FXR1

Functionⁱ

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity).By similarity

GO - Molecular functionⁱ

mRNA 3'-UTR binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7489725
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7489725
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
RNA strand annealing activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17057366
translation regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 9642279
cell differentiation Source: UniProtKB-KW
muscle organ development Source: UniProtKB-KW
negative regulation of translation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of gene silencing by miRNA
Source: UniProtKB
Inferred from direct assayⁱ
- 17057366
positive regulation of translation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mRNA stability
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, RNA-binding
Biological process	Differentiation, Myogenesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6802952 Signaling by BRAF and RAF fusions

Reactomeⁱ

R-HSA-6802952 Signaling by BRAF and RAF fusions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fragile X mental retardation syndrome-related protein 1 Short name: hFXR1p
Gene namesⁱ	Name:FXR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114416.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4023 FXR1
MIMⁱ	600819 gene
neXtProtⁱ	NX_P51114

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8087
Open Targets More...OpenTargetsⁱ	ENSG00000114416
PharmGKBⁱ	PA28439

Chemistry databases

ChEMBLⁱ	CHEMBL3879858

ChEMBLⁱ

CHEMBL3879858

Polymorphism and mutation databases

BioMutaⁱ	FXR1
DMDMⁱ	189047132

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000050106	2 – 621	Fragile X mental retardation syndrome-related protein 1Add BLAST		620

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Cross-linkⁱ	56	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	68	PhosphotyrosineBy similarity	1
Modified residueⁱ	401	PhosphothreonineCombined sources	1
Modified residueⁱ	403	PhosphoserineBy similarity	1
Modified residueⁱ	406	PhosphoserineCombined sources	1
Modified residueⁱ	409	PhosphoserineCombined sources	1
Modified residueⁱ	420	PhosphoserineCombined sources	1
Modified residueⁱ	423	PhosphoserineCombined sources	1
Modified residueⁱ	432	PhosphoserineCombined sources	1
Modified residueⁱ	483	PhosphothreonineBy similarity	1
Modified residueⁱ	485	PhosphoserineCombined sources	1
Modified residueⁱ	524	PhosphoserineBy similarity	1
Modified residueⁱ	587	PhosphoserineCombined sources	1
Modified residueⁱ	611	PhosphothreonineCombined sources	1
Isoform 2 (identifier: P51114-2)
Modified residueⁱ	524	PhosphoserineCombined sources	1
Modified residueⁱ	528	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Arg-445 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P51114
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51114
PaxDbⁱ	P51114
PeptideAtlas More...PeptideAtlasⁱ	P51114
PRIDEⁱ	P51114
ProteomicsDBⁱ	56278 56279 [P51114-2] 56280 [P51114-3]

PTM databases

iPTMnetⁱ	P51114
PhosphoSitePlusⁱ	P51114

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues examined including heart, brain, kidney and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000114416 Expressed in 232 organ(s), highest expression level in testis
CleanExⁱ	HS_FXR1
ExpressionAtlasⁱ	P51114 baseline and differential
Genevisibleⁱ	P51114 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018246 HPA055475

HPAⁱ

HPA018246
HPA055475

Interactionⁱ

Subunit structureⁱ

Interacts with FMR1 (PubMed:8668200, PubMed:7489725, PubMed:11157796). Interacts with FRX2 (PubMed:7489725). Interacts with TDRD3 (PubMed:18664458). Interacts with HABP4 (PubMed:21771594). Interacts with CYFIP2 but not with CYFIP1 (By similarity).By similarity5 Publications

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7489725
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7489725

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113760, 87 interactors
CORUMⁱ	P51114
Database of interacting proteins More...DIPⁱ	DIP-40789N
IntActⁱ	P51114, 85 interactors
Molecular INTeraction database More...MINTⁱ	P51114
STRINGⁱ	9606.ENSP00000350170

