UniProtKB - P50995 (ANX11_HUMAN)
Protein
Annexin A11
Gene
ANXA11
Organism
Homo sapiens (Human)
Status
Functioni
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.By similarity1 Publication
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB-KW
- calcium-dependent protein binding Source: UniProtKB
- calcium ion binding Source: GO_Central
- MHC class II protein complex binding Source: UniProtKB
- RNA binding Source: UniProtKB
- S100 protein binding Source: UniProtKB
GO - Biological processi
- cytokinetic process Source: UniProtKB
- phagocytosis Source: UniProtKB
- response to calcium ion Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division |
Ligand | Calcium, Calcium/phospholipid-binding |
Enzyme and pathway databases
PathwayCommonsi | P50995 |
Protein family/group databases
TCDBi | 3.A.5.9.1, the general secretory pathway (sec) family |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin A11Alternative name(s): 56 kDa autoantigen Annexin XI Annexin-11 Calcyclin-associated annexin 50 Short name: CAP-50 |
Gene namesi | Name:ANXA11 Synonyms:ANX11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:535, ANXA11 |
MIMi | 602572, gene |
neXtProti | NX_P50995 |
VEuPathDBi | HostDB:ENSG00000122359.17 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus envelope
- nucleoplasm 1 Publication
Cytoskeleton
Other locations
Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.By similarity
Cytoskeleton
- spindle Source: UniProtKB
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- azurophil granule Source: UniProtKB
Nucleus
- nuclear envelope Source: UniProtKB
- nucleoplasm Source: UniProtKB
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- cytoplasm Source: UniProtKB
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- midbody Source: UniProtKB
- phagocytic vesicle Source: UniProtKB
- specific granule Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Amyotrophic lateral sclerosis 23 (ALS23)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. ALS23 is an autosomal dominant form with incomplete penetrance.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080653 | 38 | G → R in ALS23; unknown pathological significance; changed cytoplasmic localization with decreased association with vesicle-like structures; increased interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs142083484EnsemblClinVar. | 1 | |
Natural variantiVAR_080654 | 40 | D → G in ALS23; forms cytoplasmic aggregates in patient tissues; no effect on nuclear and cytoplasmic localization; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs1247392012EnsemblClinVar. | 1 | |
Natural variantiVAR_080655 | 175 | G → R in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754594235EnsemblClinVar. | 1 | |
Natural variantiVAR_080656 | 189 | G → E in ALS23; unknown pathological significance; no effect on aggregation; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs569546089Ensembl. | 1 | |
Natural variantiVAR_080657 | 235 | R → Q in ALS23; unknown pathological significance; increased aggregation in the cytoplasm sequestering the wild-type protein in these aggregates; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs765489119Ensembl. | 1 | |
Natural variantiVAR_080658 | 346 | R → C in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770574196Ensembl. | 1 |
Keywords - Diseasei
Amyotrophic lateral sclerosis, Disease variant, NeurodegenerationOrganism-specific databases
DisGeNETi | 311 |
MalaCardsi | ANXA11 |
MIMi | 617839, phenotype |
OpenTargetsi | ENSG00000122359 |
Orphaneti | 803, Amyotrophic lateral sclerosis |
PharmGKBi | PA24825 |
Miscellaneous databases
Pharosi | P50995, Tbio |
Genetic variation databases
BioMutai | ANXA11 |
DMDMi | 1703322 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067510 | 1 – 505 | Annexin A11Add BLAST | 505 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 248 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 255 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 479 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
CPTACi | CPTAC-1217 CPTAC-1218 |
EPDi | P50995 |
jPOSTi | P50995 |
MassIVEi | P50995 |
PaxDbi | P50995 |
PeptideAtlasi | P50995 |
PRIDEi | P50995 |
ProteomicsDBi | 5263 56275 [P50995-1] |
2D gel databases
REPRODUCTION-2DPAGEi | P50995 |
PTM databases
iPTMneti | P50995 |
MetOSitei | P50995 |
PhosphoSitePlusi | P50995 |
SwissPalmi | P50995 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122359, Expressed in lower esophagus mucosa and 241 other tissues |
ExpressionAtlasi | P50995, baseline and differential |
Genevisiblei | P50995, HS |
Organism-specific databases
HPAi | ENSG00000122359, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with S100A6 (PubMed:28469040).
Interacts with PDCD6 in a calcium-dependent manner.
