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Protein

T-complex protein 1 subunit delta

Gene

CCT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).Curated2 Publications

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • unfolded protein binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
CCT-delta
Stimulator of TAR RNA-binding
Gene namesi
Name:CCT4
Synonyms:CCTD, SRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115484.14
HGNCiHGNC:1617 CCT4
MIMi605142 gene
neXtProtiNX_P50991

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10575
OpenTargetsiENSG00000115484
PharmGKBiPA26181

Polymorphism and mutation databases

BioMutaiCCT4
DMDMi52001478

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001283322 – 539T-complex protein 1 subunit deltaAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Omega-N-methylarginineCombined sources1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei36PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei288N6-acetyllysineCombined sources1
Modified residuei302N6-acetyllysineCombined sources1
Modified residuei319N6-acetyllysineCombined sources1
Modified residuei326N6-acetyllysineCombined sources1
Modified residuei444PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP50991
MaxQBiP50991
PaxDbiP50991
PeptideAtlasiP50991
PRIDEiP50991
ProteomicsDBi56273
TopDownProteomicsiP50991-1 [P50991-1]

2D gel databases

REPRODUCTION-2DPAGEiIPI00302927
UCD-2DPAGEiP50991

PTM databases

iPTMnetiP50991
PhosphoSitePlusiP50991
SwissPalmiP50991

Miscellaneous databases

PMAP-CutDBiP50991

Expressioni

Gene expression databases

BgeeiENSG00000115484 Expressed in 238 organ(s), highest expression level in female gonad
CleanExiHS_CCT4
GenevisibleiP50991 HS

Organism-specific databases

HPAiHPA029349

Interactioni

Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with DNAAF4 (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
OLR1P783803EBI-356876,EBI-7151999

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115826, 227 interactors
CORUMiP50991
DIPiDIP-32971N
IntActiP50991, 121 interactors
MINTiP50991
STRINGi9606.ENSP00000377958

Structurei

3D structure databases

ProteinModelPortaliP50991
SMRiP50991
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0358 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074956
HOGENOMiHOG000226735
HOVERGENiHBG106507
InParanoidiP50991
KOiK09496
OMAiQFCLSPP
OrthoDBiEOG091G05G4
PhylomeDBiP50991
TreeFamiTF106332

Family and domain databases

CDDicd03338 TCP1_delta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02342 chap_CCT_delta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P50991-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPENVAPRSG ATAGAAGGRG KGAYQDRDKP AQIRFSNISA AKAVADAIRT
60 70 80 90 100
SLGPKGMDKM IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI
110 120 130 140 150
EAGDGTTSVV IIAGSLLDSC TKLLQKGIHP TIISESFQKA LEKGIEILTD
160 170 180 190 200
MSRPVELSDR ETLLNSATTS LNSKVVSQYS SLLSPMSVNA VMKVIDPATA
210 220 230 240 250
TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVSNSGITR VEKAKIGLIQ
260 270 280 290 300
FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI
310 320 330 340 350
QKSILRDALS DLALHFLNKM KIMVIKDIER EDIEFICKTI GTKPVAHIDQ
360 370 380 390 400
FTADMLGSAE LAEEVNLNGS GKLLKITGCA SPGKTVTIVV RGSNKLVIEE
410 420 430 440 450
AERSIHDALC VIRCLVKKRA LIAGGGAPEI ELALRLTEYS RTLSGMESYC
460 470 480 490 500
VRAFADAMEV IPSTLAENAG LNPISTVTEL RNRHAQGEKT AGINVRKGGI
510 520 530
SNILEELVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR
Length:539
Mass (Da):57,924
Last modified:January 23, 2007 - v4
Checksum:i39913C0D0735180D
GO
Isoform 2 (identifier: P50991-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-89: Missing.

