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Protein

Basal cell adhesion molecule

Gene

BCAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling.1 Publication

GO - Molecular functioni

  • laminin binding Source: BHF-UCL
  • laminin receptor activity Source: BHF-UCL
  • protein C-terminus binding Source: CACAO
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionBlood group antigen, Receptor
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
Auberger B antigen
B-CAM cell surface glycoprotein
F8/G253 antigen
Lutheran antigen
Lutheran blood group glycoprotein
CD_antigen: CD239
Gene namesi
Name:BCAM
Synonyms:LU, MSK19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000187244.10
HGNCiHGNC:6722 BCAM
MIMi612773 gene
neXtProtiNX_P50895

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 547ExtracellularSequence analysisAdd BLAST516
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 628CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi621S → A: Dramatically reduced cell adhesion. 1 Publication1

Organism-specific databases

DisGeNETi4059
MalaCardsiBCAM
MIMi111200 phenotype
247420 phenotype
OpenTargetsiENSG00000187244
PharmGKBiPA30484

Polymorphism and mutation databases

BioMutaiBCAM
DMDMi92058724

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000001485032 – 628Basal cell adhesion moleculeAdd BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi172 ↔ 237PROSITE-ProRule annotation1 Publication
Disulfide bondi291 ↔ 3371 Publication
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi384 ↔ 4241 Publication
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi473 ↔ 5221 Publication
Modified residuei596Phosphoserine; by GSK31 Publication1
Modified residuei598Phosphoserine; by CK21 Publication1
Modified residuei600PhosphoserineCombined sources1
Modified residuei621Phosphoserine; by PKA1 Publication1

Post-translational modificationi

Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP50895
MaxQBiP50895
PaxDbiP50895
PeptideAtlasiP50895
PRIDEiP50895
ProteomicsDBi56268

PTM databases

GlyConnecti1026
iPTMnetiP50895
PhosphoSitePlusiP50895
SwissPalmiP50895

Expressioni

Tissue specificityi

Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.

Developmental stagei

Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.

Gene expression databases

BgeeiENSG00000187244 Expressed in 198 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_BCAM
ExpressionAtlasiP50895 baseline and differential
GenevisibleiP50895 HS

Organism-specific databases

HPAiHPA005654

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KLHL2O951986EBI-10212133,EBI-746999

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110237, 23 interactors
ELMiP50895
IntActiP50895, 8 interactors
STRINGi9606.ENSP00000270233

Structurei

Secondary structure

1628
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP50895
SMRiP50895
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50895

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 142Ig-like V-type 1Add BLAST111
Domaini147 – 257Ig-like V-type 2Add BLAST111
Domaini274 – 355Ig-like C2-type 1Add BLAST82
Domaini363 – 441Ig-like C2-type 2Add BLAST79
Domaini448 – 541Ig-like C2-type 3Add BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni309 – 312Interaction with laminin alpha54

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJIS Eukaryota
ENOG4111XZT LUCA
GeneTreeiENSGT00530000063457
HOGENOMiHOG000113409
InParanoidiP50895
KOiK06578
OMAiDHFVLEW
OrthoDBiEOG091G05IA
PhylomeDBiP50895
TreeFamiTF330534

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P50895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI
60 70 80 90 100
LDCTPTGTHD HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP
110 120 130 140 150
PYQLDSQGRL VLAEAQVGDE RDYVCVVRAG AAGTAEATAR LNVFAKPEAT
160 170 180 190 200
EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA PKITWYRNGQ RLEVPVEMNP
210 220 230 240 250
EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH YSLPEGRHGR
260 270 280 290 300
LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE
310 320 330 340 350
YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL
360 370 380 390 400
SKTLELRVAY LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS
410 420 430 440 450
TPLGDGPMLS LSSITFDSNG TYVCEASLPT VPVLSRTQNF TLLVQGSPEL
460 470 480 490 500
KTAEIEPKAD GSWREGDEVT LICSARGHPD PKLSWSQLGG SPAEPIPGRQ
510 520 530 540 550
GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV SPQTSQAGVA
560 570 580 590 600
VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAPPP GEPGLSHSGS
610 620
EQPEQTGLLM GGASGGARGG SGGFGDEC
Length:628
Mass (Da):67,405
Last modified:March 7, 2006 - v2
Checksum:iC88F4F5C640C3F5B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENU8K7ENU8_HUMAN
Basal cell adhesion molecule
BCAM
286Annotation score:
A0A087WXM8A0A087WXM8_HUMAN
Basal cell adhesion molecule
BCAM
588Annotation score:
K7ERB7K7ERB7_HUMAN
Basal cell adhesion molecule
BCAM
61Annotation score:

Sequence cautioni

The sequence EAW57297 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225 – 226RL → PC in CAA56327 (PubMed:7954395).Curated2
Sequence conflicti355 – 356EL → DV in CAA56327 (PubMed:7954395).Curated2
Sequence conflicti532R → L in ABY27636 (Ref. 7) Curated1

