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UniProtKB - P50895 (BCAM_HUMAN)
Protein
Basal cell adhesion molecule
Gene
BCAM
Organism
Homo sapiens (Human)
Status
Functioni
Laminin alpha-5 receptor. May mediate intracellular signaling.
1 PublicationGO - Molecular functioni
- laminin binding Source: BHF-UCL
- laminin receptor activity Source: BHF-UCL
- protein C-terminus binding Source: CACAO
- transmembrane signaling receptor activity Source: ProtInc
GO - Biological processi
- cell adhesion Source: ProtInc
- cell-matrix adhesion Source: BHF-UCL
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Blood group antigen, Receptor |
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P50895 |
SignaLinki | P50895 |
Names & Taxonomyi
Protein namesi | Recommended name: Basal cell adhesion moleculeAlternative name(s): Auberger B antigen B-CAM cell surface glycoprotein F8/G253 antigen Lutheran antigen Lutheran blood group glycoprotein CD_antigen: CD239 |
Gene namesi | Name:BCAM Synonyms:LU, MSK19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6722, BCAM |
MIMi | 612773, gene |
neXtProti | NX_P50895 |
VEuPathDBi | HostDB:ENSG00000187244 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
Plasma Membrane
- external side of plasma membrane Source: BHF-UCL
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 547 | ExtracellularSequence analysisAdd BLAST | 516 | |
Transmembranei | 548 – 568 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 569 – 628 | CytoplasmicSequence analysisAdd BLAST | 60 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 621 | S → A: Dramatically reduced cell adhesion. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4059 |
MalaCardsi | BCAM |
MIMi | 111200, phenotype 247420, phenotype |
OpenTargetsi | ENSG00000187244 |
PharmGKBi | PA30484 |
Miscellaneous databases
Pharosi | P50895, Tbio |
Genetic variation databases
BioMutai | BCAM |
DMDMi | 92058724 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | 1 PublicationAdd BLAST | 31 | |
ChainiPRO_0000014850 | 32 – 628 | Basal cell adhesion moleculeAdd BLAST | 597 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 125 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 172 ↔ 237 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 291 ↔ 337 | 1 Publication | ||
Glycosylationi | 321 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 377 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 383 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 384 ↔ 424 | 1 Publication | ||
Glycosylationi | 419 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 439 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 473 ↔ 522 | 1 Publication | ||
Modified residuei | 596 | Phosphoserine; by GSK31 Publication | 1 | |
Modified residuei | 598 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 600 | PhosphoserineCombined sources | 1 | |
Modified residuei | 621 | Phosphoserine; by PKA1 Publication | 1 |
Post-translational modificationi
Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-174 CPTAC-175 |
EPDi | P50895 |
jPOSTi | P50895 |
MassIVEi | P50895 |
MaxQBi | P50895 |
PaxDbi | P50895 |
PeptideAtlasi | P50895 |
PRIDEi | P50895 |
ProteomicsDBi | 56268 |
PTM databases
GlyConnecti | 1026, 9 N-Linked glycans (2 sites) |
GlyGeni | P50895, 5 sites, 9 N-linked glycans (2 sites) |
iPTMneti | P50895 |
PhosphoSitePlusi | P50895 |
SwissPalmi | P50895 |
Expressioni
Tissue specificityi
Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
Developmental stagei
Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.
