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UniProtKB - P50995 (ANX11_HUMAN)

Entry version 188 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Annexin A11

Gene

ANXA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division
LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P50995

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.5.9.1, the general secretory pathway (sec) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Annexin A11
Alternative name(s):
56 kDa autoantigen
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name:
CAP-50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANXA11
Synonyms:ANX11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:535, ANXA11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602572, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P50995

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000122359.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyotrophic lateral sclerosis 23 (ALS23)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. ALS23 is an autosomal dominant form with incomplete penetrance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08065338G → R in ALS23; unknown pathological significance; changed cytoplasmic localization with decreased association with vesicle-like structures; increased interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs142083484EnsemblClinVar.1
Natural variantiVAR_08065440D → G in ALS23; forms cytoplasmic aggregates in patient tissues; no effect on nuclear and cytoplasmic localization; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs1247392012EnsemblClinVar.1
Natural variantiVAR_080655175G → R in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754594235EnsemblClinVar.1
Natural variantiVAR_080656189G → E in ALS23; unknown pathological significance; no effect on aggregation; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs569546089Ensembl.1
Natural variantiVAR_080657235R → Q in ALS23; unknown pathological significance; increased aggregation in the cytoplasm sequestering the wild-type protein in these aggregates; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs765489119Ensembl.1
Natural variantiVAR_080658346R → C in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770574196Ensembl.1

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		311

MalaCards human disease database

More...MalaCardsi		ANXA11
MIMi617839, phenotype

Open Targets

More...OpenTargetsi		ENSG00000122359

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		803, Amyotrophic lateral sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24825

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P50995, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANXA11

Domain mapping of disease mutations (DMDM)

More...DMDMi		1703322

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000675101 – 505Annexin A11Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei248N6-acetyllysineCombined sources1
Modified residuei255N6-acetyllysineCombined sources1
Modified residuei479N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1217
CPTAC-1218

Encyclopedia of Proteome Dynamics

More...EPDi		P50995

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P50995

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P50995

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P50995

PeptideAtlas

More...PeptideAtlasi		P50995

PRoteomics IDEntifications database

More...PRIDEi		P50995

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5263
56275 [P50995-1]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		P50995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P50995

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P50995

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P50995

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P50995

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000122359, Expressed in lower esophagus mucosa and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P50995, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P50995, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000122359, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with S100A6 (PubMed:28469040).

Interacts with PDCD6 in a calcium-dependent manner.

Interacts with KIF23 during cytokinesis.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106808, 67 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P50995

Protein interaction database and analysis system

More...IntActi		P50995, 30 interactors

Molecular INTeraction database

More...MINTi		P50995

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000398610

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P50995, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P50995

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati200 – 271Annexin 1PROSITE-ProRule annotationAdd BLAST72
Repeati272 – 343Annexin 2PROSITE-ProRule annotationAdd BLAST72
Repeati355 – 427Annexin 3PROSITE-ProRule annotationAdd BLAST73
Repeati431 – 502Annexin 4PROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the annexin family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0819, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156914

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025300_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P50995

Identification of Orthologs from Complete Genome Data

More...OMAi		MTYPGQQ

Database of Orthologous Groups

More...OrthoDBi		856254at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P50995

TreeFam database of animal gene trees

More...TreeFami		TF105452

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.220.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001464, Annexin
IPR018502, Annexin_repeat
IPR018252, Annexin_repeat_CS
IPR037104, Annexin_sf
IPR008157, ANX11

The PANTHER Classification System

More...PANTHERi		PTHR10502:SF29, PTHR10502:SF29, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00191, Annexin, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00196, ANNEXIN
PR01810, ANNEXINXI

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00335, ANX, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47874, SSF47874, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00223, ANNEXIN_1, 4 hits
PS51897, ANNEXIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P50995-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN 
        60         70         80         90        100
QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV 
       110        120        130        140        150
PPYGMYPPPG GNPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV 
       160        170        180        190        200
TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF 
       210        220        230        240        250
DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL 
       260        270        280        290        300
IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA 
       310        320        330        340        350
SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST 
       360        370        380        390        400
NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR 
       410        420        430        440        450
MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK 
       460        470        480        490        500
DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI 

CGGND
Length:505
Mass (Da):54,390
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4ADCAC8F270BFEE4
GO
Isoform 2 (identifier: P50995-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:472
Mass (Da):51,242
Checksum:i477704C7C6863AE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0G7Q5T0G7_HUMAN
Annexin A11
ANXA11
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6E1H0Y6E1_HUMAN
Annexin A11
ANXA11
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08065338G → R in ALS23; unknown pathological significance; changed cytoplasmic localization with decreased association with vesicle-like structures; increased interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs142083484EnsemblClinVar.1
Natural variantiVAR_08065440D → G in ALS23; forms cytoplasmic aggregates in patient tissues; no effect on nuclear and cytoplasmic localization; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs1247392012EnsemblClinVar.1
Natural variantiVAR_080655175G → R in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754594235EnsemblClinVar.1
Natural variantiVAR_080656189G → E in ALS23; unknown pathological significance; no effect on aggregation; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs569546089Ensembl.1
Natural variantiVAR_048259191R → Q. Corresponds to variant dbSNP:rs2229554Ensembl.1
Natural variantiVAR_012006230R → C. Corresponds to variant dbSNP:rs1049550Ensembl.1
Natural variantiVAR_080657235R → Q in ALS23; unknown pathological significance; increased aggregation in the cytoplasm sequestering the wild-type protein in these aggregates; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs765489119Ensembl.1
Natural variantiVAR_080658346R → C in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770574196Ensembl.1
Natural variantiVAR_012007457I → V. Corresponds to variant dbSNP:rs1802932EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545531 – 33Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L19605 mRNA Translation: AAA19734.1
AJ278463 mRNA Translation: CAB94995.1
AJ278464 mRNA Translation: CAB94996.1
AJ278465 mRNA Translation: CAB94997.1
AK301047 mRNA Translation: BAG62659.1
AL356095 Genomic DNA No translation available.
AL513174 Genomic DNA No translation available.
BC007564 mRNA Translation: AAH07564.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS60576.1 [P50995-2]
CCDS7364.1 [P50995-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A53152