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 9	Combined sources	5
Beta strandⁱ	15 – 23	Combined sources	9
Beta strandⁱ	28 – 34	Combined sources	7
Beta strandⁱ	40 – 42	Combined sources	3
Helixⁱ	44 – 46	Combined sources	3
Beta strandⁱ	64 – 69	Combined sources	6
Beta strandⁱ	78 – 88	Combined sources	11
Beta strandⁱ	91 – 95	Combined sources	5
Beta strandⁱ	104 – 108	Combined sources	5
Helixⁱ	109 – 111	Combined sources	3
Beta strandⁱ	112 – 114	Combined sources	3
Beta strandⁱ	213 – 216	Combined sources	4
Beta strandⁱ	218 – 224	Combined sources	7
Helixⁱ	227 – 234	Combined sources	8
Helixⁱ	239 – 245	Combined sources	7
Beta strandⁱ	250 – 256	Combined sources	7
Turnⁱ	257 – 260	Combined sources	4
Beta strandⁱ	261 – 268	Combined sources	8
Helixⁱ	269 – 279	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P51114
SMRⁱ	P51114
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P51114

EvolutionaryTraceⁱ

P51114

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	4 – 50	Agenet-like 1PROSITE-ProRule annotationAdd BLAST	47
Domainⁱ	63 – 115	Agenet-like 2PROSITE-ProRule annotationAdd BLAST	53
Domainⁱ	222 – 251	KH 1PROSITE-ProRule annotationAdd BLAST	30
Domainⁱ	285 – 314	KH 2PROSITE-ProRule annotationAdd BLAST	30

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	442 – 457	RNA-binding RGG-boxAdd BLAST		16

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	50 – 53	Poly-Pro		4
Compositional biasⁱ	502 – 510	Poly-Arg		9

Domainⁱ

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.1 Publication

Sequence similaritiesⁱ

Belongs to the FMR1 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IF9J Eukaryota ENOG410ZDJG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017033
HOGENOMⁱ	HOG000293377
HOVERGENⁱ	HBG005739
InParanoidⁱ	P51114
KEGG Orthology (KO) More...KOⁱ	K15516
OMAⁱ	DACANEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08EZ
PhylomeDBⁱ	P51114
TreeFamⁱ	TF105427

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 2 hits
InterProⁱ	View protein in InterPro IPR008395 Agenet-like_dom IPR022034 FXMRP1_C_core IPR032172 FXR_C1 IPR032177 FXR_C3 IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05641 Agenet, 2 hits PF12235 FXMRP1_C_core, 2 hits PF16096 FXR_C1, 1 hit PF16097 FXR_C3, 1 hit PF00013 KH_1, 2 hits
SMARTⁱ	View protein in SMART SM00322 KH, 2 hits
SUPFAMⁱ	SSF54791 SSF54791, 2 hits
PROSITEⁱ	View protein in PROSITE PS51641 AGENET_LIKE, 2 hits PS50084 KH_TYPE_1, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Alternative splicing appears to be tissue-specific.

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P51114-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP 
        60         70         80         90        100
PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD 
       110        120        130        140        150
ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF 
       160        170        180        190        200
KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS 
       210        220        230        240        250
RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV 
       260        270        280        290        300
TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 
       310        320        330        340        350
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL 
       360        370        380        390        400
LEYHIAYLKE VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG 
       410        420        430        440        450
TNSELSNPSE TESERKDELS DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS 
       460        470        480        490        500
GGRGRGGPRG GKSSISSVLK DPDSNPYSLL DNTESDQTAD TDASESHHST 
       510        520        530        540        550
NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY ISRAESQSRQ 
       560        570        580        590        600
RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDD ISKLQRTPGE 
       610        620 
EKINTLKEEN TQEAAVLNGV S

Length:621

Mass (Da):69,721

Last modified:May 20, 2008 - v3

Checksum:ⁱ0474A9B593C7C228

GO

Isoform 2 (identifier: P51114-2) [UniParc]FASTA Add to basket

Also known as: b, Short

The sequence of this isoform differs from the canonical sequence as follows:
535-539: VTVAD → GKRCD
540-621: Missing.

