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Protein

Fragile X mental retardation syndrome-related protein 2

Gene

FXR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mRNA 3'-UTR binding Source: GO_Central
  • mRNA binding Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: UniProtKB
  • translation regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FXR2
Synonyms:FMR1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000129245.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4024 FXR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605339 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51116

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9513

Open Targets

More...
OpenTargetsi
ENSG00000129245

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28440

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FXR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90177782

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000501101 – 673Fragile X mental retardation syndrome-related protein 2Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphotyrosineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei411PhosphothreonineCombined sources1
Modified residuei450PhosphoserineBy similarity1
Modified residuei453PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei598PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P51116

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P51116

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51116

PeptideAtlas

More...
PeptideAtlasi
P51116

PRoteomics IDEntifications database

More...
PRIDEi
P51116

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56281

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P51116

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51116

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51116

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P51116

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129245 Expressed in 233 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_FXR2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P51116 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51116 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011205
HPA022997

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FMR1 (PubMed:7489725, PubMed:8668200, PubMed:11157796). Interacts with FXR1 (PubMed:7489725). Interacts with TDRD3 (PubMed:18664458). Interacts with HABP4 (PubMed:21771594). Interacts with CYFIP2 but not with CYFIP1 (By similarity).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114890, 140 interactors

Protein interaction database and analysis system

More...
IntActi
P51116, 121 interactors

Molecular INTeraction database

More...
MINTi
P51116

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000250113

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P51116

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51116

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P51116

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 60Agenet-like 1PROSITE-ProRule annotationAdd BLAST47
Domaini73 – 125Agenet-like 2PROSITE-ProRule annotationAdd BLAST53
Domaini232 – 261KH 1PROSITE-ProRule annotationAdd BLAST30
Domaini295 – 324KH 2PROSITE-ProRule annotationAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi414 – 418Poly-Ser5
Compositional biasi544 – 552Poly-Arg9
Compositional biasi584 – 594Poly-ArgAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FMR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF9J Eukaryota
ENOG410ZDJG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293377

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005739

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51116

KEGG Orthology (KO)

More...
KOi
K15516

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTTRTYG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08EZ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51116

TreeFam database of animal gene trees

More...
TreeFami
TF105427

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008395 Agenet-like_dom
IPR040148 FMR1
IPR022034 FXMRP1_C_core
IPR032172 FXR_C1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10603 PTHR10603, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05641 Agenet, 1 hit
PF12235 FXMRP1_C_core, 1 hit
PF16096 FXR_C1, 1 hit
PF00013 KH_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00322 KH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54791 SSF54791, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51641 AGENET_LIKE, 2 hits
PS50084 KH_TYPE_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P51116-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER
60 70 80 90 100
QIPFGDVRLP PPADYNKEIT EGDEVEVYSR ANEQEPCGWW LARVRMMKGD
110 120 130 140 150
FYVIEYAACD ATYNEIVTLE RLRPVNPNPL ATKGSFFKVT MAVPEDLREA
160 170 180 190 200
CSNENVHKEF KKALGANCIF LNITNSELFI LSTTEAPVKR ASLLGDMHFR
210 220 230 240 250
SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM GLAIGTHGAN
260 270 280 290 300
IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR
310 320 330 340 350
NLVGKVIGKN GKVIQEIVDK SGVVRVRVEG DNDKKNPREE GMVPFIFVGT
360 370 380 390 400
RENISNAQAL LEYHLSYLQE VEQLRLERLQ IDEQLRQIGL GFRPPGSGRG
410 420 430 440 450
SGGSDKAGYS TDESSSSSLH ATRTYGGSYG GRGRGRRTGG PAYGPSSDVS
460 470 480 490 500
TASETESEKR EEPNRAGPGD RDPPTRGEES RRRPTGGRGR GPPPAPRPTS
510 520 530 540 550
RYNSSSISSV LKDPDSNPYS LLDTSEPEPP VDSEPGEPPP ASARRRRSRR
560 570 580 590 600
RRTDEDRTVM DGGLESDGPN MTENGLEDES RPQRRNRSRR RRNRGNRTDG
610 620 630 640 650
SISGDRQPVT VADYISRAES QSRQRPPLER TKPSEDSLSG QKGDSVSKLP
660 670
KGPSENGELS APLELGSMVN GVS
Length:673
Mass (Da):74,223
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8A498C3F634D41F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1Z2I3L1Z2_HUMAN
Fragile X mental retardation syndro...
FXR2
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti625 – 626RP → SA in AAC50292 (PubMed:7489725).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067039252Q → H1 PublicationCorresponds to variant dbSNP:rs17854734Ensembl.1
Natural variantiVAR_055979591R → P. Corresponds to variant dbSNP:rs36013555Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U31501 mRNA Translation: AAC50292.1
BT009817 mRNA Translation: AAP88819.1
AK313836 mRNA Translation: BAG36569.1
CH471108 Genomic DNA Translation: EAW90154.1
CH471108 Genomic DNA Translation: EAW90155.1
BC020090 mRNA Translation: AAH20090.1
BC051907 mRNA Translation: AAH51907.1
BC067272 mRNA Translation: AAH67272.1
AF044263 Genomic DNA Translation: AAC03357.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45604.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S60173

