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Protein

Potassium voltage-gated channel subfamily A member 5

Gene

KCNA5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:7556635). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:7556635). Homotetrameric channels display rapid activation and slow inactivation (PubMed:7556635). May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 5
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.5
Gene namesi
Name:KCNA5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 231CytoplasmicBy similarityAdd BLAST231
Transmembranei232 – 253Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini254 – 308ExtracellularBy similarityAdd BLAST55
Transmembranei309 – 330Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini331 – 341CytoplasmicBy similarityAdd BLAST11
Transmembranei342 – 362Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini363 – 380ExtracellularBy similarityAdd BLAST18
Transmembranei381 – 401Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini402 – 416CytoplasmicBy similarityAdd BLAST15
Transmembranei417 – 438Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini439 – 452ExtracellularBy similarityAdd BLAST14
Intramembranei453 – 464Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei465 – 472By similarity8
Transmembranei480 – 508Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini509 – 598CytoplasmicBy similarityAdd BLAST90

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539881 – 598Potassium voltage-gated channel subfamily A member 5Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Lipidationi331S-palmitoyl cysteineSequence analysis1
Cross-linki521Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

PRIDEiP50638

Expressioni

Gene expression databases

BgeeiENSOCUG00000000674

Interactioni

Subunit structurei

Homotetramer and heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with KCNAB1 (By similarity). Interacts with UBE2I (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017544

Structurei

3D structure databases

ProteinModelPortaliP50638
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni403 – 416S4-S5 linkerBy similarityAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi465 – 470Selectivity filterBy similarity6
Motifi596 – 598PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi78 – 83Poly-Glu6
Compositional biasi367 – 372Poly-Gly6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity
The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. Interacts with UBE2I.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231015
HOVERGENiHBG052230
InParanoidiP50638
KOiK04878
OMAiLPRNEFQ
OrthoDBiEOG091G10NU
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004052 K_chnl_volt-dep_Kv1.5
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01512 KV15CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

P50638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIALGPLEN GGAMTIRGGG EETAGCSQAA PTAGLGDGSQ EPAPRGRGCS
60 70 80 90 100
ARRGAEPGER PLPPQPPELP QSRRSPLEEE EGEGDPGLSV AEEQTLGAGA
110 120 130 140 150
LHHQRVLINI SGLRFETQLG TLAQFPNTLL GDPAKRLRYF DPLRNEYFFD
160 170 180 190 200
RNRPSFDGIL YYYQSGGRLR RPVNVSLDVF ADEIRFYQLG DEAMERFRED
210 220 230 240 250
EGFIKDEEKP LPRNEFQRQV WLIFEYPESS GSARAIAIVS VLVILISIIT
260 270 280 290 300
FCLETLPEFK DERELLRHPP VPHQPPAAPA LGANGSGAVA PASGSTVAPL
310 320 330 340 350
LPRTLADPFF IVETTCVIWF TFELLVRFFA CPSKAEFSRN IMNIIDIVAI
360 370 380 390 400
FPYFITLGTE LAEQQPGGGG GGQNGQQAMS LAILRVIRLV RVFRIFKLSR
410 420 430 440 450
HSKGLQILGK TLQASMRELG LLIFFLFIGV ILFSSAVYFA EADNQGTHFS
460 470 480 490 500
SIPDAFWWAV VTMTTVGYGD MRPITVGGKI VGSLCAIAGV LTIALPVPVI
510 520 530 540 550
VSNFNYFYHR ETDHEEQAAL KEEPGSQSRG TSLDAGGQRK ASWSKASLCK
560 570 580 590
AGGSLETADS VRRGSCLLEK YNLKAKSNVD LRRSLYALCL DTSRETDL
Length:598
Mass (Da):65,476
Last modified:October 1, 1996 - v1
Checksum:iB06D235AC7A8E1F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45025 mRNA Translation: BAA08082.1
AF056943 mRNA Translation: AAC13312.1
AF149787 mRNA Translation: AAD56772.1
PIRiS66669
RefSeqiNP_001075505.1, NM_001082036.1
UniGeneiOcu.2386

Genome annotation databases

EnsembliENSOCUT00000000674; ENSOCUP00000017544; ENSOCUG00000000674
GeneIDi100008684
KEGGiocu:100008684

Similar proteinsi

Entry informationi

Entry nameiKCNA5_RABIT
AccessioniPrimary (citable) accession number: P50638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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