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UniProtKB - P50866 (CLPX_BACSU)

Entry version 146 (12 Aug 2020)
Sequence version 3 (07 Jul 2009)
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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Probably the major protease that degrades proteins tagged by trans-translation (PubMed:11395451).UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi13ZincPROSITE-ProRule annotation1
Metal bindingi16ZincPROSITE-ProRule annotation1
Metal bindingi35ZincPROSITE-ProRule annotation1
Metal bindingi38ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi117 – 124ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		BSUB:BSU28220-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:BSU28220
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No degradation of trans-translationally tagged-peptides.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001603131 – 420ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST420

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P50866

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P50866

PRoteomics IDEntifications database

More...PRIDEi		P50866

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By heat shock.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ClpX-ClpP complex.

Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

UniRule annotation

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P50866, 1 interactor

Molecular INTeraction database

More...MINTi		P50866

STRING: functional protein association networks

More...STRINGi		224308.BSU28220

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P50866

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 54ClpX-type ZBPROSITE-ProRule annotationAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1219, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P50866

KEGG Orthology (KO)

More...KOi		K03544

Identification of Orthologs from Complete Genome Data

More...OMAi		HYKRVQA

Database for complete collections of gene phylogenies

More...PhylomeDBi		P50866

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.50.30, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00175, ClpX, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR019489, Clp_ATPase_C
IPR004487, Clp_protease_ATP-bd_su_ClpX
IPR027417, P-loop_NTPase
IPR010603, Znf_CppX_C4
IPR038366, Znf_CppX_C4_sf

The PANTHER Classification System

More...PANTHERi		PTHR11262, PTHR11262, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07724, AAA_2, 1 hit
PF10431, ClpB_D2-small, 1 hit
PF06689, zf-C4_ClpX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM01086, ClpB_D2-small, 1 hit
SM00994, zf-C4_ClpX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00382, clpX, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51902, CLPX_ZB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50866-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKFNEEKGQ LKCSFCGKTQ DQVRKLVAGP GVYICDECIE LCTEIVEEEL 
        60         70         80         90        100
GTEEEVEFKD VPKPQEIREI LNEYVIGQDQ AKKSLAVAVY NHYKRINSNS 
       110        120        130        140        150
KVDDVELSKS NISLIGPTGS GKTLLAQTLA RILNVPFAIA DATSLTEAGY 
       160        170        180        190        200
VGEDVENILL KLIQAADYDV EKAEKGIIYI DEIDKVARKS ENPSITRDVS 
       210        220        230        240        250
GEGVQQALLK ILEGTVASVP PQGGRKHPHQ EFIQIDTTNI LFICGGAFDG 
       260        270        280        290        300
IEQIIKRRLG QKVIGFGADN KAADLEKEDL LSKVLPEDLL RFGLIPEFIG 
       310        320        330        340        350
RLPVIASLEK LDEEALVAIL TKPKNALVKQ FKKMLELDNV ELEFEEEALS 
       360        370        380        390        400
EIAKKAIERK TGARGLRSII EGIMLDVMFE LPSRDDIEKC VITGATVTHG 
       410        420
EPPRLLLKDG TEVSQDKTSA
Length:420
Mass (Da):46,350
Last modified:July 7, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9ADB3F134CAE08CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109K → Q in CAA64618 (PubMed:8973311).Curated1
Sequence conflicti109K → Q in CAA99537 (PubMed:8969504).Curated1
Sequence conflicti161K → E in CAA64618 (PubMed:8973311).Curated1
Sequence conflicti161K → E in CAA99537 (PubMed:8969504).Curated1
Sequence conflicti173 – 174AE → TG in CAA64618 (PubMed:8973311).Curated2
Sequence conflicti173 – 174AE → TG in CAA99537 (PubMed:8969504).Curated2
Sequence conflicti247A → R in CAA99537 (PubMed:8969504).Curated1
Sequence conflicti247A → R in AAA84743 (Ref. 5) Curated1
Sequence conflicti260G → A in CAA99537 (PubMed:8969504).Curated1
Sequence conflicti260G → A in AAA84743 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X95306 Genomic DNA Translation: CAA64618.1
Z75208 Genomic DNA Translation: CAA99537.1
AL009126 Genomic DNA Translation: CAB14782.2
U18229 Genomic DNA Translation: AAA84743.1

Protein sequence database of the Protein Information Resource

More...PIRi		D69601

NCBI Reference Sequences

More...RefSeqi		NP_390700.2, NC_000964.3
WP_003229613.1, NZ_JNCM01000036.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CAB14782; CAB14782; BSU28220

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51992441
937482

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bsu:BSU28220

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|224308.179.peg.3065

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95306 Genomic DNA Translation: CAA64618.1
Z75208 Genomic DNA Translation: CAA99537.1
AL009126 Genomic DNA Translation: CAB14782.2
U18229 Genomic DNA Translation: AAA84743.1
PIRiD69601
RefSeqiNP_390700.2, NC_000964.3
WP_003229613.1, NZ_JNCM01000036.1

3D structure databases

SMRiP50866
ModBaseiSearch...

Protein-protein interaction databases

IntActiP50866, 1 interactor
MINTiP50866
STRINGi224308.BSU28220

Proteomic databases

jPOSTiP50866
PaxDbiP50866
PRIDEiP50866

Genome annotation databases

EnsemblBacteriaiCAB14782; CAB14782; BSU28220
GeneIDi51992441
937482
KEGGibsu:BSU28220
PATRICifig|224308.179.peg.3065

Phylogenomic databases

eggNOGiCOG1219, Bacteria
InParanoidiP50866
KOiK03544
OMAiHYKRVQA
PhylomeDBiP50866

Enzyme and pathway databases

BioCyciBSUB:BSU28220-MONOMER

Family and domain databases

Gene3Di3.30.50.30, 1 hit
HAMAPiMF_00175, ClpX, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR019489, Clp_ATPase_C
IPR004487, Clp_protease_ATP-bd_su_ClpX
IPR027417, P-loop_NTPase
IPR010603, Znf_CppX_C4
IPR038366, Znf_CppX_C4_sf
PANTHERiPTHR11262, PTHR11262, 1 hit
PfamiView protein in Pfam
PF07724, AAA_2, 1 hit
PF10431, ClpB_D2-small, 1 hit
PF06689, zf-C4_ClpX, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM01086, ClpB_D2-small, 1 hit
SM00994, zf-C4_ClpX, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00382, clpX, 1 hit
PROSITEiView protein in PROSITE
PS51902, CLPX_ZB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLPX_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50866
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: August 12, 2020
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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