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UniProtKB - P50637 (TSPO_MOUSE)

Entry version 152 (23 Feb 2022)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Translocator protein

Gene

Tspo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity).

Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060).

By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processLipid transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-196108, Pregnenolone biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translocator protein
Alternative name(s):
Mitochondrial benzodiazepine receptor
PKBS
Peripheral-type benzodiazepine receptor
Short name:
PBR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tspo
Synonyms:Bzrp, Mbr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:88222, Tspo

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000041736

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 5Mitochondrial intermembrane1 Publication5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26Helical; Name=1Add BLAST21
Topological domaini27 – 46Cytoplasmic1 PublicationAdd BLAST20
Transmembranei47 – 67Helical; Name=2Add BLAST21
Topological domaini68 – 79Mitochondrial intermembrane1 PublicationAdd BLAST12
Transmembranei80 – 100Helical; Name=3Add BLAST21
Topological domaini101 – 105Cytoplasmic1 Publication5
Transmembranei106 – 126Helical; Name=4Add BLAST21
Topological domaini127 – 134Mitochondrial intermembrane1 Publication8
Transmembranei135 – 155Helical; Name=5Add BLAST21
Topological domaini156 – 169Cytoplasmic1 PublicationAdd BLAST14

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No obvious phenotype. Mice are viable and fertile and present only very minor changes in gonadal and adrenal steroid hormone production. testis-specific gene disruption (PubMed:24174323) does not affect testosterone production, gametogenesis and male fertility.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi147A → T: No effect. 1 Publication1
Mutagenesisi153Y → S: Abolishes cholesterol transport. 1 Publication1
Mutagenesisi156R → L: Abolishes cholesterol transport. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2149

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001909981 – 169Translocator proteinAdd BLAST169

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P50637

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P50637

PeptideAtlas

More...PeptideAtlasi		P50637

PRoteomics IDEntifications database

More...PRIDEi		P50637

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		297667

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P50637

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P50637

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P50637

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver (at protein level). Ubiquitous.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By dimethyl sulfoxide and diazepam.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000041736, Expressed in adrenal gland and 280 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P50637, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P50637, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TSPOAP1.

Interacts with MOST-1. May interact with STAR.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		198410, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000037039

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P50637

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P50637, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P50637

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P50637

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TspO/BZRP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3797, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_091805_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P50637

Identification of Orthologs from Complete Genome Data

More...OMAi		GLNLIWM

Database of Orthologous Groups

More...OrthoDBi		1592225at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P50637

TreeFam database of animal gene trees

More...TreeFami		TF342852

Family and domain databases

Conserved Domains Database

More...CDDi		cd15904, TSPO_MBR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1260.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030164, TSPO
IPR038330, TspO/MBR-related_sf
IPR004307, TspO_MBR

The PANTHER Classification System

More...PANTHERi		PTHR10057, PTHR10057, 1 hit
PTHR10057:SF5, PTHR10057:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03073, TspO_MBR, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005859, PBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P50637-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPESWVPAVG LTLVPSLGGF MGAYFVRGEG LRWYASLQKP SWHPPRWTLA 
        60         70         80         90        100
PIWGTLYSAM GYGSYIVWKE LGGFTEDAMV PLGLYTGQLA LNWAWPPIFF 
       110        120        130        140        150
GARQMGWALA DLLLVSGVAT ATTLAWHRVS PPAARLLYPY LAWLAFATVL 
       160 
NYYVWRDNSG RRGGSRLPE
Length:169
Mass (Da):18,841
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EF93420C3842A85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LIU9A0A140LIU9_MOUSE
Peripheral-type benzodiazepine rece...
Tspo
102Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36S → G in AAH02055 (PubMed:15489334).Curated1
Sequence conflicti54G → A in BAA04749 (PubMed:8125973).Curated1
Sequence conflicti168P → A in BAA04749 (PubMed:8125973).Curated1
Sequence conflicti168P → A in AAH02055 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L17306 mRNA Translation: AAA20127.1
D21207 mRNA Translation: BAA04749.1
AY079441 Genomic DNA Translation: AAL87529.1
AY079442 Genomic DNA Translation: AAL87530.1
AK149743 mRNA Translation: BAE29056.1
AK150516 mRNA Translation: BAE29628.1
AK151421 mRNA Translation: BAE30386.1
AK151569 mRNA Translation: BAE30511.1
AK151824 mRNA Translation: BAE30721.1
AK152082 mRNA Translation: BAE30932.1
AK152827 mRNA Translation: BAE31528.1
AK153159 mRNA Translation: BAE31769.1
AK153273 mRNA Translation: BAE31860.1
AK156489 mRNA Translation: BAE33730.1
AK165450 mRNA Translation: BAE38192.1
AK165822 mRNA Translation: BAE38396.1
AK166125 mRNA Translation: BAE38585.1
AK172384 mRNA Translation: BAE42976.1
CH466550 Genomic DNA Translation: EDL04468.1
BC002055 mRNA Translation: AAH02055.1
U12419 Genomic DNA Translation: AAA83253.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27705.1

