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UniProtKB - P51075 (CHSY_BETPN)
Protein
Chalcone synthase
Gene
CHS
Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Functioni
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
Catalytic activityi
- 4-coumaroyl-CoA + 2 H+ + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoAPROSITE-ProRule annotationEC:2.3.1.74PROSITE-ProRule annotation
: flavonoid biosynthesis Pathwayi
This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 164 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- chalcone synthase activity Source: UniProtKB-EC
- naringenin-chalcone synthase activity Source: UniProtKB-EC
GO - Biological processi
- flavonoid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Flavonoid biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00154 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CHS |
Organismi | Betula pendula (European white birch) (Betula verrucosa) |
Taxonomic identifieri | 3505 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fagales › Betulaceae › Betula |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215955 | 1 – 395 | Chalcone synthaseAdd BLAST | 395 |
Expressioni
Inductioni
By ozone.
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR012328, Chalcone/stilbene_synt_C IPR001099, Chalcone/stilbene_synt_N IPR018088, Chalcone/stilbene_synthase_AS IPR011141, Polyketide_synthase_type-III IPR016039, Thiolase-like |
PANTHERi | PTHR11877, PTHR11877, 1 hit |
Pfami | View protein in Pfam PF02797, Chal_sti_synt_C, 1 hit PF00195, Chal_sti_synt_N, 1 hit |
PIRSFi | PIRSF000451, PKS_III, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00441, CHALCONE_SYNTH, 1 hit |
i Sequence
Sequence statusi: Complete.
P51075-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASVEEIRKA QRAHGPATVL AIGTATPSNC ITQADYPDYY FRITKSDHMT
60 70 80 90 100
ELKEKFKRMC DKSMIKKRYM YLNEEILNEN PNMCAYMAPS LDARQTIVVV
110 120 130 140 150
EVPKLGKEAA TKAIKEWGQP KSKITHLVFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG
210 220 230 240 250
PTDTHLDSLV GQALFGDGAA AVIVGADPDT SVERPLFELI SAAQTILPDS
260 270 280 290 300
DGAIDGHLRE VGLTFHLLKD VPGIISKNIE KSLAEAFAPL GISDWNSLFW
310 320 330 340 350
IAHPGGPAIL DQVESKLGLK EEKLRATRHV LSEYGNMSSA CVLFILDEMR
360 370 380 390
RNSLEGGKVT TGEGLEWGVL FGFGPGLTVE TVVLHSVPVP VEASH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11022 mRNA Translation: CAA71904.1 X77513 Genomic DNA Translation: CAA54649.1 |
PIRi | S41957 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11022 mRNA Translation: CAA71904.1 X77513 Genomic DNA Translation: CAA54649.1 |
PIRi | S41957 |
3D structure databases
SMRi | P51075 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00154 |
Family and domain databases
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR012328, Chalcone/stilbene_synt_C IPR001099, Chalcone/stilbene_synt_N IPR018088, Chalcone/stilbene_synthase_AS IPR011141, Polyketide_synthase_type-III IPR016039, Thiolase-like |
PANTHERi | PTHR11877, PTHR11877, 1 hit |
Pfami | View protein in Pfam PF02797, Chal_sti_synt_C, 1 hit PF00195, Chal_sti_synt_N, 1 hit |
PIRSFi | PIRSF000451, PKS_III, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00441, CHALCONE_SYNTH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHSY_BETPN | |
Accessioni | P51075Primary (citable) accession number: P51075 Secondary accession number(s): P93069 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 23, 2022 | |
This is version 79 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families