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Entry version 141 (17 Jun 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Huntingtin

Gene

Htt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in microtubule-mediated transport or vesicle function.By similarity
Promotes the formation of autophagic vesicles.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Huntingtin
Alternative name(s):
Huntington disease protein homolog
Short name:
HD protein homolog
Cleaved into the following chain:
Huntingtin, myristoylated N-terminal fragmentBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Htt
Synonyms:Hd, Hdh
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
68337 Htt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2439943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000839441 – 3110HuntingtinAdd BLAST3110
ChainiPRO_0000447488522 – 555Huntingtin, myristoylated N-terminal fragmentBy similarityAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N6-acetyllysineBy similarity1
Modified residuei146N6-acetyllysineBy similarity1
Modified residuei204N6-acetyllysineBy similarity1
Modified residuei313N6-acetyllysineBy similarity1
Modified residuei387PhosphoserineBy similarity1
Modified residuei389PhosphoserineBy similarity1
Modified residuei402PhosphoserineCombined sources1
Modified residuei412N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi522N-myristoyl glycineBy similarity1
Modified residuei611PhosphoserineBy similarity1
Modified residuei614PhosphoserineBy similarity1
Modified residuei1150Phosphoserine; by CDK5By similarity1
Modified residuei1170Phosphoserine; by CDK5By similarity1
Modified residuei1845PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-1150 and Ser-1170 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.By similarity
Cleaved by caspases downstream of the polyglutamine stretch.By similarity
Myristoylated at Gly-522, following proteolytic cleavage at Asp-521.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei482 – 483Cleavage; by caspase-3By similarity2
Sitei499 – 500Cleavage; by caspase-3Sequence analysis2
Sitei521 – 522Cleavage; by caspase-3By similarity2
Sitei555 – 556Cleavage; by caspase-6By similarity2

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P51111

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51111

PeptideAtlas

More...
PeptideAtlasi
P51111

PRoteomics IDEntifications database

More...
PRIDEi
P51111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51111

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51111

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed to a high degree in all the regions of the brain of adults and in meiotic cells of the testis. In addition, very low levels are detected in various non-neuronal tissues (heart, muscle, liver, lung and kidney).

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Identified at high levels in neuronal tissues of embryos as early as day 14.5. This expression remains constant in all further development stages (up to the adult). On the other hand the expression in non-neuronal tissues is down-regulated from stage 17.5 day old embryos.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PFN1.

Interacts through its N-terminus with PRPF40A.

Interacts with PQBP1.

Interacts with SETD2.

Interacts with SH3GLB1.

Interacts with SYVN.

Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch.

Interacts with ZDHHC13 (via ANK repeats).

Interacts with ZDHHC17 (via ANK repeats).

Interacts with F8A1/F8A2/F8A3 (By similarity).

Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P51111

Protein interaction database and analysis system

More...
IntActi
P51111, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000054971

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati174 – 211HEAT 1Add BLAST38
Repeati216 – 253HEAT 2Add BLAST38
Repeati773 – 810HEAT 3Add BLAST38
Repeati873 – 911HEAT 4Add BLAST39
Repeati1395 – 1432HEAT 5Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni462 – 473Interaction with ZDHHC17By similarityAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2363 – 2372Nuclear export signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 18Poly-Gln8
Compositional biasi19 – 38Poly-ProAdd BLAST20
Compositional biasi42 – 51Poly-Pro10
Compositional biasi1408 – 1411Poly-Thr4
Compositional biasi2606 – 2611Poly-Glu6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the huntingtin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDZV Eukaryota
ENOG410XSEC LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51111