Interacts with KIF23 during cytokinesis.
By similarity4 PublicationsBinary interactionsi
Hide detailsP50995
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- S100 protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 106808, 67 interactors |
ELMi | P50995 |
IntActi | P50995, 30 interactors |
MINTi | P50995 |
STRINGi | 9606.ENSP00000398610 |
Miscellaneous databases
RNActi | P50995, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 200 – 271 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 272 – 343 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 355 – 427 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 73 | |
Repeati | 431 – 502 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 |
Domaini
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000156914 |
HOGENOMi | CLU_025300_6_0_1 |
InParanoidi | P50995 |
OMAi | MTYPGQQ |
OrthoDBi | 856254at2759 |
PhylomeDBi | P50995 |
TreeFami | TF105452 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR008157, ANX11 |
PANTHERi | PTHR10502:SF29, PTHR10502:SF29, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR01810, ANNEXINXI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P50995-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN
60 70 80 90 100
QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV
110 120 130 140 150
PPYGMYPPPG GNPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV
160 170 180 190 200
TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF
210 220 230 240 250
DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL
260 270 280 290 300
IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA
310 320 330 340 350
SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST
360 370 380 390 400
NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR
410 420 430 440 450
MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK
460 470 480 490 500
DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI
CGGND
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T0G7 | Q5T0G7_HUMAN | Annexin A11 | ANXA11 | 150 | Annotation score: | ||
H0Y6E1 | H0Y6E1_HUMAN | Annexin A11 | ANXA11 | 148 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080653 | 38 | G → R in ALS23; unknown pathological significance; changed cytoplasmic localization with decreased association with vesicle-like structures; increased interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs142083484EnsemblClinVar. | 1 | |
Natural variantiVAR_080654 | 40 | D → G in ALS23; forms cytoplasmic aggregates in patient tissues; no effect on nuclear and cytoplasmic localization; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs1247392012EnsemblClinVar. | 1 | |
Natural variantiVAR_080655 | 175 | G → R in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754594235EnsemblClinVar. | 1 | |
Natural variantiVAR_080656 | 189 | G → E in ALS23; unknown pathological significance; no effect on aggregation; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs569546089Ensembl. | 1 | |
Natural variantiVAR_048259 | 191 | R → Q. Corresponds to variant dbSNP:rs2229554Ensembl. | 1 | |
Natural variantiVAR_012006 | 230 | R → C. Corresponds to variant dbSNP:rs1049550Ensembl. | 1 | |
Natural variantiVAR_080657 | 235 | R → Q in ALS23; unknown pathological significance; increased aggregation in the cytoplasm sequestering the wild-type protein in these aggregates; loss of interaction with S100A6. 1 PublicationCorresponds to variant dbSNP:rs765489119Ensembl. | 1 | |
Natural variantiVAR_080658 | 346 | R → C in ALS23; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770574196Ensembl. | 1 | |
Natural variantiVAR_012007 | 457 | I → V. Corresponds to variant dbSNP:rs1802932EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054553 | 1 – 33 | Missing in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19605 mRNA Translation: AAA19734.1 AJ278463 mRNA Translation: CAB94995.1 AJ278464 mRNA Translation: CAB94996.1 AJ278465 mRNA Translation: CAB94997.1 AK301047 mRNA Translation: BAG62659.1 AL356095 Genomic DNA No translation available. AL513174 Genomic DNA No translation available. BC007564 mRNA Translation: AAH07564.1 |
