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Entry version 153 (12 Aug 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Vacuolar amino acid transporter 4

Gene

AVT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33129-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-352230, Amino acid transport across the plasma membrane
R-SCE-428559, Proton-coupled neutral amino acid transporters
R-SCE-71240, Tryptophan catabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.18.7.2, the amino acid/auxin permease (aaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar amino acid transporter 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AVT4
Ordered Locus Names:YNL101W
ORF Names:N2185
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YNL101W

Saccharomyces Genome Database

More...
SGDi
S000005045, AVT4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 242VacuolarSequence analysisAdd BLAST242
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 301CytoplasmicSequence analysisAdd BLAST38
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 326VacuolarSequence analysis4
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 373CytoplasmicSequence analysisAdd BLAST26
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 410VacuolarSequence analysisAdd BLAST16
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 438CytoplasmicSequence analysis7
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Topological domaini460 – 483VacuolarSequence analysisAdd BLAST24
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 515CytoplasmicSequence analysisAdd BLAST11
Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Topological domaini537 – 561VacuolarSequence analysisAdd BLAST25
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Topological domaini583 – 621CytoplasmicSequence analysisAdd BLAST39
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 648VacuolarSequence analysis6
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 692CytoplasmicSequence analysisAdd BLAST23
Transmembranei693 – 711HelicalSequence analysisAdd BLAST19
Topological domaini712 – 713VacuolarSequence analysis2

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000938371 – 713Vacuolar amino acid transporter 4Add BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei88PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50944

PRoteomics IDEntifications database

More...
PRIDEi
P50944

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50944

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35722, 57 interactors

Database of interacting proteins

More...
DIPi
DIP-6754N

Protein interaction database and analysis system

More...
IntActi
P50944, 2 interactors

Molecular INTeraction database

More...
MINTi
P50944

STRING: functional protein association networks

More...
STRINGi
4932.YNL101W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P50944, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1304, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169842

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009646_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50944

KEGG Orthology (KO)

More...
KOi
K14209

Identification of Orthologs from Complete Genome Data

More...
OMAi
YWCYYIL

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013057, AA_transpt_TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01490, Aa_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50944-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTNNGDGEH LGIRRNGNLR HPSNNMKIPR RAQSTVLNSN PFYSRKYSMS
60 70 80 90 100
TLTPRDICRS VDSRVFVDMS SPNFQTLEDP HRDEIINSVR LNYLNSSKRS
110 120 130 140 150
SVSHGNEAIP RVNPTKNSSA STIAAANVDS DDDETNLSSA GGDITHDIYK
160 170 180 190 200
LVKAEDPKRL RRPRSMENVT PKIEHHTKLS SASGLNVPGG FRREFIVNKK
210 220 230 240 250
RQEHQLNDSA SSDFTSHESD SINQSSPSSN QDIDKVPFLT RNFLEFLYVF
260 270 280 290 300
GHFAGESFED DFIPDSSNMM IRGEDERSAL LSRPDHMKVL PSAKGTTSTK
310 320 330 340 350
KVFLILLKSF IGTGVLFLPN AFHNGGLFFS VSMLAFFGIY SYWCYYILVQ
360 370 380 390 400
AKSSCGVSSF GDIGLKLYGP WMRIIILFSL VITQVGFSGA YMIFTAKNLQ
410 420 430 440 450
AFLDNVFHVG VLPLSYLMVF QTIIFIPLSF IRNISKLSLP SLLANFFIMA
460 470 480 490 500
GLVIVIIFTA KRLFFDLMGT PAMGVVYGLN ADRWTLFIGT AIFAFEGIGL
510 520 530 540 550
IIPVQDSMRN PEKFPLVLAL VILTATILFI SIATLGYLAY GSNVQTVILL
560 570 580 590 600
NLPQSNIFVN LIQLFYSIAI MLSTPLQLFP AIKIIENKFF PKFTKIYVKH
610 620 630 640 650
DDLTTRVELR PNSGKLNWKI KWLKNFIRSI IVIIVVSIAY FGSDNLDKFV
660 670 680 690 700
SVIGSLACIP LVYIYPSMLH LRGNSLPETK GEFWRFKPML DTILIFFGIA
710
SMLYTSYQSI FGV
Length:713
Mass (Da):80,026
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAB458A2FEB660FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z50161 Genomic DNA Translation: CAA90525.1
Z71377 Genomic DNA Translation: CAA95977.1
BK006947 Genomic DNA Translation: DAA10444.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S58251

NCBI Reference Sequences

More...
RefSeqi
NP_014298.1, NM_001182939.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL101W_mRNA; YNL101W; YNL101W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855622

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL101W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50161 Genomic DNA Translation: CAA90525.1
Z71377 Genomic DNA Translation: CAA95977.1
BK006947 Genomic DNA Translation: DAA10444.1
PIRiS58251
RefSeqiNP_014298.1, NM_001182939.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35722, 57 interactors
DIPiDIP-6754N
IntActiP50944, 2 interactors
MINTiP50944
STRINGi4932.YNL101W

Protein family/group databases

TCDBi2.A.18.7.2, the amino acid/auxin permease (aaap) family

PTM databases

iPTMnetiP50944

Proteomic databases

PaxDbiP50944
PRIDEiP50944

Genome annotation databases

EnsemblFungiiYNL101W_mRNA; YNL101W; YNL101W
GeneIDi855622
KEGGisce:YNL101W

Organism-specific databases

EuPathDBiFungiDB:YNL101W
SGDiS000005045, AVT4

Phylogenomic databases

eggNOGiKOG1304, Eukaryota
GeneTreeiENSGT00940000169842
HOGENOMiCLU_009646_3_2_1
InParanoidiP50944
KOiK14209
OMAiYWCYYIL

Enzyme and pathway databases

BioCyciYEAST:G3O-33129-MONOMER
ReactomeiR-SCE-352230, Amino acid transport across the plasma membrane
R-SCE-428559, Proton-coupled neutral amino acid transporters
R-SCE-71240, Tryptophan catabolism

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P50944
RNActiP50944, protein

Family and domain databases

InterProiView protein in InterPro
IPR013057, AA_transpt_TM
PfamiView protein in Pfam
PF01490, Aa_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAVT4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50944
Secondary accession number(s): D6W178
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 12, 2020
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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