ANXA11

Functionⁱ

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.By similarity1 Publication

GO - Molecular functionⁱ

calcium-dependent phospholipid binding Source: UniProtKB-KW
calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11883939
- 12445460
calcium ion binding Source: Ensembl
MHC class II protein complex binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 20458337
phosphatidylethanolamine binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889
S100 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12577318
- 19724273

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytokinetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15197175
phagocytosis
Source: UniProtKB
Inferred from expression patternⁱ
- 9188810
response to calcium ion
Source: UniProtKB
Inferred from direct assayⁱ
- 12601007
- 9188810

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division
Ligand	Calcium, Calcium/phospholipid-binding

Protein family/group databases

TCDBⁱ	3.A.5.9.1 the general secretory pathway (sec) family

TCDBⁱ

3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Annexin A11 Alternative name(s): 56 kDa autoantigen Annexin XI Annexin-11 Calcyclin-associated annexin 50 Short name: CAP-50
Gene namesⁱ	Name:ANXA11 Synonyms:ANX11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122359.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:535 ANXA11
MIMⁱ	602572 gene
neXtProtⁱ	NX_P50995

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Amyotrophic lateral sclerosis 23 (ALS23)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. ALS23 is an autosomal dominant form with incomplete penetrance.

Keywords - Diseaseⁱ

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	311
MalaCards human disease database More...MalaCardsⁱ	ANXA11
MIMⁱ	617839 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122359
PharmGKBⁱ	PA24825

Polymorphism and mutation databases

BioMutaⁱ	ANXA11
DMDMⁱ	1703322

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000067510	1 – 505	Annexin A11Add BLAST		505

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	248	N6-acetyllysineCombined sources	1
Modified residueⁱ	255	N6-acetyllysineCombined sources	1
Modified residueⁱ	479	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P50995
PaxDbⁱ	P50995
PeptideAtlas More...PeptideAtlasⁱ	P50995
PRIDEⁱ	P50995
ProteomicsDBⁱ	56275

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	P50995

REPRODUCTION-2DPAGEⁱ

P50995

PTM databases

iPTMnetⁱ	P50995
PhosphoSitePlusⁱ	P50995
SwissPalmⁱ	P50995

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000122359 Expressed in 228 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_ANXA11
ExpressionAtlasⁱ	P50995 baseline and differential
Genevisibleⁱ	P50995 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004851 HPA027545

HPAⁱ

CAB004851
HPA027545

Interactionⁱ

Subunit structureⁱ

Interacts with S100A6 (PubMed:28469040). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CEP55	Q53EZ4	5	EBI-715243,EBI-747776
PDCD6	O75340	4	EBI-715243,EBI-352915
TFG	Q92734	3	EBI-715243,EBI-357061

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106808, 49 interactors
ELMⁱ	P50995
IntActⁱ	P50995, 24 interactors
Molecular INTeraction database More...MINTⁱ	P50995
STRINGⁱ	9606.ENSP00000265447

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P50995
SMRⁱ	P50995
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	209 – 269	Annexin 1Add BLAST	61
Repeatⁱ	281 – 341	Annexin 2Add BLAST	61
Repeatⁱ	365 – 425	Annexin 3Add BLAST	61
Repeatⁱ	440 – 500	Annexin 4Add BLAST	61

Domainⁱ

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesⁱ

Belongs to the annexin family.Curated

Keywords - Domainⁱ

Annexin, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0819 Eukaryota ENOG410XPUN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118972
HOVERGENⁱ	HBG061815
InParanoidⁱ	P50995
KEGG Orthology (KO) More...KOⁱ	K17095
OMAⁱ	FDAYEIK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H6H
PhylomeDBⁱ	P50995
TreeFamⁱ	TF105452

Family and domain databases

Gene3Dⁱ	1.10.220.10, 4 hits
InterProⁱ	View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR008157 ANX11
PANTHERⁱ	PTHR10502:SF29 PTHR10502:SF29, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00191 Annexin, 4 hits
PRINTSⁱ	PR00196 ANNEXIN PR01810 ANNEXINXI
SMARTⁱ	View protein in SMART SM00335 ANX, 4 hits
PROSITEⁱ	View protein in PROSITE PS00223 ANNEXIN, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P50995-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN 
        60         70         80         90        100
QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV 
       110        120        130        140        150
PPYGMYPPPG GNPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV 
       160        170        180        190        200
TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF 
       210        220        230        240        250
DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL 
       260        270        280        290        300
IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA 
       310        320        330        340        350
SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST 
       360        370        380        390        400
NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR 
       410        420        430        440        450
MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK 
       460        470        480        490        500
DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI 

CGGND

Length:505

Mass (Da):54,390

Last modified:October 1, 1996 - v1

Checksum:ⁱ4ADCAC8F270BFEE4

GO

Isoform 2 (identifier: P50995-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.

