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Protein

60S ribosomal protein L14

Gene

RPL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication

GO - Molecular functioni

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal large subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: GO_Central
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L14
Alternative name(s):
CAG-ISL 7
Large ribosomal subunit protein eL141 Publication
Gene namesi
Name:RPL14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000188846.13
HGNCiHGNC:10305 RPL14
MIMi617414 gene
neXtProtiNX_P50914

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9045
OpenTargetsiENSG00000188846
PharmGKBiPA34673

Polymorphism and mutation databases

BioMutaiRPL14
DMDMi212276521

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001320312 – 21560S ribosomal protein L14Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei85N6-acetyllysine; alternateCombined sources1
Modified residuei85N6-succinyllysine; alternateBy similarity1
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei139PhosphoserineCombined sources1
Modified residuei204N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP50914
MaxQBiP50914
PaxDbiP50914
PeptideAtlasiP50914
PRIDEiP50914
ProteomicsDBi56271
TopDownProteomicsiP50914

2D gel databases

SWISS-2DPAGEiP50914

PTM databases

iPTMnetiP50914
PhosphoSitePlusiP50914
SwissPalmiP50914

Expressioni

Gene expression databases

BgeeiENSG00000188846
CleanExiHS_RPL14
ExpressionAtlasiP50914 baseline and differential
GenevisibleiP50914 HS

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114507, 241 interactors
CORUMiP50914
IntActiP50914, 34 interactors
MINTiP50914
STRINGi9606.ENSP00000345156

Structurei

3D structure databases

ProteinModelPortaliP50914
SMRiP50914
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati171 – 1751-15
Repeati176 – 1801-25
Repeati181 – 1851-35
Repeati186 – 1901-45
Repeati193 – 1952-13
Repeati196 – 1982-23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni171 – 1904 X 5 AA tandem repeats of Q-K-A-[PAS]-XAdd BLAST20
Regioni193 – 1982 X 3 AA tandem repeats of K-[GA]-Q6

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3421 Eukaryota
COG2163 LUCA
GeneTreeiENSGT00390000007888
HOVERGENiHBG005187
InParanoidiP50914
KOiK02875
OMAiSDFERFQ
OrthoDBiEOG091G0VTN
PhylomeDBiP50914
TreeFamiTF314356

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR014722 Rib_L2_dom2
IPR002784 Ribosomal_L14e_dom
IPR008991 Translation_prot_SH3-like_sf
PfamiView protein in Pfam
PF01929 Ribosomal_L14e, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM
60 70 80 90 100
PFKCMQLTDF ILKFPHSAHQ KYVRQAWQKA DINTKWAATR WAKKIEARER
110 120 130 140 150
KAKMTDFDRF KVMKAKKMRN RIIKNEVKKL QKAALLKASP KKAPGTKGTA
160 170 180 190 200
AAAAAAAAAK VPAKKITAAS KKAPAQKVPA QKATGQKAAP APKAQKGQKA
210
PAQKAPAPKA SGKKA
Length:215
Mass (Da):23,432
Last modified:November 4, 2008 - v4
Checksum:i4C63DE4FC8E687FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65P → L in BAA13443 (PubMed:9480843).Curated1

Polymorphismi

The poly-Ala stretch is highly polymorphic.4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013633138A → S. Corresponds to variant dbSNP:rs929099541Ensembl.1
Natural variantiVAR_047109158 – 159Missing 2 Publications2
Natural variantiVAR_013634159A → AA. 1
Natural variantiVAR_014070159A → AAA. 1
Natural variantiVAR_013635159A → AAAA. 1
Natural variantiVAR_013636159A → AAAAA. 1
Natural variantiVAR_006923159A → AAAAAA3 Publications1
Natural variantiVAR_013637159A → AAAAAAAA. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16738 mRNA Translation: AAC16021.1
D87735 mRNA Translation: BAA13443.1
AB061822 Genomic DNA Translation: BAB79460.1
DQ118667 mRNA Translation: AAZ38460.1
AK223111 mRNA Translation: BAD96831.1
AC104186 Genomic DNA No translation available.
BC000606 mRNA Translation: AAH00606.1
BC005134 mRNA Translation: AAH05134.1
BC009294 mRNA Translation: AAH09294.1
BC019651 mRNA Translation: AAH19651.1
BC022805 mRNA Translation: AAH22805.1
BC029036 mRNA Translation: AAH29036.1
AB046407 Genomic DNA Translation: BAB21253.1
CCDSiCCDS33739.1
CCDS43070.1
RefSeqiNP_001030168.1, NM_001034996.2
NP_003964.3, NM_003973.4
UniGeneiHs.446522

Genome annotation databases

EnsembliENST00000338970; ENSP00000345156; ENSG00000188846
ENST00000396203; ENSP00000379506; ENSG00000188846
GeneIDi9045
KEGGihsa:9045
UCSCiuc003ckg.5 human

Keywords - Coding sequence diversityi

Polymorphism, Triplet repeat expansion

Similar proteinsi

Entry informationi

Entry nameiRL14_HUMAN
AccessioniPrimary (citable) accession number: P50914
Secondary accession number(s): Q45RF0
, Q53G20, Q8TBD5, Q8WUT0, Q92579, Q96GR0, Q9BSB8, Q9BW65, Q9BYF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: July 18, 2018
This is version 190 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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