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Entry version 187 (13 Nov 2019)
Sequence version 2 (16 Nov 2001)
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Protein

ETS-like protein pointed

Gene

pnt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ETS transcription factor with a prominent role during development of the eye and the nervous system (PubMed:8223245, PubMed:8033205, PubMed:23757412, PubMed:28245922). Required for glial-neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic CNS (PubMed:8223245).4 Publications
Isoform P2: Required for normal EGFR-induced photoreceptor development probably as a downstream effector of Ras85D (PubMed:8033205, PubMed:23757412). In larval eye imaginal disks, activated by MAPK phosphorylation following EGFR activation, induces transcription of isoform P1 which in turn activates transcription of target genes essential for photoreceptor development (PubMed:23757412).
Isoform P1: Required for normal EGFR-induced photoreceptor development (PubMed:23757412). Following transcriptional activation by isoform P2, acts as a constitutive activator of transcription, leading to induction of target genes essential for photoreceptor development (PubMed:8033205, PubMed:23757412). In larval brains, involved in the maintenance of type II neuroblast self-renewal and identity together with brat, btd and pros; prevents intermediate neuronal progenitor (INP) dedifferentiation by regulating the expression of erm probably via Notch signaling; suppresses Ase expression in type II neuroblasts and promotes the generation of intermediate neuronal progenitors (PubMed:22143802, PubMed:27151950, PubMed:27510969, PubMed:28899667, PubMed:28245922).7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi610 – 690ETSPROSITE-ProRule annotation3 PublicationsAdd BLAST81

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-DME-2559585 Oncogene Induced Senescence

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P51023

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ETS-like protein pointedCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pntImported
Synonyms:DMPOINT1AImported, ETS2Imported, Ets58AB1 Publication, pointedImported
ORF Names:CG17077
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0003118 pnt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal showing loss of photoreceptors (PubMed:8033205, PubMed:8223245, PubMed:23757412). In larvae, RNAi-mediated knockdown results in a transformation of type II neuroblasts into type I neuroblasts, elimination of intermediary neuronal progenitors (INP) and generation of extra type II neuroblasts; in the ventral nerve cord, results in increased numbers of type I neuroblasts (PubMed:27510969, PubMed:28899667, PubMed:27151950). Simultaneous RNAi-mediated knockdown of the zinc-finger transcriptional repressor erm, the transcriptional repressor E(spl)mdelta-HLH or the transcriptional repressor dpn restore normal neuroblast numbers (PubMed:28899667). Simultaneous RNAi-mediated knockdown of N partially restores normal neuroblast numbers and inhibits ectopic erm expression in the central brain and ventral nerve cord (PubMed:27151950).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi151T → A: Reduced activity and lack of response to Ras85D or rl stimulation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041301 – 718ETS-like protein pointedAdd BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei151Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform P2: Phosphorylated at Thr-151 by rl.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P51023

PRoteomics IDEntifications database

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PRIDEi
P51023

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P51023

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in type II neuroblasts in larval brain (at protein level) (PubMed:27151950, PubMed:28245922). Expressed in a complex dynamic pattern in early embryos, including the midline and midline glial cells (PubMed:8223245, PubMed:1577186, PubMed:2834248). Expressed throughout development with lower levels during larval development (PubMed:1577186). Expressed in the eye imaginal disk in and posterior to the morphogenetic furrow (PubMed:8033205). Isoform P2: Detected in the precellular blastoderm stage localized at the anterior tip of the embryo (PubMed:8223245). Detected during gastrulation in the mesoderm (PubMed:8223245, PubMed:23757412). As the germband retracts (stage 12) detected in a few cells located at the dorsal roof at the midline of the CNS (PubMed:8223245). These cells correspond to the midline glial cells, in which expression continues until the end of embryogenesis (PubMed:8223245). Major isoform expressed in the eye imaginal disk in and posterior to the morphogenetic furrow (PubMed:8033205). Isoform P1: Expressed within the differentiated region of the disk including and posterior to the morphogenetic furrow in the proneural photoreptor clusters (at protein level) (PubMed:23757412). Detected during the cellular blastoderm stage in two broad stripes in the lateral neurogenic region (PubMed:8223245). At the beginning of gastrulation detected in the dorsal edge of the neurogenic region (PubMed:8223245). During segmentation (stage 11), detected in the ventral ectoderm and in a group of cells surrounding the future tracheal pits, in the head region and the lateral body wall (PubMed:8223245). In the CNS, detected during germband retraction, in the glial cells and in the midline (PubMed:8223245). In larval brains, major neuroblast-specific isoform (PubMed:22143802).8 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0003118 Expressed in 78 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P51023 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
67700, 41 interactors

Database of interacting proteins

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DIPi
DIP-19576N

Protein interaction database and analysis system

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IntActi
P51023, 7 interactors