NCBI Reference Sequences

More...
RefSeqi
NP_004851.2, NM_004860.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.52788

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000250113; ENSP00000250113; ENSG00000129245

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9513

UCSC genome browser

More...
UCSCi
uc002gia.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31501 mRNA Translation: AAC50292.1
BT009817 mRNA Translation: AAP88819.1
AK313836 mRNA Translation: BAG36569.1
CH471108 Genomic DNA Translation: EAW90154.1
CH471108 Genomic DNA Translation: EAW90155.1
BC020090 mRNA Translation: AAH20090.1
BC051907 mRNA Translation: AAH51907.1
BC067272 mRNA Translation: AAH67272.1
AF044263 Genomic DNA Translation: AAC03357.1
CCDSiCCDS45604.1
PIRiS60173
RefSeqiNP_004851.2, NM_004860.3
UniGeneiHs.52788

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H8ZX-ray1.92A13-136[»]
ProteinModelPortaliP51116
SMRiP51116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114890, 140 interactors
IntActiP51116, 121 interactors
MINTiP51116
STRINGi9606.ENSP00000250113

PTM databases

CarbonylDBiP51116
iPTMnetiP51116
PhosphoSitePlusiP51116
SwissPalmiP51116

Polymorphism and mutation databases

BioMutaiFXR2
DMDMi90177782

Proteomic databases

EPDiP51116
MaxQBiP51116
PaxDbiP51116
PeptideAtlasiP51116
PRIDEiP51116
ProteomicsDBi56281

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9513
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250113; ENSP00000250113; ENSG00000129245
GeneIDi9513
KEGGihsa:9513
UCSCiuc002gia.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9513
DisGeNETi9513
EuPathDBiHostDB:ENSG00000129245.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FXR2
HGNCiHGNC:4024 FXR2
HPAiCAB011205
HPA022997
MIMi605339 gene
neXtProtiNX_P51116
OpenTargetsiENSG00000129245
PharmGKBiPA28440

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF9J Eukaryota
ENOG410ZDJG LUCA
GeneTreeiENSGT00940000153851
HOGENOMiHOG000293377
HOVERGENiHBG005739
InParanoidiP51116
KOiK15516
OMAiHTTRTYG
OrthoDBiEOG091G08EZ
PhylomeDBiP51116
TreeFamiTF105427

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FXR2 human
EvolutionaryTraceiP51116

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FXR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9513

Protein Ontology

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PROi
PR:P51116

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000129245 Expressed in 233 organ(s), highest expression level in apex of heart
CleanExiHS_FXR2
ExpressionAtlasiP51116 baseline and differential
GenevisibleiP51116 HS

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR008395 Agenet-like_dom
IPR040148 FMR1
IPR022034 FXMRP1_C_core
IPR032172 FXR_C1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PANTHERiPTHR10603 PTHR10603, 1 hit
PfamiView protein in Pfam
PF05641 Agenet, 1 hit
PF12235 FXMRP1_C_core, 1 hit
PF16096 FXR_C1, 1 hit
PF00013 KH_1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS51641 AGENET_LIKE, 2 hits
PS50084 KH_TYPE_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFXR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51116
Secondary accession number(s): B2R9M2
, D3DTQ1, Q86V09, Q8WUM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 7, 2006
Last modified: December 5, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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