Protein sequence database of the Protein Information Resource

More...PIRi		A53405
I57953

NCBI Reference Sequences

More...RefSeqi		NP_033905.3, NM_009775.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000047419; ENSMUSP00000037039; ENSMUSG00000041736

Database of genes from NCBI RefSeq genomes

More...GeneIDi		12257

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:12257

UCSC genome browser

More...UCSCi		uc007xbg.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17306 mRNA Translation: AAA20127.1
D21207 mRNA Translation: BAA04749.1
AY079441 Genomic DNA Translation: AAL87529.1
AY079442 Genomic DNA Translation: AAL87530.1
AK149743 mRNA Translation: BAE29056.1
AK150516 mRNA Translation: BAE29628.1
AK151421 mRNA Translation: BAE30386.1
AK151569 mRNA Translation: BAE30511.1
AK151824 mRNA Translation: BAE30721.1
AK152082 mRNA Translation: BAE30932.1
AK152827 mRNA Translation: BAE31528.1
AK153159 mRNA Translation: BAE31769.1
AK153273 mRNA Translation: BAE31860.1
AK156489 mRNA Translation: BAE33730.1
AK165450 mRNA Translation: BAE38192.1
AK165822 mRNA Translation: BAE38396.1
AK166125 mRNA Translation: BAE38585.1
AK172384 mRNA Translation: BAE42976.1
CH466550 Genomic DNA Translation: EDL04468.1
BC002055 mRNA Translation: AAH02055.1
U12419 Genomic DNA Translation: AAA83253.1
CCDSiCCDS27705.1
PIRiA53405
I57953
RefSeqiNP_033905.3, NM_009775.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MGYNMR-A1-167[»]
2N02NMR-A1-169[»]
BMRBiP50637
SMRiP50637
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi198410, 2 interactors
STRINGi10090.ENSMUSP00000037039

Chemistry databases

BindingDBiP50637
ChEMBLiCHEMBL2149

PTM databases

iPTMnetiP50637
PhosphoSitePlusiP50637

Proteomic databases

jPOSTiP50637
PaxDbiP50637
PeptideAtlasiP50637
PRIDEiP50637
ProteomicsDBi297667
TopDownProteomicsiP50637

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27480, 289 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		12257

Genome annotation databases

EnsembliENSMUST00000047419; ENSMUSP00000037039; ENSMUSG00000041736
GeneIDi12257
KEGGimmu:12257
UCSCiuc007xbg.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		706
MGIiMGI:88222, Tspo
VEuPathDBiHostDB:ENSMUSG00000041736

Phylogenomic databases

eggNOGiKOG3797, Eukaryota
GeneTreeiENSGT00390000012980
HOGENOMiCLU_091805_2_1_1
InParanoidiP50637
OMAiGLNLIWM
OrthoDBi1592225at2759
PhylomeDBiP50637
TreeFamiTF342852

Enzyme and pathway databases

ReactomeiR-MMU-196108, Pregnenolone biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		12257, 5 hits in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tspo, mouse

Protein Ontology

More...PROi		PR:P50637
RNActiP50637, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000041736, Expressed in adrenal gland and 280 other tissues
ExpressionAtlasiP50637, baseline and differential
GenevisibleiP50637, MM

Family and domain databases

CDDicd15904, TSPO_MBR, 1 hit
Gene3Di1.20.1260.100, 1 hit
InterProiView protein in InterPro
IPR030164, TSPO
IPR038330, TspO/MBR-related_sf
IPR004307, TspO_MBR
PANTHERiPTHR10057, PTHR10057, 1 hit
PTHR10057:SF5, PTHR10057:SF5, 1 hit
PfamiView protein in Pfam
PF03073, TspO_MBR, 1 hit
PIRSFiPIRSF005859, PBR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSPO_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50637
Secondary accession number(s): Q541E3
, Q62118, Q6LCZ0, Q99M32
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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