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Protein

Ras association domain-containing protein 2

Gene

RASSF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.3 Publications

GO - Molecular functioni

  • protein kinase activity Source: MGI

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 2
Gene namesi
Name:RASSF2
Synonyms:CENP-341 Publication, KIAA0168
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101265.15
HGNCiHGNC:9883 RASSF2
MIMi609492 gene
neXtProtiNX_P50749

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi9770
OpenTargetsiENSG00000101265
PharmGKBiPA34246

Polymorphism and mutation databases

BioMutaiRASSF2
DMDMi1723118

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971721 – 326Ras association domain-containing protein 2Add BLAST326

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP50749
MaxQBiP50749
PaxDbiP50749
PeptideAtlasiP50749
PRIDEiP50749
ProteomicsDBi56262

PTM databases

iPTMnetiP50749
PhosphoSitePlusiP50749

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.1 Publication

Gene expression databases

BgeeiENSG00000101265 Expressed in 224 organ(s), highest expression level in subthalamic nucleus
CleanExiHS_RASSF2
GenevisibleiP50749 HS

Organism-specific databases

HPAiHPA051200

Interactioni

Subunit structurei

Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115115, 29 interactors
IntActiP50749, 28 interactors
MINTiP50749
STRINGi9606.ENSP00000368684

Structurei

3D structure databases

ProteinModelPortaliP50749
SMRiP50749
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 264Ras-associatingPROSITE-ProRule annotationAdd BLAST89
Domaini272 – 319SARAHPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiKOG4239 Eukaryota
ENOG410Y2N1 LUCA
GeneTreeiENSGT00510000046426
HOGENOMiHOG000231738
HOVERGENiHBG054302
InParanoidiP50749
KOiK09851
OMAiTVLRLMI
OrthoDBiEOG091G0BOA
PhylomeDBiP50749
TreeFamiTF319243

Family and domain databases

InterProiView protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033618 RASSF2
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF14 PTHR22738:SF14, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P50749-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDYSHQTSLV PCGQDKYISK NELLLHLKTY NLYYEGQNLQ LRHREEEDEF
60 70 80 90 100
IVEGLLNISW GLRRPIRLQM QDDNERIRPP PSSSSWHSGC NLGAQGTTLK
110 120 130 140 150
PLTVPKVQIS EVDAPPEGDQ MPSSTDSRGL KPLQEDTPQL MRTRSDVGVR
160 170 180 190 200
RRGNVRTPSD QRRIRRHRFS INGHFYNHKT SVFTPAYGSV TNVRINSTMT
210 220 230 240 250
TPQVLKLLLN KFKIENSAEE FALYVVHTSG EKQKLKATDY PLIARILQGP
260 270 280 290 300
CEQISKVFLM EKDQVEEVTY DVAQYIKFEM PVLKSFIQKL QEEEDREVKK
310 320
LMRKYTVLRL MIRQRLEEIA ETPATI
Length:326
Mass (Da):37,790
Last modified:October 1, 1996 - v1
Checksum:iC29D16376904249E
GO
Isoform 2 (identifier: P50749-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: MDYSHQTSLV...HSGCNLGAQG → MSLNWNLTLQNEWPLLEFSK
     231-326: EKQKLKATDY...EEIAETPATI → GPM

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,879
Checksum:i77E624A912E98685
GO

Sequence cautioni

The sequence BAA11485 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166R → C in BAD96370 (Ref. 4) Curated1
Sequence conflicti256K → Q in BAD96370 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035825144R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs758816530Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558511 – 96MDYSH…LGAQG → MSLNWNLTLQNEWPLLEFSK in isoform 2. 2 PublicationsAdd BLAST96
Alternative sequenceiVSP_055852231 – 326EKQKL…TPATI → GPM in isoform 2. 2 PublicationsAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154470 mRNA Translation: AAN59975.1
AY154471 mRNA Translation: AAN59976.1
AY154472 mRNA Translation: AAN59977.1
D79990 mRNA Translation: BAA11485.2 Different initiation.
AK291458 mRNA Translation: BAF84147.1
AK222650 mRNA Translation: BAD96370.1
CR627436 mRNA Translation: CAH10522.1
AL133354 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10445.1
BC110385 mRNA Translation: AAI10386.1
BC117118 mRNA Translation: AAI17119.1
BC117120 mRNA Translation: AAI17121.1
CCDSiCCDS13083.1 [P50749-1]
RefSeqiNP_055552.1, NM_014737.2 [P50749-1]
NP_739580.1, NM_170774.1 [P50749-1]
XP_005260952.1, XM_005260895.3 [P50749-1]
XP_016883639.1, XM_017028150.1 [P50749-1]
XP_016883640.1, XM_017028151.1 [P50749-1]
XP_016883641.1, XM_017028152.1 [P50749-1]
XP_016883642.1, XM_017028153.1 [P50749-1]
UniGeneiHs.631504

