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Entry version 153 (29 Sep 2021)
Sequence version 2 (13 Aug 2002)
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Protein

Calpastatin

Gene

Cast

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1474228, Degradation of the extracellular matrix

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I27.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpastatin
Alternative name(s):
Calpain inhibitor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cast
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1098236, Cast

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000021585

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001476331 – 788CalpastatinAdd BLAST788

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei129N6-acetyllysineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei216PhosphothreonineBy similarity1
Modified residuei219PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei324PhosphoserineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei446PhosphoserineBy similarity1
Modified residuei453PhosphoserineBy similarity1
Modified residuei479PhosphothreonineCombined sources1
Modified residuei518PhosphoserineBy similarity1
Modified residuei594PhosphoserineBy similarity1
Modified residuei605PhosphoserineBy similarity1
Modified residuei653PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3825

Encyclopedia of Proteome Dynamics

More...
EPDi
P51125

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P51125

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P51125

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51125

PeptideAtlas

More...
PeptideAtlasi
P51125

PRoteomics IDEntifications database

More...
PRIDEi
P51125

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
273251 [P51125-1]
273252 [P51125-2]
273253 [P51125-3]
273254 [P51125-4]
273255 [P51125-5]
273256 [P51125-6]
273257 [P51125-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51125

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51125

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is the major form in all tissues examined. Isoform 1 accounts for 5-10% in tissues such as skeletal muscle, liver and brain, and 30% in myoblasts. Isoforms 4 and 5 are testis-specific. Isoform 6 is highly expressed in heart and skeletal muscle with lower levels in liver, brain and testis. Isoform 7 is expressed at high levels in liver.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
198509, 13 interactors

Protein interaction database and analysis system

More...
IntActi
P51125, 2 interactors

Molecular INTeraction database

More...
MINTi
P51125

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000065275

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P51125, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51125

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati251 – 303Inhibitory domain 1Add BLAST53
Repeati384 – 436Inhibitory domain 2Add BLAST53
Repeati524 – 577Inhibitory domain 3Add BLAST54
Repeati661 – 714Inhibitory domain 4Add BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 262DisorderedSequence analysisAdd BLAST262
Regioni289 – 493DisorderedSequence analysisAdd BLAST205
Regioni514 – 580DisorderedSequence analysisAdd BLAST67
Regioni620 – 788DisorderedSequence analysisAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 93Polar residuesSequence analysisAdd BLAST45
Compositional biasi100 – 143Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi152 – 179Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi216 – 230Polar residuesSequence analysisAdd BLAST15
Compositional biasi233 – 255Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi314 – 330Polar residuesSequence analysisAdd BLAST17
Compositional biasi352 – 366Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi370 – 389Polar residuesSequence analysisAdd BLAST20
Compositional biasi394 – 444Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi471 – 485Polar residuesSequence analysisAdd BLAST15
Compositional biasi522 – 574Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi637 – 730Basic and acidic residuesSequence analysisAdd BLAST94
Compositional biasi733 – 753Polar residuesSequence analysisAdd BLAST21
Compositional biasi755 – 788Basic and acidic residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RHIZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002993

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51125

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKEKDHT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51125

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026998, Calpastatin
IPR001259, Prot_inh_calpain

