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Entry version 160 (26 Feb. 2020)
Sequence version 1 (01 Oct. 1996)
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Protein

Ras association domain-containing protein 2

Gene

RASSF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras association domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASSF2
Synonyms:CENP-341 Publication, KIAA0168
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9883 RASSF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609492 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
9770

Open Targets

More...
OpenTargetsi
ENSG00000101265

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34246

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P50749 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASSF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1723118

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971721 – 326Ras association domain-containing protein 2Add BLAST326

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P50749

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P50749

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P50749

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50749

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50749

PeptideAtlas

More...
PeptideAtlasi
P50749

PRoteomics IDEntifications database

More...
PRIDEi
P50749

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56262 [P50749-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50749

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P50749

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101265 Expressed in subthalamic nucleus and 223 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P50749 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051200

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with activated KRAS in a GTP-dependent manner.

Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115115, 30 interactors

Protein interaction database and analysis system

More...
IntActi
P50749, 31 interactors

Molecular INTeraction database

More...
MINTi
P50749

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368710

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P50749 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P50749

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini176 – 264Ras-associatingPROSITE-ProRule annotationAdd BLAST89
Domaini272 – 319SARAHPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4239 Eukaryota
ENOG410Y2N1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018893_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50749

KEGG Orthology (KO)

More...
KOi
K09851

Identification of Orthologs from Complete Genome Data

More...
OMAi
YNYLRCI

Database of Orthologous Groups

More...
OrthoDBi
1043350at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P50749

TreeFam database of animal gene trees

More...
TreeFami
TF319243

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033618 RASSF2
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR22738 PTHR22738, 1 hit
PTHR22738:SF14 PTHR22738:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00314 RA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P50749-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDYSHQTSLV PCGQDKYISK NELLLHLKTY NLYYEGQNLQ LRHREEEDEF
60 70 80 90 100
IVEGLLNISW GLRRPIRLQM QDDNERIRPP PSSSSWHSGC NLGAQGTTLK
110 120 130 140 150
PLTVPKVQIS EVDAPPEGDQ MPSSTDSRGL KPLQEDTPQL MRTRSDVGVR
160 170 180 190 200
RRGNVRTPSD QRRIRRHRFS INGHFYNHKT SVFTPAYGSV TNVRINSTMT
210 220 230 240 250
TPQVLKLLLN KFKIENSAEE FALYVVHTSG EKQKLKATDY PLIARILQGP
260 270 280 290 300
CEQISKVFLM EKDQVEEVTY DVAQYIKFEM PVLKSFIQKL QEEEDREVKK
310 320
LMRKYTVLRL MIRQRLEEIA ETPATI
Length:326
Mass (Da):37,790
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC29D16376904249E
GO
Isoform 2 (identifier: P50749-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: MDYSHQTSLV...HSGCNLGAQG → MSLNWNLTLQNEWPLLEFSK
     231-326: EKQKLKATDY...EEIAETPATI → GPM

Show »
Length:157
Mass (Da):17,879
Checksum:i77E624A912E98685
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11485 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti166R → C in BAD96370 (Ref. 4) Curated1
Sequence conflicti256K → Q in BAD96370 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035825144R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs758816530Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0558511 – 96MDYSH…LGAQG → MSLNWNLTLQNEWPLLEFSK in isoform 2. 2 PublicationsAdd BLAST96
Alternative sequenceiVSP_055852231 – 326EKQKL…TPATI → GPM in isoform 2. 2 PublicationsAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY154470 mRNA Translation: AAN59975.1
AY154471 mRNA Translation: AAN59976.1
AY154472 mRNA Translation: AAN59977.1
D79990 mRNA Translation: BAA11485.2 Different initiation.
AK291458 mRNA Translation: BAF84147.1
AK222650 mRNA Translation: BAD96370.1
CR627436 mRNA Translation: CAH10522.1
AL133354 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10445.1
BC110385 mRNA Translation: AAI10386.1
BC117118 mRNA Translation: AAI17119.1
BC117120 mRNA Translation: AAI17121.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13083.1 [P50749-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055552.1, NM_014737.2 [P50749-1]
NP_739580.1, NM_170774.1 [P50749-1]
XP_005260952.1, XM_005260895.3 [P50749-1]
XP_016883639.1, XM_017028150.1 [P50749-1]
XP_016883640.1, XM_017028151.1 [P50749-1]
XP_016883641.1, XM_017028152.1 [P50749-1]
XP_016883642.1, XM_017028153.1 [P50749-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379376; ENSP00000368684; ENSG00000101265 [P50749-1]
ENST00000379400; ENSP00000368710; ENSG00000101265 [P50749-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9770

