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Protein

60S ribosomal protein L14

Gene

RPL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L14
Alternative name(s):
CAG-ISL 7
Large ribosomal subunit protein eL141 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188846.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10305 RPL14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617414 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50914

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9045

Open Targets

More...
OpenTargetsi
ENSG00000188846

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34673

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPL14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276521

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001320312 – 21560S ribosomal protein L14Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79N6-acetyllysineCombined sources1
Modified residuei85N6-acetyllysine; alternateCombined sources1
Modified residuei85N6-succinyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei139PhosphoserineCombined sources1
Modified residuei204N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P50914

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50914

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50914

PeptideAtlas

More...
PeptideAtlasi
P50914

PRoteomics IDEntifications database

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PRIDEi
P50914

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56271

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P50914

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P50914

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50914

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P50914

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P50914

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188846 Expressed in 192 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_RPL14

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P50914 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P50914 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114507, 244 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P50914

Protein interaction database and analysis system

More...
IntActi
P50914, 35 interactors

Molecular INTeraction database

More...
MINTi
P50914

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345156

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P50914

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P50914

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati171 – 1751-15
Repeati176 – 1801-25
Repeati181 – 1851-35
Repeati186 – 1901-45
Repeati193 – 1952-13
Repeati196 – 1982-23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 1904 X 5 AA tandem repeats of Q-K-A-[PAS]-XAdd BLAST20
Regioni193 – 1982 X 3 AA tandem repeats of K-[GA]-Q6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3421 Eukaryota
COG2163 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007888

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005187

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P50914

KEGG Orthology (KO)

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KOi
K02875

Identification of Orthologs from Complete Genome Data

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OMAi
CAVSTDF

Database of Orthologous Groups

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OrthoDBi
EOG091G0VTN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P50914

TreeFam database of animal gene trees

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TreeFami
TF314356

Family and domain databases

Conserved Domains Database

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CDDi
cd06088 KOW_RPL14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014722 Rib_L2_dom2
IPR002784 Ribosomal_L14e_dom
IPR039660 Ribosomal_protein_L14
IPR008991 Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11127 PTHR11127, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01929 Ribosomal_L14e, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104 SSF50104, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P50914-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM
60 70 80 90 100
PFKCMQLTDF ILKFPHSAHQ KYVRQAWQKA DINTKWAATR WAKKIEARER
110 120 130 140 150
KAKMTDFDRF KVMKAKKMRN RIIKNEVKKL QKAALLKASP KKAPGTKGTA
160 170 180 190 200
AAAAAAAAAK VPAKKITAAS KKAPAQKVPA QKATGQKAAP APKAQKGQKA
210
PAQKAPAPKA SGKKA
Length:215
Mass (Da):23,432
Last modified:November 4, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C63DE4FC8E687FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPB3E7EPB3_HUMAN
60S ribosomal protein L14
RPL14
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDZ7F8WDZ7_HUMAN
60S ribosomal protein L14
RPL14
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65P → L in BAA13443 (PubMed:9480843).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-Ala stretch is highly polymorphic.4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013633138A → S. Corresponds to variant dbSNP:rs929099541Ensembl.1
Natural variantiVAR_047109158 – 159Missing 2 Publications2
Natural variantiVAR_013634159A → AA. 1
Natural variantiVAR_014070159A → AAA. 1
Natural variantiVAR_013635159A → AAAA. 1
Natural variantiVAR_013636159A → AAAAA. 1
Natural variantiVAR_006923159A → AAAAAA3 Publications1
Natural variantiVAR_013637159A → AAAAAAAA. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U16738 mRNA Translation: AAC16021.1
D87735 mRNA Translation: BAA13443.1
AB061822 Genomic DNA Translation: BAB79460.1
DQ118667 mRNA Translation: AAZ38460.1
AK223111 mRNA Translation: BAD96831.1
AC104186 Genomic DNA No translation available.
BC000606 mRNA Translation: AAH00606.1
BC005134 mRNA Translation: AAH05134.1
BC009294 mRNA Translation: AAH09294.1
BC019651 mRNA Translation: AAH19651.1
BC022805 mRNA Translation: AAH22805.1
BC029036 mRNA Translation: AAH29036.1
AB046407 Genomic DNA Translation: BAB21253.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33739.1
CCDS43070.1