Genome annotation databases

EnsembliENST00000379376; ENSP00000368684; ENSG00000101265 [P50749-1]
ENST00000379400; ENSP00000368710; ENSG00000101265 [P50749-1]
GeneIDi9770
KEGGihsa:9770
UCSCiuc002wld.4 human [P50749-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154470 mRNA Translation: AAN59975.1
AY154471 mRNA Translation: AAN59976.1
AY154472 mRNA Translation: AAN59977.1
D79990 mRNA Translation: BAA11485.2 Different initiation.
AK291458 mRNA Translation: BAF84147.1
AK222650 mRNA Translation: BAD96370.1
CR627436 mRNA Translation: CAH10522.1
AL133354 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10445.1
BC110385 mRNA Translation: AAI10386.1
BC117118 mRNA Translation: AAI17119.1
BC117120 mRNA Translation: AAI17121.1
CCDSiCCDS13083.1 [P50749-1]
RefSeqiNP_055552.1, NM_014737.2 [P50749-1]
NP_739580.1, NM_170774.1 [P50749-1]
XP_005260952.1, XM_005260895.3 [P50749-1]
XP_016883639.1, XM_017028150.1 [P50749-1]
XP_016883640.1, XM_017028151.1 [P50749-1]
XP_016883641.1, XM_017028152.1 [P50749-1]
XP_016883642.1, XM_017028153.1 [P50749-1]
UniGeneiHs.631504

3D structure databases

ProteinModelPortaliP50749
SMRiP50749
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115115, 29 interactors
IntActiP50749, 28 interactors
MINTiP50749
STRINGi9606.ENSP00000368684

PTM databases

iPTMnetiP50749
PhosphoSitePlusiP50749

Polymorphism and mutation databases

BioMutaiRASSF2
DMDMi1723118

Proteomic databases

EPDiP50749
MaxQBiP50749
PaxDbiP50749
PeptideAtlasiP50749
PRIDEiP50749
ProteomicsDBi56262

Protocols and materials databases

DNASUi9770
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379376; ENSP00000368684; ENSG00000101265 [P50749-1]
ENST00000379400; ENSP00000368710; ENSG00000101265 [P50749-1]
GeneIDi9770
KEGGihsa:9770
UCSCiuc002wld.4 human [P50749-1]

Organism-specific databases

CTDi9770
DisGeNETi9770
EuPathDBiHostDB:ENSG00000101265.15
GeneCardsiRASSF2
HGNCiHGNC:9883 RASSF2
HPAiHPA051200
MIMi609492 gene
neXtProtiNX_P50749
OpenTargetsiENSG00000101265
PharmGKBiPA34246
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4239 Eukaryota
ENOG410Y2N1 LUCA
GeneTreeiENSGT00510000046426
HOGENOMiHOG000231738
HOVERGENiHBG054302
InParanoidiP50749
KOiK09851
OMAiTVLRLMI
OrthoDBiEOG091G0BOA
PhylomeDBiP50749
TreeFamiTF319243

Miscellaneous databases

ChiTaRSiRASSF2 human
GeneWikiiRASSF2
GenomeRNAii9770
PROiPR:P50749
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101265 Expressed in 224 organ(s), highest expression level in subthalamic nucleus
CleanExiHS_RASSF2
GenevisibleiP50749 HS

Family and domain databases

InterProiView protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033618 RASSF2
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF14 PTHR22738:SF14, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASF2_HUMAN
AccessioniPrimary (citable) accession number: P50749
Secondary accession number(s): A6NIX9
, A8K5Z3, Q17S06, Q53HD0, Q6AHZ2, Q8IZA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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