« Hide

        10         20         30         40         50
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP 
        60         70         80         90        100
PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD 
       110        120        130        140        150
ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF 
       160        170        180        190        200
KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS 
       210        220        230        240        250
RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV 
       260        270        280        290        300
TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 
       310        320        330        340        350
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL 
       360        370        380        390        400
LEYHIAYLKE VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG 
       410        420        430        440        450
TNSELSNPSE TESERKDELS DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS 
       460        470        480        490        500
GGRGRGGPRG GKSSISSVLK DPDSNPYSLL DNTESDQTAD TDASESHHST 
       510        520        530 
NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLGKRCD

Show »

Length:539

Mass (Da):60,792

Checksum:ⁱ7D9452D150FC9EE7

GO

Isoform 3 (identifier: P51114-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-85: Missing.

« Hide

        10         20         30         40         50
MMKGEFYVIE YAACDATYNE IVTFERLRPV NQNKTVKKNT FFKCTVDVPE 
        60         70         80         90        100
DLREACANEN AHKDFKKAVG ACRIFYHPET TQLMILSASE ATVKRVNILS 
       110        120        130        140        150
DMHLRSIRTK LMLMSRNEEA TKHLECTKQL AAAFHEEFVV REDLMGLAIG 
       160        170        180        190        200
THGSNIQQAR KVPGVTAIEL DEDTGTFRIY GESADAVKKA RGFLEFVEDF 
       210        220        230        240        250
IQVPRNLVGK VIGKNGKVIQ EIVDKSGVVR VRIEGDNENK LPREDGMVPF 
       260        270        280        290        300
VFVGTKESIG NVQVLLEYHI AYLKEVEQLR MERLQIDEQL RQIGSRSYSG 
       310        320        330        340        350
RGRGRRGPNY TSGYGTNSEL SNPSETESER KDELSDWSLA GEDDRDSRHQ 
       360        370        380        390        400
RDSRRRPGGR GRSVSGGRGR GGPRGGKSSI SSVLKDPDSN PYSLLDNTES 
       410        420        430        440        450
DQTADTDASE SHHSTNRRRR SRRRRTDEDA VLMDGMTESD TASVNENGLV 
       460        470        480        490        500
TVADYISRAE SQSRQRNLPR ETLAKNKKEM AKDVIEEHGP SEKAINGPTS 
       510        520        530 
ASGDDISKLQ RTPGEEKINT LKEENTQEAA VLNGVS

Note: No experimental confirmation available.

Show »

Length:536

Mass (Da):59,920

Checksum:ⁱ4E66F53C3A15BFF8

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7EU85	E7EU85_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	454	Annotation score:
B4DXZ6	B4DXZ6_HUMAN	cDNA FLJ58644, highly similar to Fr... cDNA FLJ58644, highly similar to Fragile X mental retardation syndrome-related protein 1	FXR1	608	Annotation score:
E9PFF5	E9PFF5_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	490	Annotation score:
H7C4S4	H7C4S4_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	246	Annotation score:
C9JAJ4	C9JAJ4_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	151	Annotation score:
C9JY20	C9JY20_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	123	Annotation score:
C9IZ22	C9IZ22_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	94	Annotation score:
C9J5B4	C9J5B4_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	75	Annotation score:
C9JZE0	C9JZE0_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	119	Annotation score:
C9JYQ6	C9JYQ6_HUMAN	Fragile X mental retardation syndro... Fragile X mental retardation syndrome-related protein 1	FXR1	19	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	3 – 4	EL → DV in AAC50155 (PubMed:7781595).Curated		2
Sequence conflictⁱ	27	S → P in BAF85322 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036050	233	A → T in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_016077	429	D → N1 PublicationCorresponds to variant dbSNP:rs1051080Ensembl.	1
Natural variantⁱVAR_014890	614	A → V. Corresponds to variant dbSNP:rs11499Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_019709	1 – 85	Missing in isoform 3. 1 PublicationAdd BLAST	85
Alternative sequenceⁱVSP_019710	535 – 539	VTVAD → GKRCD in isoform 2. 2 Publications	5
Alternative sequenceⁱVSP_019711	540 – 621	Missing in isoform 2. 2 PublicationsAdd BLAST	82

