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Protein

Troponin T, cardiac muscle

Gene

Tnnt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • calcium ion binding Source: GO_Central
  • protein binding, bridging Source: MGI
  • structural constituent of cytoskeleton Source: MGI
  • tropomyosin binding Source: UniProtKB
  • troponin C binding Source: UniProtKB
  • troponin I binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, cardiac muscle
Short name:
TnTc
Alternative name(s):
Cardiac muscle troponin T
Short name:
cTnT
Gene namesi
Name:Tnnt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104597 Tnnt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861742 – 301Troponin T, cardiac muscleAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by CK2By similarity1
Modified residuei207Phosphothreonine; by PKC/PRKCA1 Publication1
Modified residuei211Phosphoserine; by PKC/PRKCA1 Publication1
Modified residuei216Phosphothreonine; by PKC/PRKCA and RAF11 Publication1
Modified residuei297Phosphothreonine; by PKC/PRKCA1 Publication1

Post-translational modificationi

Phosphorylation at Thr-216 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50752
PRIDEiP50752

PTM databases

iPTMnetiP50752
PhosphoSitePlusiP50752

Miscellaneous databases

PMAP-CutDBiP50752

Expressioni

Gene expression databases

BgeeiENSMUSG00000026414 Expressed in 221 organ(s), highest expression level in cardiac ventricle
CleanExiMM_TNNT2
ExpressionAtlasiP50752 baseline and differential
GenevisibleiP50752 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-16 Cardiac Troponin complex
IntActiP50752, 4 interactors
MINTiP50752
STRINGi10090.ENSMUSP00000137093

Structurei

3D structure databases

ProteinModelPortaliP50752
SMRiP50752
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00390000013611
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiP50752
KOiK12045

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform Embryonic (identifier: P50752-1) [UniParc]FASTAAdd to basket
Also known as: EA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDAEEVVEE YEEEQEEEDW SEEEEDEQEE AVEEEEAGGA EPEPEGEAET
60 70 80 90 100
EEANVEEVGP DEEAKDAEEG PVEDTKPKPS RLFMPNLVPP KIPDGERVDF
110 120 130 140 150
DDIHRKRVEK DLNELQTLIE AHFENRKKEE EELISLKDRI EKRRAERAEQ
160 170 180 190 200
QRIRNEREKE RQNRLAEERA RREEEENRRK AEDEARKKKA LSNMMHFGGY
210 220 230 240 250
IQKQAQTERK SGKRQTEREK KKKILAERRK ALAIDHLNED QLREKAKELW
260 270 280 290 300
QSIHNLEAEK FDLQEKFKQQ KYEINVLRNR INDNQKVSKT RGKAKVTGRW

K
Length:301
Mass (Da):35,825
Last modified:January 23, 2007 - v2
Checksum:i60B2185A140AF2D5
GO
Isoform A1 (identifier: P50752-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-26: EDWSEEEED → AVE

Show »
Length:295
Mass (Da):34,976
Checksum:i4B4C7ED7459289D5
GO
Isoform A2 (identifier: P50752-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-27: Missing.

Show »
Length:291
Mass (Da):34,547
Checksum:i9BDA2958F567B11F
GO
Isoform A3B (identifier: P50752-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-27: Missing.
     204-206: Missing.

Show »
Length:288
Mass (Da):34,220
Checksum:i002769E8DC4715B1
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P3Z7Q6P3Z7_MOUSE
Tnnt2 protein
Tnnt2
302Annotation score:
J3QQ13J3QQ13_MOUSE
Troponin T, cardiac muscle
Tnnt2
302Annotation score:
K3W4R7K3W4R7_MOUSE
Troponin T, cardiac muscle
Tnnt2
301Annotation score:
K3W4R6K3W4R6_MOUSE
Troponin T, cardiac muscle
Tnnt2
295Annotation score:
A0A087WRX3A0A087WRX3_MOUSE
Troponin T, cardiac muscle
Tnnt2
206Annotation score:
A0A087WQP1A0A087WQP1_MOUSE
Troponin T, cardiac muscle
Tnnt2
114Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00664918 – 27Missing in isoform A2 and isoform A3B. Curated10
Alternative sequenceiVSP_00791318 – 26EDWSEEEED → AVE in isoform A1. Curated9
Alternative sequenceiVSP_006650204 – 206Missing in isoform A3B. Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47549 mRNA Translation: AAA85345.1
L47550 mRNA Translation: AAA85346.1
L47551 mRNA Translation: AAA85347.1
L47552 mRNA Translation: AAA85348.1
L47553 mRNA Translation: AAA85349.1
L47570 Genomic DNA Translation: AAA85350.1
L47599 mRNA Translation: AAA85351.1
L47600 mRNA Translation: AAA85352.1
CCDSiCCDS48376.1 [P50752-4]
CCDS48377.1 [P50752-1]
CCDS48378.1 [P50752-3]
RefSeqiNP_001123648.1, NM_001130176.1 [P50752-1]
NP_001123650.1, NM_001130178.2 [P50752-4]
NP_001123651.4, NM_001130179.2
NP_001123652.1, NM_001130180.2 [P50752-3]
NP_001123653.4, NM_001130181.2
NP_035749.1, NM_011619.3 [P50752-2]
XP_006529456.1, XM_006529393.3 [P50752-1]
XP_006529457.1, XM_006529394.3 [P50752-1]
XP_006529458.1, XM_006529395.3 [P50752-3]
UniGeneiMm.247470

