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Entry version 192 (17 Jun 2020)
Sequence version 3 (19 Jul 2005)
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Protein

Transcription initiation factor TFIID subunit 1

Gene

Taf1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp.3 Publications

Caution

The C-terminal Ser/Thr kinase domain was reported to phosphorylate histone H2B at 'Ser-33' (PubMed:15143281). However, the paper was retracted because some data, results and conclusions in the paper are not reliable.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Autophosphorylates on Ser residues.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
R-DME-73776 RNA Polymerase II Promoter Escape
R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953 RNA Polymerase II Transcription Initiation
R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1 (EC:2.7.11.1)
Alternative name(s):
TAFII250
TBP-associated factor 230 kDa
Short name:
p230
Transcription initiation factor TFIID 230 kDa subunit
Short name:
TAFII-230
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Taf1
Synonyms:TAF250
ORF Names:CG17603
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010355 Taf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112161 – 2129Transcription initiation factor TFIID subunit 1Add BLAST2129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei286Phosphoserine1 Publication1
Modified residuei288Phosphoserine1 Publication1
Modified residuei290Phosphoserine1 Publication1
Modified residuei315Phosphoserine; by autocatalysisBy similarity1
Modified residuei603Phosphoserine1 Publication1
Modified residuei1740Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51123

PRoteomics IDEntifications database

More...
PRIDEi
P51123

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51123

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010355 Expressed in eye disc (Drosophila) and 28 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P51123 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51123 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Taf1 is the largest component of the TFIID complex.

Interacts with Tbp, Taf2, Taf4 and Taf6.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66011, 26 interactors

Database of interacting proteins

More...
DIPi
DIP-228N

Protein interaction database and analysis system

More...
IntActi
P51123, 16 interactors

Molecular INTeraction database

More...
MINTi
P51123

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293442

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51123

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P51123

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 423Protein kinase 1Add BLAST423
Domaini1487 – 1557Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1515 – 2065Protein kinase 2Add BLAST551
Domaini1609 – 1679Bromo 2PROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1442 – 1448Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2056 – 2120Gln-richAdd BLAST65

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF1 family.Curated

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155242

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51123

KEGG Orthology (KO)

More...
KOi
K03125

Identification of Orthologs from Complete Genome Data

More...
OMAi
KACPLYT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51123

Family and domain databases

Database of protein disorder

More...
DisProti
DP00081

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1100.10, 1 hit
1.20.920.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR040240 TAF1
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
IPR041670 Znf-CCHC_6

