UniProtKB - P51003 (PAPOA_HUMAN)

BLAST

>sp|P51003|PAPOA_HUMAN Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
LSDIPALPANPIPVIKNSIKLRLNR

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History
Entry version 179 (12 Sep 2018)
Sequence version 4 (23 Jan 2007)
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Protein

Poly(A) polymerase alpha

Gene

PAPOLA

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.1 Publication

Catalytic activityⁱ

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactorⁱ

Mg²⁺By similarity, Mn²⁺By similarityNote: Binds 2 magnesium ions. Also active with manganese.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	109	ATPBy similarity	1
Metal bindingⁱ	113	Magnesium 1; catalyticBy similarity	1
Metal bindingⁱ	113	Magnesium 2; catalyticBy similarity	1
Metal bindingⁱ	115	Magnesium 1; catalyticBy similarity	1
Metal bindingⁱ	115	Magnesium 2; catalyticBy similarity	1
Metal bindingⁱ	167	Magnesium 2; catalyticBy similarity	1
Binding siteⁱ	167	ATPBy similarity	1
Binding siteⁱ	228	ATPBy similarity	1
Binding siteⁱ	237	ATPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	100 – 102	ATPBy similarity	3
Nucleotide bindingⁱ	113 – 115	ATPBy similarity	3
Nucleotide bindingⁱ	246 – 247	ATPBy similarity	2

GO - Molecular functionⁱ

ATP binding Source: UniProtKB
magnesium ion binding Source: UniProtKB
manganese ion binding Source: UniProtKB
polynucleotide adenylyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7590244
RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 3'-end processing Source: Reactome
mRNA polyadenylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19224921
- 7590244
mRNA splicing, via spliceosome Source: Reactome
regulation of mRNA 3'-end processing
Source: UniProtKB
Inferred from direct assayⁱ
- 19224921
RNA polyadenylation Source: UniProtKB
termination of RNA polymerase II transcription Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding, Transferase
Biological process	mRNA processing
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-77595 Processing of Intronless Pre-mRNAs
SIGNORⁱ	P51003

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Poly(A) polymerase alpha (EC:2.7.7.19) Short name: PAP-alpha Alternative name(s): Polynucleotide adenylyltransferase alpha
Gene namesⁱ	Name:PAPOLA Synonyms:PAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000090060.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14981 PAPOLA
MIMⁱ	605553 gene
neXtProtⁱ	NX_P51003

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10914
Open Targets More...OpenTargetsⁱ	ENSG00000090060
PharmGKBⁱ	PA32932

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02153 3-Sulfinoalanine DB01860 Cordycepin Triphosphate DB03896 Triphospate

DrugBankⁱ

DB02153 3-Sulfinoalanine
DB01860 Cordycepin Triphosphate
DB03896 Triphospate

Polymorphism and mutation databases

BioMutaⁱ	PAPOLA
DMDMⁱ	59803092

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000051612	2 – 745	Poly(A) polymerase alphaAdd BLAST		744

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	10	PhosphoserineCombined sources	1
Modified residueⁱ	24	PhosphoserineCombined sources	1
Cross-linkⁱ	444	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)Curated
Cross-linkⁱ	445	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)Curated
Cross-linkⁱ	506	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)Curated
Cross-linkⁱ	507	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)Curated
Modified residueⁱ	537	PhosphoserineBy similarity	1
Modified residueⁱ	558	PhosphoserineCombined sources	1
Modified residueⁱ	641	N6-acetyllysineBy similarity	1
Modified residueⁱ	650	N6-acetyllysineBy similarity	1
Modified residueⁱ	736	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	736	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Modified residueⁱ	738	PhosphoserineCombined sources	1
Modified residueⁱ	740	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	740	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity

Post-translational modificationⁱ

Polysumoylated. Varying sumolyation depending on tissue- and cell-type. Highly sumoylated in bladder and NIH 3T3 cells. Sumoylation is required for nuclear localization and enhances PAP stability. Desumoylated by SENP1. Inhibits polymerase activity (By similarity).By similarity