Genome annotation databases

EnsembliENSMUST00000027671; ENSMUSP00000027671; ENSMUSG00000026414 [P50752-3]
ENSMUST00000112087; ENSMUSP00000107717; ENSMUSG00000026414 [P50752-1]
ENSMUST00000178854; ENSMUSP00000136265; ENSMUSG00000026414 [P50752-4]
ENSMUST00000189355; ENSMUSP00000139919; ENSMUSG00000026414 [P50752-3]
ENSMUST00000189732; ENSMUSP00000139669; ENSMUSG00000026414 [P50752-4]
GeneIDi21956
KEGGimmu:21956
UCSCiuc007ctu.3 mouse [P50752-4]
uc007ctw.3 mouse [P50752-3]
uc007ctx.3 mouse [P50752-2]
uc011wso.2 mouse [P50752-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47549 mRNA Translation: AAA85345.1
L47550 mRNA Translation: AAA85346.1
L47551 mRNA Translation: AAA85347.1
L47552 mRNA Translation: AAA85348.1
L47553 mRNA Translation: AAA85349.1
L47570 Genomic DNA Translation: AAA85350.1
L47599 mRNA Translation: AAA85351.1
L47600 mRNA Translation: AAA85352.1
CCDSiCCDS48376.1 [P50752-4]
CCDS48377.1 [P50752-1]
CCDS48378.1 [P50752-3]
RefSeqiNP_001123648.1, NM_001130176.1 [P50752-1]
NP_001123650.1, NM_001130178.2 [P50752-4]
NP_001123651.4, NM_001130179.2
NP_001123652.1, NM_001130180.2 [P50752-3]
NP_001123653.4, NM_001130181.2
NP_035749.1, NM_011619.3 [P50752-2]
XP_006529456.1, XM_006529393.3 [P50752-1]
XP_006529457.1, XM_006529394.3 [P50752-1]
XP_006529458.1, XM_006529395.3 [P50752-3]
UniGeneiMm.247470

3D structure databases

ProteinModelPortaliP50752
SMRiP50752
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-16 Cardiac Troponin complex
IntActiP50752, 4 interactors
MINTiP50752
STRINGi10090.ENSMUSP00000137093

PTM databases

iPTMnetiP50752
PhosphoSitePlusiP50752

Proteomic databases

PaxDbiP50752
PRIDEiP50752

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027671; ENSMUSP00000027671; ENSMUSG00000026414 [P50752-3]
ENSMUST00000112087; ENSMUSP00000107717; ENSMUSG00000026414 [P50752-1]
ENSMUST00000178854; ENSMUSP00000136265; ENSMUSG00000026414 [P50752-4]
ENSMUST00000189355; ENSMUSP00000139919; ENSMUSG00000026414 [P50752-3]
ENSMUST00000189732; ENSMUSP00000139669; ENSMUSG00000026414 [P50752-4]
GeneIDi21956
KEGGimmu:21956
UCSCiuc007ctu.3 mouse [P50752-4]
uc007ctw.3 mouse [P50752-3]
uc007ctx.3 mouse [P50752-2]
uc011wso.2 mouse [P50752-1]

Organism-specific databases

CTDi7139
MGIiMGI:104597 Tnnt2

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00390000013611
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiP50752
KOiK12045

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRSiTnnt2 mouse
PMAP-CutDBiP50752
PROiPR:P50752
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026414 Expressed in 221 organ(s), highest expression level in cardiac ventricle
CleanExiMM_TNNT2
ExpressionAtlasiP50752 baseline and differential
GenevisibleiP50752 MM

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNNT2_MOUSE
AccessioniPrimary (citable) accession number: P50752
Secondary accession number(s): Q64360, Q64377
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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