NCBI Reference Sequences

More...RefSeqi		NP_001148.1, NM_001157.2 [P50995-1]
NP_001265336.1, NM_001278407.1 [P50995-1]
NP_001265337.1, NM_001278408.1 [P50995-1]
NP_001265338.1, NM_001278409.1 [P50995-2]
NP_665875.1, NM_145868.1 [P50995-1]
NP_665876.1, NM_145869.1 [P50995-1]
XP_011538038.1, XM_011539736.2 [P50995-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265447; ENSP00000265447; ENSG00000122359 [P50995-2]
ENST00000372231; ENSP00000361305; ENSG00000122359 [P50995-1]
ENST00000422982; ENSP00000404412; ENSG00000122359 [P50995-1]
ENST00000438331; ENSP00000398610; ENSG00000122359 [P50995-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		311

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:311

UCSC genome browser

More...UCSCi		uc057umu.1, human [P50995-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19605 mRNA Translation: AAA19734.1
AJ278463 mRNA Translation: CAB94995.1
AJ278464 mRNA Translation: CAB94996.1
AJ278465 mRNA Translation: CAB94997.1
AK301047 mRNA Translation: BAG62659.1
AL356095 Genomic DNA No translation available.
AL513174 Genomic DNA No translation available.
BC007564 mRNA Translation: AAH07564.1
CCDSiCCDS60576.1 [P50995-2]
CCDS7364.1 [P50995-1]
PIRiA53152
RefSeqiNP_001148.1, NM_001157.2 [P50995-1]
NP_001265336.1, NM_001278407.1 [P50995-1]
NP_001265337.1, NM_001278408.1 [P50995-1]
NP_001265338.1, NM_001278409.1 [P50995-2]
NP_665875.1, NM_145868.1 [P50995-1]
NP_665876.1, NM_145869.1 [P50995-1]
XP_011538038.1, XM_011539736.2 [P50995-1]

3D structure databases

SMRiP50995
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106808, 67 interactors
ELMiP50995
IntActiP50995, 30 interactors
MINTiP50995
STRINGi9606.ENSP00000398610

Protein family/group databases

TCDBi3.A.5.9.1, the general secretory pathway (sec) family

PTM databases

iPTMnetiP50995
MetOSiteiP50995
PhosphoSitePlusiP50995
SwissPalmiP50995

Genetic variation databases

BioMutaiANXA11
DMDMi1703322

2D gel databases

REPRODUCTION-2DPAGEiP50995

Proteomic databases

CPTACiCPTAC-1217
CPTAC-1218
EPDiP50995
jPOSTiP50995
MassIVEiP50995
PaxDbiP50995
PeptideAtlasiP50995
PRIDEiP50995
ProteomicsDBi5263
56275 [P50995-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3904, 312 antibodies

The DNASU plasmid repository

More...DNASUi		311

Genome annotation databases

EnsembliENST00000265447; ENSP00000265447; ENSG00000122359 [P50995-2]
ENST00000372231; ENSP00000361305; ENSG00000122359 [P50995-1]
ENST00000422982; ENSP00000404412; ENSG00000122359 [P50995-1]
ENST00000438331; ENSP00000398610; ENSG00000122359 [P50995-1]
GeneIDi311
KEGGihsa:311
UCSCiuc057umu.1, human [P50995-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		311
DisGeNETi311

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANXA11
HGNCiHGNC:535, ANXA11
HPAiENSG00000122359, Low tissue specificity
MalaCardsiANXA11
MIMi602572, gene
617839, phenotype
neXtProtiNX_P50995
OpenTargetsiENSG00000122359
Orphaneti803, Amyotrophic lateral sclerosis
PharmGKBiPA24825
VEuPathDBiHostDB:ENSG00000122359.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0819, Eukaryota
GeneTreeiENSGT00940000156914
HOGENOMiCLU_025300_6_0_1
InParanoidiP50995
OMAiMTYPGQQ
OrthoDBi856254at2759
PhylomeDBiP50995
TreeFamiTF105452

Enzyme and pathway databases

PathwayCommonsiP50995

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		311, 5 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANXA11, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ANXA11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		311
PharosiP50995, Tbio

Protein Ontology

More...PROi		PR:P50995
RNActiP50995, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000122359, Expressed in lower esophagus mucosa and 241 other tissues
ExpressionAtlasiP50995, baseline and differential
GenevisibleiP50995, HS

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464, Annexin
IPR018502, Annexin_repeat
IPR018252, Annexin_repeat_CS
IPR037104, Annexin_sf
IPR008157, ANX11
PANTHERiPTHR10502:SF29, PTHR10502:SF29, 1 hit
PfamiView protein in Pfam
PF00191, Annexin, 4 hits
PRINTSiPR00196, ANNEXIN
PR01810, ANNEXINXI
SMARTiView protein in SMART
SM00335, ANX, 4 hits
SUPFAMiSSF47874, SSF47874, 1 hit
PROSITEiView protein in PROSITE
PS00223, ANNEXIN_1, 4 hits
PS51897, ANNEXIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANX11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50995
Secondary accession number(s): B4DVE7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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