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9770

UCSC genome browser

More...
UCSCi
uc002wld.4 human [P50749-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY154470 mRNA Translation: AAN59975.1
AY154471 mRNA Translation: AAN59976.1
AY154472 mRNA Translation: AAN59977.1
D79990 mRNA Translation: BAA11485.2 Different initiation.
AK291458 mRNA Translation: BAF84147.1
AK222650 mRNA Translation: BAD96370.1
CR627436 mRNA Translation: CAH10522.1
AL133354 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10445.1
BC110385 mRNA Translation: AAI10386.1
BC117118 mRNA Translation: AAI17119.1
BC117120 mRNA Translation: AAI17121.1
CCDSiCCDS13083.1 [P50749-1]
RefSeqiNP_055552.1, NM_014737.2 [P50749-1]
NP_739580.1, NM_170774.1 [P50749-1]
XP_005260952.1, XM_005260895.3 [P50749-1]
XP_016883639.1, XM_017028150.1 [P50749-1]
XP_016883640.1, XM_017028151.1 [P50749-1]
XP_016883641.1, XM_017028152.1 [P50749-1]
XP_016883642.1, XM_017028153.1 [P50749-1]

3D structure databases

SMRiP50749
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115115, 30 interactors
IntActiP50749, 31 interactors
MINTiP50749
STRINGi9606.ENSP00000368710

PTM databases

iPTMnetiP50749
PhosphoSitePlusiP50749

Polymorphism and mutation databases

BioMutaiRASSF2
DMDMi1723118

Proteomic databases

EPDiP50749
jPOSTiP50749
MassIVEiP50749
MaxQBiP50749
PaxDbiP50749
PeptideAtlasiP50749
PRIDEiP50749
ProteomicsDBi56262 [P50749-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9770

Genome annotation databases

EnsembliENST00000379376; ENSP00000368684; ENSG00000101265 [P50749-1]
ENST00000379400; ENSP00000368710; ENSG00000101265 [P50749-1]
GeneIDi9770
KEGGihsa:9770
UCSCiuc002wld.4 human [P50749-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9770
DisGeNETi9770

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RASSF2
HGNCiHGNC:9883 RASSF2
HPAiHPA051200
MIMi609492 gene
neXtProtiNX_P50749
OpenTargetsiENSG00000101265
PharmGKBiPA34246

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4239 Eukaryota
ENOG410Y2N1 LUCA
GeneTreeiENSGT00940000158546
HOGENOMiCLU_018893_1_0_1
InParanoidiP50749
KOiK09851
OMAiYNYLRCI
OrthoDBi1043350at2759
PhylomeDBiP50749
TreeFamiTF319243

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RASSF2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RASSF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9770
PharosiP50749 Tbio

Protein Ontology

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PROi
PR:P50749
RNActiP50749 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000101265 Expressed in subthalamic nucleus and 223 other tissues
GenevisibleiP50749 HS

Family and domain databases

InterProiView protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033618 RASSF2
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF14 PTHR22738:SF14, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50749
Secondary accession number(s): A6NIX9
, A8K5Z3, Q17S06, Q53HD0, Q6AHZ2, Q8IZA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 26, 2020
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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