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UniProtKB - P51110 (DFRA_VITVI)
Protein
Dihydroflavonol 4-reductase
Gene
DFR
Organism
Vitis vinifera (Grape)
Status
Functioni
Bifunctional enzyme involved in flavonoid metabolism.
By similarityCatalytic activityi
: anthocyanin biosynthesis Pathwayi
This protein is involved in the pathway anthocyanin biosynthesis, which is part of Pigment biosynthesis.View all proteins of this organism that are known to be involved in the pathway anthocyanin biosynthesis and in Pigment biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 37 | NADPCombined sources1 Publication | 1 | |
Binding sitei | 44 | NADPCombined sources1 Publication | 1 | |
Binding sitei | 128 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 133 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 163 | NADPBy similarity | 1 | |
Binding sitei | 163 | SubstrateCombined sources1 Publication | 1 | |
Active sitei | 167 | Proton donorBy similarity | 1 | |
Binding sitei | 167 | NADPCombined sources1 Publication | 1 | |
Binding sitei | 204 | Substrate; via carbonyl oxygenCombined sources1 Publication | 1 | |
Binding sitei | 205 | NADPCombined sources1 Publication | 1 | |
Binding sitei | 208 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 227 | SubstrateCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 18 | NADPCombined sources1 Publication | 7 | |
Nucleotide bindingi | 64 – 65 | NADPCombined sources1 Publication | 2 | |
Nucleotide bindingi | 84 – 86 | NADPCombined sources1 Publication | 3 | |
Nucleotide bindingi | 190 – 193 | NADPCombined sources1 Publication | 4 |
GO - Molecular functioni
- dihydrokaempferol 4-reductase activity Source: UniProtKB-EC
- flavanone 4-reductase activity Source: UniProtKB-EC
GO - Biological processi
- anthocyanin-containing compound biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Flavonoid biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
UniPathwayi | UPA00009 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DFR |
Organismi | Vitis vinifera (Grape) |
Taxonomic identifieri | 29760 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › Vitales › Vitaceae › Viteae › Vitis |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215572 | 1 – 337 | Dihydroflavonol 4-reductaseAdd BLAST | 337 |
Proteomic databases
PRIDEi | P51110 |
Expressioni
Inductioni
By light.
Gene expression databases
ExpressionAtlasi | P51110, baseline and differential |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P51110 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P51110 |
Family & Domainsi
Sequence similaritiesi
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1502, Eukaryota |
Family and domain databases
InterProi | View protein in InterPro IPR001509, Epimerase_deHydtase IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01370, Epimerase, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
P51110-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSQSETVCV TGASGFIGSW LVMRLLERRL TVRATVRDPT NVKKVKHLLD
60 70 80 90 100
LPKAETHLTL WKADLADEGS FDEAIKGCTG VFHVATPMDF ESKDPENEVI
110 120 130 140 150
KPTIEGMLGI MKSCAAAKTV RRLVFTSSAG TVNIQEHQLP VYDESCWSDM
160 170 180 190 200
EFCRAKKMTA WMYFVSKTLA EQAAWKYAKE NNIDFITIIP TLVVGPFIMS
210 220 230 240 250
SMPPSLITAL SPITGNEAHY SIIRQGQFVH LDDLCNAHIY LFENPKAEGR
260 270 280 290 300
YICSSHDCII LDLAKMLREK YPEYNIPTEF KGVDENLKSV CFSSKKLTDL
310 320 330
GFEFKYSLED MFTGAVDTCR AKGLLRPSHE KPVDGKT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75964 mRNA Translation: CAA53578.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75964 mRNA Translation: CAA53578.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2IOD | X-ray | 2.06 | A/B/C/D | 1-337 | [»] | |
2NNL | X-ray | 2.10 | D/F | 1-337 | [»] | |
3BXX | X-ray | 2.90 | A/B/C/D/E/F | 1-337 | [»] | |
3C1T | X-ray | 2.25 | A/B/C/D | 1-337 | [»] | |
SMRi | P51110 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 29760.VIT_18s0001g12800.t01 |
Proteomic databases
PRIDEi | P51110 |
Phylogenomic databases
eggNOGi | KOG1502, Eukaryota |
Enzyme and pathway databases
UniPathwayi | UPA00009 |
Miscellaneous databases
EvolutionaryTracei | P51110 |
Gene expression databases
ExpressionAtlasi | P51110, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001509, Epimerase_deHydtase IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01370, Epimerase, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DFRA_VITVI | |
Accessioni | P51110Primary (citable) accession number: P51110 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | June 2, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families