The PANTHER Classification System

More...
PANTHERi
PTHR13900 PTHR13900, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PF15288 zf-CCHC_6, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003047 TAF1_animal, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00384 AT_hook, 2 hits
SM00297 BROMO, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P51123-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEMESDNSDD EGSIGNGLDL TGILFGNIDS EGRLLQDDDG EGRGGTGFDA
60 70 80 90 100
ELRENIGSLS KLGLDSMLLE VIDLKEAEPP SDDEEEEDAR PSAVSASEGM
110 120 130 140 150
SAFDALKAGV KREDGAVKAQ DDAIDYSDIT ELSEDCPRTP PEETSTYDDL
160 170 180 190 200
EDAIPASKVE AKLTKDDKEL MPPPSAPMRS GSGGGIEEPA KSNDASSPSD
210 220 230 240 250
DSKSTDSKDA DRKLDTPLAD ILPSKYQNVD VRELFPDFRP QKVLRFSRLF
260 270 280 290 300
GPGKPTSLPQ IWRHVRKRRR KRNQSRDQKT TNTGGSDSPS DTEEPRKRGF
310 320 330 340 350
SLHYAAEPTP AECMSDDEDK LLGDFNSEDV RPEGPDNGEN SDQKPKVADW
360 370 380 390 400
RFGPAQIWYD MLEVPDSGEG FNYGFKTKAA STSSQPQLKD ERRVKSPEDD
410 420 430 440 450
VEDPSIADDA FLMVSQLHWE DDVVWDGNDI KAKVLQKLNS KTNAAGWLPS
460 470 480 490 500
SGSRTAGAFS QPGKPSMPVG SGSSKQGSGA SSKKAQQNAQ AKPAEAPDDT
510 520 530 540 550
WYSLFPVENE ELIYYKWEDE VIWDAQQVSK VPKPKVLTLD PNDENIILGI
560 570 580 590 600
PDDIDPSKIN KSTGPPPKIK IPHPHVKKSK ILLGKAGVIN VLAEDTPPPP
610 620 630 640 650
PKSPDRDPFN ISNDTYYTPK TEPTLRLKVG GNLIQHSTPV VELRAPFVPT
660 670 680 690 700
HMGPMKLRAF HRPPLKKYSH GPMAQSIPHP VFPLLKTIAK KAKQREVERI
710 720 730 740 750
ASGGGDVFFM RNPEDLSGRD GDIVLAEFCE EHPPLINQVG MCSKIKNYYK
760 770 780 790 800
RKAEKDSGPQ DFVYGEVAFA HTSPFLGILH PGQCIQAIEN NMYRAPIYPH
810 820 830 840 850
KMAHNDFLVI RTRNNYWIRS VNSIYTVGQE CPLYEVPGPN SKRANNFTRD
860 870 880 890 900
FLQVFIYRLF WKSRDNPRRI RMDDIKQAFP AHSESSIRKR LKQCADFKRT
910 920 930 940 950
GMDSNWWVIK PEFRLPSEEE IRAMVSPEQC CAYFSMIAAE QRLKDAGYGE
960 970 980 990 1000
KFLFAPQEDD DEEAQLKLDD EVKVAPWNTT RAYIQAMRGK CLLQLSGPAD
1010 1020 1030 1040 1050
PTGCGEGFSY VRVPNKPTQT KEEQESQPKR SVTGTDADLR RLPLQRAKEL
1060 1070 1080 1090 1100
LRQFKVPEEE IKKLSRWEVI DVVRTLSTEK AKAGEEGMDK FSRGNRFSIA
1110 1120 1130 1140 1150
EHQERYKEEC QRIFDLQNRV LASSEVLSTD EAESSASEES DLEELGKNLE
1160 1170 1180 1190 1200
NMLSNKKTST QLSREREELE RQELLRQLDE EHGGPSGSGG AKGAKGKDDP
1210 1220 1230 1240 1250
GQQMLATNNQ GRILRITRTF RGNDGKEYTR VETVRRQPVI DAYIKIRTTK
1260 1270 1280 1290 1300
DEQFIKQFAT LDEQQKEEMK REKRRIQEQL RRIKRNQERE RLAQLAQNQK
1310 1320 1330 1340 1350
LQPGGMPTSL GDPKSSGGHS HKERDSGYKE VSPSRKKFKL KPDLKLKCGA
1360 1370 1380 1390 1400
CGQVGHMRTN KACPLYSGMQ SSLSQSNPSL ADDFDEQSEK EMTMDDDDLV
1410 1420 1430 1440 1450
NVDGTKVTLS SKILKRHGGD DGKRRSGSSS GFTLKVPRDA MGKKKRRVGG
1460 1470 1480 1490 1500
DLHCDYLQRH NKTANRRRTD PVVVLSSILE IIHNELRSMP DVSPFLFPVS
1510 1520 1530 1540 1550
AKKVPDYYRV VTKPMDLQTM REYIRQRRYT SREMFLEDLK QIVDNSLIYN
1560 1570 1580 1590 1600
GPQSAYTLAA QRMFSSCFEL LAEREDKLMR LEKAINPLLD DDDQVALSFI
1610 1620 1630 1640 1650
FDKLHSQIKQ LPESWPFLKP VNKKQVKDYY TVIKRPMDLE TIGKNIEAHR
1660 1670 1680 1690 1700
YHSRAEYLAD IELIATNCEQ YNGSDTRYTK FSKKILEYAQ TQLIEFSEHC
1710 1720 1730 1740 1750
GQLENNIAKT QERARENAPE FDEAWGNDDY NFDRGSRASS PGDDYIDVEG
1760 1770 1780 1790 1800
HGGHASSSNS IHRSMGAEAG SSHTAPAVRK PAPPGPGEVK RGRGRPRKQR
1810 1820 1830 1840 1850
DPVEEVKSQN PVKRGRGRPR KDSLASNMSH TQAYFLDEDL QCSTDDEDDD
1860 1870 1880 1890 1900
EEEDFQEVSE DENNAASILD QGERINAPAD AMDGMFDPKN IKTEIDLEAH
1910 1920 1930 1940 1950
QMAEEPIGED DSQQVAEAMV QLSGVGGYYA QQQQDESMDV DPNYDPSDFL
1960 1970 1980 1990 2000
AMHKQRQSLG EPSSLQGAFT NFLSHEQDDN GPYNPAEAST SAASGADLGM
2010 2020 2030 2040 2050
DASMAMQMAP EMPVNTMNNG MGIDDDLDIS ESDEEDDGSR VRIKKEVFDD
2060 2070 2080 2090 2100
GDYALQHQQM GQAASQSQIY MVDSSNEPTT LDYQQPPQLD FQQVQEMEQL
2110 2120
QHQVMPPMQS EQLQQQQTPQ GDNDYAWTF
Length:2,129
Mass (Da):239,315
Last modified:July 19, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BF505E5A3EFF160
GO
Isoform A (identifier: P51123-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1805-1837: Missing.
     1904-1934: Missing.

