRule annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 623 | Interaction with nkdAdd BLAST | 458 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 119 – 146 | Poly-GlnAdd BLAST | 28 | |
Compositional biasi | 154 – 159 | Poly-Gln | 6 | |
Compositional biasi | 551 – 557 | Poly-Ser | 7 | |
Compositional biasi | 599 – 608 | Poly-Gly | 10 |
Sequence similaritiesi
Belongs to the DSH family.Curated
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
GeneTreei | ENSGT00950000182903 |
HOGENOMi | CLU_012601_3_0_1 |
InParanoidi | P51140 |
OMAi | HHQKMMG |
OrthoDBi | 474724at2759 |
PhylomeDBi | P51140 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR026542, Dsh IPR015506, Dsh/Dvl-rel IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF25, PTHR10878:SF25, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
P51140-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDADRGGGQE TKVIYHIDDE TTPYLVKIPI PSAQVTLRDF KLVLNKQNNN
60 70 80 90 100
YKYFFKSMDA DFGVVKEEIA DDSTILPCFN GRVVSWLVSA DGTNQSDNCS
110 120 130 140 150
ELPTSECELG MGLTNRKLQQ QQQQHQQQQQ QQQQQHQQQQ QQQQQQVQPV
160 170 180 190 200
QLAQQQQQQV LHHQKMMGNP LLQPPPLTYQ SASVLSSDLD STSLFGTESE
210 220 230 240 250
LTLDRDMTDY SSVQRLQVRK KPQRRKKRAP SMSRTSSYSS ITDSTMSLNI
260 270 280 290 300
ITVSINMEAV NFLGISIVGQ SNRGGDGGIY VGSIMKGGAV ALDGRIEPGD
310 320 330 340 350
MILQVNDVNF ENMTNDEAVR VLREVVQKPG PIKLVVAKCW DPNPKGYFTI
360 370 380 390 400
PRTEPVRPID PGAWVAHTQA LTSHDSIIAD IAEPIKERLD QNNLEEIVKA
410 420 430 440 450
MTKPDSGLEI RDRMWLKITI PNAFIGADAV NWVLENVEDV QDRREARRIV
460 470 480 490 500
SAMLRSNYIK HTVNKLTFSE QCYYVVNEER NPNLLGRGHL HPHQLPHGHG
510 520 530 540 550
GHALSHADTE SITSDIGPLP NPPIYMPYSA TYNPSHGYQP IQYGIAERHI
560 570 580 590 600
SSGSSSSDVL TSKDISASQS DITSVIHQAN QLTIAAHGSN KSSGSSNRGG
610 620
GGGGGGGGNN TNDQDVSVFN YVL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 276 | D → N in AAA20216 (PubMed:8149913).Curated | 1 | |
Sequence conflicti | 565 | I → T in AAA16535 (PubMed:8288125).Curated | 1 | |
Sequence conflicti | 619 | F → S in AAA16535 (PubMed:8288125).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02491 mRNA Translation: AAA20216.1 L26974 mRNA Translation: AAA16535.1 AE014298 Genomic DNA Translation: AAF48033.1 BT023781 mRNA Translation: AAZ41790.1 |
PIRi | A49840 |
RefSeqi | NP_511118.2, NM_078563.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0073454; FBpp0073310; FBgn0000499 |
GeneIDi | 32078 |
KEGGi | dme:Dmel_CG18361 |
UCSCi | CG18361-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02491 mRNA Translation: AAA20216.1 L26974 mRNA Translation: AAA16535.1 AE014298 Genomic DNA Translation: AAF48033.1 BT023781 mRNA Translation: AAZ41790.1 |
PIRi | A49840 |
RefSeqi | NP_511118.2, NM_078563.3 |
3D structure databases
SMRi | P51140 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 58490, 131 interactors |
IntActi | P51140, 17 interactors |
MINTi | P51140 |
STRINGi | 7227.FBpp0073310 |
PTM databases
iPTMneti | P51140 |
Proteomic databases
PaxDbi | P51140 |
PRIDEi | P51140 |
Genome annotation databases
EnsemblMetazoai | FBtr0073454; FBpp0073310; FBgn0000499 |
GeneIDi | 32078 |
KEGGi | dme:Dmel_CG18361 |
UCSCi | CG18361-RA, d. melanogaster |
Organism-specific databases
CTDi | 32078 |
FlyBasei | FBgn0000499, dsh |
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
GeneTreei | ENSGT00950000182903 |
HOGENOMi | CLU_012601_3_0_1 |
InParanoidi | P51140 |
OMAi | HHQKMMG |
OrthoDBi | 474724at2759 |
PhylomeDBi | P51140 |
Enzyme and pathway databases
Reactomei | R-DME-201688, WNT mediated activation of DVL R-DME-209440, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-350368, Activation of RHO1 by FZ:DSH complex R-DME-350369, Negative feedback loop regulates asymmetric localisation R-DME-350376, Activation of RAC1:GTP by FZ:DSH complex R-DME-350411, Formation and asymmetric localisation of transmembrane complexes R-DME-350480, Activation of non-muscle Myosin II R-DME-4086400, PCP/CE pathway R-DME-450728, Inhibition of actin polymerisation R-DME-4608870, Asymmetric localization of PCP proteins R-DME-4641258, Degradation of DVL R-DME-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-5099900, WNT5A-dependent internalization of FZD4 R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis R-DME-8856828, Clathrin-mediated endocytosis |
SignaLinki | P51140 |
Miscellaneous databases
BioGRID-ORCSi | 32078, 0 hits in 3 CRISPR screens |
GenomeRNAii | 32078 |
PROi | PR:P51140 |
Gene expression databases
Bgeei | FBgn0000499, Expressed in embryo and 33 other tissues |
Genevisiblei | P51140, DM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR026542, Dsh IPR015506, Dsh/Dvl-rel IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF25, PTHR10878:SF25, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DSH_DROME | |
Accessioni | P51140Primary (citable) accession number: P51140 Secondary accession number(s): Q494J5, Q9VYZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | June 21, 2005 | |
Last modified: | December 2, 2020 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families