UniProtKB - P50690 (COX2_PANTR)
Protein
Cytochrome c oxidase subunit 2
Gene
MT-CO2
Organism
Pan troglodytes (Chimpanzee)
Status
Functioni
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Cofactori
Cu cationNote: Binds a copper A center.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 161 | Copper ABy similarity | 1 | |
Metal bindingi | 196 | Copper ABy similarity | 1 | |
Metal bindingi | 200 | Copper ABy similarity | 1 | |
Metal bindingi | 204 | Copper ABy similarity | 1 |
GO - Molecular functioni
- copper ion binding Source: InterPro
- cytochrome-c oxidase activity Source: Ensembl
GO - Biological processi
- ATP synthesis coupled electron transport Source: GO_Central
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | Copper, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 2Alternative name(s): Cytochrome c oxidase polypeptide II |
Gene namesi | Name:MT-CO2 Synonyms:COII, COX2, COXII, MTCO2 |
Encoded oni | Mitochondrion |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:11715 MT-CO2 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respiratory chain complex IV Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | Mitochondrial intermembraneSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 48 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 49 – 62 | Mitochondrial matrixSequence analysisAdd BLAST | 14 | |
Transmembranei | 63 – 82 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 83 – 227 | Mitochondrial intermembraneSequence analysisAdd BLAST | 145 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183648 | 1 – 227 | Cytochrome c oxidase subunit 2Add BLAST | 227 |
Proteomic databases
PaxDbi | P50690 |
Expressioni
Gene expression databases
Bgeei | ENSPTRG00000042660 Expressed in 6 organ(s), highest expression level in prefrontal cortex |
Interactioni
Subunit structurei
Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16.By similarity
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000061402 |
Structurei
3D structure databases
ProteinModelPortali | P50690 |
SMRi | P50690 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome c oxidase subunit 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4767 Eukaryota COG1622 LUCA |
GeneTreei | ENSGT00390000017410 |
HOGENOMi | HOG000264988 |
HOVERGENi | HBG012727 |
InParanoidi | P50690 |
KOi | K02261 |
OMAi | WSYEYTD |
OrthoDBi | 1432833at2759 |
Family and domain databases
CDDi | cd13912 CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR002429 CcO_II-like_C IPR034210 CcO_II_C IPR001505 Copper_CuA IPR008972 Cupredoxin IPR014222 Cyt_c_oxidase_su2 IPR011759 Cyt_c_oxidase_su2_TM_dom IPR036257 Cyt_c_oxidase_su2_TM_sf |
Pfami | View protein in Pfam PF00116 COX2, 1 hit PF02790 COX2_TM, 1 hit |
SUPFAMi | SSF49503 SSF49503, 1 hit SSF81464 SSF81464, 1 hit |
TIGRFAMsi | TIGR02866 CoxB, 1 hit |
PROSITEi | View protein in PROSITE PS00078 COX2, 1 hit PS50857 COX2_CUA, 1 hit PS50999 COX2_TM, 1 hit |
i Sequence
Sequence statusi: Complete.
P50690-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHAAQVGLQ DATSPIMEEL IIFHDHALMI IFLICFLVLY ALFLTLTTKL
60 70 80 90 100
TNTSISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSFTIKSI
110 120 130 140 150
GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPVEAPV
160 170 180 190 200
RMMITSQDVL HSWAVPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC
210 220
GANHSFMPIV LELIPLKIFE MGPVFTL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 225 | F → L in AAA20850 (PubMed:8277847).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12697 Genomic DNA Translation: AAA20850.1 U12705 Genomic DNA Translation: AAA61414.1 U12706 Genomic DNA Translation: AAA61415.1 D38113 Genomic DNA Translation: BAA07299.1 |
PIRi | I61893 T14146 |
RefSeqi | NP_008189.1, NC_001643.1 |
Genome annotation databases
Ensembli | ENSPTRT00000076397; ENSPTRP00000061402; ENSPTRG00000042660 |
GeneIDi | 807864 |
KEGGi | ptr:807864 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12697 Genomic DNA Translation: AAA20850.1 U12705 Genomic DNA Translation: AAA61414.1 U12706 Genomic DNA Translation: AAA61415.1 D38113 Genomic DNA Translation: BAA07299.1 |
PIRi | I61893 T14146 |
RefSeqi | NP_008189.1, NC_001643.1 |
3D structure databases
ProteinModelPortali | P50690 |
SMRi | P50690 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000061402 |
Proteomic databases
PaxDbi | P50690 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSPTRT00000076397; ENSPTRP00000061402; ENSPTRG00000042660 |
GeneIDi | 807864 |
KEGGi | ptr:807864 |
Organism-specific databases
CTDi | 4513 |
VGNCi | VGNC:11715 MT-CO2 |
Phylogenomic databases
eggNOGi | KOG4767 Eukaryota COG1622 LUCA |
GeneTreei | ENSGT00390000017410 |
HOGENOMi | HOG000264988 |
HOVERGENi | HBG012727 |
InParanoidi | P50690 |
KOi | K02261 |
OMAi | WSYEYTD |
OrthoDBi | 1432833at2759 |
Gene expression databases
Bgeei | ENSPTRG00000042660 Expressed in 6 organ(s), highest expression level in prefrontal cortex |
Family and domain databases
CDDi | cd13912 CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR002429 CcO_II-like_C IPR034210 CcO_II_C IPR001505 Copper_CuA IPR008972 Cupredoxin IPR014222 Cyt_c_oxidase_su2 IPR011759 Cyt_c_oxidase_su2_TM_dom IPR036257 Cyt_c_oxidase_su2_TM_sf |
Pfami | View protein in Pfam PF00116 COX2, 1 hit PF02790 COX2_TM, 1 hit |
SUPFAMi | SSF49503 SSF49503, 1 hit SSF81464 SSF81464, 1 hit |
TIGRFAMsi | TIGR02866 CoxB, 1 hit |
PROSITEi | View protein in PROSITE PS00078 COX2, 1 hit PS50857 COX2_CUA, 1 hit PS50999 COX2_TM, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | COX2_PANTR | |
Accessioni | P50690Primary (citable) accession number: P50690 Secondary accession number(s): Q37759 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 13, 2019 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families