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25165 mRNA Translation: AAC50155.1 AY341428 mRNA Translation: AAQ20045.1 AK292633 mRNA Translation: BAF85322.1 BC028983 mRNA Translation: AAH28983.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3238.1 [P51114-1] CCDS33894.1 [P51114-3] CCDS46965.1 [P51114-2]
PIRⁱ	S55330
NCBI Reference Sequences More...RefSeqⁱ	NP_001013456.1, NM_001013438.2 [P51114-2] NP_001013457.1, NM_001013439.2 [P51114-3] NP_005078.2, NM_005087.3 [P51114-1]
UniGeneⁱ	Hs.478407

Genome annotation databases

Ensemblⁱ	ENST00000305586; ENSP00000307633; ENSG00000114416 [P51114-3] ENST00000357559; ENSP00000350170; ENSG00000114416 [P51114-1] ENST00000445140; ENSP00000388828; ENSG00000114416 [P51114-2]
GeneIDⁱ	8087
KEGGⁱ	hsa:8087
UCSC genome browser More...UCSCⁱ	uc003fkp.4 human [P51114-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51114	FMR1 autosomal homolog 1		MACMU		621	UniRef100_P51114
FXR1 isoform 1		PANTR		621
FMR1 autosomal homolog 1		PONAB		621
Uncharacterized protein		CERAT		621
Uncharacterized protein		RHIRO		621
+12
P51114-2	Fragile X mental retardation syndrome-related protein 1		HUMAN		454	UniRef100_E7EU85
FXR1 isoform 3		PANTR		539
FMR1 autosomal homolog 1		MACMU		539
FMR1 autosomal homolog 1		CALJA		539
fragile X mental retardation syndrome-related protein 1 isoform X8		ERIEU		539
+14

Protein	Similar proteins		Species	Score	Length	Source
P51114	Isoform G of Fragile X mental retardation syndrome-related protein 1		MOUSE		651	UniRef90_Q61584-7
Uncharacterized protein		PANTR		782
Uncharacterized protein		PANPA		782
Uncharacterized protein		MACFA		779
Uncharacterized protein		AOTNA		699
+115

Protein	Similar proteins		Species	Score	Length	Source
P51114	Isoform G of Fragile X mental retardation syndrome-related protein 1		MOUSE		651	UniRef50_Q61584-7
Fragile X mental retardation syndrome-related protein 1 homolog		XENTR		674
Fragile X mental retardation syndrome-related protein 1 homolog A		XENLA		676
Fragile X mental retardation syndrome-related protein 1		RAT		568
Fragile X mental retardation syndrome-related protein 1		BOVIN		621
+795

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25165 mRNA Translation: AAC50155.1 AY341428 mRNA Translation: AAQ20045.1 AK292633 mRNA Translation: BAF85322.1 BC028983 mRNA Translation: AAH28983.1
CCDSⁱ	CCDS3238.1 [P51114-1] CCDS33894.1 [P51114-3] CCDS46965.1 [P51114-2]
PIRⁱ	S55330
RefSeqⁱ	NP_001013456.1, NM_001013438.2 [P51114-2] NP_001013457.1, NM_001013439.2 [P51114-3] NP_005078.2, NM_005087.3 [P51114-1]
UniGeneⁱ	Hs.478407