Molecular INTeraction database

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MINTi
P51023

STRING: functional protein association networks

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STRINGi
7227.FBpp0088658

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P51023

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini164 – 250PNTPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi280 – 415Asn-richPROSITE-ProRule annotationAdd BLAST136
Compositional biasi432 – 522Gly-richPROSITE-ProRule annotationAdd BLAST91

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3806 Eukaryota
ENOG410Z0ZF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000166428

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P51023

KEGG Orthology (KO)

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KOi
K02678

Identification of Orthologs from Complete Genome Data

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OMAi
GNAYYTD

Database for complete collections of gene phylogenies

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PhylomeDBi
P51023

Family and domain databases

Database of protein disorder

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DisProti
DP01749

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform P21 Publication (identifier: P51023-1) [UniParc]FASTAAdd to basket
Also known as: BImported

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELAICKTDL SATKFMLPPA LPSSAAIGSS SAVASTASHF LDKAAHELFQ
60 70 80 90 100
LNAINGHLFK SPASSHLNSV GSPSILSQLN GIGNSGNHSG QVSTMRLKKN
110 120 130 140 150
RKVTFLSSLV ESKNIFIKEE PIHGCKDLCS LSDISDHEAS LEVPTALPPL
160 170 180 190 200
TPGTNRKVNE VLKASFASWE KEVQKCNITK DPREWTEEHV IYWLNWAKNE
210 220 230 240 250
FSLVSMNLDP FYKMKGRAMV DLGKEKFLAI TPPFTGDILW EHLDILQKDC
260 270 280 290 300
EKPNEDIVHG NSFESATTAS VCGSDHQVAN YPNETHANSN NSSINSRLSM
310 320 330 340 350
DYVTSAGNSD NKNFHRATPH SHNGYNTSNT HDRINNSTPP QQQQSQQPTV
360 370 380 390 400
NGSGSASSNN NNSMLPPAVQ QSNNENNNTS SSNTNNSSNN NNNSGGSNNS
410 420 430 440 450
NAGSNNNNNN NNNINFMAAA AIFQHHLKEE PGTQNGNIGG YGGGSNSQND
460 470 480 490 500
PTDLSSYGLP AHLAAYGGGS GSGPTGGRSS GGGGDESDYH STISAQDHQS
510 520 530 540 550
QQSSGGNGSG GASGGSTGNS NGYLDSSSEF YGSYAGRNRF HDGYPPEFTP
560 570 580 590 600
YDAQSFQSMG PQPTAMDQWG AAHAHQHPAA YMSTLGLDKG LLGGYTTQGG
610 620 630 640 650
VPCFTGSGPI QLWQFLLELL LDKTCQSFIS WTGDGWEFKL TDPDEVARRW
660 670 680 690 700
GIRKNKPKMN YEKLSRGLRY YYDKNIIHKT AGKRYVYRFV CDLQNLVGHT
710
PEELVAKYDL KIEKKDVD
Length:718
Mass (Da):77,683
Last modified:November 16, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD6AFD0F4BCD69C5
GO
Isoform DImported (identifier: P51023-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: MELAICKTDL...SDISDHEASL → MTNEWIDWND...QLTTNHSKLK

Show »
Length:636
Mass (Da):69,890
Checksum:iF868CB584F432C9B
GO
Isoform P11 Publication (identifier: P51023-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: CImported

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: MELAICKTDL...FHRATPHSHN → MPPSAFLVNA...TDSDVNFFSS

Show »
Length:623
Mass (Da):66,866
Checksum:iF47083D860EB6480
GO
Isoform EImported (identifier: P51023-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: MELAICKTDL...FHRATPHSHN → MPPSAFLVNA...SDVNFFSSGT

Show »
Length:625
Mass (Da):67,024
Checksum:iD719C80B7C07B9D2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN71682 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133 – 135DIS → VYP in CAA48917 (PubMed:8223245).Curated3
Sequence conflicti420A → AM in CAA48917 (PubMed:8223245).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0595951 – 323MELAI…PHSHN → MPPSAFLVNASIISAANALD SDKEQQLQEHLNQSHFTSSS SSSNSSNNNNCHTAPNYNMV LQSYENYPSYHLAQHHHHHH HHHSHPHHQLAQQTGLHSHH TMQQQLQQQQQSLLLQHPQQ QQQQHSHQSQQQQQHGYGSS AQLPHHRLSGGSTGSTTTTS SGSSSSGSSSSASSQGFANG SATANNLVGALSSSTAASLG LGYFNDMAPFVGDANAYYTD SDVNFFSSGT in isoform E. CuratedAdd BLAST323
Alternative sequenceiVSP_0595961 – 323MELAI…PHSHN → MPPSAFLVNASIISAANALD SDKEQQLQEHLNQSHFTSSS SSSNSSNNNNCHTAPNYNMV LQSYENYPSYHLAQHHHHHH HHHSHPHHQLAQQTGLHSHH TMQQQLQQQQQSLLLQHPQQ QQQQHSHQSQQQQQHGYGSS AQLPHHRLSGGSTGSTTTTS SGSSSSGSSSSASSQGFANG SATANNLVGALSSSTAASLG LGYFNDMAPFVGDANAYYTD SDVNFFSS in isoform P1. CuratedAdd BLAST323
Alternative sequenceiVSP_0595971 – 141MELAI…HEASL → MTNEWIDWNDSRMLPPLRSA NYNYHPQTFLPNNYQCFTGK FHLKGQKLQQLTTNHSKLK in isoform D. CuratedAdd BLAST141