Gene expression databases
Bgeei | ENSG00000187244, Expressed in adult mammalian kidney and 210 other tissues |
ExpressionAtlasi | P50895, baseline and differential |
Genevisiblei | P50895, HS |
Organism-specific databases
HPAi | ENSG00000187244, Tissue enhanced (kidney) |
Interactioni
Binary interactionsi
P50895
GO - Molecular functioni
- laminin binding Source: BHF-UCL
- laminin receptor activity Source: BHF-UCL
- protein C-terminus binding Source: CACAO
Protein-protein interaction databases
BioGRIDi | 110237, 42 interactors |
ELMi | P50895 |
IntActi | P50895, 34 interactors |
STRINGi | 9606.ENSP00000270233 |
Miscellaneous databases
RNActi | P50895, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P50895 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P50895 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 142 | Ig-like V-type 1Add BLAST | 111 | |
Domaini | 147 – 257 | Ig-like V-type 2Add BLAST | 111 | |
Domaini | 274 – 355 | Ig-like C2-type 1Add BLAST | 82 | |
Domaini | 363 – 441 | Ig-like C2-type 2Add BLAST | 79 | |
Domaini | 448 – 541 | Ig-like C2-type 3Add BLAST | 94 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 309 – 312 | Interaction with laminin alpha5 | 4 | |
Regioni | 579 – 628 | DisorderedSequence analysisAdd BLAST | 50 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWC8, Eukaryota |
GeneTreei | ENSGT00940000161038 |
HOGENOMi | CLU_028888_1_0_1 |
InParanoidi | P50895 |
OMAi | CCRRREK |
OrthoDBi | 864786at2759 |
PhylomeDBi | P50895 |
TreeFami | TF330534 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF13895, Ig_2, 2 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P50895-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI
60 70 80 90 100
LDCTPTGTHD HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP
110 120 130 140 150
PYQLDSQGRL VLAEAQVGDE RDYVCVVRAG AAGTAEATAR LNVFAKPEAT
160 170 180 190 200
EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA PKITWYRNGQ RLEVPVEMNP
210 220 230 240 250
EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH YSLPEGRHGR
260 270 280 290 300
LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE
310 320 330 340 350
YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL
360 370 380 390 400
SKTLELRVAY LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS
410 420 430 440 450
TPLGDGPMLS LSSITFDSNG TYVCEASLPT VPVLSRTQNF TLLVQGSPEL
460 470 480 490 500
KTAEIEPKAD GSWREGDEVT LICSARGHPD PKLSWSQLGG SPAEPIPGRQ
510 520 530 540 550
GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV SPQTSQAGVA
560 570 580 590 600
VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAPPP GEPGLSHSGS
610 620
EQPEQTGLLM GGASGGARGG SGGFGDEC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WXM8 | A0A087WXM8_HUMAN | Basal cell adhesion molecule | BCAM | 588 | Annotation score: | ||
K7ENU8 | K7ENU8_HUMAN | Basal cell adhesion molecule | BCAM | 286 | Annotation score: | ||
K7ERB7 | K7ERB7_HUMAN | Basal cell adhesion molecule | BCAM | 61 | Annotation score: |
Sequence cautioni
The sequence EAW57297 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 225 – 226 | RL → PC in CAA56327 (PubMed:7954395).Curated | 2 | |
Sequence conflicti | 355 – 356 | EL → DV in CAA56327 (PubMed:7954395).Curated | 2 | |
Sequence conflicti | 532 | R → L in ABY27636 (Ref. 7) Curated | 1 |
Polymorphismi
BCAM is responsible for the Lutheran blood group system (LU) [MIMi:111200]. Lutheran is a complex blood group system consisting of 19 antigens. Antigens Lu(a) and Lu(b) are defined by a polymorphism at position 77: Lu(a) has His-77 and Lu(b) has Arg-77.2 Publications
Inactivating variants in BCAM are responsible for the recessive Lutheran null phenotype Lu(a-b-) of the Lutheran blood group [MIMi:247420]. Autosomal recessive inheritance of the Lutheran null blood group phenotype is extremely rare. There is no obvious associated clinical or hematologic pathology, and all patients have been identified through identification of anti-Lu3 antibodies in their serum.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021348 | 77 | R → H Defines the Lu(a) antigen. 1 PublicationCorresponds to variant dbSNP:rs28399653EnsemblClinVar. | 1 | |
Natural variantiVAR_021349 | 196 | V → I1 PublicationCorresponds to variant dbSNP:rs28399654Ensembl. | 1 | |
Natural variantiVAR_021350 | 204 | M → K1 PublicationCorresponds to variant dbSNP:rs28399656Ensembl. | 1 | |
Natural variantiVAR_021351 | 282 | R → H1 PublicationCorresponds to variant dbSNP:rs9967601EnsemblClinVar. | 1 | |
Natural variantiVAR_021352 | 381 | V → I1 PublicationCorresponds to variant dbSNP:rs28399626EnsemblClinVar. | 1 | |