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CPQ	NMR	-	A	212-289	[»]
	3KUF	X-ray	2.70	A	2-132	[»]
	3O8V	X-ray	2.50	A	2-132	[»]
ProteinModelPortalⁱ	P51114
SMRⁱ	P51114
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113760, 87 interactors
CORUMⁱ	P51114
DIPⁱ	DIP-40789N
IntActⁱ	P51114, 85 interactors
MINTⁱ	P51114
STRINGⁱ	9606.ENSP00000350170

Chemistry databases

ChEMBLⁱ	CHEMBL3879858

ChEMBLⁱ

CHEMBL3879858

PTM databases

iPTMnetⁱ	P51114
PhosphoSitePlusⁱ	P51114

Polymorphism and mutation databases

BioMutaⁱ	FXR1
DMDMⁱ	189047132

Proteomic databases

EPDⁱ	P51114
MaxQBⁱ	P51114
PaxDbⁱ	P51114
PeptideAtlasⁱ	P51114
PRIDEⁱ	P51114
ProteomicsDBⁱ	56278 56279 [P51114-2] 56280 [P51114-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8087
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000305586; ENSP00000307633; ENSG00000114416 [P51114-3] ENST00000357559; ENSP00000350170; ENSG00000114416 [P51114-1] ENST00000445140; ENSP00000388828; ENSG00000114416 [P51114-2]
GeneIDⁱ	8087
KEGGⁱ	hsa:8087
UCSCⁱ	uc003fkp.4 human [P51114-1]

Organism-specific databases

CTDⁱ	8087
DisGeNETⁱ	8087
EuPathDBⁱ	HostDB:ENSG00000114416.17
GeneCardsⁱ	FXR1
HGNCⁱ	HGNC:4023 FXR1
HPAⁱ	HPA018246 HPA055475
MIMⁱ	600819 gene
neXtProtⁱ	NX_P51114
OpenTargetsⁱ	ENSG00000114416
PharmGKBⁱ	PA28439
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF9J Eukaryota ENOG410ZDJG LUCA
GeneTreeⁱ	ENSGT00390000017033
HOGENOMⁱ	HOG000293377
HOVERGENⁱ	HBG005739
InParanoidⁱ	P51114
KOⁱ	K15516
OMAⁱ	DACANEN
OrthoDBⁱ	EOG091G08EZ
PhylomeDBⁱ	P51114
TreeFamⁱ	TF105427

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6802952 Signaling by BRAF and RAF fusions

Reactomeⁱ

R-HSA-6802952 Signaling by BRAF and RAF fusions

Miscellaneous databases

ChiTaRSⁱ	FXR1 human
EvolutionaryTraceⁱ	P51114
GeneWikiⁱ	FXR1
GenomeRNAiⁱ	8087
Protein Ontology More...PROⁱ	PR:P51114
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114416 Expressed in 232 organ(s), highest expression level in testis
CleanExⁱ	HS_FXR1
ExpressionAtlasⁱ	P51114 baseline and differential
Genevisibleⁱ	P51114 HS

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 2 hits
InterProⁱ	View protein in InterPro IPR008395 Agenet-like_dom IPR022034 FXMRP1_C_core IPR032172 FXR_C1 IPR032177 FXR_C3 IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf
Pfamⁱ	View protein in Pfam PF05641 Agenet, 2 hits PF12235 FXMRP1_C_core, 2 hits PF16096 FXR_C1, 1 hit PF16097 FXR_C3, 1 hit PF00013 KH_1, 2 hits
SMARTⁱ	View protein in SMART SM00322 KH, 2 hits
SUPFAMⁱ	SSF54791 SSF54791, 2 hits
PROSITEⁱ	View protein in PROSITE PS51641 AGENET_LIKE, 2 hits PS50084 KH_TYPE_1, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FXR1_HUMAN
Accessionⁱ	P51114Primary (citable) accession number: P51114 Secondary accession number(s): A8K9B8, Q7Z450, Q8N6R8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	May 20, 2008
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P51114 (FXR1_HUMAN)

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Fragile X mental retardation syndrome-related protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