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Protein

Annexin A11

Gene

ANXA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytokinetic process Source: UniProtKB
  • phagocytosis Source: UniProtKB
  • response to calcium ion Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division
LigandCalcium, Calcium/phospholipid-binding

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A11
Alternative name(s):
56 kDa autoantigen
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name:
CAP-50
Gene namesi
Name:ANXA11
Synonyms:ANX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000122359.17
HGNCiHGNC:535 ANXA11
MIMi602572 gene
neXtProtiNX_P50995

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Amyotrophic lateral sclerosis 23 (ALS23)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. ALS23 is an autosomal dominant form with incomplete penetrance.
See also OMIM:617839
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08065338G → R in ALS23; unknown pathological significance; changed cytoplasmic localization with decreased association with vesicle-like structures; increased interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs142083484EnsemblClinVar.1
Natural variantiVAR_08065440D → G in ALS23; forms cytoplasmic aggregates in patient tissues; no effect on nuclear and cytoplasmic localization; loss of interaction with S100A6. 1 Publication1
Natural variantiVAR_080655175G → R in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754594235EnsemblClinVar.1
Natural variantiVAR_080656189G → E in ALS23; unknown pathological significance; no effect on aggregation; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs569546089Ensembl.1
Natural variantiVAR_080657235R → Q in ALS23; unknown pathological significance; increased aggregation in the cytoplasm sequestering the wild-type protein in these aggregates; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs765489119Ensembl.1
Natural variantiVAR_080658346R → C in ALS23; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi311
MalaCardsiANXA11
MIMi617839 phenotype
OpenTargetsiENSG00000122359
PharmGKBiPA24825

Polymorphism and mutation databases

BioMutaiANXA11
DMDMi1703322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675101 – 505Annexin A11Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248N6-acetyllysineCombined sources1
Modified residuei255N6-acetyllysineCombined sources1
Modified residuei479N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP50995
PaxDbiP50995
PeptideAtlasiP50995
PRIDEiP50995
ProteomicsDBi56275

2D gel databases

REPRODUCTION-2DPAGEiP50995

PTM databases

iPTMnetiP50995
PhosphoSitePlusiP50995
SwissPalmiP50995

Expressioni

Gene expression databases

BgeeiENSG00000122359 Expressed in 228 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_ANXA11
ExpressionAtlasiP50995 baseline and differential
GenevisibleiP50995 HS

Organism-specific databases

HPAiCAB004851
HPA027545

Interactioni

Subunit structurei

Interacts with S100A6 (PubMed:28469040). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106808, 49 interactors
ELMiP50995
IntActiP50995, 24 interactors
MINTiP50995
STRINGi9606.ENSP00000265447

Structurei

3D structure databases

ProteinModelPortaliP50995
SMRiP50995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati209 – 269Annexin 1Add BLAST61
Repeati281 – 341Annexin 2Add BLAST61
Repeati365 – 425Annexin 3Add BLAST61
Repeati440 – 500Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOVERGENiHBG061815
InParanoidiP50995
KOiK17095
OMAiFDAYEIK
OrthoDBiEOG091G0H6H
PhylomeDBiP50995
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR008157 ANX11
PANTHERiPTHR10502:SF29 PTHR10502:SF29, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01810 ANNEXINXI
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50995-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN
60 70 80 90 100
QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV
110 120 130 140 150
PPYGMYPPPG GNPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV
160 170 180 190 200
TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF
210 220 230 240 250
DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL
260 270 280 290 300
IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA
310 320 330 340 350
SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST
360 370 380 390 400
NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR
410 420 430 440 450
MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK
460 470 480 490 500
DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI

CGGND
Length:505
Mass (Da):54,390
Last modified:October 1, 1996 - v1
Checksum:i4ADCAC8F270BFEE4
GO
Isoform 2 (identifier: P50995-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):51,242
Checksum:i477704C7C6863AE0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6E1H0Y6E1_HUMAN
Annexin A11
ANXA11
148Annotation score:
Q5T0G7Q5T0G7_HUMAN
Annexin A11
ANXA11
150Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08065338G → R in ALS23; unknown pathological significance; changed cytoplasmic localization with decreased association with vesicle-like structures; increased interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs142083484EnsemblClinVar.1
Natural variantiVAR_08065440D → G in ALS23; forms cytoplasmic aggregates in patient tissues; no effect on nuclear and cytoplasmic localization; loss of interaction with S100A6. 1 Publication1
Natural variantiVAR_080655175G → R in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754594235EnsemblClinVar.1
Natural variantiVAR_080656189G → E in ALS23; unknown pathological significance; no effect on aggregation; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs569546089Ensembl.1
Natural variantiVAR_048259191R → Q. Corresponds to variant dbSNP:rs2229554Ensembl.1
Natural variantiVAR_012006230R → C. Corresponds to variant dbSNP:rs1049550Ensembl.1
Natural variantiVAR_080657235R → Q in ALS23; unknown pathological significance; increased aggregation in the cytoplasm sequestering the wild-type protein in these aggregates; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs765489119Ensembl.1
Natural variantiVAR_080658346R → C in ALS23; unknown pathological significance. 1 Publication1
Natural variantiVAR_012007457I → V. Corresponds to variant dbSNP:rs1802932Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545531 – 33Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19605 mRNA Translation: AAA19734.1
AJ278463 mRNA Translation: CAB94995.1
AJ278464 mRNA Translation: CAB94996.1
AJ278465 mRNA Translation: CAB94997.1
AK301047 mRNA Translation: BAG62659.1
AL356095 Genomic DNA No translation available.
AL513174 Genomic DNA No translation available.
BC007564 mRNA Translation: AAH07564.1
CCDSiCCDS60576.1 [P50995-2]
CCDS7364.1 [P50995-1]
PIRiA53152
RefSeqiNP_001148.1, NM_001157.2 [P50995-1]
NP_001265336.1, NM_001278407.1 [P50995-1]
NP_001265337.1, NM_001278408.1 [P50995-1]
NP_001265338.1, NM_001278409.1 [P50995-2]
NP_665875.1, NM_145868.1 [P50995-1]
NP_665876.1, NM_145869.1 [P50995-1]
XP_011538038.1, XM_011539736.2 [P50995-1]
UniGeneiHs.530291