Natural variantiVAR_021353 | 451 | K → Q1 PublicationCorresponds to variant dbSNP:rs28399630Ensembl. | 1 | |
Natural variantiVAR_021354 | 539 | T → A3 PublicationsCorresponds to variant dbSNP:rs1135062EnsemblClinVar. | 1 | |
Natural variantiVAR_021355 | 581 | Q → L1 PublicationCorresponds to variant dbSNP:rs28399659Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83425 mRNA Translation: CAA58449.1 AY845133 Genomic DNA Translation: AAV88096.1 AC092306 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57297.1 Sequence problems. BC050450 mRNA Translation: AAH50450.1 X80026 mRNA Translation: CAA56327.1 EU307108 Genomic DNA Translation: ABY27636.1 EU307109 Genomic DNA Translation: ABY27637.1 |
CCDSi | CCDS12644.1 |
PIRi | I37202 I38000 |
RefSeqi | NP_001013275.1, NM_001013257.2 NP_005572.2, NM_005581.4 |
Genome annotation databases
Ensembli | ENST00000270233; ENSP00000270233; ENSG00000187244 |
GeneIDi | 4059 |
KEGGi | hsa:4059 |
MANE-Selecti | ENST00000270233.12; ENSP00000270233.5; NM_005581.5; NP_005572.2 |
UCSCi | uc002ozu.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
dbRBC/BGMUT Blood group antigen gene mutation database |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83425 mRNA Translation: CAA58449.1 AY845133 Genomic DNA Translation: AAV88096.1 AC092306 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57297.1 Sequence problems. BC050450 mRNA Translation: AAH50450.1 X80026 mRNA Translation: CAA56327.1 EU307108 Genomic DNA Translation: ABY27636.1 EU307109 Genomic DNA Translation: ABY27637.1 |
CCDSi | CCDS12644.1 |
PIRi | I37202 I38000 |
RefSeqi | NP_001013275.1, NM_001013257.2 NP_005572.2, NM_005581.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PET | X-ray | 1.70 | A | 32-262 | [»] | |
2PF6 | X-ray | 2.20 | A/B | 32-262 | [»] | |
SMRi | P50895 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110237, 42 interactors |
ELMi | P50895 |
IntActi | P50895, 34 interactors |
STRINGi | 9606.ENSP00000270233 |
PTM databases
GlyConnecti | 1026, 9 N-Linked glycans (2 sites) |
GlyGeni | P50895, 5 sites, 9 N-linked glycans (2 sites) |
iPTMneti | P50895 |
PhosphoSitePlusi | P50895 |
SwissPalmi | P50895 |
Genetic variation databases
BioMutai | BCAM |
DMDMi | 92058724 |
Proteomic databases
CPTACi | CPTAC-174 CPTAC-175 |
EPDi | P50895 |
jPOSTi | P50895 |
MassIVEi | P50895 |
MaxQBi | P50895 |
PaxDbi | P50895 |
PeptideAtlasi | P50895 |
PRIDEi | P50895 |
ProteomicsDBi | 56268 |
Protocols and materials databases
ABCDi | P50895, 1 sequenced antibody |
Antibodypediai | 17750, 424 antibodies from 35 providers |
DNASUi | 4059 |
Genome annotation databases
Ensembli | ENST00000270233; ENSP00000270233; ENSG00000187244 |
GeneIDi | 4059 |
KEGGi | hsa:4059 |
MANE-Selecti | ENST00000270233.12; ENSP00000270233.5; NM_005581.5; NP_005572.2 |
UCSCi | uc002ozu.5, human |
Organism-specific databases
CTDi | 4059 |
DisGeNETi | 4059 |
GeneCardsi | BCAM |
HGNCi | HGNC:6722, BCAM |
HPAi | ENSG00000187244, Tissue enhanced (kidney) |
MalaCardsi | BCAM |
MIMi | 111200, phenotype 247420, phenotype 612773, gene |
neXtProti | NX_P50895 |
OpenTargetsi | ENSG00000187244 |
PharmGKBi | PA30484 |
VEuPathDBi | HostDB:ENSG00000187244 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWC8, Eukaryota |
GeneTreei | ENSGT00940000161038 |
HOGENOMi | CLU_028888_1_0_1 |
InParanoidi | P50895 |
OMAi | CCRRREK |
OrthoDBi | 864786at2759 |
PhylomeDBi | P50895 |
TreeFami | TF330534 |
Enzyme and pathway databases
PathwayCommonsi | P50895 |
SignaLinki | P50895 |
Miscellaneous databases
BioGRID-ORCSi | 4059, 11 hits in 1037 CRISPR screens |
ChiTaRSi | BCAM, human |
EvolutionaryTracei | P50895 |
GeneWikii | BCAM |
GenomeRNAii | 4059 |
Pharosi | P50895, Tbio |
PROi | PR:P50895 |
RNActi | P50895, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187244, Expressed in adult mammalian kidney and 210 other tissues |
ExpressionAtlasi | P50895, baseline and differential |
Genevisiblei | P50895, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF13895, Ig_2, 2 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BCAM_HUMAN | |
Accessioni | P50895Primary (citable) accession number: P50895 Secondary accession number(s): A8MYF9 Q86VC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | March 7, 2006 | |
Last modified: | February 23, 2022 | |
This is version 196 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Blood group antigen proteins
Nomenclature of blood group antigens and list of entries - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references