Hyperphosphorylation on multiple CDK2 consensus and non-consensus sites in the C-terminal Ser/Thr-rich region represses PAP activity in late M-phase. Phosphorylation/dephosphorylation may regulate the interaction between PAP and CPSF (By similarity).By similarity

Acetylated in the C-terminus. Acetylation decreases interaction with NUDT21 and KPNB1, and inhibits nuclear localization through inhibiting binding to the importin alpha/beta complex (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P51003
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51003
PaxDbⁱ	P51003
PeptideAtlas More...PeptideAtlasⁱ	P51003
PRIDEⁱ	P51003
ProteomicsDBⁱ	56276 56277 [P51003-2]

PTM databases

iPTMnetⁱ	P51003
PhosphoSitePlusⁱ	P51003

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000090060 Expressed in 232 organ(s), highest expression level in testis
CleanExⁱ	HS_PAPOLA
ExpressionAtlasⁱ	P51003 baseline and differential
Genevisibleⁱ	P51003 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001788

HPAⁱ

HPA001788

Interactionⁱ

Subunit structureⁱ

Monomer. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with AHCYL1 and FIP1L1; the interaction with AHCYL1 seems to increase interaction with FIP1L1 (PubMed:19224921). Interacts with NUDT21; the interaction is diminished by acetylation. Interacts with KPNB1; the interaction promotes PAP nuclear import and is inhibited by acetylation of PAP (By similarity).By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	153	Interaction with RNABy similarity	1
Siteⁱ	158	Interaction with RNABy similarity	1
Siteⁱ	328	Interaction with RNABy similarity	1
Siteⁱ	399	Interaction with RNABy similarity	1
Siteⁱ	524	Interaction with RNABy similarity	1

Protein-protein interaction databases

BioGridⁱ	116119, 50 interactors
CORUMⁱ	P51003
Database of interacting proteins More...DIPⁱ	DIP-27610N DIP-40865N
IntActⁱ	P51003, 13 interactors
Molecular INTeraction database More...MINTⁱ	P51003
STRINGⁱ	9606.ENSP00000216277

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51003
SMRⁱ	P51003
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	508 – 643	Ser/Thr-richAdd BLAST		136
Regionⁱ	677 – 745	Required for interaction with NUDT21Add BLAST		69

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	490 – 507	Nuclear localization signal 1By similarityAdd BLAST		18
Motifⁱ	650 – 665	Nuclear localization signal 2By similarityAdd BLAST		16

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	53 – 57	Poly-Glu		5
Compositional biasⁱ	504 – 507	Poly-Lys		4

Sequence similaritiesⁱ

Belongs to the poly(A) polymerase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2245 Eukaryota COG5186 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017928
HOVERGENⁱ	HBG053502
InParanoidⁱ	P51003
KEGG Orthology (KO) More...KOⁱ	K14376
OMAⁱ	MGIVVRH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0571
PhylomeDBⁱ	P51003
TreeFamⁱ	TF300842

