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Entry version 170 (12 Aug 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Protein Tob1

Gene

TOB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P50616

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P50616

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P50616

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Tob1
Alternative name(s):
Transducer of erbB-2 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOB1
Synonyms:TOB, TROB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000141232.4

Human Gene Nomenclature Database

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HGNCi
HGNC:11979, TOB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605523, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P50616

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi45Y → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi55F → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi65D → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi93W → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1
Mutagenesisi95D → A: Impairs interaction with CNOT7 and CNOT8. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10140

Open Targets

More...
OpenTargetsi
ENSG00000141232

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36663

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P50616, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TOB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1729989

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001438121 – 345Protein Tob1Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei204PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser and Thr residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P50616

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P50616

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P50616

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P50616

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P50616

PeptideAtlas

More...
PeptideAtlasi
P50616

PRoteomics IDEntifications database

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PRIDEi
P50616

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56259

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P50616

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P50616

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141232, Expressed in mucosa of paranasal sinus and 251 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P50616, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000141232, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ERBB2 (PubMed:8632892).

Interacts with CNOT7 (PubMed:19276069, PubMed:21336257, PubMed:23236473).

Interacts with CPEB3 (via C-terminal RNA-binding region); recruits CNOT7 to CPEB3 to form a ternary complex required for mRNA deadenylation and decay (PubMed:21336257).

Interacts with CNOT8 (PubMed:23236473).

Interacts with CPEB4 (PubMed:21336257).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115443, 39 interactors

Protein interaction database and analysis system

More...
IntActi
P50616, 37 interactors

Molecular INTeraction database

More...
MINTi
P50616

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000427695

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P50616, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P50616

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P50616

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni82 – 92Important for nuclear localizationBy similarityAdd BLAST11
Regioni161 – 218Required for interaction with CPEB31 PublicationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi22 – 39Bipartite nuclear localization signalBy similarityAdd BLAST18
Motifi226 – 234Nuclear export signalBy similarity9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi237 – 245Poly-Gln9
Compositional biasi249 – 256Poly-Pro8
Compositional biasi257 – 262Poly-Gln6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4006, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154208

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034687_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P50616

KEGG Orthology (KO)

More...
KOi
K14443

Identification of Orthologs from Complete Genome Data

More...
OMAi
MKNSGRG

Database of Orthologous Groups

More...
OrthoDBi
1439942at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P50616

TreeFam database of animal gene trees

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TreeFami
TF105274

Family and domain databases

Database of protein disorder

More...
DisProti
DP00794

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1120, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID00453

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002087, Anti_prolifrtn
IPR036054, BTG-like_sf
IPR015677, Tob1
IPR015676, Tob1/2

The PANTHER Classification System

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PANTHERi
PTHR17537, PTHR17537, 1 hit
PTHR17537:SF6, PTHR17537:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07742, BTG, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00310, ANTIPRLFBTG1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00099, btg1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160696, SSF160696, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00960, BTG_1, 1 hit
PS01203, BTG_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P50616-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY
60 70 80 90 100
KGSGFRCIHI GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS
110 120 130 140 150
YQIGEKGPVK VLYVDDNNEN GCELDKEIKN SFNPEAQVFM PISDPASSVS
160 170 180 190 200
SSPSPPFGHS AAVSPTFMPR STQPLTFTTA TFAATKFGST KMKNSGRSNK
210 220 230 240 250
VARTSPINLG LNVNDLLKQK AISSSMHSLY GLGLGSQQQP QQQQQPAQPP
260 270 280 290 300
PPPPPPQQQQ QQKTSALSPN AKEFIFPNMQ GQGSSTNGMF PGDSPLNLSP
310 320 330 340
LQYSNAFDVF AAYGGLNEKS FVDGLNFSLN NMQYSNQQFQ PVMAN
Length:345
Mass (Da):38,155
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C8AC51B49E1E69F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037840319K → R. Corresponds to variant dbSNP:rs3316Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D38305 mRNA Translation: BAA07423.1
CR536487 mRNA Translation: CAG38726.1
CR541686 mRNA Translation: CAG46487.1
BT019380 mRNA Translation: AAV38187.1
BT019381 mRNA Translation: AAV38188.1
AK313904 mRNA Translation: BAG36627.1
CH471109 Genomic DNA Translation: EAW94577.1
CH471109 Genomic DNA Translation: EAW94578.1
BC031406 mRNA Translation: AAH31406.1
BC070493 mRNA Translation: AAH70493.1
BC098415 mRNA Translation: AAH98415.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11576.1