Genome annotation databases

EnsembliENST00000265447; ENSP00000265447; ENSG00000122359 [P50995-2]
ENST00000372231; ENSP00000361305; ENSG00000122359 [P50995-1]
ENST00000422982; ENSP00000404412; ENSG00000122359 [P50995-1]
ENST00000438331; ENSP00000398610; ENSG00000122359 [P50995-1]
GeneIDi311
KEGGihsa:311
UCSCiuc057umu.1 human [P50995-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19605 mRNA Translation: AAA19734.1
AJ278463 mRNA Translation: CAB94995.1
AJ278464 mRNA Translation: CAB94996.1
AJ278465 mRNA Translation: CAB94997.1
AK301047 mRNA Translation: BAG62659.1
AL356095 Genomic DNA No translation available.
AL513174 Genomic DNA No translation available.
BC007564 mRNA Translation: AAH07564.1
CCDSiCCDS60576.1 [P50995-2]
CCDS7364.1 [P50995-1]
PIRiA53152
RefSeqiNP_001148.1, NM_001157.2 [P50995-1]
NP_001265336.1, NM_001278407.1 [P50995-1]
NP_001265337.1, NM_001278408.1 [P50995-1]
NP_001265338.1, NM_001278409.1 [P50995-2]
NP_665875.1, NM_145868.1 [P50995-1]
NP_665876.1, NM_145869.1 [P50995-1]
XP_011538038.1, XM_011539736.2 [P50995-1]
UniGeneiHs.530291

3D structure databases

ProteinModelPortaliP50995
SMRiP50995
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106808, 49 interactors
ELMiP50995
IntActiP50995, 24 interactors
MINTiP50995
STRINGi9606.ENSP00000265447

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

PTM databases

iPTMnetiP50995
PhosphoSitePlusiP50995
SwissPalmiP50995

Polymorphism and mutation databases

BioMutaiANXA11
DMDMi1703322

2D gel databases

REPRODUCTION-2DPAGEiP50995

Proteomic databases

EPDiP50995
PaxDbiP50995
PeptideAtlasiP50995
PRIDEiP50995
ProteomicsDBi56275

Protocols and materials databases

DNASUi311
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265447; ENSP00000265447; ENSG00000122359 [P50995-2]
ENST00000372231; ENSP00000361305; ENSG00000122359 [P50995-1]
ENST00000422982; ENSP00000404412; ENSG00000122359 [P50995-1]
ENST00000438331; ENSP00000398610; ENSG00000122359 [P50995-1]
GeneIDi311
KEGGihsa:311
UCSCiuc057umu.1 human [P50995-1]

Organism-specific databases

CTDi311
DisGeNETi311
EuPathDBiHostDB:ENSG00000122359.17
GeneCardsiANXA11
HGNCiHGNC:535 ANXA11
HPAiCAB004851
HPA027545
MalaCardsiANXA11
MIMi602572 gene
617839 phenotype
neXtProtiNX_P50995
OpenTargetsiENSG00000122359
PharmGKBiPA24825
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOVERGENiHBG061815
InParanoidiP50995
KOiK17095
OMAiFDAYEIK
OrthoDBiEOG091G0H6H
PhylomeDBiP50995
TreeFamiTF105452

Miscellaneous databases

ChiTaRSiANXA11 human
GeneWikiiANXA11
GenomeRNAii311
PROiPR:P50995
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122359 Expressed in 228 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_ANXA11
ExpressionAtlasiP50995 baseline and differential
GenevisibleiP50995 HS

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR008157 ANX11
PANTHERiPTHR10502:SF29 PTHR10502:SF29, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01810 ANNEXINXI
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANX11_HUMAN
AccessioniPrimary (citable) accession number: P50995
Secondary accession number(s): B4DVE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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