NCBI Reference Sequences

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RefSeqi
NP_001030168.1, NM_001034996.2
NP_003964.3, NM_003973.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.446522

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338970; ENSP00000345156; ENSG00000188846
ENST00000396203; ENSP00000379506; ENSG00000188846

Database of genes from NCBI RefSeq genomes

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GeneIDi
9045

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9045

UCSC genome browser

More...
UCSCi
uc003ckg.5 human

Keywords - Coding sequence diversityi

Polymorphism, Triplet repeat expansion

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16738 mRNA Translation: AAC16021.1
D87735 mRNA Translation: BAA13443.1
AB061822 Genomic DNA Translation: BAB79460.1
DQ118667 mRNA Translation: AAZ38460.1
AK223111 mRNA Translation: BAD96831.1
AC104186 Genomic DNA No translation available.
BC000606 mRNA Translation: AAH00606.1
BC005134 mRNA Translation: AAH05134.1
BC009294 mRNA Translation: AAH09294.1
BC019651 mRNA Translation: AAH19651.1
BC022805 mRNA Translation: AAH22805.1
BC029036 mRNA Translation: AAH29036.1
AB046407 Genomic DNA Translation: BAB21253.1
CCDSiCCDS33739.1
CCDS43070.1
RefSeqiNP_001030168.1, NM_001034996.2
NP_003964.3, NM_003973.4
UniGeneiHs.446522

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LM1-215[»]
4V6Xelectron microscopy5.00CM1-215[»]
5AJ0electron microscopy3.50AM1-215[»]
5LKSelectron microscopy3.60LM1-215[»]
5T2Celectron microscopy3.60s1-215[»]
6EK0electron microscopy2.90LM1-215[»]
ProteinModelPortaliP50914
SMRiP50914
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114507, 244 interactors
CORUMiP50914
IntActiP50914, 35 interactors
MINTiP50914
STRINGi9606.ENSP00000345156

PTM databases

iPTMnetiP50914
PhosphoSitePlusiP50914
SwissPalmiP50914

Polymorphism and mutation databases

BioMutaiRPL14
DMDMi212276521

2D gel databases

SWISS-2DPAGEiP50914

Proteomic databases

EPDiP50914
MaxQBiP50914
PaxDbiP50914
PeptideAtlasiP50914
PRIDEiP50914
ProteomicsDBi56271
TopDownProteomicsiP50914

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9045
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338970; ENSP00000345156; ENSG00000188846
ENST00000396203; ENSP00000379506; ENSG00000188846
GeneIDi9045
KEGGihsa:9045
UCSCiuc003ckg.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9045
DisGeNETi9045
EuPathDBiHostDB:ENSG00000188846.13

GeneCards: human genes, protein and diseases

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GeneCardsi
RPL14

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0003196
HIX0036844
HGNCiHGNC:10305 RPL14
MIMi617414 gene
neXtProtiNX_P50914
OpenTargetsiENSG00000188846
PharmGKBiPA34673

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3421 Eukaryota
COG2163 LUCA
GeneTreeiENSGT00390000007888
HOVERGENiHBG005187
InParanoidiP50914
KOiK02875
OMAiCAVSTDF
OrthoDBiEOG091G0VTN
PhylomeDBiP50914
TreeFamiTF314356

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPL14 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
60S_ribosomal_protein_L14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9045

Protein Ontology

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PROi
PR:P50914

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000188846 Expressed in 192 organ(s), highest expression level in testis
CleanExiHS_RPL14
ExpressionAtlasiP50914 baseline and differential
GenevisibleiP50914 HS

Family and domain databases

CDDicd06088 KOW_RPL14, 1 hit
Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR014722 Rib_L2_dom2
IPR002784 Ribosomal_L14e_dom
IPR039660 Ribosomal_protein_L14
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11127 PTHR11127, 1 hit
PfamiView protein in Pfam
PF01929 Ribosomal_L14e, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50914
Secondary accession number(s): Q45RF0
, Q53G20, Q8TBD5, Q8WUT0, Q92579, Q96GR0, Q9BSB8, Q9BW65, Q9BYF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: December 5, 2018
This is version 194 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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