NCBI Reference Sequences

More...
RefSeqi
NP_001230806.1, NM_001243877.1
NP_001230814.1, NM_001243885.1
NP_005740.1, NM_005749.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000268957; ENSP00000268957; ENSG00000141232
ENST00000499247; ENSP00000427695; ENSG00000141232

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10140

UCSC genome browser

More...
UCSCi
uc002isw.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38305 mRNA Translation: BAA07423.1
CR536487 mRNA Translation: CAG38726.1
CR541686 mRNA Translation: CAG46487.1
BT019380 mRNA Translation: AAV38187.1
BT019381 mRNA Translation: AAV38188.1
AK313904 mRNA Translation: BAG36627.1
CH471109 Genomic DNA Translation: EAW94577.1
CH471109 Genomic DNA Translation: EAW94578.1
BC031406 mRNA Translation: AAH31406.1
BC070493 mRNA Translation: AAH70493.1
BC098415 mRNA Translation: AAH98415.1
CCDSiCCDS11576.1
RefSeqiNP_001230806.1, NM_001243877.1
NP_001230814.1, NM_001243885.1
NP_005740.1, NM_005749.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D5RX-ray2.50B1-115[»]
2Z15X-ray2.30A/B/C/D1-117[»]
5CI8X-ray2.33A1-345[»]
5CI9X-ray2.30A1-345[»]
SMRiP50616
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115443, 39 interactors
IntActiP50616, 37 interactors
MINTiP50616
STRINGi9606.ENSP00000427695

PTM databases

iPTMnetiP50616
PhosphoSitePlusiP50616

Polymorphism and mutation databases

BioMutaiTOB1
DMDMi1729989

Proteomic databases

EPDiP50616
jPOSTiP50616
MassIVEiP50616
MaxQBiP50616
PaxDbiP50616
PeptideAtlasiP50616
PRIDEiP50616
ProteomicsDBi56259

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4398, 267 antibodies

The DNASU plasmid repository

More...
DNASUi
10140

Genome annotation databases

EnsembliENST00000268957; ENSP00000268957; ENSG00000141232
ENST00000499247; ENSP00000427695; ENSG00000141232
GeneIDi10140
KEGGihsa:10140
UCSCiuc002isw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10140
DisGeNETi10140
EuPathDBiHostDB:ENSG00000141232.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TOB1
HGNCiHGNC:11979, TOB1
HPAiENSG00000141232, Low tissue specificity
MIMi605523, gene
neXtProtiNX_P50616
OpenTargetsiENSG00000141232
PharmGKBiPA36663

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4006, Eukaryota
GeneTreeiENSGT00940000154208
HOGENOMiCLU_034687_0_0_1
InParanoidiP50616
KOiK14443
OMAiMKNSGRG
OrthoDBi1439942at2759
PhylomeDBiP50616
TreeFamiTF105274

Enzyme and pathway databases

PathwayCommonsiP50616
SignaLinkiP50616
SIGNORiP50616

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10140, 3 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TOB1, human
EvolutionaryTraceiP50616

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TOB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10140
PharosiP50616, Tbio

Protein Ontology

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PROi
PR:P50616
RNActiP50616, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000141232, Expressed in mucosa of paranasal sinus and 251 other tissues
GenevisibleiP50616, HS

Family and domain databases

DisProtiDP00794
Gene3Di1.20.120.1120, 1 hit
IDEALiIID00453
InterProiView protein in InterPro
IPR002087, Anti_prolifrtn
IPR036054, BTG-like_sf
IPR015677, Tob1
IPR015676, Tob1/2
PANTHERiPTHR17537, PTHR17537, 1 hit
PTHR17537:SF6, PTHR17537:SF6, 1 hit
PfamiView protein in Pfam
PF07742, BTG, 1 hit
PRINTSiPR00310, ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099, btg1, 1 hit
SUPFAMiSSF160696, SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960, BTG_1, 1 hit
PS01203, BTG_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P50616
Secondary accession number(s): B2R9T0, D3DTY3, Q4KMQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 12, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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