« Hide

        10         20         30         40         50
MPPIGLDNVA TYAGQFNQDY LSGMAANMSG TFGGANMPNL YPGAPGAGYP 
        60         70         80         90        100
PVPPGGFGQP PSAQQPVPPY GMYPPPGGNP PSRMPSYPPY PGAPVPGQPM 
       110        120        130        140        150
PPPGQQPPGA YPGQPPVTYP GQPPVPLPGQ QQPVPSYPGY PGSGTVTPAV 
       160        170        180        190        200
PPTQFGSRGT ITDAPGFDPL RDAEVLRKAM KGFGTDEQAI IDCLGSRSNK 
       210        220        230        240        250
QRQQILLSFK TAYGKDLIKD LKSELSGNFE KTILALMKTP VLFDIYEIKE 
       260        270        280        290        300
AIKGVGTDEA CLIEILASRS NEHIRELNRA YKAEFKKTLE EAIRSDTSGH 
       310        320        330        340        350
FQRLLISLSQ GNRDESTNVD MSLAQRDAQE LYAAGENRLG TDESKFNAVL 
       360        370        380        390        400
CSRSRAHLVA VFNEYQRMTG RDIEKSICRE MSGDLEEGML AVVKCLKNTP 
       410        420        430        440        450
AFFAERLNKA MRGAGTKDRT LIRIMVSRSE TDLLDIRSEY KRMYGKSLYH 
       460        470 
DISGDTSGDY RKILLKICGG ND

Note: No experimental confirmation available.

Show »

Length:472

Mass (Da):51,242

Checksum:ⁱ477704C7C6863AE0

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y6E1	H0Y6E1_HUMAN	Annexin A11 Annexin A11	ANXA11	148	Annotation score:
Q5T0G7	Q5T0G7_HUMAN	Annexin A11 Annexin A11	ANXA11	150	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_080653	38	G → R in ALS23; unknown pathological significance; changed cytoplasmic localization with decreased association with vesicle-like structures; increased interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs142083484EnsemblClinVar.	1
Natural variantⁱVAR_080654	40	D → G in ALS23; forms cytoplasmic aggregates in patient tissues; no effect on nuclear and cytoplasmic localization; loss of interaction with S100A6. 1 Publication	1
Natural variantⁱVAR_080655	175	G → R in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754594235EnsemblClinVar.	1
Natural variantⁱVAR_080656	189	G → E in ALS23; unknown pathological significance; no effect on aggregation; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs569546089Ensembl.	1
Natural variantⁱVAR_048259	191	R → Q. Corresponds to variant dbSNP:rs2229554Ensembl.	1
Natural variantⁱVAR_012006	230	R → C. Corresponds to variant dbSNP:rs1049550Ensembl.	1
Natural variantⁱVAR_080657	235	R → Q in ALS23; unknown pathological significance; increased aggregation in the cytoplasm sequestering the wild-type protein in these aggregates; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs765489119Ensembl.	1
Natural variantⁱVAR_080658	346	R → C in ALS23; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_012007	457	I → V. Corresponds to variant dbSNP:rs1802932Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054553	1 – 33	Missing in isoform 2. 1 PublicationAdd BLAST		33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19605 mRNA Translation: AAA19734.1 AJ278463 mRNA Translation: CAB94995.1 AJ278464 mRNA Translation: CAB94996.1 AJ278465 mRNA Translation: CAB94997.1 AK301047 mRNA Translation: BAG62659.1 AL356095 Genomic DNA No translation available. AL513174 Genomic DNA No translation available. BC007564 mRNA Translation: AAH07564.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS60576.1 [P50995-2] CCDS7364.1 [P50995-1]
PIRⁱ	A53152
NCBI Reference Sequences More...RefSeqⁱ	NP_001148.1, NM_001157.2 [P50995-1] NP_001265336.1, NM_001278407.1 [P50995-1] NP_001265337.1, NM_001278408.1 [P50995-1] NP_001265338.1, NM_001278409.1 [P50995-2] NP_665875.1, NM_145868.1 [P50995-1] NP_665876.1, NM_145869.1 [P50995-1] XP_011538038.1, XM_011539736.2 [P50995-1]
UniGeneⁱ	Hs.530291

Genome annotation databases

Ensemblⁱ	ENST00000265447; ENSP00000265447; ENSG00000122359 [P50995-2] ENST00000372231; ENSP00000361305; ENSG00000122359 [P50995-1] ENST00000422982; ENSP00000404412; ENSG00000122359 [P50995-1] ENST00000438331; ENSP00000398610; ENSG00000122359 [P50995-1]
GeneIDⁱ	311
KEGGⁱ	hsa:311
UCSC genome browser More...UCSCⁱ	uc057umu.1 human [P50995-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P50995	Annexin		HUMAN		505	UniRef100_P50995
Annexin		PANTR		505
Annexin		PANPA		505
P50995-2	Annexin		PANTR		472	UniRef100_A0A2J8ILB6
UPI000387DC28		HUMAN		605

Protein	Similar proteins		Species	Score	Length	Source
P50995	Annexin A11		RABIT		503	UniRef90_P50995
Annexin A11		MOUSE		503
Annexin A11		BOVIN		503
Annexin		HUMAN		505
Annexin		PANTR		505
+72