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):54,720
Checksum:i53EDE4CD2799D28B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti435R → A in AAC50384 (PubMed:8626763).Curated1
Sequence conflicti531K → R in BAH13897 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052266112I → V. Corresponds to variant dbSNP:rs2272428Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04553760 – 89Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38846 mRNA Translation: AAC50384.1
AF026291 mRNA Translation: AAC96010.1
AK303082 mRNA Translation: BAH13897.1
AK312586 mRNA Translation: BAG35480.1
AC107081 Genomic DNA Translation: AAY24140.1
BC014676 mRNA Translation: AAH14676.1
BC106934 mRNA Translation: AAI06935.1
BC106933 mRNA Translation: AAI06934.1
CCDSiCCDS33206.1 [P50991-1]
CCDS58711.1 [P50991-2]
RefSeqiNP_001243650.1, NM_001256721.1 [P50991-2]
NP_006421.2, NM_006430.3 [P50991-1]
UniGeneiHs.421509

Genome annotation databases

EnsembliENST00000394440; ENSP00000377958; ENSG00000115484 [P50991-1]
ENST00000544079; ENSP00000443061; ENSG00000115484 [P50991-2]
GeneIDi10575
KEGGihsa:10575
UCSCiuc002sbo.5 human [P50991-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38846 mRNA Translation: AAC50384.1
AF026291 mRNA Translation: AAC96010.1
AK303082 mRNA Translation: BAH13897.1
AK312586 mRNA Translation: BAG35480.1
AC107081 Genomic DNA Translation: AAY24140.1
BC014676 mRNA Translation: AAH14676.1
BC106934 mRNA Translation: AAI06935.1
BC106933 mRNA Translation: AAI06934.1
CCDSiCCDS33206.1 [P50991-1]
CCDS58711.1 [P50991-2]
RefSeqiNP_001243650.1, NM_001256721.1 [P50991-2]
NP_006421.2, NM_006430.3 [P50991-1]
UniGeneiHs.421509

3D structure databases

ProteinModelPortaliP50991
SMRiP50991
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115826, 227 interactors
CORUMiP50991
DIPiDIP-32971N
IntActiP50991, 121 interactors
MINTiP50991
STRINGi9606.ENSP00000377958

PTM databases

iPTMnetiP50991
PhosphoSitePlusiP50991
SwissPalmiP50991

Polymorphism and mutation databases

BioMutaiCCT4
DMDMi52001478

2D gel databases

REPRODUCTION-2DPAGEiIPI00302927
UCD-2DPAGEiP50991

Proteomic databases

EPDiP50991
MaxQBiP50991
PaxDbiP50991
PeptideAtlasiP50991
PRIDEiP50991
ProteomicsDBi56273
TopDownProteomicsiP50991-1 [P50991-1]

Protocols and materials databases

DNASUi10575
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394440; ENSP00000377958; ENSG00000115484 [P50991-1]
ENST00000544079; ENSP00000443061; ENSG00000115484 [P50991-2]
GeneIDi10575
KEGGihsa:10575
UCSCiuc002sbo.5 human [P50991-1]

Organism-specific databases

CTDi10575
DisGeNETi10575
EuPathDBiHostDB:ENSG00000115484.14
GeneCardsiCCT4
HGNCiHGNC:1617 CCT4
HPAiHPA029349
MIMi605142 gene
neXtProtiNX_P50991
OpenTargetsiENSG00000115484
PharmGKBiPA26181
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0358 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074956
HOGENOMiHOG000226735
HOVERGENiHBG106507
InParanoidiP50991
KOiK09496
OMAiQFCLSPP
OrthoDBiEOG091G05G4
PhylomeDBiP50991
TreeFamiTF106332

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRSiCCT4 human
GeneWikiiCCT4
GenomeRNAii10575
PMAP-CutDBiP50991
PROiPR:P50991
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115484 Expressed in 238 organ(s), highest expression level in female gonad
CleanExiHS_CCT4
GenevisibleiP50991 HS

Family and domain databases

CDDicd03338 TCP1_delta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02342 chap_CCT_delta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCPD_HUMAN
AccessioniPrimary (citable) accession number: P50991
Secondary accession number(s): B2R6I3
, B7Z8B1, F5H5W3, O14870, Q53QP9, Q96C51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 182 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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