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51111

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat

The PANTHER Classification System

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PANTHERi
PTHR10170 PTHR10170, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12372 DUF3652, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00375 HUNTINGTIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P51111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAFESLKSF QQQQQQQQPP PQPPPPPPPP PQPPQPPPQG QPPPPPPLPG
60 70 80 90 100
PAEEPLHRPK KELSATKKDR VNHCLTICEN IVAQSLRNSP EFQKLLGIAM
110 120 130 140 150
ELFLLCSDDA SRRRMVADEC LNKVIKALMD SNLPRLQLEL YKEIKKNGAP
160 170 180 190 200
RSLRAALWRF AELAHLVRPQ KCRPYLVNLL PCLTRTSKRP EESVQETLAA
210 220 230 240 250
AVPKIMASFG NFANDNEIKV LLKAFIANLK SSSPTVRRTA AGSAVSICQH
260 270 280 290 300
SRRTQYFYNW LLNVLLGLLV PMEEDHPTLL ILGVLLTLRC LVPLLQQQVK
310 320 330 340 350
DTSLKGSFGV TRKEMEVSPS AEQLVQVYEL TLHHTQHQDH NVVTGALELL
360 370 380 390 400
QQLFRTPPPE LLQALTTPGG LGQLTLVREE AGGRGRSGSI VELLAGGGSS
410 420 430 440 450
CSPVLSRKQK GKVLLGEEEA LEDDSESRSD VSSSAFAASV KSEIGGELAA
460 470 480 490 500
SSSGVSTPGS VGHDIITEQP RSQHTLQADS VDLSGCDLTS AATDGDEEDI
510 520 530 540 550
LSHSSSQFSA VPSDPAMDLN DGTQASSPIS DSSQTTTEGP DSAVTPSDSS
560 570 580 590 600
EIVLDGADSQ YLGVQIGQPQ EEDREAAGVL SGEVSDVFRN SSLALQQAHL
610 620 630 640 650
LERMGHSRQP SDSSVDKFVS KDEVAEAGDP ESKPCRIKGD IGQPNDDDSA
660 670 680 690 700
PLVHCVRLLS ASFLLTGEKK ALVPDRDVRV SVKALALSCI GAAVALHPES
710 720 730 740 750
FFSKLYKVPL STMESTEEQY VSDILNYIDH GDPQVRGATA ILCGTLVYSI
760 770 780 790 800
LSRSRLRVGD WLGTIRALTG NTFSLVDCIP LLQKTLKDES SVTCKLACTA
810 820 830 840 850
VRHCVLSLCS SSYSDLGLQL LIDMLPLKNS SYWLVRTELL ETLAEIDFRL
860 870 880 890 900
VSFLEAKAES LHRGPHHYTG FLKLQERVLN NVVIYLLGDE DPRVRHVAAT
910 920 930 940 950
TLTRLVPKLF YKCDQGQADP VEAVARDQSS VYLKLLMHET QPPSHFSVST
960 970 980 990 1000
ITRIYRGYSL LPSVTDVTME NNLSRVVAAV SHELITSTTR ALTFGCCEAL
1010 1020 1030 1040 1050
CVLSAAFPVC TWSLGWHCGV PPLSASDESR KSCTVGMASM ILTLLSSAWF
1060 1070 1080 1090 1100
PLDLSAIQDA LILAGNLLAA SAPKSLRSSW ASEEEGSSAA TRQEEIWPAL
1110 1120 1130 1140 1150
GDRTLVPMVE QLFSHLLKVI NICAHVLDDE TPGPAIKAAL PSLTNPPSLS
1160 1170 1180 1190 1200
PIRRKGKEKE PGEQTSTPMS PKKGGEASTA SRQSDTSGPV TASKSSSLGS
1210 1220 1230 1240 1250
FYHLPSYLRL HDVLKATHAN YKVTLDLQNS TEKFGGFLRS ALDVLSQILE
1260 1270 1280 1290 1300
LATLQDIGKC VEEVLGYLKS CFSREPMMAT VCVQQLLKTL FGTNLASQFD
1310 1320 1330 1340 1350
GLSSNPSKSQ CRAQRLGSSS VRPGLYHYCF MAPYTHFTQA LADASLRNMV
1360 1370 1380 1390 1400
QADQEHDASG WFDVLQKVSA QLKTNLTSVT KNRADKNAIH NHIRLFEPLV
1410 1420 1430 1440 1450
IKALKQYTTT TSVQLQKQVL DLLAQLVQLR VNYCLLDSDQ VFIGFVLKQF
1460 1470 1480 1490 1500
EYIEVGQFRE SEAIIPNIFF FLVLLSYERY HSKQIIGIPK IIQLCDGIMA
1510 1520 1530 1540 1550
SGRKAVTHAI PALQPIVHDL FVLRGTNKAD AGKELETQKE VVVSMLLRLI
1560 1570 1580 1590 1600
QYHQVLEMFI LVLQQCHKEN EDKWKRLSRQ VADIILPMLA KQQMHIDSHE
1610 1620 1630 1640 1650
ALGVLNTLFE ILAPSSLRPV DMLLRSMFIT PSTMASVSTV QLWISGILAI
1660 1670 1680 1690 1700
LRVLISQSTE DIVLSRIQEL SFSPYLISCP VINRLRDGDS NPTLGERSRG
1710 1720 1730 1740 1750
KQVKNLPEDT FSRFLLQLVG ILLEDIVTKQ LKVDMSEQQH TFYCQELGTL
1760 1770 1780 1790 1800
LMCLIHIFKS GMFRRITAAA TRLFTSDGCE GSFYTLDSLN ARVRAMVPTH
1810 1820 1830 1840 1850
PALVLLWCQI LLLINHTDHR WWAEVQQTPK RHSLSCTKSL NPQISAEEDS
1860 1870 1880 1890 1900
GSAAQLGMCN REIVRRGALI LFCDYVCQNL HDSEHLTWLI VNHIQDLISL
1910 1920 1930 1940 1950
SHEPPVQDFI SAIHRNSAAS GLFIQAIQSR CENLSTPTTL KKTLQCLEGI
1960 1970 1980 1990 2000
HLSQSGAVLT LYVDRLLGTP FRALARMVDT LACRRVEMLL AANLQSSMAQ