Family and domain databases

InterProⁱ	View protein in InterPro IPR011068 NuclTrfase_I-like_C IPR007012 PolA_pol_cen_dom IPR007010 PolA_pol_RNA-bd_dom IPR014492 PolyA_polymerase IPR002934 Polymerase_NTP_transf_dom
PANTHERⁱ	PTHR10682 PTHR10682, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01909 NTP_transf_2, 1 hit PF04928 PAP_central, 1 hit PF04926 PAP_RNA-bind, 1 hit
PIRSFⁱ	PIRSF018425 PolyA_polymerase, 1 hit
SUPFAMⁱ	SSF55003 SSF55003, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P51003-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFPVTTQGS QQTQPPQKHY GITSPISLAA PKETDCVLTQ KLIETLKPFG 
        60         70         80         90        100
VFEEEEELQR RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF 
       110        120        130        140        150
GSYRLGVHTK GADIDALCVA PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE 
       160        170        180        190        200
EAFVPVIKLC FDGIEIDILF ARLALQTIPE DLDLRDDSLL KNLDIRCIRS 
       210        220        230        240        250
LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI LGFLGGVSWA 
       260        270        280        290        300
MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW 
       310        320        330        340        350
DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRMVMVEE FKQGLAITDE 
       360        370        380        390        400
ILLSKAEWSK LFEAPNFFQK YKHYIVLLAS APTEKQRLEW VGLVESKIRI 
       410        420        430        440        450
LVGSLEKNEF ITLAHVNPQS FPAPKENPDK EEFRTMWVIG LVFKKTENSE 
       460        470        480        490        500
NLSVDLTYDI QSFTDTVYRQ AINSKMFEVD MKIAAMHVKR KQLHQLLPNH 
       510        520        530        540        550
VLQKKKKHST EGVKLTALND SSLDLSMDSD NSMSVPSPTS ATKTSPLNSS 
       560        570        580        590        600
GSSQGRNSPA PAVTAASVTN IQATEVSVPQ VNSSESSGGT SSESIPQTAT 
       610        620        630        640        650
QPAISPPPKP TVSRVVSSTR LVNPPPRSSG NAATSGNAAT KIPTPIVGVK 
       660        670        680        690        700
RTSSPHKEES PKKTKTEEDE TSEDANCLAL SGHDKTEAKE QLDTETSTTQ 
       710        720        730        740 
SETIQTAASL LASQKTSSTD LSDIPALPAN PIPVIKNSIK LRLNR

Length:745

Mass (Da):82,843

Last modified:January 23, 2007 - v4

Checksum:ⁱ14A00CCCDAD9B374

Isoform 2 (identifier: P51003-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
280-285: EWPNPV → YVFRLY
286-745: Missing.

« Hide

        10         20         30         40         50
MPFPVTTQGS QQTQPPQKHY GITSPISLAA PKETDCVLTQ KLIETLKPFG 
        60         70         80         90        100
VFEEEEELQR RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF 
       110        120        130        140        150
GSYRLGVHTK GADIDALCVA PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE 
       160        170        180        190        200
EAFVPVIKLC FDGIEIDILF ARLALQTIPE DLDLRDDSLL KNLDIRCIRS 
       210        220        230        240        250
LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI LGFLGGVSWA 
       260        270        280 
MLVARTCQLY PNAIASTLVH KFFLVFSKWY VFRLY

Show »

Length:285

Mass (Da):32,626

Checksum:ⁱ5967D93F0375C54C

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3XAH6	G3XAH6_HUMAN	Poly(A) polymerase alpha Poly(A) polymerase alpha	PAPOLA	724	Annotation score:
G3V2A0	G3V2A0_HUMAN	Poly(A) polymerase alpha Poly(A) polymerase alpha	PAPOLA	475	Annotation score:
H0YJL4	H0YJL4_HUMAN	Poly(A) polymerase alpha Poly(A) polymerase alpha	PAPOLA	181	Annotation score:
A0A0C4DGK1	A0A0C4DGK1_HUMAN	Poly(A) polymerase alpha, isoform C... Poly(A) polymerase alpha, isoform CRA_e	PAPOLA hCG_24516	238	Annotation score:
G3V457	G3V457_HUMAN	Poly(A) polymerase alpha Poly(A) polymerase alpha	PAPOLA	111	Annotation score:
H0YJ00	H0YJ00_HUMAN	Poly(A) polymerase alpha Poly(A) polymerase alpha	PAPOLA	203	Annotation score:
G3V3I9	G3V3I9_HUMAN	Poly(A) polymerase alpha Poly(A) polymerase alpha	PAPOLA	177	Annotation score:
H0YJZ9	H0YJZ9_HUMAN	Poly(A) polymerase alpha Poly(A) polymerase alpha	PAPOLA	73	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	2 – 3	PF → GTSNSPGHSSFSAPSTKKIK TTRKQNIAWC in CAD62628 (Ref. 2) Curated		2
Sequence conflictⁱ	204 – 238	CRVTD…HNIYS → MRKPTSFCVLQFLSDISCFY TSFVLKLFIAILLTQ in CAD61935 (Ref. 2) CuratedAdd BLAST		35

