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Entry version 141 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Protein PSP1

Gene

PSP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase alpha mutation suppressor.

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PSP1
Alternative name(s):
Growth inhibitory protein 5
Polymerase suppressor protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSP1
Synonyms:GIN5
Ordered Locus Names:YDR505C
ORF Names:D9719.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002913, PSP1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDR505C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000970681 – 841Protein PSP1Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei520PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50896

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50896

PRoteomics IDEntifications database

More...
PRIDEi
P50896

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50896

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32556, 140 interactors

Database of interacting proteins

More...
DIPi
DIP-5018N

Protein interaction database and analysis system

More...
IntActi
P50896, 7 interactors

Molecular INTeraction database

More...
MINTi
P50896

STRING: functional protein association networks

More...
STRINGi
4932.YDR505C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P50896, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini653 – 765PSP1 C-terminalPROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 57DisorderedSequence analysisAdd BLAST25
Regioni118 – 147DisorderedSequence analysisAdd BLAST30
Regioni202 – 233DisorderedSequence analysisAdd BLAST32
Regioni290 – 324DisorderedSequence analysisAdd BLAST35
Regioni337 – 369DisorderedSequence analysisAdd BLAST33
Regioni384 – 405DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi302 – 324Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PSP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4679, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176361

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012771_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50896

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRRSSYI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007557, PSP1_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04468, PSP1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51411, PSP1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50896-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLPTVNSTT SISDNVDLKN YYEDLLFKNN SGKSLSDLPR KLNDNSNNSG
60 70 80 90 100
SDTVDPLAGL NNLRNSIKSA GNGMENRRTF DDIDFMGRFP YLPPVPNQQQ
110 120 130 140 150
QPFSHQNGFI QEHPSSNLTS FQMSSSNSEP MSAPPISSNN NNLNSTQMGN
160 170 180 190 200
YQAQQRSFPQ FNGNSFHSNG NDLMGNRMDS DYMRLMNKTN IGFTSNSGSN
210 220 230 240 250
FAAPSHSAGN PSSMNNQQVP SFNWQQPSHP ESTIRRSSYI SDTLINHQMP
260 270 280 290 300
DARQKQTSQV QQQHAQGFNL FNSRFNYDNL NSTHLTAKGV PEFGNGVQPP
310 320 330 340 350
YPYDNEPNNA SISNSNNNNN SHNMVPMQQF RRNTQPVASF NPSLPTFQQQ
360 370 380 390 400
QQQPQQPQQP RNVNVPTSFN GERVDDVQLV QLQRSSSVPS STNSHNLQNE
410 420 430 440 450
NSNEGNVSLD NGLVLIQGKH LTSSKTLHDL YSDCGSGYFA SSAVFEFTDN
460 470 480 490 500
IKKMLKLHDS NESYDAKNMG LIDEEGNTYQ SLLNFLDILR SCNMNYVNDP
510 520 530 540 550
ESNNGIVSNN GGNKNRRKGS FTTELSCRNA NNSFLPYTPL VLVALKNGKL
560 570 580 590 600
ELLSTPQATN LLLKRGDLVI IDGDRGRDLV LVVEPSVDLN LALFINFLKK
610 620 630 640 650
KIHFDSLITS ESQHYRNDEF IQMLIDSKNG QKKKLNPKLY DVVELTELII
660 670 680 690 700
PSKQVLRFAT PWEVTTNLHN KFEDELKALH IAQSKLQALN DNSKSQNTND
710 720 730 740 750
SSSNNFTNAA TYSKPKLNIK ILNAEFQFDR KKLTFYYVCE ERNDFRDLIK
760 770 780 790 800
ELFKYYKTRI WLCAIPNNLS IDSKYYDKQQ KELKLYQNIV KNYNAEDLMN
810 820 830 840
VNEFSQNRGN NRVNFAPPLN EIELDNFQIA VYEELVHELF H
Length:841
Mass (Da):95,348
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03B5C27F96F71F2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116S → C in AAA93076 (PubMed:9529527).Curated1
Sequence conflicti122 – 133QMSSS…EPMSA → KCLRLIQSCVP in AAA93076 (PubMed:9529527).CuratedAdd BLAST12
Sequence conflicti198 – 210GSNFA…HSAGN → RAILLPHHTVLAT in AAA93076 (PubMed:9529527).CuratedAdd BLAST13
Sequence conflicti732K → E in AAB64947 (PubMed:9169867).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33115 Genomic DNA Translation: AAA93076.1
U33057 Genomic DNA Translation: AAB64947.1
BK006938 Genomic DNA Translation: DAA12337.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S69563

NCBI Reference Sequences

More...
RefSeqi
NP_010793.2, NM_001180813.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR505C_mRNA; YDR505C; YDR505C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR505C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33115 Genomic DNA Translation: AAA93076.1
U33057 Genomic DNA Translation: AAB64947.1
BK006938 Genomic DNA Translation: DAA12337.2
PIRiS69563
RefSeqiNP_010793.2, NM_001180813.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi32556, 140 interactors
DIPiDIP-5018N
IntActiP50896, 7 interactors
MINTiP50896
STRINGi4932.YDR505C

PTM databases

iPTMnetiP50896

Proteomic databases

MaxQBiP50896
PaxDbiP50896
PRIDEiP50896

Genome annotation databases

EnsemblFungiiYDR505C_mRNA; YDR505C; YDR505C
GeneIDi852116
KEGGisce:YDR505C

Organism-specific databases

SGDiS000002913, PSP1
VEuPathDBiFungiDB:YDR505C

Phylogenomic databases

eggNOGiKOG4679, Eukaryota
GeneTreeiENSGT00940000176361
HOGENOMiCLU_012771_0_0_1
InParanoidiP50896
OMAiIRRSSYI

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P50896
RNActiP50896, protein

Family and domain databases

InterProiView protein in InterPro
IPR007557, PSP1_C
PfamiView protein in Pfam
PF04468, PSP1, 1 hit
PROSITEiView protein in PROSITE
PS51411, PSP1_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSP1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50896
Secondary accession number(s): D6VTC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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