2010 2020 2030 2040 2050
LPEEELNRIQ EHLQNTGLAQ RHQRLYSLLD RFRLSTVQDS LSPLPPVTSH
2060 2070 2080 2090 2100
PLDGDGHTSL ETVNPDKDWY LQLVRSQCWT RSDSALLEGA ELVNRIPAED
2110 2120 2130 2140 2150
MSDFMMSSEF NLSLFAPCLS LGMSEIAGSQ KSPLFEAARR VTLDRVTNVV
2160 2170 2180 2190 2200
QQLPAVHQVF QPFLPTEPTA YWSKLNDLFG DTTSYQSLTT LARALAQYLV
2210 2220 2230 2240 2250
VLSKVPAPLH LPPEKEGHTV KFVVMTLEAL SWHLIHEQIP LSLDLQAGLD
2260 2270 2280 2290 2300
CCCLALQVPG LWGVLSSPEY VTHTCSLIHC VRFILEAIAV QPGDQLLGPE
2310 2320 2330 2340 2350
SRSHTPRAVR KEEVDSDIQN LSHITSACEM VADMVESLQS VLALGHKRNS
2360 2370 2380 2390 2400
TLPSFLTAVL KNIVVSLARL PLVNSYTRVP PLVWKLGWSP KPGGDFGTVF
2410 2420 2430 2440 2450
PEIPVEFLQE KEVLKEFIYR INTLGWTSRT QFEETWATLL GVLVTQPLVM
2460 2470 2480 2490 2500
EQEESPPEED TERTQIHVLA VQAITSLVLS AMAVPVAGNP AVSCLEQQPR
2510 2520 2530 2540 2550
NKPLKALDTR FGRKLSMIRG IVEQEIQEMV SQRENTATHH SHQAWDPVPS
2560 2570 2580 2590 2600
LLPATTGALI SHDKLLLQIN SEREPGNMSY KLGQVSIHSV WLGNNITPLR
2610 2620 2630 2640 2650
EEEWDEEEEE EADAPAPTSP PVSPVNSRKH RAGVDIHSCS QFLLELYSRW
2660 2670 2680 2690 2700
ILPSSAARRT PVILISEVVR SLLVVSDLFT DVPQFEMMYL TLTELRRVHP
2710 2720 2730 2740 2750
SEDEILIQYL VPATCKAAAV LGMDKTVAEP VSRLLESTLR STHLPSQIGA
2760 2770 2780 2790 2800
LHGILYVLEC DLLDDTVKQL IPVVSDYLLS NLKGIAHCVN IHSQQHVLVM
2810 2820 2830 2840 2850
CATAFYLMEN YPLDVGPEFS ASVIQMCGVM LSGSEESTPS VIYHCALRGL
2860 2870 2880 2890 2900
ERLLLSEQLS RLDTESLVKL SVDRVNVQSP HRAMAALGLM LTCMYTGKEK
2910 2920 2930 2940 2950
ASPGRASDPS PATPDSESVI VAMERVSVLF DRIRKGFPCE ARVVARILPQ
2960 2970 2980 2990 3000
FLDDFFPPQD VMNKVIGEFL SNQQPYPQFM ATVVYKVFQT LHSAGQSSMV
3010 3020 3030 3040 3050
RDWVMLSLSN FTQRTPVAMA MWSLSCFLVS ASTSPWVSAI LPHVISRMGK
3060 3070 3080 3090 3100
LEQVDVNLFC LVATDFYRHQ IEEEFDRRAF QSVFEVVAAP GSPYHRLLAC
3110
LQNVHKVTAC
Length:3,110
Mass (Da):343,762
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33C357E8FC141550
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V9P7G3V9P7_RAT
Huntingtin
Htt Hdh, rCG_36155
3,120Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-Gln region does not appear to be polymorphic, explaining the absence of a rodent HD-like disorder.1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U18650 mRNA Translation: AAA90987.1 Sequence problems.
U01022 mRNA Translation: AAC52133.1

Protein sequence database of the Protein Information Resource

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PIRi
S40522

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18650 mRNA Translation: AAA90987.1 Sequence problems.
U01022 mRNA Translation: AAC52133.1
PIRiS40522

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

CORUMiP51111
IntActiP51111, 1 interactor
STRINGi10116.ENSRNOP00000054971

Chemistry databases

ChEMBLiCHEMBL2439943

PTM databases

iPTMnetiP51111
PhosphoSitePlusiP51111

Proteomic databases

jPOSTiP51111
PaxDbiP51111
PeptideAtlasiP51111
PRIDEiP51111

Organism-specific databases

RGDi68337 Htt

Phylogenomic databases

eggNOGiENOG410IDZV Eukaryota
ENOG410XSEC LUCA
InParanoidiP51111
PhylomeDBiP51111

Miscellaneous databases

Protein Ontology

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PROi
PR:P51111

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat
PANTHERiPTHR10170 PTHR10170, 1 hit
PfamiView protein in Pfam
PF12372 DUF3652, 1 hit
PRINTSiPR00375 HUNTINGTIN
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHD_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51111
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 17, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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