CCDSi | CCDS60576.1 [P50995-2] CCDS7364.1 [P50995-1] |
PIRi | A53152 |
RefSeqi | NP_001148.1, NM_001157.2 [P50995-1] NP_001265336.1, NM_001278407.1 [P50995-1] NP_001265337.1, NM_001278408.1 [P50995-1] NP_001265338.1, NM_001278409.1 [P50995-2] NP_665875.1, NM_145868.1 [P50995-1] NP_665876.1, NM_145869.1 [P50995-1] XP_011538038.1, XM_011539736.2 [P50995-1] |
Genome annotation databases
Ensembli | ENST00000265447; ENSP00000265447; ENSG00000122359 [P50995-2] ENST00000372231; ENSP00000361305; ENSG00000122359 [P50995-1] ENST00000422982; ENSP00000404412; ENSG00000122359 [P50995-1] ENST00000438331; ENSP00000398610; ENSG00000122359 [P50995-1] |
GeneIDi | 311 |
KEGGi | hsa:311 |
UCSCi | uc057umu.1, human [P50995-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19605 mRNA Translation: AAA19734.1 AJ278463 mRNA Translation: CAB94995.1 AJ278464 mRNA Translation: CAB94996.1 AJ278465 mRNA Translation: CAB94997.1 AK301047 mRNA Translation: BAG62659.1 AL356095 Genomic DNA No translation available. AL513174 Genomic DNA No translation available. BC007564 mRNA Translation: AAH07564.1 |
CCDSi | CCDS60576.1 [P50995-2] CCDS7364.1 [P50995-1] |
PIRi | A53152 |
RefSeqi | NP_001148.1, NM_001157.2 [P50995-1] NP_001265336.1, NM_001278407.1 [P50995-1] NP_001265337.1, NM_001278408.1 [P50995-1] NP_001265338.1, NM_001278409.1 [P50995-2] NP_665875.1, NM_145868.1 [P50995-1] NP_665876.1, NM_145869.1 [P50995-1] XP_011538038.1, XM_011539736.2 [P50995-1] |
3D structure databases
SMRi | P50995 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106808, 67 interactors |
ELMi | P50995 |
IntActi | P50995, 30 interactors |
MINTi | P50995 |
STRINGi | 9606.ENSP00000398610 |
Protein family/group databases
TCDBi | 3.A.5.9.1, the general secretory pathway (sec) family |
PTM databases
iPTMneti | P50995 |
MetOSitei | P50995 |
PhosphoSitePlusi | P50995 |
SwissPalmi | P50995 |
Genetic variation databases
BioMutai | ANXA11 |
DMDMi | 1703322 |
2D gel databases
REPRODUCTION-2DPAGEi | P50995 |
Proteomic databases
CPTACi | CPTAC-1217 CPTAC-1218 |
EPDi | P50995 |
jPOSTi | P50995 |
MassIVEi | P50995 |
PaxDbi | P50995 |
PeptideAtlasi | P50995 |
PRIDEi | P50995 |
ProteomicsDBi | 5263 56275 [P50995-1] |
Protocols and materials databases
Antibodypediai | 3904, 312 antibodies |
DNASUi | 311 |
Genome annotation databases
Ensembli | ENST00000265447; ENSP00000265447; ENSG00000122359 [P50995-2] ENST00000372231; ENSP00000361305; ENSG00000122359 [P50995-1] ENST00000422982; ENSP00000404412; ENSG00000122359 [P50995-1] ENST00000438331; ENSP00000398610; ENSG00000122359 [P50995-1] |
GeneIDi | 311 |
KEGGi | hsa:311 |
UCSCi | uc057umu.1, human [P50995-1] |
Organism-specific databases
CTDi | 311 |
DisGeNETi | 311 |
GeneCardsi | ANXA11 |
HGNCi | HGNC:535, ANXA11 |
HPAi | ENSG00000122359, Low tissue specificity |
MalaCardsi | ANXA11 |
MIMi | 602572, gene 617839, phenotype |
neXtProti | NX_P50995 |
OpenTargetsi | ENSG00000122359 |
Orphaneti | 803, Amyotrophic lateral sclerosis |
PharmGKBi | PA24825 |
VEuPathDBi | HostDB:ENSG00000122359.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000156914 |
HOGENOMi | CLU_025300_6_0_1 |
InParanoidi | P50995 |
OMAi | MTYPGQQ |
OrthoDBi | 856254at2759 |
PhylomeDBi | P50995 |
TreeFami | TF105452 |
Enzyme and pathway databases
PathwayCommonsi | P50995 |
Miscellaneous databases
BioGRID-ORCSi | 311, 5 hits in 1001 CRISPR screens |
ChiTaRSi | ANXA11, human |
GeneWikii | ANXA11 |
GenomeRNAii | 311 |
Pharosi | P50995, Tbio |
PROi | PR:P50995 |
RNActi | P50995, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122359, Expressed in lower esophagus mucosa and 241 other tissues |
ExpressionAtlasi | P50995, baseline and differential |
Genevisiblei | P50995, HS |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR008157, ANX11 |
PANTHERi | PTHR10502:SF29, PTHR10502:SF29, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR01810, ANNEXINXI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANX11_HUMAN | |
Accessioni | P50995Primary (citable) accession number: P50995 Secondary accession number(s): B4DVE7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families