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X69166 mRNA Translation: CAA48916.1
X69167 mRNA Translation: CAA48917.1
M88472 mRNA Translation: AAC34200.1
M20408 Genomic DNA Translation: AAA28521.1
AE014297 Genomic DNA Translation: AAF56125.1
AE014297 Genomic DNA Translation: AAN13942.1
AE014297 Genomic DNA Translation: AAN13943.1
AE014297 Genomic DNA Translation: AGB96252.1
BT001893 mRNA Translation: AAN71682.1 Sequence problems.
BT024187 mRNA Translation: ABC86249.1
BT058033 mRNA Translation: ACM16754.1
BT133301 mRNA Translation: AFD10748.1

Protein sequence database of the Protein Information Resource

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PIRi
S33167
S33168

NCBI Reference Sequences

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RefSeqi
NP_001262872.1, NM_001275943.1 [P51023-4]
NP_524461.2, NM_079737.3 [P51023-1]
NP_732857.1, NM_170651.4 [P51023-2]
NP_732858.1, NM_170070.2 [P51023-3]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089715; FBpp0088656; FBgn0003118 [P51023-3]
FBtr0089716; FBpp0088657; FBgn0003118 [P51023-2]
FBtr0089717; FBpp0088658; FBgn0003118 [P51023-1]
FBtr0334554; FBpp0306621; FBgn0003118 [P51023-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
42757

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG17077

UCSC genome browser

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UCSCi
CG17077-RD d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69166 mRNA Translation: CAA48916.1
X69167 mRNA Translation: CAA48917.1
M88472 mRNA Translation: AAC34200.1
M20408 Genomic DNA Translation: AAA28521.1
AE014297 Genomic DNA Translation: AAF56125.1
AE014297 Genomic DNA Translation: AAN13942.1
AE014297 Genomic DNA Translation: AAN13943.1
AE014297 Genomic DNA Translation: AGB96252.1
BT001893 mRNA Translation: AAN71682.1 Sequence problems.
BT024187 mRNA Translation: ABC86249.1
BT058033 mRNA Translation: ACM16754.1
BT133301 mRNA Translation: AFD10748.1
PIRiS33167
S33168
RefSeqiNP_001262872.1, NM_001275943.1 [P51023-4]
NP_524461.2, NM_079737.3 [P51023-1]
NP_732857.1, NM_170651.4 [P51023-2]
NP_732858.1, NM_170070.2 [P51023-3]

3D structure databases

SMRiP51023
ModBaseiSearch...

Protein-protein interaction databases

BioGridi67700, 41 interactors
DIPiDIP-19576N
IntActiP51023, 7 interactors
MINTiP51023
STRINGi7227.FBpp0088658

PTM databases

iPTMnetiP51023

Proteomic databases

PaxDbiP51023
PRIDEiP51023

Genome annotation databases

EnsemblMetazoaiFBtr0089715; FBpp0088656; FBgn0003118 [P51023-3]
FBtr0089716; FBpp0088657; FBgn0003118 [P51023-2]
FBtr0089717; FBpp0088658; FBgn0003118 [P51023-1]
FBtr0334554; FBpp0306621; FBgn0003118 [P51023-4]
GeneIDi42757
KEGGidme:Dmel_CG17077
UCSCiCG17077-RD d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
42757
FlyBaseiFBgn0003118 pnt

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00940000166428
InParanoidiP51023
KOiK02678
OMAiGNAYYTD
PhylomeDBiP51023

Enzyme and pathway databases

ReactomeiR-DME-2559585 Oncogene Induced Senescence
SignaLinkiP51023

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
pnt fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42757

Gene expression databases

BgeeiFBgn0003118 Expressed in 78 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)
GenevisibleiP51023 DM

Family and domain databases

DisProtiDP01749
Gene3Di1.10.10.10, 1 hit
1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNT_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51023
Secondary accession number(s): A0A0B4KH96
, B9EQV8, H8F4R1, P19420, P51022, Q29R53, Q8IG92, Q8IMZ1, Q9VCN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 16, 2001
Last modified: November 13, 2019
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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