Protein	Similar proteins		Species	Score	Length	Source
P50995	Annexin A11		MOUSE		503	UniRef50_P50995
Annexin A11		BOVIN		503
Annexin A11		RABIT		503
Annexin		HUMAN		505
Annexin		PANTR		505
+589

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19605 mRNA Translation: AAA19734.1 AJ278463 mRNA Translation: CAB94995.1 AJ278464 mRNA Translation: CAB94996.1 AJ278465 mRNA Translation: CAB94997.1 AK301047 mRNA Translation: BAG62659.1 AL356095 Genomic DNA No translation available. AL513174 Genomic DNA No translation available. BC007564 mRNA Translation: AAH07564.1
CCDSⁱ	CCDS60576.1 [P50995-2] CCDS7364.1 [P50995-1]
PIRⁱ	A53152
RefSeqⁱ	NP_001148.1, NM_001157.2 [P50995-1] NP_001265336.1, NM_001278407.1 [P50995-1] NP_001265337.1, NM_001278408.1 [P50995-1] NP_001265338.1, NM_001278409.1 [P50995-2] NP_665875.1, NM_145868.1 [P50995-1] NP_665876.1, NM_145869.1 [P50995-1] XP_011538038.1, XM_011539736.2 [P50995-1]
UniGeneⁱ	Hs.530291

3D structure databases

ProteinModelPortalⁱ	P50995
SMRⁱ	P50995
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106808, 49 interactors
ELMⁱ	P50995
IntActⁱ	P50995, 24 interactors
MINTⁱ	P50995
STRINGⁱ	9606.ENSP00000265447

Protein family/group databases

TCDBⁱ	3.A.5.9.1 the general secretory pathway (sec) family

TCDBⁱ

3.A.5.9.1 the general secretory pathway (sec) family

PTM databases

iPTMnetⁱ	P50995
PhosphoSitePlusⁱ	P50995
SwissPalmⁱ	P50995

Polymorphism and mutation databases

BioMutaⁱ	ANXA11
DMDMⁱ	1703322

2D gel databases

REPRODUCTION-2DPAGEⁱ	P50995

REPRODUCTION-2DPAGEⁱ

P50995

Proteomic databases

EPDⁱ	P50995
PaxDbⁱ	P50995
PeptideAtlasⁱ	P50995
PRIDEⁱ	P50995
ProteomicsDBⁱ	56275

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	311
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000265447; ENSP00000265447; ENSG00000122359 [P50995-2] ENST00000372231; ENSP00000361305; ENSG00000122359 [P50995-1] ENST00000422982; ENSP00000404412; ENSG00000122359 [P50995-1] ENST00000438331; ENSP00000398610; ENSG00000122359 [P50995-1]
GeneIDⁱ	311
KEGGⁱ	hsa:311
UCSCⁱ	uc057umu.1 human [P50995-1]

Organism-specific databases

CTDⁱ	311
DisGeNETⁱ	311
EuPathDBⁱ	HostDB:ENSG00000122359.17
GeneCardsⁱ	ANXA11
HGNCⁱ	HGNC:535 ANXA11
HPAⁱ	CAB004851 HPA027545
MalaCardsⁱ	ANXA11
MIMⁱ	602572 gene 617839 phenotype
neXtProtⁱ	NX_P50995
OpenTargetsⁱ	ENSG00000122359
PharmGKBⁱ	PA24825
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0819 Eukaryota ENOG410XPUN LUCA
GeneTreeⁱ	ENSGT00760000118972
HOVERGENⁱ	HBG061815
InParanoidⁱ	P50995
KOⁱ	K17095
OMAⁱ	FDAYEIK
OrthoDBⁱ	EOG091G0H6H
PhylomeDBⁱ	P50995
TreeFamⁱ	TF105452

Miscellaneous databases

ChiTaRSⁱ	ANXA11 human
GeneWikiⁱ	ANXA11
GenomeRNAiⁱ	311
Protein Ontology More...PROⁱ	PR:P50995
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122359 Expressed in 228 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_ANXA11
ExpressionAtlasⁱ	P50995 baseline and differential
Genevisibleⁱ	P50995 HS

Family and domain databases

Gene3Dⁱ	1.10.220.10, 4 hits
InterProⁱ	View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR008157 ANX11
PANTHERⁱ	PTHR10502:SF29 PTHR10502:SF29, 1 hit
Pfamⁱ	View protein in Pfam PF00191 Annexin, 4 hits
PRINTSⁱ	PR00196 ANNEXIN PR01810 ANNEXINXI
SMARTⁱ	View protein in SMART SM00335 ANX, 4 hits
PROSITEⁱ	View protein in PROSITE PS00223 ANNEXIN, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANX11_HUMAN
Accessionⁱ	P50995Primary (citable) accession number: P50995 Secondary accession number(s): B4DVE7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	October 10, 2018
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - P50995 (ANX11_HUMAN)

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Annexin A11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Lysosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