Show »
Length:2,065
Mass (Da):232,222
Checksum:i221BAAC465AB224A
GO
Isoform C (identifier: P51123-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1904-1934: Missing.

Show »
Length:2,098
Mass (Da):235,978
Checksum:i7656922A4291CA4B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JJ72E1JJ72_DROME
Transcription initiation factor TFI...
Taf1 230, BG:DS00004.13, cel, cell, d230
2,096Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LGU9A0A0B4LGU9_DROME
Transcription initiation factor TFI...
Taf1 230, BG:DS00004.13, cel, cell, d230
2,097Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K602A0A0B4K602_DROME
TBP-associated factor 1, isoform E
Taf1 230, BG:DS00004.13, cel, cell, d230
2,172Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98E → G in AAB26991 (PubMed:8504928).Curated1
Sequence conflicti113E → EERE AA sequence (PubMed:8504928).Curated1
Sequence conflicti169E → D in AAO47866 (PubMed:12537569).Curated1
Sequence conflicti267 – 268KR → QS in AAB26991 (PubMed:8504928).Curated2
Sequence conflicti361M → I in AAB26991 (PubMed:8504928).Curated1
Sequence conflicti386P → Q in AAB26991 (PubMed:8504928).Curated1
Sequence conflicti656 – 657KL → NV in AAB26991 (PubMed:8504928).Curated2
Sequence conflicti670 – 671HG → QR (PubMed:8464492).Curated2
Sequence conflicti762F → Y in AAB26991 (PubMed:8504928).Curated1
Sequence conflicti932A → G (PubMed:8464492).Curated1
Sequence conflicti966L → M (PubMed:8464492).Curated1
Sequence conflicti1088M → I in AAO47866 (PubMed:12537569).Curated1
Sequence conflicti1420D → G (PubMed:8464492).Curated1
Sequence conflicti1437P → G (PubMed:8464492).Curated1
Sequence conflicti1462K → E in AAO47866 (PubMed:12537569).Curated1
Sequence conflicti1472V → G (PubMed:8464492).Curated1
Sequence conflicti1487R → G (PubMed:8464492).Curated1
Sequence conflicti1525 – 1526RQ → AKGGTRVARC (PubMed:8464492).Curated2
Sequence conflicti1534M → N (PubMed:8464492).Curated1
Sequence conflicti1611L → LG (PubMed:8464492).Curated1
Sequence conflicti1680K → E in AAO47866 (PubMed:12537569).Curated1
Sequence conflicti1685I → IRYTKFSKKI (PubMed:8464492).Curated1
Sequence conflicti2072V → G (PubMed:8464492).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti572P → S. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0147941805 – 1837Missing in isoform A. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_0147951904 – 1934Missing in isoform A and isoform C. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S61883 mRNA Translation: AAB26991.2
AE001572 Genomic DNA Translation: AAD19815.1
AE014297 Genomic DNA Translation: AAF54102.3
AE014297 Genomic DNA Translation: AAS65116.1
AE014297 Genomic DNA Translation: AAS65117.1
BT004888 mRNA Translation: AAO47866.1