The PANTHER Classification System

More...
PANTHERi
PTHR10077, PTHR10077, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00748, Calpain_inhib, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51125-1) [UniParc]FASTAAdd to basket
Also known as: MCS-A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQPGPKPAA SPRPSRGAAA RHTQEHVNEK NIGSSSKPGE KKGSDEKKAA
60 70 80 90 100
SLGSSQPSRP HVGEAATATK VTASSAATSK SPSMSTTETK AIPVNKQLEG
110 120 130 140 150
PDQKRPREQA VKTESKKPQS SEQPVVHEKK SKGGPKEGSE PKNLPKHTSS
160 170 180 190 200
TGSKHAHKEK ALSRSNEQMV SEKPSESKTK FQDVPSAGGE SVAGGGTVAT
210 220 230 240 250
ALDKVVGKKK EQKPFTPASP VQSTPSKPSD KSGMDAALDD LIDTLGGHED
260 270 280 290 300
TNRDDPPYTG PVVLDPMYST YLEALGIKEG TIPPEYRKLL EKNEGITQPL
310 320 330 340 350
PDSPKPMGTD QAIDALSSDF TCSSPTGKQS EKEKSTGEIF KAQSAGVTRS
360 370 380 390 400
SVPPKEKKRK VEEEVINDQA LQALSDSLGT RQPDPPSHVS QAEQVKEAKA
410 420 430 440 450
KEERQEKCGE DEDTVPAEYR LKPAKDKDGK PLLPEPEETS KSLSESELIG
460 470 480 490 500
ELSADFDRST YQDKPSTPAE KKSNDTSQTP PGETVPRASM CSIRSAPPKL
510 520 530 540 550
ASLKGVVPED AVETLAGSLG TREADPEHEK TVEDKVKEKA KEEEHEKLGE
560 570 580 590 600
KEETVPPDYR LEEVKDKDGK PLLPKESQEQ LAPLSDDFLL DALSQDFSSP
610 620 630 640 650
ANISSLEFED AKLSAAISEV VSQTPAPSTH AAAPLPGTEQ KDKELDDALD
660 670 680 690 700
ELSDSLGQRP PDPDENKPLD DKVKEKIKPE HSEKLGERDD TIPPEYRHLL
710 720 730 740 750
DNDGKDKPEK PPTKKTEKPD QDRDPIDALS EDLDSCPSTT ETSKNTAKGK
760 770 780
SKKTSSSKAS KDGEKTKDSS KKTEEVSKPK AKEDARHS
Length:788
Mass (Da):84,922
Last modified:August 13, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28E4D3B4A68BFEB9
GO
Isoform 2 (identifier: P51125-2) [UniParc]FASTAAdd to basket
Also known as: MCS-B

The sequence of this isoform differs from the canonical sequence as follows:
     92-110: Missing.

Show »
Length:769
Mass (Da):82,736
Checksum:i7A50CE154510369F
GO
Isoform 3 (identifier: P51125-3) [UniParc]FASTAAdd to basket
Also known as: MCS-C

The sequence of this isoform differs from the canonical sequence as follows:
     92-110: Missing.
     305-333: Missing.

Show »
Length:740
Mass (Da):79,695
Checksum:i09DD44D777D45F82
GO
Isoform 4 (identifier: P51125-4) [UniParc]FASTAAdd to basket
Also known as: TCAST1

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.
     342-396: AQSAGVTRSS...SHVSQAEQVK → MGQFLSSTFW...EEREHGSKHH

Show »
Length:446
Mass (Da):49,125
Checksum:iA2C57CE4FD7E04FC
GO
Isoform 5 (identifier: P51125-5) [UniParc]FASTAAdd to basket
Also known as: TCAST2

The sequence of this isoform differs from the canonical sequence as follows:
     1-357: Missing.
     358-397: KRKVEEEVIN...HVSQAEQVKE → MGQFLSSTFW...GETIPILQDH

Show »
Length:431
Mass (Da):47,366
Checksum:i38C6B615B38171C2
GO
Isoform 6 (identifier: P51125-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MSQPGPKPAASPRPSRGAAARHTQE → MAFASWWYKT

Show »
Length:773
Mass (Da):83,626
Checksum:i7CDE4420D3AC052B
GO
Isoform 7 (identifier: P51125-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:705
Mass (Da):76,608
Checksum:i4B65B35982DFC983
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CE80Q8CE80_MOUSE
Calpain inhibitor
Cast
754Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8CE04Q8CE04_MOUSE
Calpain inhibitor
Cast
704Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q921U7Q921U7_MOUSE
Calpain inhibitor
Cast
674Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8C281Q8C281_MOUSE
Calpain inhibitor
Cast
686Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJN8A0A1Y7VJN8_MOUSE
Calpain inhibitor
Cast
445Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6J9A0A338P6J9_MOUSE
Calpain inhibitor
Cast
520Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0007491 – 357Missing in isoform 5. CuratedAdd BLAST357
Alternative sequenceiVSP_0007471 – 341Missing in isoform 4. CuratedAdd BLAST341
Alternative sequenceiVSP_0007461 – 83Missing in isoform 7. CuratedAdd BLAST83
Alternative sequenceiVSP_0007451 – 25MSQPG…RHTQE → MAFASWWYKT in isoform 6. CuratedAdd BLAST25
Alternative sequenceiVSP_00075192 – 110Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_000752305 – 333Missing in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_000748342 – 396AQSAG…AEQVK → MGQFLSSTFWEGSPAAVWQE KLREGERKGAGETIPILQDH VICSEEREHGSKHH in isoform 4. CuratedAdd BLAST55
Alternative sequenceiVSP_000750358 – 397KRKVE…EQVKE → MGQFLSSTFWEGSPAAVWQE KLREGERKGAGETIPILQDH in isoform 5. CuratedAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB026997 mRNA Translation: BAA84768.1
AF190152 mRNA Translation: AAF25194.1
AF190151 mRNA Translation: AAF25193.1
AB044334 Genomic DNA Translation: BAB18888.1
AB044334 Genomic DNA Translation: BAB18889.1
AB044334 Genomic DNA Translation: BAB18886.1
AB044334 Genomic DNA Translation: BAB18887.1
X62519 mRNA Translation: CAA44385.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS88487.1 [P51125-5]
CCDS88491.1 [P51125-1]