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012895	280 – 285	EWPNPV → YVFRLY in isoform 2. 2 Publications		6
Alternative sequenceⁱVSP_012896	286 – 745	Missing in isoform 2. 2 PublicationsAdd BLAST		460

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC000927 mRNA Translation: AAH00927.1 BC036014 mRNA Translation: AAH36014.1 BX248301 mRNA Translation: CAD62628.1 BX248753 mRNA Translation: CAD66560.1 BX161482 mRNA Translation: CAD61935.1 X76770 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58334.1 [P51003-2] CCDS9946.1 [P51003-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001238935.1, NM_001252006.1 [P51003-2] NP_001238936.1, NM_001252007.1 NP_001280556.1, NM_001293627.1 NP_001280557.1, NM_001293628.1 NP_001280561.1, NM_001293632.1 NP_116021.2, NM_032632.4 [P51003-1]
UniGeneⁱ	Hs.253726

Genome annotation databases

Ensemblⁱ	ENST00000216277; ENSP00000216277; ENSG00000090060 [P51003-1] ENST00000557320; ENSP00000450437; ENSG00000090060 [P51003-2]
GeneIDⁱ	10914
KEGGⁱ	hsa:10914
UCSC genome browser More...UCSCⁱ	uc001yfo.5 human [P51003-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51003	Poly(A) polymerase alpha, isoform CRA_a		HUMAN		745	UniRef100_P51003
PAPOLA isoform 1		PANTR		745
PAPOLA isoform 1		PONAB		745
Uncharacterized protein		PANPA		745
Poly(A) polymerase alpha		GORGO		745
+1
P51003-2	PAPOLA isoform 18		PONAB		285	UniRef100_A0A2J8TLB7
PAPOLA isoform 17		PANTR		285

Protein	Similar proteins		Species	Score	Length	Source
P51003	Poly(A) polymerase alpha	)	BOVIN		739	UniRef90_P25500
Poly(A) polymerase alpha		MOUSE		739
Uncharacterized protein		MACMU		746
Poly(A) polymerase alpha (Fragment)		PTEAL		746
Uncharacterized protein		RHIRO		745
+327
P51003-2	PAPOLA isoform 18		PONAB		285	UniRef90_A0A2J8TLB7
PAPOLA isoform 17		PANTR		285
UPI000A3205EA		MESAU		320

Protein	Similar proteins		Species	Score	Length	Source
P51003	Poly(A) polymerase alpha	)	BOVIN		739	UniRef50_P25500
Poly(A) polymerase alpha		MOUSE		739
Poly(A) polymerase alpha (Fragment)		PTEAL		746
Uncharacterized protein		MACMU		746
Uncharacterized protein		CERAT		745
+328
P51003-2	Poly (A) polymerase alpha		RAT		317	UniRef50_A0A0G2K821
Poly(A) polymerase alpha		GORGO		319
PAPOLA isoform 17 (Fragment)		PONAB		202
PAPOLA isoform 16 (Fragment)		PANTR		202
Uncharacterized protein		Cebus capucinus imitator		318
+31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC000927 mRNA Translation: AAH00927.1 BC036014 mRNA Translation: AAH36014.1 BX248301 mRNA Translation: CAD62628.1 BX248753 mRNA Translation: CAD66560.1 BX161482 mRNA Translation: CAD61935.1 X76770 mRNA No translation available.
CCDSⁱ	CCDS58334.1 [P51003-2] CCDS9946.1 [P51003-1]
RefSeqⁱ	NP_001238935.1, NM_001252006.1 [P51003-2] NP_001238936.1, NM_001252007.1 NP_001280556.1, NM_001293627.1 NP_001280557.1, NM_001293628.1 NP_001280561.1, NM_001293632.1 NP_116021.2, NM_032632.4 [P51003-1]
UniGeneⁱ	Hs.253726