Protein sequence database of the Protein Information Resource

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PIRi
A47371

NCBI Reference Sequences

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RefSeqi
NP_476956.3, NM_057608.5 [P51123-2]
NP_996159.1, NM_206437.2 [P51123-3]
NP_996160.1, NM_206438.2 [P51123-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081684; FBpp0081184; FBgn0010355 [P51123-2]
FBtr0081685; FBpp0089369; FBgn0010355 [P51123-1]
FBtr0081686; FBpp0089420; FBgn0010355 [P51123-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40813

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17603

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S61883 mRNA Translation: AAB26991.2
AE001572 Genomic DNA Translation: AAD19815.1
AE014297 Genomic DNA Translation: AAF54102.3
AE014297 Genomic DNA Translation: AAS65116.1
AE014297 Genomic DNA Translation: AAS65117.1
BT004888 mRNA Translation: AAO47866.1
PIRiA47371
RefSeqiNP_476956.3, NM_057608.5 [P51123-2]
NP_996159.1, NM_206437.2 [P51123-3]
NP_996160.1, NM_206438.2 [P51123-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TBANMR-A11-77[»]
SMRiP51123
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi66011, 26 interactors
DIPiDIP-228N
IntActiP51123, 16 interactors
MINTiP51123
STRINGi7227.FBpp0293442

PTM databases

iPTMnetiP51123

Proteomic databases

PaxDbiP51123
PRIDEiP51123

Genome annotation databases

EnsemblMetazoaiFBtr0081684; FBpp0081184; FBgn0010355 [P51123-2]
FBtr0081685; FBpp0089369; FBgn0010355 [P51123-1]
FBtr0081686; FBpp0089420; FBgn0010355 [P51123-3]
GeneIDi40813
KEGGidme:Dmel_CG17603

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6872
FlyBaseiFBgn0010355 Taf1

Phylogenomic databases

eggNOGiKOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA
GeneTreeiENSGT00940000155242
InParanoidiP51123
KOiK03125
OMAiKACPLYT
PhylomeDBiP51123

Enzyme and pathway databases

ReactomeiR-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
R-DME-73776 RNA Polymerase II Promoter Escape
R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953 RNA Polymerase II Transcription Initiation
R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
40813 1 hit in 5 CRISPR screens
EvolutionaryTraceiP51123

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40813

Protein Ontology

More...
PROi
PR:P51123

Gene expression databases

BgeeiFBgn0010355 Expressed in eye disc (Drosophila) and 28 other tissues
ExpressionAtlasiP51123 baseline and differential
GenevisibleiP51123 DM

Family and domain databases

DisProtiDP00081
Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR040240 TAF1
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
IPR041670 Znf-CCHC_6
PANTHERiPTHR13900 PTHR13900, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PF15288 zf-CCHC_6, 1 hit
PIRSFiPIRSF003047 TAF1_animal, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00384 AT_hook, 2 hits
SM00297 BROMO, 2 hits
SUPFAMiSSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51123
Secondary accession number(s): O97068
, Q7KSX6, Q7KSX7, Q86LF7, Q9TX96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 19, 2005
Last modified: June 17, 2020
This is version 192 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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