Protein sequence database of the Protein Information Resource

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PIRi
S20610

NCBI Reference Sequences

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RefSeqi
NP_001288082.1, NM_001301153.1 [P51125-1]
NP_001288089.1, NM_001301160.1 [P51125-5]
NP_001288110.1, NM_001301181.1 [P51125-4]
XP_006517122.1, XM_006517059.1 [P51125-2]
XP_011242768.1, XM_011244466.2 [P51125-6]
XP_011242769.1, XM_011244467.2 [P51125-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000223206; ENSMUSP00000152174; ENSMUSG00000021585 [P51125-1]
ENSMUST00000223309; ENSMUSP00000152657; ENSMUSG00000021585 [P51125-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
12380

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:12380

UCSC genome browser

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UCSCi
uc007rfl.2, mouse [P51125-4]
uc007rfq.2, mouse [P51125-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026997 mRNA Translation: BAA84768.1
AF190152 mRNA Translation: AAF25194.1
AF190151 mRNA Translation: AAF25193.1
AB044334 Genomic DNA Translation: BAB18888.1
AB044334 Genomic DNA Translation: BAB18889.1
AB044334 Genomic DNA Translation: BAB18886.1
AB044334 Genomic DNA Translation: BAB18887.1
X62519 mRNA Translation: CAA44385.1
CCDSiCCDS88487.1 [P51125-5]
CCDS88491.1 [P51125-1]
PIRiS20610
RefSeqiNP_001288082.1, NM_001301153.1 [P51125-1]
NP_001288089.1, NM_001301160.1 [P51125-5]
NP_001288110.1, NM_001301181.1 [P51125-4]
XP_006517122.1, XM_006517059.1 [P51125-2]
XP_011242768.1, XM_011244466.2 [P51125-6]
XP_011242769.1, XM_011244467.2 [P51125-7]

3D structure databases

SMRiP51125
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi198509, 13 interactors
IntActiP51125, 2 interactors
MINTiP51125
STRINGi10090.ENSMUSP00000065275

Protein family/group databases

MEROPSiI27.001

PTM databases

iPTMnetiP51125
PhosphoSitePlusiP51125

Proteomic databases

CPTACinon-CPTAC-3825
EPDiP51125
jPOSTiP51125
MaxQBiP51125
PaxDbiP51125
PeptideAtlasiP51125
PRIDEiP51125
ProteomicsDBi273251 [P51125-1]
273252 [P51125-2]
273253 [P51125-3]
273254 [P51125-4]
273255 [P51125-5]
273256 [P51125-6]
273257 [P51125-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4008, 408 antibodies

The DNASU plasmid repository

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DNASUi
12380

Genome annotation databases

EnsembliENSMUST00000223206; ENSMUSP00000152174; ENSMUSG00000021585 [P51125-1]
ENSMUST00000223309; ENSMUSP00000152657; ENSMUSG00000021585 [P51125-5]
GeneIDi12380
KEGGimmu:12380
UCSCiuc007rfl.2, mouse [P51125-4]
uc007rfq.2, mouse [P51125-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
831
MGIiMGI:1098236, Cast
VEuPathDBiHostDB:ENSMUSG00000021585

Phylogenomic databases

eggNOGiENOG502RHIZ, Eukaryota
GeneTreeiENSGT00390000002993
InParanoidiP51125
OMAiIKEKDHT
PhylomeDBiP51125

Enzyme and pathway databases

ReactomeiR-MMU-1474228, Degradation of the extracellular matrix

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
12380, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cast, mouse

Protein Ontology

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PROi
PR:P51125
RNActiP51125, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR026998, Calpastatin
IPR001259, Prot_inh_calpain
PANTHERiPTHR10077, PTHR10077, 1 hit
PfamiView protein in Pfam
PF00748, Calpain_inhib, 4 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICAL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51125
Secondary accession number(s): Q9EQV4
, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 13, 2002
Last modified: September 29, 2021
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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