3D structure databases

ProteinModelPortalⁱ	P51003
SMRⁱ	P51003
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116119, 50 interactors
CORUMⁱ	P51003
DIPⁱ	DIP-27610N DIP-40865N
IntActⁱ	P51003, 13 interactors
MINTⁱ	P51003
STRINGⁱ	9606.ENSP00000216277

Chemistry databases

DrugBankⁱ	DB02153 3-Sulfinoalanine DB01860 Cordycepin Triphosphate DB03896 Triphospate

DrugBankⁱ

DB02153 3-Sulfinoalanine
DB01860 Cordycepin Triphosphate
DB03896 Triphospate

PTM databases

iPTMnetⁱ	P51003
PhosphoSitePlusⁱ	P51003

Polymorphism and mutation databases

BioMutaⁱ	PAPOLA
DMDMⁱ	59803092

Proteomic databases

EPDⁱ	P51003
MaxQBⁱ	P51003
PaxDbⁱ	P51003
PeptideAtlasⁱ	P51003
PRIDEⁱ	P51003
ProteomicsDBⁱ	56276 56277 [P51003-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000216277; ENSP00000216277; ENSG00000090060 [P51003-1] ENST00000557320; ENSP00000450437; ENSG00000090060 [P51003-2]
GeneIDⁱ	10914
KEGGⁱ	hsa:10914
UCSCⁱ	uc001yfo.5 human [P51003-1]

Organism-specific databases

CTDⁱ	10914
DisGeNETⁱ	10914
EuPathDBⁱ	HostDB:ENSG00000090060.17
GeneCardsⁱ	PAPOLA
HGNCⁱ	HGNC:14981 PAPOLA
HPAⁱ	HPA001788
MIMⁱ	605553 gene
neXtProtⁱ	NX_P51003
OpenTargetsⁱ	ENSG00000090060
PharmGKBⁱ	PA32932
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2245 Eukaryota COG5186 LUCA
GeneTreeⁱ	ENSGT00390000017928
HOVERGENⁱ	HBG053502
InParanoidⁱ	P51003
KOⁱ	K14376
OMAⁱ	MGIVVRH
OrthoDBⁱ	EOG091G0571
PhylomeDBⁱ	P51003
TreeFamⁱ	TF300842

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-77595 Processing of Intronless Pre-mRNAs
SIGNORⁱ	P51003

Miscellaneous databases

ChiTaRSⁱ	PAPOLA human
GeneWikiⁱ	PAPOLA
GenomeRNAiⁱ	10914
Protein Ontology More...PROⁱ	PR:P51003
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000090060 Expressed in 232 organ(s), highest expression level in testis
CleanExⁱ	HS_PAPOLA
ExpressionAtlasⁱ	P51003 baseline and differential
Genevisibleⁱ	P51003 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011068 NuclTrfase_I-like_C IPR007012 PolA_pol_cen_dom IPR007010 PolA_pol_RNA-bd_dom IPR014492 PolyA_polymerase IPR002934 Polymerase_NTP_transf_dom
PANTHERⁱ	PTHR10682 PTHR10682, 1 hit
Pfamⁱ	View protein in Pfam PF01909 NTP_transf_2, 1 hit PF04928 PAP_central, 1 hit PF04926 PAP_RNA-bind, 1 hit
PIRSFⁱ	PIRSF018425 PolyA_polymerase, 1 hit
SUPFAMⁱ	SSF55003 SSF55003, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PAPOA_HUMAN
Accessionⁱ	P51003Primary (citable) accession number: P51003 Secondary accession number(s): Q86SX4 , Q86TV0, Q8IYF5, Q9BVU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 179 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments
Index of protein domains and families
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P51003 (PAPOA_HUMAN)

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Poly(A) polymerase alpha

PAPOLA

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