Polymorphismi

BCAM is responsible for the Lutheran blood group system (LU) [MIMi:111200]. Lutheran is a complex blood group system consisting of 19 antigens. Antigens Lu(a) and Lu(b) are defined by a polymorphism at position 77: Lu(a) has His-77 and Lu(b) has Arg-77.2 Publications
Inactivating variants in BCAM are responsible for the recessive Lutheran null phenotype Lu(a-b-) of the Lutheran blood group [MIMi:247420]. Autosomal recessive inheritance of the Lutheran null blood group phenotype is extremely rare. There is no obvious associated clinical or hematologic pathology, and all patients have been identified through identification of anti-Lu3 antibodies in their serum.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02134877R → H Defines the Lu(a) antigen. 1 PublicationCorresponds to variant dbSNP:rs28399653EnsemblClinVar.1
Natural variantiVAR_021349196V → I1 PublicationCorresponds to variant dbSNP:rs28399654Ensembl.1
Natural variantiVAR_021350204M → K1 PublicationCorresponds to variant dbSNP:rs28399656Ensembl.1
Natural variantiVAR_021351282R → H1 PublicationCorresponds to variant dbSNP:rs9967601Ensembl.1
Natural variantiVAR_021352381V → I1 PublicationCorresponds to variant dbSNP:rs28399626Ensembl.1
Natural variantiVAR_021353451K → Q1 PublicationCorresponds to variant dbSNP:rs28399630Ensembl.1
Natural variantiVAR_021354539T → A3 PublicationsCorresponds to variant dbSNP:rs1135062EnsemblClinVar.1
Natural variantiVAR_021355581Q → L1 PublicationCorresponds to variant dbSNP:rs28399659Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83425 mRNA Translation: CAA58449.1
AY845133 Genomic DNA Translation: AAV88096.1
AC092306 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57297.1 Sequence problems.
BC050450 mRNA Translation: AAH50450.1
X80026 mRNA Translation: CAA56327.1
EU307108 Genomic DNA Translation: ABY27636.1
EU307109 Genomic DNA Translation: ABY27637.1
CCDSiCCDS12644.1
PIRiI37202
I38000
RefSeqiNP_001013275.1, NM_001013257.2
NP_005572.2, NM_005581.4
UniGeneiHs.625725

Genome annotation databases

EnsembliENST00000270233; ENSP00000270233; ENSG00000187244
GeneIDi4059
KEGGihsa:4059
UCSCiuc002ozu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83425 mRNA Translation: CAA58449.1
AY845133 Genomic DNA Translation: AAV88096.1
AC092306 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57297.1 Sequence problems.
BC050450 mRNA Translation: AAH50450.1
X80026 mRNA Translation: CAA56327.1
EU307108 Genomic DNA Translation: ABY27636.1
EU307109 Genomic DNA Translation: ABY27637.1
CCDSiCCDS12644.1
PIRiI37202
I38000
RefSeqiNP_001013275.1, NM_001013257.2
NP_005572.2, NM_005581.4
UniGeneiHs.625725

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PETX-ray1.70A32-262[»]
2PF6X-ray2.20A/B32-262[»]
ProteinModelPortaliP50895
SMRiP50895
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110237, 23 interactors
ELMiP50895
IntActiP50895, 8 interactors
STRINGi9606.ENSP00000270233

PTM databases

GlyConnecti1026
iPTMnetiP50895
PhosphoSitePlusiP50895
SwissPalmiP50895

Polymorphism and mutation databases

BioMutaiBCAM
DMDMi92058724

Proteomic databases

EPDiP50895
MaxQBiP50895
PaxDbiP50895
PeptideAtlasiP50895
PRIDEiP50895
ProteomicsDBi56268

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270233; ENSP00000270233; ENSG00000187244
GeneIDi4059
KEGGihsa:4059
UCSCiuc002ozu.5 human

Organism-specific databases

CTDi4059
DisGeNETi4059
EuPathDBiHostDB:ENSG00000187244.10
GeneCardsiBCAM
HGNCiHGNC:6722 BCAM
HPAiHPA005654
MalaCardsiBCAM
MIMi111200 phenotype
247420 phenotype
612773 gene
neXtProtiNX_P50895
OpenTargetsiENSG00000187244
PharmGKBiPA30484
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJIS Eukaryota
ENOG4111XZT LUCA
GeneTreeiENSGT00530000063457
HOGENOMiHOG000113409
InParanoidiP50895
KOiK06578
OMAiDHFVLEW
OrthoDBiEOG091G05IA
PhylomeDBiP50895
TreeFamiTF330534

Miscellaneous databases

ChiTaRSiBCAM human
EvolutionaryTraceiP50895
GeneWikiiBCAM
GenomeRNAii4059
PROiPR:P50895
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187244 Expressed in 198 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_BCAM
ExpressionAtlasiP50895 baseline and differential
GenevisibleiP50895 HS

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBCAM_HUMAN
AccessioniPrimary (citable) accession number: P50895
Secondary accession number(s): A8MYF9
, A9YWT5, A9YWT6, Q86VC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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