A1 - Dihydroflavonol 4-reductase - Zea mays (Maize)

Functionⁱ

Bifunctional enzyme involved in flavonoid metabolism.By similarity

Catalytic activityⁱ

A (2R,3S,4S)-leucoanthocyanidin + NADP⁺ = a (2R,3R)-dihydroflavonol + NADPH.By similarity

(2S)-flavan-4-ol + NADP⁺ = (2S)-flavanone + NADPH.By similarity

Pathwayⁱ: anthocyanin biosynthesis

This protein is involved in the pathway anthocyanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway anthocyanin biosynthesis and in Pigment biosynthesis.

GO - Molecular functionⁱ

coenzyme binding Source: InterPro
dihydrokaempferol 4-reductase activity Source: UniProtKB-EC
flavanone 4-reductase activity Source: UniProtKB-EC
oxidoreductase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anthocyanin-containing compound biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Flavonoid biosynthesis
Ligand	NADP

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER-18488
UniPathwayⁱ	UPA00009

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dihydroflavonol 4-reductase (EC:1.1.1.219By similarity) Short name: DFR Alternative name(s): Dihydrokaempferol 4-reductase Flavanone 4-reductase (EC:1.1.1.234By similarity) Short name: FNR
Gene namesⁱ	Name:A1
Organismⁱ	Zea mays (Maize)
Taxonomic identifierⁱ	4577 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea
Proteomesⁱ	UP000007305 Componentⁱ: Unplaced

Organism-specific databases

MaizeGDBⁱ	13795

MaizeGDBⁱ

13795

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215569	1 – 357	Dihydroflavonol 4-reductaseAdd BLAST		357

Proteomic databases

PaxDbⁱ	P51108
PRIDEⁱ	P51108

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	P51108 baseline and differential

ExpressionAtlasⁱ

P51108 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	4577.GRMZM2G026930_P01

STRINGⁱ

4577.GRMZM2G026930_P01

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51108
SMRⁱ	P51108
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1502 Eukaryota COG0451 LUCA
HOGENOMⁱ	HOG000167998

Family and domain databases

InterProⁱ	View protein in InterPro IPR001509 Epimerase_deHydtase IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01370 Epimerase, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P51108-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERGAGASEK GTVLVTGASG FVGSWLVMKL LQAGYTVRAT VRDPANVGKT 
        60         70         80         90        100
KPLMDLPGAT ERLSIWKADL AEEGSFHDAI RGCTGVFHVA TPMDFLSKDP 
       110        120        130        140        150
ENEVIKPTVE GMISIMRACK EAGTVRRIVF TSSAGTVNLE ERQRPVYDEE 
       160        170        180        190        200
SWTDVDFCRR VKMTGWMYFV SKTLAEKAAL AYAAEHGLDL VTIIPTLVVG 
       210        220        230        240        250
PFISASMPPS LITALALITG NAPHYSILKQ VQLIHLDDLC DAEIFLFENP 
       260        270        280        290        300
AAAGRYVCSS HDVTIHGLAA MLRDRYPEYD VPQRFPGIQD DLQPVRFSSK 
       310        320        330        340        350
KLQDLGFTFR YKTLEDMFDA AIRTCQEKGL IPLATAAGGD GFASVRAPGE 

TEATIGA

Length:357

Mass (Da):38,856

Last modified:October 1, 1996 - v1

Checksum:ⁱ6892B51E30E52804

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X05068 Genomic DNA Translation: CAA28734.1
UniGeneⁱ	Zm.95153

Protein	Similar proteins		Species	Score	Length	Source
P51108	NADPH-dependent reductase		MAIZE		357	UniRef100_P51108
NADPH-dependent reductase (Fragment)		MAIZE		175
Uncharacterized protein		MAIZE		246

Protein	Similar proteins		Species	Score	Length	Source
P51108	NADPH-dependent reductase		MAIZE		357	UniRef90_P51108
NADPH-dependent reductase (Fragment)		ZEAMM		175
NADPH-dependent reductase (Fragment)		ZEADI		175
NADPH-dependent reductase (Fragment)		MAIZE		175
Uncharacterized protein		MAIZE		246
+10

Protein	Similar proteins		Species	Score	Length	Source
P51108	Dihydroflavonol 4-reductase	)	VITVI		337	UniRef50_P51110
Dihydroflavonol 4-reductase		CALCH		364
Bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase		MALDO		348
Bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase		PYRCO		347
Dihydroflavonol 4-reductase		GERHY		366
+356

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X05068 Genomic DNA Translation: CAA28734.1
UniGeneⁱ	Zm.95153

3D structure databases

ProteinModelPortalⁱ	P51108
SMRⁱ	P51108
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	4577.GRMZM2G026930_P01

STRINGⁱ

4577.GRMZM2G026930_P01

Proteomic databases

PaxDbⁱ	P51108
PRIDEⁱ	P51108

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

MaizeGDBⁱ	13795

MaizeGDBⁱ

13795

Phylogenomic databases

eggNOGⁱ	KOG1502 Eukaryota COG0451 LUCA
HOGENOMⁱ	HOG000167998

Enzyme and pathway databases

UniPathwayⁱ	UPA00009
BioCycⁱ	MetaCyc:MONOMER-18488

Gene expression databases

ExpressionAtlasⁱ	P51108 baseline and differential

ExpressionAtlasⁱ

P51108 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR001509 Epimerase_deHydtase IPR036291 NAD(P)-bd_dom_sf
Pfamⁱ	View protein in Pfam PF01370 Epimerase, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DFRA_MAIZE
Accessionⁱ	P51108Primary (citable) accession number: P51108
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

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Supporting data

UniProtKB - P51108 (DFRA_MAIZE)

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Dihydroflavonol 4-reductase

A1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: anthocyanin biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Pathwayⁱ: anthocyanin biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